Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06737809Recruiting
Silver-coated hip revision for infection
This trial tests a new silver-coated hip implant for people who need a revision due to a chronic infection around the joint. It may help control the infection while replacing the implant.
BerlinAges 18 years+ - NCT06732167Recruiting
Lyoplant for bone regrowth in dental implant surgery
This trial tests a special membrane called Lyoplant® that helps your jawbone grow back around a new dental implant. If you need a dental implant and your jawbone has a small gap or defect, this study might be a good fit for you.
Barcelona, CataloniaAges 18 years+ - NCT06733935RecruitingPhase 1/Phase 2
Study of NKX019 for immune diseases
This trial tests an investigational cell therapy called NKX019 for people with certain autoimmune diseases like scleroderma, myositis, vasculitis, or rheumatoid arthritis. It aims to see if NKX019 can help control the disease when standard treatments have not worked well enough.
Orange, CaliforniaAges 18–75 - NCT06737601Enrolling by invitation
Shockwave or splint for trigger finger
This study compares two treatments for trigger finger: a special hand splint and shockwave therapy (a non-invasive treatment that uses sound waves to help the finger move smoothly). Researchers want to see which works better.
BariAges 18 years+ - NCT06734949Enrolling by invitation
Computational models for neuromuscular disease
This study uses advanced computer models to better understand inherited neuromuscular diseases. It may help doctors find new ways to group patients and personalize care.
MunichAges Any age - NCT06731608Recruiting
Fracture prevention study for older adults in rehab
This study tests a system to help prevent another broken bone after a hip, leg, or pelvis fracture. It is for people 65+ who are in a skilled nursing facility for rehab and plan to return home or to assisted living.
Baltimore, MarylandAges 65 years+ - NCT06728579RecruitingPhase 2
Group therapy for joint pain in breast cancer survivors
This study tests two supportive group programs—one using mindfulness skills, the other providing supportive talk therapy—to help breast cancer survivors manage joint pain caused by hormone-blocking pills. If you have ongoing joint pain and are taking an aromatase inhibitor, you may be able to join a free, video-based group.
San Diego, CaliforniaAges 18 years+ - NCT06734364Recruiting
Buddy tape vs. splint for finger bone fracture recovery
This study compares two non-surgical ways to treat a broken bone in the hand (metacarpal shaft fracture) that is not out of place. It tests whether taping the injured finger to a neighbor (buddy tape) works as well as using a padded splint.
Corbeil-EssonnesAges 18 years+ - NCT06729437Recruiting
Transcranial brain stimulation for patellar tendon pain
This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve knee function and reduce pain in people with long-term patellar tendinopathy (jumper's knee). It may help by calming pain signals in the brain.
Valencia, ValenciaAges 18–50 - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT06736106Recruiting
Spine surgery recovery markers study
This trial looks at how certain markers of bone and muscle health might predict complications after spinal surgery. It could help doctors better understand which patients are at risk and improve recovery.
BolognaAges 18 years+ - NCT06734689Recruiting
Genes and heart inflammation from immunotherapy
This study looks at genetic factors that may affect the risk of heart inflammation (myocarditis) caused by immune checkpoint inhibitors (ICIs), a type of cancer immunotherapy. It aims to find out if your genes make you more likely to develop this side effect.
ParisAges 18 years+ - NCT06733597Recruiting
Bone density change after knee replacement with or without cement
This study looks at how bone density in the thigh bone changes after knee replacement surgery, comparing two ways of attaching the new joint (with cement or without). It may help people who have normal bone density or early bone thinning but not full osteoporosis.
Madison, WisconsinAges 55 years+ - NCT06731855Recruiting
Recovery study: blood markers in newborns after intestine surgery
This study looks at blood markers in newborns after major stomach or intestine surgery. It aims to understand recovery and could help improve care for babies with similar conditions.
Liverpool, MerseysideAges Up to 5 days - NCT06728735Recruiting
Genetic study for congenital hypothyroidism with normal thyroid location
This study uses advanced genetic testing to find the cause of permanent congenital hypothyroidism in children who have a thyroid gland in the normal position. It may help families understand why their child developed this condition.
Bologna, BolognaAges Up to 18 years - NCT06738160RecruitingPhase 2
Combination therapy for advanced lung cancer with bone metastases
This trial tests a new combination of drugs and radiation to improve the effects of first-line chemotherapy and immunotherapy for patients with advanced non-small cell lung cancer that has spread to the bones. The goal is to help shrink tumors and potentially improve overall outcomes.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06735027Recruiting
Steroid shot vs nerve block for shoulder arthritis
This trial compares two kinds of injections for shoulder pain caused by arthritis or rotator cuff problems. The goal is to see which one works better for pain relief.
Minneapolis, MinnesotaAges 18–99 - NCT04084795Recruiting
EMDR plus brain stimulation for fibromyalgia pain and stress
This trial tests whether combining EMDR therapy with a mild form of brain stimulation can reduce fibromyalgia symptoms, including pain and trauma-related emotional distress. It may help people whose fibromyalgia is closely linked to past trauma and current anxiety or depression.
Barcelona, CataloniaAges 18–70 - NCT04901273Recruiting
PRP shot vs placebo for knee osteoarthritis in adults 65+
This trial compares an injection made from your own platelets (PRP) to a placebo shot to see if it helps knee osteoarthritis symptoms and function. It is designed for people over 65 with arthritis affecting only one knee.
BolognaAges 65 years+ - NCT05848895Recruiting
Osteopathy treatment for infants with positional head shape
This study tests an osteopathic manual therapy plan (hands-on treatment) for babies with positional plagiocephaly, aiming to improve head shape and comfort. It also asks families to attend multiple treatment and measurement visits so researchers can track change over time.
San Diego, CaliforniaAges 1 day–4 months - NCT05964712Recruiting
Therapies for acromegaly and effects on body movement
This study looks at how treatments for acromegaly affect how you function and move, especially in your hands, feet, and overall body structure. You may be asked to do assessments to understand changes over time and whether certain groups respond differently.
MilanAges 18–90 - NCT06012097RecruitingPhase 4
Aromatherapy gel for De Quervain's wrist pain
This trial tests if a gel made with essential oils can help reduce pain from De Quervain's disease, a painful wrist condition. If it works, it could be a natural option to relieve discomfort.
StrasbourgAges 18–75 - NCT06114043Recruiting
Surgery vs. non-surgery for mild to moderate bunion pain
This trial compares two approaches for treating mild-to-moderate bunion pain: surgery versus non-surgical options like wearing wider shoes, toe spacers, or physical therapy. The goal is to see which works better for relieving pain and improving daily life.
SarpsborgAges 18–80 - NCT06342843Recruiting
Comparing two ways to do hip replacement surgery
This trial compares two different surgical approaches for total hip replacement: the direct superior approach and the posterolateral approach. It aims to see which one leads to better recovery and outcomes for people with severe hip arthritis.
Breda, North BrabantAges 18–99
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.