Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT06004817Recruiting
Dermatomyositis severity in children and adults
This study looks at how severe dermatomyositis is in people who develop it as children or adults. It aims to better understand the disease and may help guide future treatments.
NancyAges Any age - NCT06005246Recruiting
Munich ME/CFS Study for Young People
This study is tracking children, teens, and young adults (up to age 25) who developed ME/CFS after an infection. It aims to better understand the condition in younger people.
Munich, BavariaAges Up to 25 years - NCT06007456Recruiting
Study of Juvenile Idiopathic Arthritis in Children
This study looks at children with arthritis to better understand their condition using clinical exams, lab tests, and ultrasounds. It may help doctors learn more about different types of juvenile arthritis.
TriesteAges Up to 18 years - NCT06009159Recruiting
Vagus nerve stimulation for fibromyalgia pain
This trial tests if a non-invasive device that stimulates the vagus nerve can help reduce pain in people with fibromyalgia. It is a potential treatment option for those who have had persistent pain for at least three months.
Boston, MassachusettsAges 18–80 - NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT06011889RecruitingPhase 2/Phase 3
Etanercept for treating SAPHO syndrome
This study tests if etanercept, a biologic drug that targets inflammation, safely reduces pain and disease activity in people with SAPHO syndrome.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06012097RecruitingPhase 4
Aromatherapy gel for De Quervain's wrist pain
This trial tests if a gel made with essential oils can help reduce pain from De Quervain's disease, a painful wrist condition. If it works, it could be a natural option to relieve discomfort.
StrasbourgAges 18–75 - NCT06017960Recruiting
Dry needling for leg stiffness after stroke
This study checks if a treatment called dry needling (putting thin needles into tight muscles) can help reduce leg stiffness after a stroke. It uses ultrasound and muscle activity readings to see how well it works.
Madrid, MadridAges 18 years+ - NCT06019182Recruiting
MEHMO syndrome: Understanding the condition over time
This study follows people with or at risk for MEHMO syndrome over time to better understand the condition and identify biological markers. It may include both affected individuals and their family members to see how the condition runs in families.
Bethesda, MarylandAges 1 week–100 years - NCT06023719Recruiting
Study of Disc Care device for preventing repeat lumbar disc herniation
This trial tests a new device (Disc Care) implanted during surgery to repair a herniated disc in the lower back. It is designed to reduce the chance of the hernia coming back.
L'Hospitalet de Llobregat, BarcelonaAges 18–75 - NCT06024460Recruiting
Non-Drug vs Drug Therapy for Chronic Slipped Disc
This study compares non-medication treatments (like acupuncture and manual therapy) with standard pain medication for people with a slipped disc in the lower back that has lasted at least a month. It tests whether natural therapies can work just as well or better than drugs.
Seoul, Gangnam-GuAges 19–69 - NCT06024785Recruiting
Vertebropexy trial for lumbar spine surgery
This trial compares a new surgical technique called vertebropexy to standard fusion surgery for people with lower back problems like spinal canal narrowing or slipped vertebrae. The goal is to see if vertebropexy works as well or better with less recovery time.
ZurichAges 18 years+ - NCT06024850Recruiting
Predicting good results after knee ligament repair
This study looks at people who had surgery to repair several torn knee ligaments. It aims to find out what factors lead to better results after the surgery.
Saint-EtienneAges 18 years+ - NCT06027580Recruiting
Garment to Improve Trunk Control in Infants Age 6-18 Months
This study tests a special compression garment (SPIO Core-MAX) to help babies aged 6-18 months with abnormal muscle tone improve their trunk control. The garment is worn like a tight shirt or vest to provide support.
Milwaukee, WisconsinAges 6 months–1.5 years - NCT06028646Recruiting
Using CT scans to diagnose airway collapse in children
This trial tests if a special CT scan can help diagnose tracheomalacia (a condition where the airway collapses during breathing) in children who have already had a bronchoscopy.
New York, New YorkAges birth–18 years - NCT06030570Recruiting
Spine rehab program: how well does it work?
This trial tests a spine rehabilitation program that combines different types of care (like physical therapy and counseling) for adults with spine problems that haven't gotten better on their own. It aims to see if this program helps improve function and quality of life.
LeuvenAges 18 years+ - NCT06034262RecruitingPhase 2
Umbilical cord tissue for finger joint arthritis
This trial tests a special, sterilized piece of umbilical cord tissue (amniotic membrane) that is placed in the finger joint during surgery to help reduce pain and improve function for people with arthritis in the middle joint of the finger. It's for patients who haven't gotten better with standard medical treatments and are considering surgery.
BesançonAges 18–75 - NCT06034405Recruiting
Checking spine tissue for heart amyloidosis signs
This trial is looking at leftover tissue from past spine surgeries to see if it contains signs of a heart condition called TTR amyloidosis. It may help find people who have this condition early.
Beverly Hills, CaliforniaAges 50 years+ - NCT06037811RecruitingPhase 2
Adalimumab for Immunotherapy-Related Arthritis
This study tests if a medicine called adalimumab (a type of TNF blocker) can help with new joint pain and swelling (inflammatory arthritis) caused by some immunotherapy drugs. It aims to reduce the need for high-dose steroids and improve symptoms.
London, OntarioAges 18 years+ - NCT06040203Recruiting
Platelet-Rich Plasma for Chronic Tennis Elbow
This study compares two types of platelet-rich plasma (PRP) injections—one with a lot of white blood cells and one without—against a placebo injection to see which works best for persistent tennis elbow. If other treatments haven't helped your elbow pain for at least 3 months, this trial might be a good option.
BolognaAges 18–65 - NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+ - NCT06040957Recruiting
Bone marrow vs fat cells for knee osteoarthritis treatment
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
BolognaAges 40–75 - NCT06041282Recruiting
Comparing treatments for early frozen shoulder
This study compares two ways to treat early frozen shoulder (also called adhesive capsulitis): manual release by a therapist versus a home exercise program. It is for people who have had symptoms for 3 months or less and have not had shoulder surgery before.
Hangzhou, ZhejiangAges 40–80 - NCT06041789RecruitingPhase 2
Testing donepezil for bone health in memory loss
This study tests whether a memory medication called donepezil (Aricept) can help strengthen bones in people with memory problems. If you have mild cognitive impairment or dementia and are not already on a similar medication, you may be able to join.
Durham, North CarolinaAges 50 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.