Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06669702Recruiting
Exercise therapy for axial spondyloarthritis on biologics
This study tests whether a supervised exercise program can help people with axial spondyloarthritis (a type of inflammatory arthritis affecting the spine) who are already on biologic medications. It aims to see if exercise reduces inflammation and improves symptoms.
Loughborough, LeicestershireAges 18 years+ - NCT06671054RecruitingPhase 2
Testing AP1189 for newly diagnosed active rheumatoid arthritis
This study tests an oral drug called AP1189 for people just diagnosed with active rheumatoid arthritis who haven't yet taken standard arthritis medicines. You may be able to take part if your disease is very active and you're ready to try a new treatment option.
Cutler Bay, FloridaAges 18 years+ - NCT06671665Recruiting
Manual therapy for low back pain in women with osteopenia
This study tests if manual therapy (hands-on treatment by a therapist) can reduce low back pain in postmenopausal women who have osteopenia, a condition where bones are weaker than normal but not yet osteoporosis. It aims to help with pain located in the lower back area.
GizaAges 50–60 - NCT06672328Recruiting
Can watching movements boost function in kids with CP?
This study tests whether watching and then practicing movements (action observation training) can improve everyday functional skills in children with spastic cerebral palsy. It could help children move better and more independently.
IslamabadAges 5–12 - NCT06672822RecruitingPhase 2
STS injections for calcinosis in scleroderma
This trial tests if injecting a medication called STS directly into calcium deposits can relieve pain and symptoms. It may help patients with scleroderma or related conditions who have painful calcium lumps.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06674057Recruiting
Taping with physical therapy for arm function after stroke
This study tests whether adding kinesio-taping to standard physical therapy helps improve arm movement and reduce stiffness in people recovering from a recent stroke.
IslamabadAges 40–65 - NCT06674668Recruiting
Vibration therapy for tennis elbow pain
This study tests whether gentle vibrations applied to the elbow can help reduce pain and improve function in people with tennis elbow (lateral epicondylitis). It compares the effects of this new therapy to standard care.
IstanbulAges 18–65 - NCT06674707Recruiting
Agility training with foot exercises for kneecap pain
This trial tests whether adding foot exercises to agility training can better relieve long-lasting knee pain (patellofemoral pain syndrome) in adults ages 20 to 40. Eligible participants will have had pain behind the kneecap for over 6 months.
Lahore, Punjab ProvinceAges 20–40 - NCT06674785Recruiting
Shock wave therapy for shoulder spasticity after stroke
This trial tests if shock wave therapy can reduce shoulder stiffness caused by a stroke. It may help improve shoulder movement and daily comfort.
TaipeiAges 18 years+ - NCT06687109Recruiting
Joint replacement surgery registry study
This study collects information from people having joint replacement surgery to track how they do over time and improve care.
Spokane, WashingtonAges 18 years+ - NCT06674980Recruiting
Testing placenta-based wound treatment for diabetic and venous leg ulcers
This trial tests if adding a special placenta-based wound covering to standard care helps heal diabetic foot ulcers and venous leg ulcers faster. It's for people with wounds that haven't healed after standard treatment for at least 4 weeks.
Metairie, LouisianaAges 18 years+ - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT06678438RecruitingPhase 4
Nerve block vs. hematoma block for wrist fracture realignment
This study compares two ways to numb your arm before a doctor moves your broken wrist back into place: one is a nerve block (injection near the shoulder), and the other is a hematoma block (injection into the fracture site). The goal is to see which method works better for pain relief during the procedure.
Hillerød, Capital RegionAges 18 years+ - NCT06679283Recruiting
Surgery for implant gum infection with platelet-rich fibrin
This study tests whether adding a natural blood concentrate (platelet-rich fibrin) to standard surgery improves healing of gum infections around dental implants. It's for people with moderate to advanced implant problems who have good oral hygiene.
BernAges 18 years+ - NCT06680518Recruiting
Tourniquet use during bunion surgery
This trial studies whether using a tourniquet (a tight band to control bleeding) during bunion surgery affects recovery. If you're having both feet corrected on the same day, this study may help doctors decide the best way to do the surgery.
Saint-Jean-de-VédasAges 18 years+ - NCT06681051Recruiting
OSTENIL TENDON for tendon pain study
This study tests whether OSTENIL TENDON, a gel-like substance injected into the tendon, can safely reduce pain and improve movement in people with common tendon problems (like jumper's knee or tennis elbow). It may be a good option if other treatments haven't worked for you.
Berlin, State of BerlinAges 18–99 - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06682208Recruiting
Pain relief catheter vs freeze ablation for pectus surgery recovery
This trial compares two ways to manage pain after the Nuss procedure for pectus excavatum. One uses a special catheter that numbs nerves, the other freezes them. The goal is to see which works better for teens and young adults.
Cincinnati, OhioAges 12–21 - NCT06684314Recruiting
Efanesoctocog alfa for long-term joint health in hemophilia A
This study tests how well a new factor VIII medicine, efanesoctocog alfa, protects your joints over time. It's for people with moderate or severe hemophilia A who are just starting this treatment.
ChanghuaAges Any age - NCT06684587Recruiting
Telehealth exercise and mindfulness for knee osteoarthritis pain
This study tests whether a telehealth program combining exercise and mindfulness can help reduce knee pain from osteoarthritis. It is designed for people who have had knee pain for at least 3 months and can attend sessions remotely.
Boston, MassachusettsAges 50 years+ - NCT06685042RecruitingPhase 1/Phase 2
CAR T-cell therapy for severe autoimmune diseases
This study tests a new treatment called CAR T-cell therapy for people with severe autoimmune diseases that haven't gotten better with standard treatments. The goal is to see if it can help control the disease by reprogramming your immune cells.
Rome, LazioAges 18–65 - NCT06685094Recruiting
Pain, movement, and quality of life study for Albanian speakers
This study is translating health questionnaires into Albanian to better understand pain, movement, mood, and quality of life. It aims to help people with muscle, joint, or back pain.
Murcia, MurciaAges 18–80 - NCT06686277Recruiting
Comparing two hand-on treatments for frozen shoulder
This study compares two gentle hand-on techniques (Gong’s and Mulligan mobilization) to see which one works better for people with frozen shoulder. If you are 40–50 years old and your shoulder is in the stiff, hard-to-move phase, this trial may be able to help you improve movement and reduce pain.
Lahore, Punjab ProvinceAges 40–50 - NCT06686524RecruitingPhase 1
CD19-targeted UCAR-T for refractory juvenile dermatomyositis
This trial tests a new type of immune cell therapy (UCAR-T) that targets a protein called CD19 to treat children with a severe form of juvenile dermatomyositis that hasn't responded to standard treatments. It aims to calm the overactive immune system and reduce symptoms like muscle weakness and skin rashes.
Hangzhou, ZhejiangAges 5 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.