Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT06148818Recruiting
Neck exercises for jaw pain relief
This study tests whether special neck exercises can help reduce jaw pain in people who have both jaw (TMJ) problems and neck pain. If you have had jaw pain for at least 3 months and also have achy neck pain, you may be able to join.
TrabzonAges 18–55 - NCT06148779Recruiting
Digital first-line OA treatment for equal access
This study looks at whether a digital program for osteoarthritis (OA) of the hip or knee helps more people get the care they need. It tests if the program works well and is fair for everyone.
MalmöAges 18 years+ - NCT06151028Recruiting
Menopause Symptoms in Women After Ovary Removal for Gynecologic Cancer
This study looks at menopause symptoms in women who have had their ovaries removed as part of gynecologic cancer treatment. It aims to understand how these symptoms affect patients over time.
Hefei, AnhuiAges 18–55 - NCT06154889Recruiting
Rehab program after shoulder stabilization surgery (Latarjet)
This study tests a new rehab program after a shoulder stabilization surgery called Latarjet. It may help you recover better if you have had a dislocated shoulder and need this surgery.
AnnecyAges 18–67 - NCT06154252RecruitingPhase 2/Phase 3
Study of CABA-201 for active myositis in adults and children
This trial tests a new treatment called CABA-201, which uses your own immune cells modified to attack the overactive cells causing myositis. It is for people with active disease that hasn't improved enough with standard therapies.
Orange, CaliforniaAges 6–75 - NCT06156384Recruiting
FITBONE nail for leg lengthening and quality of life
This study looks at pain, satisfaction, and quality of life in people who get a FITBONE lengthening nail to correct a leg length difference of more than 30mm. It will help doctors understand how well this treatment works from a patient's perspective.
Saint-Etienne, Auvergne-Rhône-AlpesAges 12 years+ - NCT06156813Recruiting
Turkish lower limb movement log for stroke patients
This study aims to adapt a questionnaire that measures how well stroke survivors can use their legs in daily life. It may help doctors better understand your recovery and guide your rehabilitation.
GaziantepAges 18–80 - NCT06157177RecruitingPhase 4
M640 for acute low back pain study
This trial tests a new treatment (M640) for people with acute low back pain, with or without sciatica. It aims to see if M640 can help reduce pain quickly.
Auburn, AlabamaAges 18–80 - NCT06157268Recruiting
Study of muscle tiredness in congenital myopathies
This study follows patients with congenital myopathies to understand how their muscles get tired over time. It may help develop better treatments.
Nijmegen, GelderlandAges 2 years+ - NCT06158646Recruiting
Comparing knee replacement alignment methods
This study compares two ways to align a total knee replacement (mechanically vs. kinematically) to see which leads to better function one year after surgery. If you've had a knee replacement a year ago and are generally healthy enough to walk without major issues from other leg joints or nervous system problems, you might be eligible.
MérignacAges 18 years+ - NCT06157866Recruiting
Cognitive training with acupuncture for fibromyalgia pain
This study tests whether a type of mental training (cognitive training) can help your brain respond better to acupuncture for fibromyalgia pain. You would receive acupuncture while doing a thinking task, and the study will use brain scans to see how your brain changes.
Charlestown, MassachusettsAges 18–65 - NCT06163300Recruiting
MRI study of spine degeneration over time
This study uses MRI scans to track changes in the spine over time in people with spinal disease. It aims to better understand how spinal problems progress, which could help improve future treatments.
SetúbalAges 50–85 - NCT06165419RecruitingPhase 2
High-dose radiation for spine metastases from solid tumors
This trial tests a new way of giving high-dose radiation to solid tumors that have spread to the spine. It is for people whose spine is stable, have not had prior treatment to that area, and have only minor weakness (if any).
Stony Brook, New YorkAges 18 years+ - NCT06166628Recruiting
Comparing two procedures for knee osteoarthritis pain
This study compares two minimally invasive procedures—embolization (blocking blood flow) and nerve ablation (blocking pain signals)—to see which works better for knee osteoarthritis pain. If you have long-lasting knee pain and are considering knee replacement surgery, this trial may help find another option.
Kingston, OntarioAges 40 years+ - NCT06167928Recruiting
Developing new treatments from donated tissue
This study collects tissue from children having surgery for polydactyly or hip dislocation, so researchers can develop new treatments for muscle and bone problems.
Oswestry, ShropshrieAges Any age - NCT06170645Recruiting
Vagus nerve stimulation for fatigue in fibromyalgia or long COVID
This trial tests whether a gentle electrical stimulation device on the ear (vagus nerve) can help reduce fatigue when combined with exercise. It is for people with fibromyalgia or long COVID who still feel exhausted after a rehab program.
Saint-EtienneAges 18 years+ - NCT06171282RecruitingEarly Phase 1
Virus therapy for advanced bone and soft tissue tumors
This trial tests an investigational virus therapy (R130) injected directly into tumors for people with advanced bone or soft tissue cancer who have exhausted standard treatments or choose not to pursue them.
ShanghaiAges 16–75 - NCT06172361RecruitingPhase 3
Tofacitinib and steroid taper for PMR
This study tests whether a daily pill (tofacitinib) combined with a short course of steroids can help people with active PMR use less steroids over time. You must have high disease activity and not have taken steroids or biologics in the past two weeks.
Hangzhou, ZhejiangAges 50–88 - NCT06173713Recruiting
Hip replacement study with precise X-ray tracking
This trial tests a new way of tracking how well hip replacements settle in over time using special X-ray images. It is for adults who need a first-time total hip replacement due to conditions like arthritis, injury, or hip deformity.
Winnipeg, ManitobaAges 21 years+ - NCT06176508RecruitingPhase 2
New medicine for active psoriatic arthritis
This trial tests a new oral medicine (HS-10374) for people with active psoriatic arthritis who have not responded well to standard treatments. It compares the drug to a placebo to see if it reduces joint pain, swelling, and skin symptoms.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06184100Recruiting
Online Self-Management Program for Teens with JIA
This study tests an online self-management program for teens with newly diagnosed JIA. It helps you learn skills to manage your condition, connect with others, and feel more in control.
Calgary, AlbertaAges 12–17 - NCT06184451Recruiting
TENS with exercise for knee osteoarthritis
This study tests if adding TENS (a pain-relieving electrical stimulation) to a standard exercise program helps people with knee osteoarthritis feel better and move better.
São PauloAges 40–75 - NCT06184646Recruiting
Prunes for bone health in postmenopausal women
This trial tests how many prunes per day can best improve bone health in postmenopausal women. It may help you if you have lower bone density but not severe bone loss.
San Diego, CaliforniaAges Any age - NCT06185608Recruiting
Ropivacaine strength and effect in ankle block for foot surgery
This study tests different strengths of a numbing medicine (ropivacaine) used in an ankle block for foot surgery. The goal is to find the best dose that starts working quickly and lasts the right amount of time for pain relief after bunion repair.
Genk, LimburgAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.