Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07105657Recruiting
Rehabilitation after hip or knee replacement
This trial tests if three weeks of intensive rehabilitation helps people who still have physical problems after a total hip or knee replacement. It aims to improve your recovery and function.
BrædstrupAges 18 years+ - NCT07106931Recruiting
Early arthritis: identifying the cause quickly
This trial aims to quickly identify the type of arthritis in people with recent joint swelling (less than 12 weeks). It may help doctors start the right treatment sooner.
OsloAges 18 years+ - NCT07108400Recruiting
Combination therapy for hip osteoarthritis pain and function
This trial tests if combining ultrasound-guided hyaluronic acid injections with laser therapy and rehabilitation can improve hip function and reduce pain in people with hip osteoarthritis. It may be an option if you have moderate hip pain and are not currently taking anti-inflammatory medications.
Catanzaro, CZAges 18–85 - NCT07111325RecruitingPhase 1/Phase 2
iEVs injection for tennis elbow
This trial tests an injection called iEVs for people with tennis elbow (lateral epicondylitis) that hasn't gotten better with physical therapy or anti-inflammatory drugs. It aims to see if the treatment is safe and helps reduce pain.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07111858Recruiting
Pavlik harness vs monitoring for hip dysplasia in babies
This trial compares using a soft brace (Pavlik harness) versus simply monitoring for babies diagnosed with a certain type of hip condition (Graf type 2b or 2c). Researchers want to see which approach leads to better hip development and avoids the need for more intensive treatment.
Royal Tunbridge WellsAges birth–4 months - NCT07112508Recruiting
A dashboard to help physiotherapists improve care
This trial tests a new online dashboard that helps physiotherapists see how their treatment choices compare to others. It aims to improve care for people with muscle, bone, or joint problems in primary care.
LondonAges 18 years+ - NCT07115225Recruiting
Shoulder tests for athletes after a dislocation
This study tests a set of physical tests to see how well they measure shoulder function in people who have had a shoulder dislocation and plan to return to sports. It may help you understand if you are ready to go back to your sport safely.
AntwerpAges 16–55 - NCT07115745RecruitingPhase 1
Donor CAR T cells for severe autoimmune diseases
This study tests a new type of CAR T-cell therapy made from healthy donor cells. It is designed to help people with severe autoimmune diseases that have not improved with standard treatments.
Boston, MassachusettsAges 18 years+ - NCT07116876Recruiting
Placental membrane vs standard care for diabetic foot ulcers
This study tests a special wound covering made from donated placental tissue to see if it helps diabetic foot ulcers heal better than usual care. It may be an option for people with diabetes who have a foot sore that hasn't healed after 30 days.
Tucson, ArizonaAges 21–80 - NCT07118228Recruiting
Ultrasound study of muscle in children with spastic cerebral palsy
This study uses ultrasound to look at muscle shape and function in children with spastic cerebral palsy. It aims to see how these muscle features relate to movement abilities, which could help guide future treatments.
KocaeliAges 4–18 - NCT07118241RecruitingPhase 2
Testing a new eye drop for Sjögren's dry eye
This trial tests a new eye drop made from a natural protein (rhPRG4) to see if it safely and effectively relieves dry eye symptoms in people with Sjögren's syndrome. You'll be randomly assigned to receive the study drop or a placebo (inactive) drop for several weeks.
Sydney, New South WalesAges 18–80 - NCT07118280Recruiting
Oral health and saliva study in OPMD patients and families
This study looks at the mouth health and saliva of people with OPMD and their household members. By understanding saliva changes, researchers hope to learn more about the disease and find ways to help manage symptoms.
Ramat GanAges 18 years+ - NCT07119255Recruiting
PRP acupuncture for long-term neck pain from muscle tightness
This study tests whether a treatment called platelet-rich plasma (PRP) acupuncture — using your own blood proteins — can reduce chronic neck pain caused by a common muscle condition. It may be a good option if you have had neck pain for months and want a non-surgical approach.
JakartaAges 18–59 - NCT07120997Recruiting
Prunes to prevent bone loss during perimenopause
This study tests whether eating prunes every day can help prevent bone loss in women going through perimenopause. If you are between 44 and 55, not severely obese, and have irregular periods, you may be able to join.
University Park, PennsylvaniaAges 44–55 - NCT07121556Recruiting
Fat tissue vs fat tissue plus gel for knee osteoarthritis
This trial compares two injections for knee arthritis: one uses your own fat tissue, the other adds a lubricating gel. Researchers want to see if the combination helps pain and function more than fat tissue alone.
BolognaAges 18–75 - NCT07121777Recruiting
CAR T cell therapy for autoimmune diseases
This study tests a new type of cell therapy (CAR T cells) that targets certain immune cells to treat autoimmune diseases like rheumatoid arthritis, lupus, Sjögren's syndrome, and systemic sclerosis. It may help people whose disease is not well controlled with standard treatments.
Hefei, AnhuiAges 18 years+ - NCT07123038Recruiting
Long-term safety study for gene-modified Treg therapy recipients
This study follows people who previously received a gene-modified Treg (regulatory T cell) therapy from Sonoma Biotherapeutics. It checks for long-term safety and does not involve any new treatment.
San Francisco, CaliforniaAges 18–71 - NCT07123532Recruiting
Shoulder blade movement study in physical therapists
This trial looks at how common a certain shoulder blade movement problem (scapular dyskinesis) is among physical therapists. It will help researchers understand why some therapists might have shoulder issues and how to prevent them.
CairoAges 27–40 - NCT07123519RecruitingPhase 1
YTS109 cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with certain severe autoimmune diseases that have not responded to standard treatments, such as lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. The goal is to see if it can safely reduce disease activity.
TianjinAges 18–65 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT07125833Recruiting
Cold therapy for shoulder replacement pain
This trial tests if freezing a nerve near the shoulder before surgery can reduce pain after a reverse total shoulder replacement. It may help you recover with less discomfort.
Rockwall, TexasAges 30–85 - NCT07125963Recruiting
Custom vs. standard jaw positioning for jaw surgery
This study compares two ways of positioning your jaw during surgery to correct jaw alignment. The goal is to see if using a custom-made guide based on your own CT scans leads to better results than the standard method.
Istanbul, BağcılarAges 18 years+ - NCT07126431Recruiting
Study of hard-to-treat rheumatoid arthritis
This study is observing people with a hard-to-treat form of rheumatoid arthritis (RA). Researchers want to understand what treatments and outcomes are like for people whose RA doesn't get better with standard medications like methotrexate.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.