Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT06120426Recruiting
Surgery types and radiation for spinal tumors that have spread
This study compares two types of spinal surgery combined with radiation for people whose cancer has spread to the spine in a limited way (no more than 5 spots). It aims to find which approach better controls pain, tumor growth, and spinal stability.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT06123286RecruitingEarly Phase 1
Tart cherry and omega-3s for joint pain from hormone therapy
This study tests whether taking tart cherry and omega-3 supplements can help reduce joint pain and stiffness caused by aromatase inhibitors (a common breast cancer treatment). If you have bothersome joint pain while on this hormone therapy, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06123481Recruiting
Bone marrow treatment for early hip bone loss
This trial tests whether injecting your own bone marrow into the hip can help heal early-stage osteonecrosis (bone death) before the bone collapses. It is for people who have not had prior hip surgery and do not have certain conditions like sickle cell disease.
Los Angeles, CaliforniaAges 18–90 - NCT06124196Recruiting
Wearable device study for Duchenne muscular dystrophy
This study uses a wearable device to track your blood sugar levels and heart rate patterns over time. It aims to understand how these are related to Duchenne muscular dystrophy (DMD) and may help improve care.
Nashville, TennesseeAges 10 years+ - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT06128746Recruiting
Brain stimulation for muscle tightness in children with cerebral palsy
This trial tests a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to see if it can reduce muscle tightness (spasticity) in the arm of children with cerebral palsy or hemiplegia caused by a brain injury. It is a randomized controlled trial, meaning some children will receive the active treatment and others a placebo, to find out if it really helps.
Hong Kong, Hong KongAges 7–18 - NCT06129110Recruiting
Weight loss and muscle fat study for adults aged 18-70
This study looks at how losing weight affects the fat that sits inside your muscles (called intermuscular fat). It might help people with overweight to better understand how weight loss can improve muscle health.
Aurora, ColoradoAges 18–70 - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT06129682Recruiting
Self-rehab at home after lumbar fusion (SAHARA)
This trial tests a self-guided rehab program you can do at home after lower back fusion surgery. It may help you recover strength and movement without needing frequent clinic visits.
Paris, Île-de-France RegionAges 18 years+ - NCT06129903Recruiting
Early psychiatric help for people with sarcoma
This study tests if getting a psychiatric consultation soon after a sarcoma diagnosis can improve mental health and quality of life. If you have a new sarcoma and need surgery at MSK, you may be able to join.
Basking Ridge, New JerseyAges 18 years+ - NCT06134908Recruiting
Preventing another fracture after first hip or spine break
This study aims to prevent another fracture in older adults who have just had their first hip or spine fracture from a minor fall. Participants will receive guidance to help strengthen bones and reduce future fracture risk.
ChangshaAges 50 years+ - NCT06135753Recruiting
Mind-Body Treatment for Fibromyalgia
This study tests a mind-body (psychosomatic) approach for people with fibromyalgia to see if it can help manage symptoms. It is not a medication trial, but a psychological treatment program.
Florence, Italia/FirenzeAges 18 years+ - NCT06136039Recruiting
Muscle loss and knee replacement recovery in older women
This study looks at how muscle loss (sarcopenia) affects recovery after total knee replacement in older women. If you join, you'll have some simple walking and strength tests to see how your muscles impact your surgical outcome.
SeoulAges 60 years+ - NCT06138639RecruitingPhase 1/Phase 2
Gene therapy SGT-003 for Duchenne muscular dystrophy
This trial tests a new gene therapy called SGT-003 for children with Duchenne muscular dystrophy. It aims to help the body produce a working version of dystrophin, the protein missing in Duchenne.
Little Rock, ArkansasAges birth–17 years - NCT06140927RecruitingPhase 3
Ketamine's effect on spinal monitoring during back surgery
This study tests if giving ketamine during certain back surgeries affects how well doctors can monitor your spinal nerves during the operation. It's for adults having a posterior spinal fusion.
San Francisco, CaliforniaAges 18–100 - NCT06142669Recruiting
Knee revision study using EVOLUTION parts
This study checks how well a specific knee replacement system works in people who need a revision knee surgery (replacing a previous implant). If you have had or will have this surgery with the EVOLUTION parts, researchers will follow you for 10 years to see how the implant performs.
Milan, Piazza C. Ferrari 1 20122 MilanAges 21 years+ - NCT06142929Recruiting
Nerve study in Dupuytren surgery
This study looks at tiny nerves in Dupuytren disease and whether removing them during surgery helps prevent the disease from coming back. It may help you understand if this surgical approach is right for you.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06142747Recruiting
Tracking blood flow in healthy and injured tendons
This study uses a special ultrasound to see how blood flows in tendons, comparing healthy people to those with overuse injuries. It may help doctors better understand and treat tendon problems.
CopenhagenAges 18–70 - NCT06143254Recruiting
Infant sign training for speech development
This trial tests whether teaching infants with cleft palate simple signs can help them communicate before they can speak. It may support their speech and language development.
Ghent, East FlandersAges 1–2 - NCT06143813Recruiting
Precision treatment for lumbar nerve pain with targeted block
This trial tests if a targeted nerve root injection can improve outcomes for people with persistent leg pain from a compressed nerve in the lower back, with the goal of tailoring surgery more precisely.
Aarhus CAges 18 years+ - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06146231Recruiting
Breast reconstruction with Motiva implants and fat grafting
This study tests a new breast reconstruction method using Motiva Flora implants and your own fat to rebuild the breast after a mastectomy. It is for women who need tissue expansion as part of their reconstruction and have completed cancer treatments at least one year earlier.
GhentAges 18 years+ - NCT06147414Recruiting
Blood test for genetic disorders in pregnancy
This study tests a safer blood test to check for certain genetic disorders during pregnancy, instead of an invasive procedure like amniocentesis. It's for pregnant women who are at risk of passing on a known genetic condition.
ParisAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.