Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06900049RecruitingEarly Phase 1
Testing LE051 for boys with Duchenne muscular dystrophy (exon 51)
This study tests a new medicine called LE051 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change that allows 'exon 51 skipping.' The goal is to see if it is safe and can help improve muscle function. Boys who join will be closely monitored for heart and lung health.
Shanghai, Shanghai MunicipalityAges 4–8 - NCT06902168Recruiting
Diving and pool exercises for muscle tightness in kids with cerebral palsy
This study tests whether diving and swimming-type exercises can help reduce muscle stiffness and improve movement in young children with spastic cerebral palsy. It is for children ages 2 to 5 who have significant mobility challenges (GMFCS levels IV or V).
Banhā, BenhaAges 2–5 - NCT06902805RecruitingPhase 2/Phase 3
Testing botox injections and splints for thumb arthritis pain
This study tests if botox injections into the thumb joint, along with a custom splint, can reduce pain from thumb base arthritis. It may be an option if you have persistent pain and have not had recent thumb surgery or certain other treatments.
Paris, Île-de-France RegionAges 18 years+ - NCT06904937Recruiting
Kidney problems in muscle inflammation disease
This study looks at kidney issues in people with inflammatory muscle disease. Researchers want to understand how the kidneys are affected in this condition.
StrasbourgAges 18 years+ - NCT06905678Recruiting
Cleft palate cost and emotion study
This study looks at how having a cleft palate affects your family's finances and emotions. You may be able to join if you are 5, 12, or 18 years old and have a cleft lip or palate.
GhentAges 4–22 - NCT06906406Recruiting
Quality of life in children with clubfoot
This study looks at how clubfoot affects the daily life and well-being of children aged 2 to 15. It uses questionnaires to understand their physical and emotional health, which can help improve care and support for kids with this condition.
Drammen, BuskerudAges 2–15 - NCT06906549RecruitingPhase 4
Testing a lower dose of rituximab every 6 months for rheumatoid arthritis
This study tests whether a lower dose (200 mg) of rituximab given every 6 months is effective for maintaining control of rheumatoid arthritis. It is for people who are already on rituximab maintenance therapy and have low to moderate disease activity.
StrasbourgAges 18 years+ - NCT06906874RecruitingPhase 2
Activated charcoal for kidney disease patients on dialysis
This trial tests if taking activated charcoal by mouth can help people with advanced kidney disease who are already on dialysis. It may improve how the body handles certain waste products and reduce the need for other medicines.
Al Mansurah, Please SelectAges 18 years+ - NCT06907745Recruiting
Accuracy of 3D virtual surgery planning for jaw correction
This trial tests a new digital method for planning jaw surgery that uses virtual guides instead of traditional splints. It may help make surgery more precise and reduce discomfort.
Milan, MilanAges Any age - NCT06907901Recruiting
Testing a measurement tool for rounded upper back
This study is testing how reliable a measurement tool (called PHAS) is for people with postural hyperkyphosis—a condition where the upper back is overly rounded. It may help researchers understand if this tool works well for people like you.
Istanbul, IstanbulAges 8–65 - NCT06907914Recruiting
Special exercises for hyperkyphosis in children
This study tests whether special exercises (Schroth and scapular muscle activation) can improve posture and reduce the curve in children with a rounded upper back (hyperkyphosis). It may help if you are a young person with a moderate curve and no other spinal issues.
Istanbul, IstanbulAges 7–18 - NCT06911190Recruiting
10-year follow-up study for FSHD patients
This study follows FSHD patients for 10 years to see how the disease progresses. It includes people who were in earlier FSHD studies and some new patients with genetic confirmation of FSHD.
NijmegenAges 6 years+ - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75 - NCT06912061Recruiting
New needle technique for Achilles tendon lengthening in kids
This study tests a new needle-based method to lengthen a tight Achilles tendon in children, which can help with toe walking or foot pain. The goal is to see if it works well and is safe.
DrammenAges 5–16 - NCT06912334Recruiting
Vagus nerve stimulation for fibromyalgia pain relief
This trial tests a device that uses gentle electrical pulses on the ear to stimulate the vagus nerve, which may help reduce fibromyalgia pain and sensitivity. You will not know if you are receiving the real stimulation or a placebo to ensure unbiased results.
Athens, GreeceAges 18–79 - NCT06913868Recruiting
Comparing two types of physical therapy for fibromyalgia pain
This study compares a standard physical therapy approach with one based on group consensus to see which works better for fibromyalgia pain. It may help find a more personalized treatment for your condition.
CairoAges 18–65 - NCT06913907RecruitingPhase 4
Methotrexate injection for new rheumatoid arthritis patients
This study tests a methotrexate injection (given under the skin) for people with moderate to severe rheumatoid arthritis who haven't taken methotrexate before. Researchers want to see how the medicine builds up in your body and if it helps control your symptoms.
Shinjuku-ku, TokyoAges 18 years+ - NCT06914960Recruiting
Ultrasound-guided nerve radiofrequency for knee pain
This trial tests a treatment that uses radio waves to reduce pain signals from the nerves around the knee. It might help if you have long-lasting knee pain from osteoarthritis and find certain movements very painful.
Ankara, AnkaraAges 30–75 - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT06915701RecruitingPhase 2/Phase 3
Vitamin E for rheumatoid arthritis inflammation
This study tests whether adding vitamin E to standard rheumatoid arthritis treatment can reduce inflammation and disease activity. It is designed for women with early RA who are not getting enough vitamin E from their diet.
Guadalajara, JaliscoAges 18 years+ - NCT06915935Recruiting
Osteoporosis study in older adults in Shandong
This trial is a study to understand how common osteoporosis is in people aged 65 and older living in Shandong province. By joining, you help researchers learn more about bone health in older adults.
Jinan, ShandongAges 65 years+ - NCT06916650Recruiting
Comparing therapies for frozen shoulder relief
This study compares three treatments for frozen shoulder: high-intensity laser therapy, steroid injection, and manual therapy. It aims to find which approach works best for reducing pain and improving movement in people with this condition.
CairoAges 40–70 - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06916806RecruitingPhase 1
Study of AZD5492 for lupus, myositis, or rheumatoid arthritis
This trial tests an investigational drug called AZD5492 for people with active lupus, inflammatory myositis, or rheumatoid arthritis who haven't responded well to other treatments. It aims to see if the drug is safe and how it works in the body.
Anniston, AlabamaAges 18–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.