Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07062523RecruitingPhase 1/Phase 2
FAPI PET scan for Sjögren's syndrome inflammation
This study uses a special PET scan (FAPI PET) to look at inflammation in people with Sjögren's syndrome. It helps doctors understand how active the disease is. You may join if you have Sjögren's syndrome or a solid tumor that needs this scan, and you are not on certain medications.
BeijingAges 18–80 - NCT07056881Recruiting
Single vs Combination Antibiotics for Pseudomonas Bone Infections
This trial compares using one antibiotic alone versus a combination of two antibiotics to treat bone infections caused by Pseudomonas aeruginosa. The goal is to see which approach works better for treating the infection.
Saint-Denis, FranceAges 18 years+ - NCT07062146Recruiting
Reiki for pain after back fusion surgery
This study tests whether Reiki (a gentle hands-on energy therapy) can help reduce pain after lower back fusion surgery. It aims to see if adding Reiki to standard care improves recovery.
ParisAges 18–75 - NCT07061782Recruiting
Neck stretching techniques for IT workers with upper cross syndrome
This trial compares two types of stretching exercises to see which one helps reduce neck and shoulder pain in IT professionals with upper cross syndrome. It may help you move better and feel less pain from long hours at the computer.
IslamabadAges 20–40 - NCT07058376Enrolling by invitation
Herbal medicine for chronic low back pain
This trial tests whether a herbal medicine strategy can safely and effectively reduce chronic low back pain lasting over 3 months. It may be an option if your pain has been moderate to severe and you are looking for alternative treatments.
Seoul, Gangnam-GuAges 19–69 - NCT07056920Recruiting
Bone growth for lower jaw implants using a custom shell
This study tests whether a custom-made porous zirconia shell can help grow new bone in a narrow lower jaw so a dental implant can be placed. It might be a good option if you have a missing back tooth and need more jawbone for an implant.
Giza, Giza GovernorateAges 18 years+ - NCT07060781Recruiting
Managing fluid buildup after lower back surgery
This trial tests ways to prevent or reduce seroma (fluid buildup) after elective lower back decompression surgery. It aims to improve recovery and comfort for patients.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT07055113Recruiting
Home rehab program for hip or knee arthritis
This study tests a home-based rehab program for people with hip or knee arthritis who do not need joint replacement yet. It aims to help improve function and reduce pain through online sessions.
Edmonton, AlbertaAges Any age - NCT07056322Enrolling by invitation
Optimal meals to reduce bone loss in women with thinning bones
This trial tests whether specific meals can lower bone breakdown in postmenopausal women with osteopenia (thinning bones). It may help prevent osteoporosis by identifying a meal plan that protects bone health.
Aarhus NAges Up to 80 years - NCT07061223Enrolling by invitation
Comparing two nerve block methods for hip replacement surgery
This trial tests two types of nerve blocks (SFIB and PENG) to find which provides better anesthesia during total hip replacement. It may help you understand which pain control approach could work best for your surgery.
MoscowAges 50–75 - NCT07060430Recruiting
Comparing two wrist therapies after Colle's fracture
This study compares two types of gentle hand exercises to help people whose wrists have become stiff after a Colle's fracture. The goal is to see which approach works better for restoring wrist movement.
IslamabadAges 40–70 - NCT07060235Enrolling by invitation
Mobile app for disc herniation recovery
This trial tests a mobile app that guides you through exercises for disc herniation. The app is designed to help strengthen the muscles that support your spine and may reduce pain.
AnkaraAges 20–55 - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT07057063Recruiting
Light therapy for knee pain and swelling
This study tests if light therapy can reduce knee pain and swelling (synovitis) caused by arthritis. If you have long-lasting knee pain and arthritis, this treatment might offer a non-drug option to help you feel better.
ShenzhenAges 40–80 - NCT07057817Recruiting
Using Cerament for heel infections to save the leg
This trial tests a special bone filler called Cerament to treat heel bone infections in people with diabetes, aiming to avoid leg amputation. It may help heal the bone after partial heel removal surgery.
GalwayAges 18 years+ - NCT05587569Recruiting
Foot surgery outcomes study for bunion and forefoot alignment
This trial studies results after a combined bunion and forefoot alignment surgery to improve foot shape and function. It may help people whose foot angles show significant bunion and front-of-foot deformity.
Greeley, ColoradoAges 14–65 - NCT06988813Recruiting
Nanfang Spondyloarthritis Study
This study follows patients with spondyloarthritis over time to better understand the condition. It collects information from hospital visits and may help improve care for people with this type of arthritis.
Guangzhou, GuangdongAges 10–59 - NCT07052565Recruiting
CAR-T cell therapy for autoimmune diseases
This trial uses your own engineered immune cells (CAR-T cells) to treat severe autoimmune diseases like rheumatoid arthritis, lupus, Sjögren's syndrome, or systemic sclerosis that haven't improved with standard medicines. The goal is to see if this treatment can calm the immune system and reduce disease activity.
HefeiAges 18 years+ - NCT05004129RecruitingPhase 2/Phase 3
Tideglusib for genetic childhood myotonic dystrophy
This trial studies how safe and effective tideglusib is for children and young adults with congenital or childhood-onset myotonic dystrophy type 1 (DM1). It may help researchers learn whether the medicine improves symptoms while tracking side effects closely.
Little Rock, ArkansasAges 6–45 - NCT07052929RecruitingPhase 1/Phase 2
Gene therapy study for young boys with XLMTM on ventilators
This study tests a new gene therapy called ASP2957 in young boys with X-linked myotubular myopathy who are dependent on a ventilator. The goal is to see if it can help improve their breathing and muscle strength.
Chicago, IllinoisAges Up to 3 years - NCT07050277RecruitingPhase 3
Morphine for bladder issues after knee replacement
This study tests whether adding morphine to spinal anesthesia can reduce trouble urinating after a second knee replacement surgery. It may help you avoid needing a catheter after surgery.
Toronto, OntarioAges 21 years+ - NCT07045714Recruiting
Endoscopic back surgery for spinal stenosis
This study looks at a newer, less invasive type of back surgery called endoscopic laminotomy. It may help people with lumbar spinal stenosis (narrowing of the spinal canal) who still have leg or back pain after trying physical therapy and pain medicines for at least 3 months.
San Pedro Garza García, Nuevo LeónAges 18–74 - NCT07045896Recruiting
Fucoidan for active rheumatoid arthritis
This trial tests a seaweed extract called fucoidan to see if it can help people with active rheumatoid arthritis that is not well controlled by their current treatments. If you have moderate-to-high disease activity despite therapy, you may be able to join.
BeijingAges 18–65 - NCT07054450Enrolling by invitation
Assessment and rehabilitation for chronic pinched nerve in the neck
This trial tests a program of assessment and rehabilitation (including physical exercise and possibly a nutraceutical supplement) for people with chronic cervical radiculopathy — a pinched nerve in the neck causing pain, numbness, or weakness in the arm. It may help reduce pain and improve function without surgery.
CraiovaAges 50–79
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.