Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06974253Recruiting
Guided Implant Placement for Full Upper Jaw
This study tests a technology that uses a computer-guided system (dynamic navigation) to place multiple implants in the upper jaw of people who have no teeth left. It aims to improve placement accuracy and make the surgery safer.
Ho Chi Minh CityAges 18 years+ - NCT06975709Recruiting
Link between jaw pain and sleep problems
This study looks at how jaw joint disorders (TMJ) are related to sleep issues like insomnia, sleep apnea, or restless legs. If you have a sleep disorder, you may help researchers understand the connection.
Milan, ItalyAges 18 years+ - NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80 - NCT06976671RecruitingPhase 2
Testing bevacizumab injection for frozen shoulder
This trial tests an injection of bevacizumab into the shoulder joint for people with frozen shoulder (adhesive capsulitis). The goal is to see if it can reduce pain and stiffness.
North Ryde, New South WalesAges 18 years+ - NCT07080814Recruiting
Balance exercises after knee replacement
This study tests whether special balance exercises on a platform can help people who have recently had a knee replacement walk better and feel steadier.
Ankara, YenimahalleAges 18 years+ - NCT07078877Recruiting
Laser therapy for knee osteoarthritis: a new option?
This study tests whether low-level laser therapy (a painless, non-surgical treatment using light) can reduce knee pain and improve knee function, cartilage health, and muscle strength in people with moderate knee osteoarthritis. It may be an option if you haven't had recent knee injections or physical therapy.
Ankara, YENIMAHALLEAges 50 years+ - NCT07080450Recruiting
Safety and performance of a rotator cuff repair device
This study collects information on how well a specific suture anchor system works for rotator cuff repair and how safe it is. It may help doctors understand its benefits for patients recovering from this shoulder surgery.
QuimperAges 18 years+ - NCT07085104RecruitingPhase 1
Study of ALLO-329 for lupus, myositis, or scleroderma
This trial tests a new one-time cell therapy (ALLO-329) made from donor cells to target and calm overactive immune cells in people with lupus, myositis, or scleroderma that hasn't improved with usual medications. It aims to see if this treatment is safe and can help reduce disease activity.
Phoenix, ArizonaAges 18–74 - NCT06975254Recruiting
Smartphone nursing support for hip fracture recovery
This study tests a special nursing program that uses a smartphone app to support people recovering from a hip fracture caused by fragile bones. It aims to improve recovery and prevent future fractures.
Yiwu, ZhejiangAges 18 years+ - NCT06975202Recruiting
Trunk Muscle Activation in Pain-Free Adults
This study checks how reliably trunk muscle activity can be measured in healthy people. It helps researchers understand normal muscle function without pain.
GhentAges 18–65 - NCT07080528Enrolling by invitationPhase 4
Measuring muscle relaxant duration in infants during skull surgery
This trial tests how long a muscle relaxant (rocuronium) works in infants aged 3-12 months having skull surgery for a condition called craniosynostosis. The results may help doctors give safer and more effective doses.
Debrecen, Hajdú-BiharAges 3 months–1 year - NCT07085676RecruitingPhase 1
CAR-T cell therapy for autoimmune diseases that resist treatment
This study tests a new cell therapy called CAR-T (using your own immune cells) for people with severe autoimmune diseases like lupus, scleroderma, or myositis that have not improved with standard treatments. The goal is to see if it can safely reduce disease activity.
JerusalemAges 18–80 - NCT07078890Recruiting
Bone graft with implant removal for better reimplant success
This study tests whether adding a bone graft at the same time a failed dental implant is removed helps the new implant placed later in the same spot heal better. It may be a good option if you need a failed implant replaced and want to improve bone support for the new one.
Wuhan, HubeiAges 18–90 - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07079254Recruiting
Meniscus repair vs. partial removal for bucket-handle tears
This trial compares two surgeries for a specific type of meniscus tear that blocks knee straightening: repairing the torn meniscus versus removing the damaged part. The goal is to see which leads to better recovery.
Hässleholm, Skåne CountyAges 15 years+ - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07083557Recruiting
Validation study for lab tests on hormones and metabolism
This study checks if lab tests used for hormone, heart, metabolism, and muscle disorders are accurate and reliable. You might be eligible if you are an adult with a body mass index between 16 and 60.
Columbia, MissouriAges 18–100 - NCT07079865Recruiting
Nerve stimulation for pain after spine fracture
This trial tests a 60-day nerve stimulation treatment to reduce pain and improve mobility after a recent spine fracture caused by osteoporosis. It may help patients who still have significant pain despite over-the-counter pain relievers.
Avenel, New JerseyAges 18 years+ - NCT07077304Recruiting
Cardiac imaging study for inflammatory heart diseases
This study uses heart scans (MRI or nuclear imaging) to better understand inflammatory heart conditions. If you have a suspected inflammatory heart disease and are already scheduled for one of these scans, you may be able to join.
ParisAges 18 years+ - NCT07076602Recruiting
Walking and energy use in children with leg amputations
This study looks at how children with a leg amputation walk and how much energy they use when walking. It aims to better understand gait and energy use to improve care and prosthetic fitting.
BerckAges 7–17 - NCT07081880Recruiting
Understanding SAPHO syndrome: genetics and immune response
This study looks at the causes of SAPHO syndrome—a rare condition that affects the skin, bones, and joints. Researchers want to understand how genes and the immune system play a role, which may help improve future treatments.
ParisAges 18 years+ - NCT07082972RecruitingPhase 4
Study of splint therapy and Botox for jaw muscle pain
This trial compares two treatments—a dental splint and Botox injections into the jaw muscle (masseter)—to see which one better relaxes head and neck muscles in people with myofascial pain syndrome. It may help you if you have facial pain related to muscle tension.
Istanbul, VeznecilerAges 18–55 - NCT07080710Recruiting
Same-day dental implants for front teeth
This trial tests placing a dental implant right after removing a failing front tooth. It aims to see if this immediate approach works well in the upper jaw area between the canine teeth.
Ghent, East FlandersAges 20 years+ - NCT07081620Recruiting
Freezing rib nerves before chest-wall repair
This study tests how the timing of a nerve-freezing procedure (cryoneurolysis) in the ribs affects recovery from pectus excavatum surgery. It may help reduce pain after the operation.
Bergamo, BGAges 12–40
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.