Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07154654Recruiting
Long-term study of mexiletine in young children with myotonic disorders
This study follows children under 6 years old with genetic myotonic disorders who are taking or may take mexiletine. It helps doctors understand how well the medicine works and if it is safe over time.
Clermont-FerrandAges Up to 6 years - NCT04460872RecruitingPhase 2
Testosterone plus walking training to support bones and muscles
This Phase 2 study tests whether testosterone therapy combined with walking training can improve bone and muscle health after a spinal cord injury. It aims to help men with low testosterone and walking problems by improving strength, body composition, and related health markers.
Gainesville, FloridaAges 18 years+ - NCT07146074Recruiting
Early radiation vs. observation for high-risk bone metastases
This trial tests whether giving radiation therapy early to high-risk but pain-free or nearly pain-free bone metastases can prevent future problems, compared to waiting and monitoring them. It is for people whose cancer has spread to multiple bones and who have certain risky features in those spots.
Wilrijk, AntwerpAges 18 years+ - NCT07147530RecruitingPhase 4
Powered exercise device for walking in hip disease
This study tests a new powered exercise device designed to help people with hip problems walk better. It may be a good option if you have hip osteoarthritis or avascular necrosis and can do some standing and walking with support.
Yongin-si, Gyeonggi-do, South KoreaAges 19 years+ - NCT07154719RecruitingPhase 4
Testing a weight loss drug's effect on muscle and bone
This study tests a medication called tirzepatide (a type of GLP-1 drug) to see how it affects muscle and bone health during weight loss. It is for people with obesity who are not menopausal and do not have diabetes or bone disease.
Baton Rouge, LouisianaAges 18–50 - NCT07148466Recruiting
Shoulder and arm exercises for stroke with shoulder blade issues
This trial tests if specific shoulder and arm exercises can improve movement and walking in people who had a stroke and have shoulder blade problems. It may help if you have some muscle tightness but can still follow instructions.
Islamabad, Punjab ProvinceAges 40–65 - NCT07149792RecruitingPhase 4
Personalized treatment study for psoriasis and joint health
This study tests whether a personalized treatment plan can help people with psoriasis and psoriatic arthritis, and also looks at how these conditions affect the heart. The goal is to find better ways to treat you and protect your heart health.
Taichung, TaiwanAges 18–75 - NCT07153302Recruiting
Can almonds help heal broken leg bones?
This study tests if eating almonds can help femur (thigh) or tibia (shin) fractures heal faster. If you have a fresh leg break and are 18 to 55, you may be able to join.
KarachiAges 18–55 - NCT07147491RecruitingPhase 4
Study of a powered exercise device after hip surgery
This study tests a powered exercise device to help people walk better after hip surgery. It's for adults who are medically stable and can sit and stand with support.
Yongin-si, Gyeonggi-do, South KoreaAges 19 years+ - NCT07150650Enrolling by invitation
Biomarkers for ICU weakness in children on breathing machines
This study looks for early warning signs (biomarkers) of muscle weakness that can happen in children who need a breathing machine for more than a few days. If your child is in the PICU on a ventilator for at least 3 days, this team may be able to test for clues that help prevent or manage this weakness.
Shanghai, Shanghai MunicipalityAges 1 month–18 years - NCT07147543RecruitingPhase 4
Study of a powered exercise device for walking problems
This trial tests if a motorized leg exercise machine can help improve walking and balance in adults with gait disorders. It may be suitable for people who have difficulty walking but can stand with or without help.
Yongin-si, Gyeonggi-do, South KoreaAges 19 years+ - NCT07153276RecruitingPhase 4
Laser vs estrogen cream for vaginal dryness in Sjögren's
This trial compares two treatments for vaginal dryness in women with Sjögren's disease: a CO2 laser procedure versus a topical estrogen cream called promestriene. The goal is to see which option works better to relieve dryness and discomfort.
São Paulo, São PauloAges 30–65 - NCT07150143Recruiting
Massage and exercises for chronic neck pain
This trial tests whether adding a special type of massage (connective tissue massage) and other physical therapies to standard neck stabilization exercises helps people with long-term neck pain feel better.
Ataşehir, IstanbulAges 18–65 - NCT07146685RecruitingPhase 4
Testing different strengths of numbing medicine for shoulder replacement
This study compares two different strengths of local anesthetic used in a nerve block for shoulder replacement surgery. The goal is to see if one strength helps reduce pain that can come back as the block wears off.
Charlottesville, VirginiaAges 18 years+ - NCT07150637Enrolling by invitation
Predicting muscle weakness in children on a breathing machine
This study aims to predict muscle weakness that can happen to children on breathing machines in the ICU. It could help doctors start treatments earlier to prevent this weakness.
Shanghai, Shanghai MunicipalityAges 1 month–18 years - NCT07146776Recruiting
Injectable PRF and bone graft for gum disease bone defects
This trial tests a treatment for deep gum disease pockets using a combination of your own blood components (injectable platelet-rich fibrin) and a bone graft material. It aims to help regenerate bone lost to periodontitis.
Istanbul, ÜsküdarAges 18–65 - NCT07154550Recruiting
Comparing Mastisol bandage for clubfoot casting
This study compares two types of sticky bandage (Mastisol vs. standard) used during Ponseti casting for babies with clubfoot in both feet. It aims to see which one works better for keeping the casts on and preventing skin problems.
Madison, WisconsinAges birth–3 months - NCT07151066Enrolling by invitation
Foot shape and plantar fasciitis study
This study looks at how foot measurements relate to plantar fasciitis, a common cause of heel pain. It may help understand why some people get this condition.
Istanbul, BeykozAges 18–65 - NCT07149129Enrolling by invitation
Biofeedback therapy after stroke
This trial tests if a therapy called biofeedback can help people with arm stiffness after a stroke. It may help you gain better control and movement in your affected arm.
Curitiba, ParanáAges 20–60 - NCT07150364Recruiting
Step exercise vs. wobble board for older adults' balance
This study compares two types of exercise—square stepping and wobble board—to see which is better at improving balance in people aged 60 and over. If you are an older adult who can walk on your own and have moderate balance ability, you may be able to take part.
Lahore, Punjab ProvinceAges 60 years+ - NCT07150000Recruiting
Rheumatic disease research study for patients and healthy volunteers
This study is for people with certain rheumatic conditions (like arthritis, lupus, or vasculitis) and for healthy volunteers. It aims to learn more about these diseases and improve how they are treated.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07145957Recruiting
Pre-surgery exercise program for better shoulder rotation after replacement
This study tests if a special exercise program before shoulder replacement surgery improves how well you can rotate your arm inward after the operation. Participants do exercises for 6 weeks before surgery and are followed for 2 years.
Gainesville, FloridaAges 40–80 - NCT06311058Recruiting
Protein supplement study for ACL surgery recovery
This trial tests whether a protein supplement can help you recover strength and muscle after ACL surgery. You will continue your standard rehab and take a protein drink daily for several weeks.
Houston, TexasAges 16–40 - NCT06958341Recruiting
Brain and nerve disease registry with optional fluid collection
This study collects extra fluid from a spinal tap to learn more about brain and nerve diseases. It may help find better treatments in the future.
Berlin, State of BerlinAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.