Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07085676RecruitingPhase 1
CAR-T cell therapy for autoimmune diseases that resist treatment
This study tests a new cell therapy called CAR-T (using your own immune cells) for people with severe autoimmune diseases like lupus, scleroderma, or myositis that have not improved with standard treatments. The goal is to see if it can safely reduce disease activity.
JerusalemAges 18–80 - NCT07080528Enrolling by invitationPhase 4
Measuring muscle relaxant duration in infants during skull surgery
This trial tests how long a muscle relaxant (rocuronium) works in infants aged 3-12 months having skull surgery for a condition called craniosynostosis. The results may help doctors give safer and more effective doses.
Debrecen, Hajdú-BiharAges 3 months–1 year - NCT04609735Recruiting
Compare manual therapy, exercise, and ultrasound for golfer’s elbow
This study compares two treatment plans for golfer’s elbow—manual therapy plus exercise, and whether adding ultrasound helps more. It aims to reduce elbow and inner-forearm pain and improve how well you can use your arm.
Fort Wayne, IndianaAges 18–60 - NCT03968614Recruiting
Needling plus exercises for Achilles tendon pain
This trial studies whether electrical “deep needling” (a clinician inserts very thin needles and uses electricity) added to stretching and exercises can reduce Achilles tendon pain. It’s mainly for people with Achilles tendinopathy that started at least 3 months ago.
Columbia, South CarolinaAges 18 years+ - NCT06330350Recruiting
Talking about family planning for genetic skin conditions
This study interviews people with inherited skin conditions (genodermatoses) who want to have children, and the doctors who care for them. The goal is to learn how to better support family planning decisions, like counseling about genetics and pregnancy risks.
Maastricht, LimburgAges Any age - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT06979271Recruiting
Testing a new drug combo for tough rheumatoid arthritis
This trial tests whether combining Telitacicept and Tofacitinib can help people with rheumatoid arthritis that hasn't improved with at least two other advanced treatments. The goal is to see if these drugs work better together for hard-to-treat cases.
Hangzhou, ZhejiangAges 18–85 - NCT05982119Recruiting
Assessing muscle disease patients with activity monitors
This study assesses physical activity in people with different muscle diseases (like Duchenne, FSHD, and others) and in healthy volunteers. It helps doctors understand how these conditions affect daily movement and function.
LiègeAges 1–80 - NCT06316752Recruiting
Natural history study of sialidosis type I
This study follows people with sialidosis type I over time to understand how the condition progresses. Participants will have regular exams, blood draws, brain scans, and eye tests.
Taipei, TaipeiAges 12–80 - NCT06980597RecruitingPhase 1
Testing OL-108 for active autoimmune diseases
This trial tests an investigational drug called OL-108 for people with certain autoimmune diseases (lupus, myositis, scleroderma, or vasculitis) that have come back or not responded to standard treatments. The goal is to see if it's safe and if it can help control the disease.
BeijingAges 18–65 - NCT06298019RecruitingPhase 1
CAR T-cell therapy for tough dermatomyositis
This study tests a new immune therapy called CAR T-cells (KYV-101) for people with active, tough-to-treat dermatomyositis. It aims to see if the treatment is safe and can reduce muscle weakness and skin rash.
Palo Alto, CaliforniaAges 25–72 - NCT06316583Recruiting
Dry needling for painful periods study
This trial tests whether dry needling (a type of acupuncture) can help relieve primary dysmenorrhea (painful periods without another cause). It compares the effects on specific acupoints to see which works best.
Beijing, Beijing MunicipalityAges 18–30 - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT06654349Recruiting
Recovery after thumb surgery: a diary study
This study compares how quickly people recover after two types of thumb surgery for arthritis. You will keep a diary and do some simple check-ups to track your recovery.
Zoetermeer, South HollandAges 18 years+ - NCT06971016Recruiting
Mobilization and balance exercises for knee osteoarthritis
This study tests whether a special hands-on technique (Mulligan mobilization) combined with balance exercises can help people with knee osteoarthritis feel better and move easier. It's for people with mild to moderate knee OA who can walk without help.
Karachi, SindhAges 40 years+ - NCT07069426Recruiting
Protein and muscle loss during leg immobilization
This study tests how different amounts of dietary protein affect your muscles when your leg is temporarily immobilized in a brace. If you are a healthy, active adult, you might help researchers learn how to prevent muscle loss during periods of reduced activity.
Natick, MassachusettsAges 17–39 - NCT07075471Recruiting
MOVE: TGCT patient experience with vimseltinib
This study is collecting real-world data from people with TGCT who have been prescribed vimseltinib. It is not testing the drug itself — it simply tracks your experience to help doctors understand how the treatment works outside of a clinical trial.
Wilmington, North CarolinaAges 18 years+ - NCT07073014Enrolling by invitationPhase 3
Long-term continuation of a follow-up study for a children's genetic condition called something in the world of a person who is like a head or foot specialist? Probably? (shortest version? of? a? person? condition? that? is? so? far? less? than? 60?? (time? of? a? person? limited???)?
this study is a long-term extension of the main study for the drug which from Bio? bi? whatever? in the name? by?...????
Phoenix, ArizonaAges Any age - NCT06053255Recruiting
Testing a new device for low back pain from sacroiliitis
This trial tests a device called the Neurolyser XR to treat chronic low back pain caused by inflammation of the sacroiliac joint. It may help if you've had pain for over a year and other treatments haven't worked.
Charlottesville, VirginiaAges 18 years+ - NCT06985836Recruiting
Gentle therapy for frozen shoulder: comparing two approaches
This study compares two types of gentle, hands-on physical therapy (Mulligan mobilization with or without the Niel Asher technique) for treating frozen shoulder. It aims to find which approach reduces pain and improves movement better.
Multan Khurd, Punjab ProvinceAges 40–60 - NCT07065747Recruiting
Understanding inflammation in uveitis using advanced eye imaging
This study uses a special eye scan (OCT) to measure and classify inflammatory cells inside the eye. It aims to better understand different types of uveitis and improve diagnosis and treatment.
Portland, OregonAges 5–85 - NCT07070245Enrolling by invitation
Comparing two therapies for plantar fasciitis pain
This study compares two hands-on treatments for plantar fasciitis: a technique using tools to massage the tissue and a method that involves holding the foot in a specific position. It aims to see which better reduces heel pain and improves movement.
Port Said, Port Said GovernorateAges 30–50 - NCT07075276Recruiting
Comparing a new growth factor treatment to standard care for jaw joint pain
This study tests a new treatment for a common jaw joint problem called disc displacement. It compares a concentrated growth factor from your own blood to standard care to see which helps more with pain and jaw movement.
Damietta, New DamiettaAges 18–45
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.