Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07288970Recruiting
Comparing two numbing injections for knee replacement pain
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
PoznanAges 65–100 - NCT07288983Recruiting
Pain blocks after hip surgery: testing three approaches
This trial compares three different numbing injections (nerve blocks) to see which provides the best pain relief after hip replacement surgery. It may help older adults with moderate health status who are having hip surgery.
PoznanAges 65–100 - NCT07289620Recruiting
Nerve block boosters for kids' leg surgery
This study tests whether adding dexamethasone, dexmedetomidine, or both to a numbing shot (nerve block) provides better pain relief after leg surgery in children. The goal is to find which combination works best to keep your child comfortable with fewer side effects.
PoznanAges 3–12 - NCT07289893Recruiting
Kettlebell training for shoulder pain in athletes
This trial tests whether kettlebell training can help people with long-lasting shoulder pain caused by rotator cuff tendon problems or small tears. You would do kettlebell exercises and see if your pain and strength improve.
AnkaraAges 18–35 - NCT07290296Recruiting
Comparing muscle release and taping for knee pain
This trial compares two treatments for kneecap pain that has lasted at least 3 months: a muscle release technique and kinesio taping. The goal is to see which one helps reduce pain from daily activities like climbing stairs, running, or sitting for long periods.
CairoAges 18–30 - NCT07290582Recruiting
Nerve Pain Relief During Chest Wall Surgery Recovery
This trial tests a freezing technique applied to a nerve during minimally invasive chest wall surgery (Nuss procedure) to help reduce pain after the operation. The goal is to see if this approach helps children recover with less pain medication.
Bergamo, BGAges 14 years+ - NCT07290660Recruiting
Motor imagery and exercise for shoulder pain
This study tests whether combining mental movement training with targeted exercises can reduce shoulder pain caused by impingement syndrome. It aims to improve your shoulder function without surgery.
IstanbulAges 25–65 - NCT07292168RecruitingPhase 1/Phase 2
Study of a new antibody for advanced tumors with FGFR1 protein
This trial tests an experimental antibody, OM-RCA-01, in people with advanced solid tumors that have high levels of a protein called FGFR1. It aims to see if the drug is safe and effective for those who have already tried other treatments.
Kazan'Ages 18 years+ - NCT07293676Recruiting
Massage and vibration for low back disc pain
This study tests if hand-held massage tools (IASTM) and gentle vibration therapy can reduce pain, improve movement, and lessen fear of movement in people with a bulging disc in their lower back. It is for adults aged 30-60 with moderate to severe pain lasting 3 months or longer.
IstanbulAges 30–60 - NCT07293702Recruiting
IASTM therapy for shoulder pain from impingement
This study tests a hands-on therapy called IASTM (instrument-assisted soft tissue mobilization) to see if it can reduce pain, improve movement, and help your shoulder feel more stable. It is for people with subacromial impingement syndrome, a common cause of shoulder pain.
IstanbulAges 40–60 - NCT07293767Recruiting
Silymarin vs Hesperidin/Diosmin for Fibromyalgia Pain
This trial tests two natural supplements—silymarin (milk thistle) and a combination of hesperidin and diosmin (citrus compounds)—to see if they help reduce fibromyalgia pain. It is for people whose pain persists despite current treatments.
CairoAges 18–60 - NCT07294014Recruiting
Foot Arch Study in Women With Lipedema
This study looks at the arch of the foot and how the foot works in women with lipedema, a condition where fat builds up unevenly, usually in the legs. Participants will have their existing foot X-rays reviewed to compare foot structure between those with and without lipedema.
IstanbulAges 18–65 - NCT07294196Recruiting
Needle therapy for chronic foot pain in adults
This trial tests a new treatment for chronic plantar fasciitis (heel pain) using very thin needles that deliver a mild electrical current to the muscles and fascia. It may help people who have had heel pain for at least 6 weeks and haven't tried other treatments.
Sivas, MerkezAges 18–70 - NCT07295457Recruiting
Exercise to prevent pain from hormone therapy in breast cancer
This trial tests whether starting a gentle exercise program early can help prevent or reduce joint and muscle pain caused by aromatase inhibitors (a common breast cancer medicine). It is for women with hormone-sensitive breast cancer who are not yet experiencing severe pain from their treatment.
LyonAges 18–75 - NCT07295509RecruitingPhase 2/Phase 3
Testing picankibart for active psoriatic arthritis
This trial tests a new drug called picankibart to see if it helps people with active psoriatic arthritis who haven't gotten enough relief from standard treatments like NSAIDs or non-biologic DMARDs. It may be an option if you have at least 3 tender and 3 swollen joints and active or past plaque psoriasis.
Hangzhou, ZhejiangAges 18–75 - NCT07298265Recruiting
Screening for psoriatic arthritis in people with psoriasis
This study compares two ways to find psoriatic arthritis (joint pain and swelling related to psoriasis) in people who only have psoriasis so far. Your answers to a simple questionnaire or a doctor's exam may help detect joint problems early.
Toronto, OntarioAges 18 years+ - NCT07300384Recruiting
Blood flow restriction training for knee pain relief before surgery
This study tests whether a special type of strength training (called blood flow restriction training) can reduce pain in people with severe knee arthritis who are waiting for knee replacement surgery. The training uses a cuff on the thigh to lightly restrict blood flow while doing exercises until failure.
Valencia, ValenciaAges 50–85 - NCT07301242Recruiting
Study of ciprofol in older adults having limb surgery
This trial studies how the drug ciprofol works in older adults undergoing elective orthopedic limb surgery. The goal is to understand how the body processes the drug and how it affects patients, which may help improve its use for anesthesia in the elderly.
ShanghaiAges 65 years+ - NCT07301463Recruiting
Study of a new drug for children with achondroplasia
This trial tests a new medicine for children with achondroplasia (a common form of dwarfism). It aims to see if the drug can improve growth. The study is for children aged 2.5 to under 11 years old who have not started puberty and can walk without help.
Beijing, Beijing MunicipalityAges 2.5 years–11 years - NCT07301749Recruiting
Study of VCFix device for spine fractures
This trial tests a new device called VCFix to treat a single broken vertebra in the mid-to-lower back. It aims to see if the device is safe and effective for relieving pain and restoring spine function.
ChambéryAges 21–85 - NCT07301892Recruiting
AI help for rheumatoid arthritis diagnosis
This trial tests whether artificial intelligence (AI) can improve how doctors spot complications in people newly diagnosed with rheumatoid arthritis (RA), a condition that causes joint pain and swelling. The goal is to see if AI can make diagnosis faster and more accurate in real-world hospital settings.
Beijing, Beijing MunicipalityAges Any age - NCT07301918Recruiting
Comparing two expanders for crossbite in children
This trial compares two types of expanders (Leaf Expander vs. Hyrax Expander) to fix crossbites in children who still have some baby teeth. The goal is to see which device works better and is more comfortable.
CairoAges 6–12 - NCT07302074Recruiting
Comparing Rare vs. Common Inflammatory Arthritis
This study compares rare inflammatory arthritis (from rare autoimmune diseases or drugs) to more common types (like rheumatoid arthritis). Researchers will look at tissue samples to understand the differences and help improve diagnosis and treatment.
BordeauxAges 18 years+ - NCT07302204Recruiting
Exercise for knee osteoarthritis pain relief
This study compares two types of exercise — aerobic (like walking or cycling) versus specific therapeutic exercises — to see which one better helps people with knee osteoarthritis who do not get pain relief from exercise. It aims to find an exercise plan that reduces knee pain and improves movement.
São PauloAges 40–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.