Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06751238RecruitingPhase 1
Secukinumab for children with psoriatic arthritis
This study tests a drug called secukinumab (given through an IV) in children with juvenile psoriatic arthritis. The goal is to see how well it works and if it's safe over time, for up to 6 years.
Loma Linda, CaliforniaAges 2–17 - NCT00313677Recruiting
Trial readiness for dystroglycan-related muscle conditions
This trial is for people who have signs that they may have a dystroglycanopathy—a group of muscle conditions. It helps study how ready participants are for care and possibly future treatments by using lab and genetic/pathology information to confirm the condition.
Iowa City, IowaAges Any age - NCT04639388Recruiting
Learning about psychosis in children with 22q11.2 deletion syndrome
This study looks at how “psychotic disorders” (like unusual beliefs, hallucinations, or thought changes) show up in children with 22q11.2 deletion syndrome. It mainly focuses on understanding the condition and may help improve care in the future.
Lyon, Auvergne-Rhône-AlpesAges 4–13 - NCT06606574Recruiting
Baclofen pump for children with cerebral palsy and dystonia
This study tests if a pump that delivers baclofen directly into the spinal fluid can help children with cerebral palsy who have severe dystonia (uncontrolled muscle tightness). It looks at how well the treatment works and tracks progress over time.
Houston, TexasAges Up to 17 years - NCT06749366Recruiting
Finding Genes Linked to Cartilage Tumors and Blood Vessel Issues
This study uses genetic testing to find genes that cause certain types of cartilage tumors and blood vessel problems. If you or your child has one of these conditions, joining could help doctors understand what causes them and find better treatments.
Bethesda, MarylandAges 2–100 - NCT06748976Recruiting
Brain activity study during attention tasks
This study looks at how your brain controls attention by measuring brain activity while you perform tasks. It may help researchers understand attention better.
Oro Verde, Entre Ríos ProvinceAges 18–60 - NCT06745791Recruiting
Testing a new spine MRI technique (BoneMRI)
This study is testing a new MRI technique called BoneMRI that may show bones more clearly than standard MRI. If you already need both a CT and an MRI of your spine, your scans could be used to compare this new method with the regular ones.
GhentAges 12 years+ - NCT06748885Recruiting
Mpact 3D metal hip replacement study
This trial tests a new 3D-printed metal hip implant for people who need a first-time hip replacement. It aims to see how well the implant works and helps you recover.
NantesAges 18–75 - NCT06741527Recruiting
Integrity Implant for rotator cuff repair study
This study is testing a new shoulder implant called the Integrity Implant System to see how well it works for people with rotator cuff tears. It may be a good fit if you need surgery to repair your torn tendon and meet the safety requirements.
Gilbert, ArizonaAges 18 years+ - NCT06747949RecruitingPhase 3
Long term extension study of dazodalibep for Sjogren's syndrome
This study gives continued access to the study drug dazodalibep for people with Sjogren's syndrome who completed a prior phase 3 study. The goal is to see how safe and effective the medication is over a longer period.
Avondale, ArizonaAges 18 years+ - NCT06741514Enrolling by invitation
Parent survey on Precice limb lengthening
This trial asks parents of children who have already had limb lengthening with the Precice system to share their thoughts on how well the procedure worked. Your answers can help doctors understand the benefits of this treatment.
West Palm Beach, FloridaAges Any age - NCT05264025RecruitingPhase 1/Phase 2
Fexofenadine for active rheumatoid arthritis
This Phase 1/2 study tests whether fexofenadine (an allergy medicine) can improve symptoms and inflammation in people with active rheumatoid arthritis. Participants may be assigned to different treatment groups, and the study looks at safety and early signs of benefit.
Banī SuwayfAges 18–60 - NCT06744257Recruiting
Online education for kneecap pain while waiting for physio
This trial tests whether an online education program is helpful for people with kneecap pain who are waiting for in-person physiotherapy. It aims to see if this approach is practical and beneficial.
ColchesterAges 16–44 - NCT06749431Enrolling by invitation
Meniscus transplant study: long-term outcomes
This study looks at how well meniscus transplants work over time — including how long the graft lasts and how it protects knee cartilage. It may be a good fit if you are getting your first or a repeat meniscus transplant, sometimes along with other knee repairs.
Plano, TexasAges 10–65 - NCT06741956Enrolling by invitation
Wearable device for osteoporosis prevention in women
This trial tests a wearable device designed to help prevent osteoporosis and reduce fracture risk in women who have recently gone through menopause. The goal is to see if the device can help you stay active and lower your chances of breaking a bone.
Seville, SpainAges 40 years+ - NCT06747884Recruiting
Study for children with myotonic dystrophy
This study looks at how to best measure muscle health and function in children with myotonic dystrophy. It may help prepare for future treatment trials.
Little Rock, ArkansasAges 3–17 - NCT06739720RecruitingPhase 2/Phase 3
Test of CP003 for chronic fatigue or long COVID tiredness
This study tests a new supplement called CP003 to see if it helps reduce tiredness in people with chronic fatigue syndrome or long COVID fatigue.
Hong KongAges 40–60 - NCT06744036Recruiting
Exercise and electrical stimulation for knee arthritis
This study tests whether adding a gentle electrical current (interferential therapy) to a personalized exercise program can reduce pain and improve function in people with knee osteoarthritis. If you have knee pain from arthritis and have not had physical therapy or certain injections in the past six months, you may be able to join.
São PauloAges 40–75 - NCT06739369Recruiting
Arterial stiffness and arthritis features study
This study looks at how stiff your blood vessels (arteries) are and how that relates to arthritis symptoms in people with ankylosing spondylitis. It involves simple tests to measure blood vessel health along with your regular arthritis care.
KırşehirAges 18–85 - NCT06747494Recruiting
Comparing general vs spinal anesthesia for hip or knee replacement
This study compares two types of anesthesia (general and spinal) for people having a total hip or knee replacement. The goal is to see which approach is better for recovery and overall outcomes.
Miami, FloridaAges 18 years+ - NCT06745544Recruiting
Exercise program to prevent falls in older adults with diabetes
This trial tests whether a special exercise program (with music and multitasking) can help reduce falls and fractures and improve heart health in older adults with diabetes. If you are 65+ and have diabetes, you may be able to join and get free exercise classes.
Aalborg, NorhAges 65 years+ - NCT06740162Recruiting
Physical activity program for adults with intellectual disabilities
This study tests a program to help adults with intellectual disabilities become more physically active. You and your caregiver will work with a coach to increase your daily movement, with the goal of improving health and community connection.
Fayetteville, ArkansasAges 18 years+ - NCT06737237Enrolling by invitation
Nerve block vs. local numbing for collarbone surgery
This trial compares two ways to numb the area during collarbone surgery: a nerve block (cervical plexus block) or local anesthetic injections. The goal is to see which provides better pain relief and recovery.
Marine Corps Base Camp Lejeune, North CarolinaAges 18–64 - NCT06733025Recruiting
Comparing surgery and Botox for arm spasticity
This trial compares two treatments—Botox injections or surgery—for arm and hand spasticity after a stroke, brain injury, or spinal cord injury. It may help you decide which option works best for you.
MölndalAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.