Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06773000Recruiting
Nutritional supplement study for hip fracture recovery in older adults
This trial tests whether a nutritional supplement can help older adults recover better after hip fracture surgery. It may improve strength and healing during the recovery period.
New York, New YorkAges 65 years+ - NCT06774547Recruiting
Early jumping exercises for leg tendon pain
This study tests whether adding jumping exercises early helps people with long-lasting leg tendon pain recover faster.
AalborgAges 18–50 - NCT06780319Recruiting
Digital rehab after hip replacement surgery
This trial compares a digital (app-based) rehabilitation program with standard care after hip replacement surgery. If you have a smartphone and speak French, this study could help you recover from home.
MérignacAges 18–80 - NCT06772103Recruiting
Shoulder tendon surgery study
This study compares two ways to fix a specific tendon in the shoulder. It is for people who have a problem with that long tendon but do not have a full tear of the other important shoulder tendons.
AnnecyAges 40 years+ - NCT04939922Recruiting
Headache and dizziness registry for people with headache disorders
This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.
Hangzhou, ZhejiangAges 4–99 - NCT05580315Recruiting
Study of treatment for a painful discoid meniscus in children
This trial is for children who have a painful discoid meniscus (a cartilage in the knee) confirmed by an orthopedic exam and MRI. It tests whether a specific study approach can help symptoms in children, while avoiding people who may need different knee treatments.
LeuvenAges 1–18 - NCT06764693Recruiting
Study on treatment with Risankizumab for psoriatic arthritis
This study tests how well a medicine called Risankizumab works for people with psoriatic arthritis. It is for adults who have had symptoms for at least 6 months and have not had enough help from at least one other arthritis medicine.
Quilmes, Buenos AiresAges 18–75 - NCT06763783Enrolling by invitationPhase 4
Shingles vaccine study for people with rheumatic diseases
This study offers the Shingrix shingles vaccine for free to adults with inflammatory rheumatic diseases. It compares how well the vaccine works in people taking immune-suppressing drugs versus those not taking them.
LundAges 18 years+ - NCT06767631Recruiting
Muscle and nerve changes after botox for stroke foot tightness
This study looks at how botulinum toxin (botox) injections affect the muscles, tendons, and nerves in the lower leg of people who have had a stroke and have a tight, twisted foot (equinovarus). It aims to understand these changes to improve future treatments.
LeuvenAges 40–60 - NCT06764654Recruiting
Comparing two guided surgery methods for back jaw implants
This study compares two types of guided surgery methods for placing dental implants in the back of the jaw (where there are missing teeth). It aims to find which technique works better for patients who need implants in that area.
Alicante, AlicanteAges 18 years+ - NCT06768762Recruiting
Home activity program for knee replacement recovery
This study tests a home-based physical activity program for adults who have had a knee replacement at least a year ago. It aims to help you become more active with remote support and coaching.
Columbia, South CarolinaAges 18 years+ - NCT06767150RecruitingPhase 4
Bone treatment after stopping denosumab for osteoporosis
This trial tests whether giving zoledronic acid (a bone-strengthening infusion) right after stopping denosumab can help prevent bone loss in women with post-menopausal osteoporosis. It may be a good option if you have finished at least 2 years of denosumab and your doctor says it's safe to stop.
AmiensAges 18 years+ - NCT06762730RecruitingPhase 4
Zoledronic acid to prevent bone loss from HIV treatment
This trial tests if zoledronic acid, a drug that strengthens bones, can prevent bone loss caused by starting HIV treatment. It is for people newly diagnosed with HIV who have not yet taken any HIV medication.
HaifaAges 18 years+ - NCT06771323RecruitingPhase 2
Adding valbenazine to botox for neck muscle spasms
This study tests if adding a daily pill (valbenazine) to regular botox injections can better reduce neck muscle spasms. It helps people whose botox works but may not be enough.
Richmond, VirginiaAges 18–75 - NCT06762990Enrolling by invitation
Back and hip movement during Muslim prayer
This study looks at how the spine and pelvis move during common Muslim prayer positions. It might help if you are healthy, can pray comfortably, and want to help researchers learn more.
Asyut, Asyut GovernorateAges 18–55 - NCT06771050RecruitingPhase 4
Antibiotics and surgery for hip and knee joint infections
This trial tests different antibiotic types and durations, plus surgical approaches, for people with a current joint infection in a hip or knee. It aims to find the best way to treat the infection and prevent it from coming back.
Garran, Australian Capital TerritoryAges 18 years+ - NCT06762392Recruiting
Blood flow restriction for ACL rehab: a pilot study
This study tests whether using a special band that slightly restricts blood flow (blood flow restriction) during rehabilitation can help people recover better after ACL knee surgery. It's a small early study to see if this method is safe and effective.
Valencia, ValenciaAges 18 years+ - NCT06268795Recruiting
Comparing biopsy vs. aspiration for shoulder/elbow revision surgery
This study compares two methods—biopsy (taking a small tissue sample) and aspiration (drawing fluid)—to see which one better detects infection in people having repeat shoulder or elbow replacement surgery. The results will help doctors choose the best test for future patients.
Wigan, LancashireAges 18 years+ - NCT06674785Recruiting
Shock wave therapy for shoulder spasticity after stroke
This trial tests if shock wave therapy can reduce shoulder stiffness caused by a stroke. It may help improve shoulder movement and daily comfort.
TaipeiAges 18 years+ - NCT06758986Enrolling by invitation
Gender and shoulder pain study
This study looks at whether gender affects shoulder pain from subacromial impingement. It may help tailor future treatments.
Kırşehir, MerkezAges 18–65 - NCT06749509Enrolling by invitation
Musculoskeletal rehab courses and work ability study
This study looks at whether face-to-face or online rehabilitation courses help people with musculoskeletal disorders stay at work or return to work. It compares these courses to standard care.
HelsinkiAges 18 years+ - NCT06755697Recruiting
Comparing injection methods for knee osteoarthritis
This trial compares two ways to give dextrose injections for knee osteoarthritis: one into the joint space and one guided by MRI into the tissues around the knee. It aims to see which approach works better for pain and function.
TaipeiAges 45–80 - NCT06754098RecruitingPhase 2
Testing two drugs for TK2 deficiency
This trial tests two experimental drugs, Doxecitin and Doxribthymine, for adults with a rare genetic condition called TK2 deficiency that causes muscle weakness and breathing problems. The goal is to see if these drugs can slow or stop the disease.
Madrid, MadridAges 18 years+ - NCT06754150Recruiting
Shoulder Innovations shoulder replacement registry study
This study follows people who have or will have a shoulder replacement using a Shoulder Innovations device. Researchers will collect information on how well the device works and how your shoulder feels over time.
Birmingham, AlabamaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.