Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07157852Recruiting
Testing pregabalin vs mirogabalin for fibromyalgia pain
This study tests two medications, pregabalin and mirogabalin, for people with fibromyalgia who have not yet tried prescription drugs. It aims to see which one works better for pain relief.
BeijingAges 18 years+ - NCT07160231RecruitingPhase 4
Lowering dose of JAK inhibitors for rheumatoid arthritis or psoriatic arthritis
This trial tests if reducing the dose of a JAK inhibitor can keep your inflammatory arthritis under control. If you have rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis and are in a stable remission, you may be able to take a lower dose.
Nijmegen, GelderlandAges 16 years+ - NCT07160205RecruitingPhase 2/Phase 3
Study of ULSC for dermatomyositis and polymyositis
This trial tests a new treatment called ULSC to see if it can improve muscle strength and skin symptoms, and help reduce steroid use in people with dermatomyositis or polymyositis. It may be an option if standard treatments haven't worked well enough.
Gainesville, FloridaAges 18 years+ - NCT07161232Recruiting
When to start rehab after UBE spine surgery
This study looks at whether starting rehabilitation exercises earlier or later after a specific type of minimally invasive back surgery (UBE) for a slipped disc improves your recovery. It's for people who have had leg pain for less than a year and are scheduled for this surgery.
Beijing, Beijing MunicipalityAges 19–65 - NCT07161336RecruitingPhase 2
Methotrexate for knee arthritis with swelling seen on ultrasound
This trial tests if methotrexate (a medicine that reduces inflammation) can improve knee pain and swelling in people with knee osteoarthritis. It is for patients who have signs of synovitis (inflammation inside the joint) that can be seen on an ultrasound.
Dhaka, Dhaka DivisionAges 40–70 - NCT07161973Recruiting
Beetroot for preventing muscle loss in healthy men
This study tests if a natural substance (nitrate) from beets can help prevent muscle loss in young men when a leg is immobilized. You would stay at a research center for about 10 days with one leg in a cast to simulate a temporary injury.
Indianapolis, IndianaAges 18–44 - NCT07163221Recruiting
At-home ultrasound therapy for rheumatoid arthritis
This trial tests if a device that uses ultrasound waves, used at home, can help treat rheumatoid arthritis (RA). It is for people with moderate to severe RA who still have symptoms despite taking standard medications.
Glendale, ArizonaAges 18 years+ - NCT07166016Recruiting
Walking study for people with hammertoe and nerve damage
This study looks at how different treatments affect walking in people with hammertoe and nerve damage in their feet. It may help find better ways to improve foot function and comfort.
Harlingen, TexasAges Any age - NCT07166068Recruiting
Movement therapy for knee osteoarthritis inflammation
This study tests whether specific mobilization exercises can reduce inflammation in people with knee osteoarthritis. It aims to see if these movements help lower markers of inflammation and improve pain.
Jizan, Jazan RegionAges 18 years+ - NCT07166198Recruiting
Stopping age-related muscle weakness in women during inactivity
This study tests if a gentle hand exercise or a noninvasive brain stimulation can prevent muscle weakness in middle-aged women when they limit arm use for a period. It may help protect your strength and nerve function during recovery or downtime.
Manhattan, KansasAges 40–65 - NCT07166315Recruiting
Comparing new treatments for arthritis of the spine or joints
This study looks at how well different newer medications work for people with axial spondyloarthritis or psoriatic arthritis. It focuses on those just starting treatment with bimekizumab, risankizumab, guselkumab, upadacitinib, or a TNF inhibitor.
Bath, SomersetAges 18 years+ - NCT07166874Recruiting
Gluten-free diet for ankylosing spondylitis
This study looks at how a gluten-free diet affects people with ankylosing spondylitis (a type of arthritis that mainly affects the spine). You would eat no gluten (found in wheat, barley, and rye) for a period of time to see if it helps reduce symptoms.
IstanbulAges 18–64 - NCT07168330Recruiting
How well does ankle replacement work? A long-term look
This study checks how well total ankle replacements work over time, using patient reports and X-rays. It may help you understand your own recovery and improve care for others.
MilanAges 18–90 - NCT07168590Recruiting
Knee X-ray and its link to pain and fear of movement in osteoarthritis
This study looks at whether the shape of your knee on an X-ray is related to how much pain you feel and how afraid you are of moving. It may help doctors better understand knee osteoarthritis.
IstanbulAges 18 years+ - NCT07168603RecruitingPhase 1/Phase 2
Testing own disc cells for low back pain from a herniated disc
This trial tests whether your own disc cells (nucleus pulposus cells) can help heal a herniated disc and reduce pain. It is for people who have had low back pain for more than six weeks and are scheduled for disc surgery.
TaipeiAges 20 years+ - NCT07171008Recruiting
Ney music for comfort after lumbar disc surgery
This study tests whether listening to ney music can help reduce pain and anxiety after lumbar disc surgery. If you are eligible, you would listen to the music in the hospital, and researchers will measure how you feel.
YalovaAges 18–70 - NCT07171151Recruiting
Cyst fluid study for disease markers
This trial looks at fluid from cysts to find markers that might show disease. If you have a cyst and are not pregnant or breastfeeding, you may be able to join.
SanliurfaAges 12–80 - NCT07171216Recruiting
Parathyroid hormone control and bone density in kidney disease
This trial tests whether regulating parathyroid hormone (PTH) can improve bone density in people with advanced chronic kidney disease (CKD) who are not on dialysis. It may help you if you have stage 4-5 CKD and high PTH levels.
Herlev, Capital RegionAges 50 years+ - NCT07171320Recruiting
Combination therapy for fibromyalgia pain
This study tests whether combining two medications, pregabalin (often used for nerve pain) and desvenlafaxine (an antidepressant that can also help with pain), is safe and effective for people with fibromyalgia who still have moderate to severe pain after trying non-drug treatments like exercise or therapy.
BeijingAges 18 years+ - NCT07171983RecruitingPhase 1
Testing a new drug for rheumatoid arthritis
This trial tests a new medication (BMS-986454) for people with rheumatoid arthritis who haven't responded well enough to methotrexate. It aims to see if the drug is safe and how it works in the body.
Hyderabad, Andhra PradeshAges 18–65 - NCT07172568Recruiting
Blood flow restriction training for tennis elbow
This study tests whether a special type of strength training that temporarily limits blood flow to the arm can help treat tennis elbow (lateral epicondylitis). It may be an option for people who have tried physical therapy without success.
Munich, BavariaAges 18–65 - NCT07174102Recruiting
Looking at lung scans in rheumatoid arthritis and related diseases
This trial studies lung scans (HRCT) from patients with rheumatoid arthritis, interstitial lung disease, or connective tissue disease to better understand lung involvement. If you have one of these conditions and have had a lung CT, you may be able to help.
PragueAges 18 years+ - NCT07174843RecruitingEarly Phase 1
CAR-T cell therapy for autoimmune diseases
This study tests a new type of cell therapy called CAR-T cells that target three proteins (CD19, CD22, BCMA) to treat people with autoimmune diseases that have not responded to standard treatments. The goal is to see if it can reset the immune system and reduce disease activity.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07176078Recruiting
Osteopathic care plus low-FODMAP diet for fibromyalgia and IBS
This trial tests whether adding osteopathic care (a hands-on therapy) to a low-FODMAP diet helps people with both fibromyalgia and irritable bowel syndrome feel better. It compares the diet alone to the diet plus osteopathic sessions.
Brussels, Brussels CapitalAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.