Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75 - NCT06053255Recruiting
Testing a new device for low back pain from sacroiliitis
This trial tests a device called the Neurolyser XR to treat chronic low back pain caused by inflammation of the sacroiliac joint. It may help if you've had pain for over a year and other treatments haven't worked.
Charlottesville, VirginiaAges 18 years+ - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06056921RecruitingPhase 1
CAR T-cell therapy for hard-to-treat autoimmune diseases
This trial tests a new treatment using your own immune cells (CAR T-cells) targeting a protein called CD19 to control severe autoimmune diseases like lupus, Sjogren's, scleroderma, dermatomyositis, or vasculitis. The goal is to see if it's safe and can improve symptoms when other treatments haven't worked.
Taiyuan, ShanxiAges 18 years+ - NCT06057428Recruiting
Activity levels in seniors having spine surgery
This study is tracking how active people are before and after surgery for lumbar spinal stenosis (a common cause of back and leg pain in older adults). It aims to see if activity monitoring can help improve recovery.
KøgeAges 65 years+ - NCT06059599Recruiting
Testing a new way to explain surgery to patients
This trial compares a new multimedia consent process to the standard one for people having planned spine or prostate surgery. The goal is to see if patients understand the risks and benefits better.
BolognaAges 18 years+ - NCT06065852Recruiting
National registry for rare kidney diseases
This study creates a registry to collect health information from people with rare kidney diseases. It aims to improve understanding and future treatments by tracking patient experiences.
Bristol, South WestAges Any age - NCT06069479Recruiting
Surgery vs. watching: study for kids with trigonocephaly
This study compares two approaches for children with trigonocephaly (a condition where the skull has a triangular shape): surgery or careful monitoring without surgery. The goal is to understand which approach leads to better clinical results, emotional well-being, and lower costs.
Rotterdam, ROTTERDAMAges Up to 8 years - NCT06070233Recruiting
Radiosurgery for spasticity after stroke or injury
This trial tests a non-invasive radiation treatment (radiosurgery) to reduce severe muscle stiffness (spasticity) that hasn't improved with other treatments. It may help people with spasticity caused by stroke, spinal cord injury, or cerebral palsy.
Winter Park, FloridaAges 16 years+ - NCT06070558Recruiting
Study of normal and abnormal jaw joint motion using real-time MRI
This study uses real-time MRI to take detailed images of your jaw joint (the temporomandibular joint) to better understand its normal and painful variations. It may help if you have jaw pain or clicking, but you don't need to have a problem to join.
NancyAges 18 years+ - NCT06072495Recruiting
Understanding Why Some Cleft Palate Repair Patients Have Ongoing Speech Issues
This study uses special MRI scans to help doctors understand why some children who had cleft palate surgery still have difficulty with certain speech sounds. By looking at how the muscles in the back of the throat work, researchers hope to improve future surgical techniques and speech outcomes.
AmiensAges 7–12 - NCT06072768RecruitingPhase 2
Testing ways to safely lower steroid doses in rheumatoid arthritis
This study compares two different schedules for reducing prednisone (a steroid) in people with rheumatoid arthritis who are also taking another standard arthritis medicine. The goal is to find the safest and most effective way to taper off steroids without causing a flare-up.
Ann Arbor, MichiganAges 18 years+ - NCT06072976Recruiting
How feeding affects gut health in babies with bowel conditions
This study looks at whether breast milk or formula helps babies with certain bowel problems heal faster and reach full feeds sooner. It compares how different milk affects the bacteria in a baby's gut.
Seattle, WashingtonAges birth–55 years - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT06075693Recruiting
Spinal fluid markers for myotonic dystrophy
This study looks for markers in spinal fluid that could help doctors better understand myotonic dystrophy type 1 (DM1). It involves a spinal tap and MRI scan. It may help people with DM1 and healthy volunteers learn more about the condition.
Boston, MassachusettsAges 18 years+ - NCT06076083Recruiting
Microbiome study in Korean patients with ankylosing spondylitis
This study looks at the bacteria living in your body (the microbiome) in people with ankylosing spondylitis and their close family members. Researchers hope to better understand how these bacteria relate to the disease, which may lead to better treatments in the future.
Seoul, Kyungheedae-ro 23Ages 19–60 - NCT06075862Recruiting
Balance in patients with lumbar spinal stenosis
This study looks at balance problems in older adults with lumbar spinal stenosis, a condition that narrows the spinal canal and can cause pain or trouble walking. It may help doctors understand how surgery affects balance and daily life.
KøgeAges 65 years+ - NCT06077942Recruiting
FX shoulder replacement study
This study looks at how well FX shoulder replacement devices work for people who received them between 2018 and 2023. It helps doctors learn more about the outcomes of these implants.
Gilbert, ArizonaAges Any age - NCT06078865Recruiting
FX Shoulder Replacement Study
This study follows people who receive an FX shoulder replacement device to see how it works over time. It may be a good fit if you are planning this specific surgery with your doctor.
Gilbert, ArizonaAges Any age - NCT06079398RecruitingPhase 2
Weekly injection for infants with achondroplasia
This trial tests a new weekly injection called TransCon CNP for infants with achondroplasia (the most common form of dwarfism). The goal is to see if it can help children grow better than a placebo (a shot with no medicine).
Saint Paul, MinnesotaAges birth–2 years - NCT06080347Recruiting
Anti-inflammatory diet for knee osteoarthritis
This study tests whether an anti-inflammatory diet can help with knee osteoarthritis. If you have OA in one knee and are open to changing your eating habits, you may be able to join.
San Diego, CaliforniaAges 18 years+ - NCT06080633Recruiting
Facial prediction tech for people with no teeth
This study tests a new facial prediction technology that helps create better-fitting dentures for people with no natural teeth. It may improve how your dentures look and feel.
Leuven, HeverleeAges 50–100
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.