Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07081880Recruiting
Understanding SAPHO syndrome: genetics and immune response
This study looks at the causes of SAPHO syndrome—a rare condition that affects the skin, bones, and joints. Researchers want to understand how genes and the immune system play a role, which may help improve future treatments.
ParisAges 18 years+ - NCT07082972RecruitingPhase 4
Study of splint therapy and Botox for jaw muscle pain
This trial compares two treatments—a dental splint and Botox injections into the jaw muscle (masseter)—to see which one better relaxes head and neck muscles in people with myofascial pain syndrome. It may help you if you have facial pain related to muscle tension.
Istanbul, VeznecilerAges 18–55 - NCT07083557Recruiting
Validation study for lab tests on hormones and metabolism
This study checks if lab tests used for hormone, heart, metabolism, and muscle disorders are accurate and reliable. You might be eligible if you are an adult with a body mass index between 16 and 60.
Columbia, MissouriAges 18–100 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07085676RecruitingPhase 1
CAR-T cell therapy for autoimmune diseases that resist treatment
This study tests a new cell therapy called CAR-T (using your own immune cells) for people with severe autoimmune diseases like lupus, scleroderma, or myositis that have not improved with standard treatments. The goal is to see if it can safely reduce disease activity.
JerusalemAges 18–80 - NCT07086404RecruitingEarly Phase 1
GC012F injection for stubborn inflammatory muscle disease
This trial tests a new cell therapy (GC012F) for people with idiopathic inflammatory myopathy (IIM) that hasn't responded to standard treatments. It aims to see if this treatment can help control muscle inflammation and weakness.
Wuhan, HubeiAges 18–70 - NCT07086521RecruitingPhase 1
Stem cell therapy for facioscapulohumeral muscular dystrophy
This trial tests a new stem cell treatment (ULSC) for people with FSHD, a type of muscular dystrophy. It aims to see if the treatment is safe and if it can help improve arm strength and daily movement.
Palo Alto, CaliforniaAges 15 years+ - NCT07086599Recruiting
Sleep problems in psoriatic arthritis and SAPHO syndrome
This study looks at sleep problems in people with psoriatic arthritis or SAPHO syndrome. Participants will stay in the hospital for special sleep tests to understand their sleep issues better.
ParisAges 18 years+ - NCT07086924Recruiting
Gene change and methotrexate response in psoriasis
This study looks at a specific gene change (called TRAF3IP2) in people with psoriasis or psoriatic arthritis who are about to start methotrexate. The goal is to see if the gene affects how well the treatment works or if it causes side effects.
QinaAges 18–70 - NCT07087912RecruitingPhase 4
Dengue vaccine safety in people with autoimmune rheumatic diseases
This study tests the safety and immune response of a dengue vaccine in people aged 12–59 with stable autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are on low-dose or no immune-suppressing medications. It also includes healthy volunteers for comparison.
São Paulo, São PauloAges 12–59 - NCT07088055Recruiting
Chewing device vs. oral motor therapy for jaw alignment in kids
This study tests whether a special chewing device (Myo Munchee) can help improve jaw alignment and muscle function in children ages 3–5 who have both jaw alignment problems and orofacial myofunctional disorders. It compares the device to standard oral motor therapy.
Chicago, IllinoisAges 3–5 - NCT07088965Recruiting
Muscle and bone health in dentists
This study looks at muscle and bone problems in dentists who are either in advanced training or already specialists. Researchers want to find out how common these issues are and what might cause them.
BoluAges 25–60 - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT07089381Recruiting
Resveratrol for rheumatoid arthritis
This study tests whether resveratrol (a natural substance found in grapes) can help control moderate-to-high rheumatoid arthritis when added to your current RA medications. It aims to see if it reduces disease activity safely.
CairoAges 18 years+ - NCT07093853Recruiting
Comparing two ways to attach a lower denture to four implants
This trial tests two ways to attach a lower denture to four dental implants: using four small clips (locators) or a single bar that connects all four implants. The goal is to find which method is more stable and comfortable for people who are completely toothless in the lower jaw.
Al Mansurah, MenoufiaAges 40–70 - NCT07094100Recruiting
Repairing knee cartilage with lab-grown tissue
This study tests whether lab-made cartilage can safely and effectively repair knee joint damage in adults. It may be an option if you have a cartilage defect from an injury or other cause and haven't had recent knee surgery.
Xinxiang, HenanAges 18–65 - NCT07098754Recruiting
Physical therapy for neck pain and posture improvement
This study compares different physical therapy techniques to improve neck posture and reduce pain in people with myofascial pain syndrome. It may help if you have mild to moderate neck pain from muscle knots and are open to physiotherapy.
Bahawalpur, Punjab ProvinceAges 20–40 - NCT07100873RecruitingPhase 1
Testing a new drug for rheumatoid arthritis
This trial tests a new medication called ADI-001 to see if it can help people with rheumatoid arthritis. It is for adults who meet the standard criteria for RA and are in generally good health otherwise.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07101250RecruitingPhase 4
Study of acetazolamide before laparoscopic hysterectomy
This trial tests a medication called acetazolamide given before surgery to see if it can help prevent shoulder pain after a laparoscopic hysterectomy. If you are a woman scheduled for this type of hysterectomy, you may be able to join.
Greenville, South CarolinaAges 21–65 - NCT07101562Recruiting
Repairing hip bone damage with your own stem cells
This study is testing a new way to repair the damaged bone in your hip by using your own bone marrow stem cells. You may be a candidate if you have femoral head necrosis (hip bone death) that did not get better with standard treatments and you are otherwise healthy enough for surgery.
Xinxiang, HenanAges 20–65 - NCT07101887Recruiting
Comparing two surgeries for thumb arthritis pain and function
This trial tests if a thumb joint replacement works better than the standard surgery for reducing pain and improving hand use in people with thumb arthritis (grades I to III).
BarcelonaAges Any age - NCT07104084Recruiting
Antiseptic wash and wound healing after hip replacement
This study tests whether using a special antiseptic wash during hip replacement surgery affects how well the wound heals. It may help doctors choose safer ways to clean the skin before your operation.
Monroeville, PennsylvaniaAges 18 years+ - NCT07104721RecruitingPhase 1
YTS109 cell therapy for severe autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with severe autoimmune diseases that have not responded to standard treatments. The goal is to see if it can reset the immune system and reduce disease activity in conditions like lupus, Sjögren's syndrome, and others.
Hefei, AnhuiAges 18–65 - NCT07105163Recruiting
Bisphosphonate and supplement adherence in postmenopausal osteoporosis
This trial looks at how well women with postmenopausal osteoporosis follow their treatment plan, which includes a bisphosphonate taken once a week or once a month along with daily calcium and vitamin D supplements. The goal is to understand patterns that may help improve care.
Santiago de Compostela, A coruñaAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.