Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07177521Recruiting
Short dental implants after tooth extraction
This study tests whether short implants placed right after a tooth is pulled are stable and work well. It may be a good option if you need a single back tooth replaced and are generally healthy.
BariAges 18–75 - NCT07178223Recruiting
Thumb base replacement surgery for arthritis
This study tests a new type of thumb joint replacement surgery for people with arthritis at the base of the thumb. The goal is to see if it relieves pain and improves function better than current treatments.
StockholmAges Any age - NCT07178288Recruiting
Pain sensitivity test for tennis elbow patients
This study measures how sensitive your elbow is to pressure and how your body controls pain, comparing people with and without tennis elbow. It aims to understand pain processing in tennis elbow.
Zarqa, Zarqa GovernorateAges Up to 60 years - NCT07178353Recruiting
How bedrest affects leg muscles in young adults
This study looks at how 5 days of complete bedrest changes the leg muscles of healthy young adults. It may help researchers understand muscle loss and how to prevent it.
Kingston, OntarioAges 18–30 - NCT07178951Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial tests a non-surgical treatment that uses ultrasound to target nerves causing pain on the inner side of your knee due to osteoarthritis. It may help reduce pain and improve function for people with moderate to severe knee pain.
North York, OntarioAges 18 years+ - NCT07179016Recruiting
Acupressure for chronic pain in rural areas
This trial tests if a self-managed acupressure program can help people living in rural areas manage long-term muscle or joint pain, like neck, back, or knee pain. You would learn to press small seeds on your ear to ease pain.
Columbia, South CarolinaAges 18–85 - NCT07179926Recruiting
Impact of pasireotide on bone health in acromegaly
This trial studies how pasireotide LAR—a drug that controls growth hormone levels—affects bone health in people with acromegaly whose disease is not well-controlled after 6 months of another therapy. It may help patients understand the bone benefits of switching to this treatment.
Rome, RMAges 18 years+ - NCT07180979RecruitingPhase 4
Nerve blocks for pain relief after hip replacement
This trial compares three types of nerve blocks to find which provides the best pain relief after a hip replacement. It may help you have less pain and a smoother recovery.
PoznanAges 65–100 - NCT07180940RecruitingPhase 4
Comparing two medicines added to a nerve block for back surgery
This study compares two medicines (dexamethasone and dexmedetomidine) added to a nerve block for pain control during and after lower back surgery. It aims to see which one works better for reducing pain and the need for other painkillers.
PoznanAges 18 years+ - NCT07182058RecruitingPhase 1/Phase 2
Brain stimulation device for Parkinson's motor symptoms
This trial tests a wearable brain stimulation device (tES) that delivers gentle electrical currents to your head to help improve Parkinson's motor symptoms like tremor, stiffness, or slowness. The treatment is done at home with remote video monitoring, and may offer a non-medication option to help with movement.
Cleveland, OhioAges 18–80 - NCT07182656RecruitingPhase 1
Safety of CIGB-814 in healthy Chinese volunteers
This is a first-in-human study in China testing a new drug called CIGB-814 in healthy volunteers. The goal is to check how safe the drug is, how well it is tolerated, and how the body processes it.
Beijing, Beijing MunicipalityAges 18–45 - NCT07183579Recruiting
Finding the right dose of burosumab for XLH
This study looks at how young people with X-linked hypophosphataemia (XLH) respond to different doses of burosumab. The goal is to find the best dose to manage the condition.
NottinghamAges 2–18 - NCT07183774Recruiting
Does muscle loss affect shoulder tear patterns?
This study looks at whether sarcopenia (age-related muscle loss) affects the type of rotator cuff tear you have. You'll get a shoulder MRI to check your rotator cuff and muscle measurements.
Istanbul, ÜsküdarAges 40–75 - NCT07184450RecruitingPhase 1
CAR-T cell therapy for children with hard-to-treat rheumatic diseases
This trial tests a new treatment using your child's own immune cells, modified to target B cells and fight severe rheumatic diseases like juvenile dermatomyositis, arthritis, scleroderma, or Sjogren's syndrome. It's for children who haven't improved with standard treatments.
Hangzhou, ZhejiangAges 5 years+ - NCT07184554Recruiting
Nerve block for chronic back pain from disc herniation
This study tests whether a nerve block (called an erector spinae plane block) can help relieve chronic low back and leg pain caused by a herniated disc at L4-L5 or L5-S1, when other treatments have not worked.
AnkaraAges 18–75 - NCT07185750Recruiting
Pain Catastrophizing in Parents of Children with JIA
This study looks at how parents of children with juvenile idiopathic arthritis (JIA) think about and react to pain. It aims to understand how parents' worry about pain might affect their child's experience.
Çankaya, AnkaraAges 7–18 - NCT07186751Recruiting
Pregabalin and venlafaxine for fibromyalgia pain
This trial tests a combination of two medicines (pregabalin and venlafaxine) for people with fibromyalgia whose pain is moderate to severe and has not been helped enough by non-drug treatments. The goal is to see if the combination works better and is safe.
BeijinAges 18 years+ - NCT07187518Recruiting
Testing a new ultrasound device for bone density
This study tests a new ultrasound device (POROUS R4C) to see if it can accurately estimate bone mineral density. If it works well, it could offer a quick, radiation-free way to check bone health.
BerlinAges 21–55 - NCT07188012RecruitingEarly Phase 1
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a new gene therapy called SPOT-03 to see if it can help the body make dystrophin, a protein that is missing in Duchenne muscular dystrophy (DMD). It is for boys ages 2 to under 8 who can still walk at least 10 meters.
Shanghai, Shanghai MunicipalityAges 2–7 - NCT07189260Recruiting
Breathing exercises to prevent pneumonia after hip fracture
This trial tests whether simple breathing exercises before and after surgery can help prevent pneumonia in people with hip fractures. It is not a medication study—you'd use a small device to help you breathe deeply.
CopenhagenAges 18 years+ - NCT07191353RecruitingPhase 2
Bone strength study: weight training and a drug for bone health
This trial tests whether combining resistance training with the drug rapamycin can improve bone formation in postmenopausal women who have lower-than-normal bone density but not osteoporosis. It aims to find a new way to strengthen bones and prevent fractures.
Bispebjerg, Region SjællandAges 60–75 - NCT07191743Recruiting
Functional Assessment in ICU Patients
This study observes how well adults in the intensive care unit (ICU) can function in daily activities, like moving and caring for themselves. It aims to understand recovery and may help improve care for future ICU patients.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07193550RecruitingPhase 2
Testing Zanzalintinib for Advanced Bone Sarcomas
This trial tests a new drug called zanzalintinib for people with advanced or metastatic bone sarcomas that have not responded to standard treatments. It aims to see if the drug can help shrink or slow the growth of these tumors.
Houston, TexasAges 18 years+ - NCT07194174Recruiting
Exercise training for periodic paralysis patients
This study tests whether a physical training program can help people with hypokalemic or hyperkalemic periodic paralysis improve their muscle strength and daily function.
CopenhagenAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.