Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07815145Recruiting
Comparing two nerve blocks for pain after hip replacement
This study compares two types of nerve blocks to see which provides better pain relief after hip replacement surgery. The blocks are given during surgery to reduce pain and may help you recover more comfortably.
Tanta, El-GharbiaAges 18–75 - NCT07813078Recruiting
Walking on an anti-gravity treadmill for knee osteoarthritis
This study tests whether walking on a special treadmill that reduces the weight on your knees can help with knee pain and function. If you have knee osteoarthritis, this type of training might be an effective way to exercise without causing more joint stress.
Sanok, Podkarpackie VoivodeshipAges 40–70 - NCT04805164Recruiting
Gentamicin bone paste to treat stubborn long-bone bone infection
This study tests a bone filler/paste called Cerament-G that releases the antibiotic gentamicin directly at the infected bone site. It aims to improve treatment of chronic bone infection (chronic osteomyelitis) in long bones after surgery.
AmiensAges 18–80 - NCT07804199Recruiting
Ear nerve stimulation for knee osteoarthritis pain in veterans
This study tests whether a small device that stimulates a nerve in your ear can help reduce knee pain caused by osteoarthritis. If you join, you'll be asked to stop taking your current knee pain medicines during the trial, but you can use a safe rescue medicine (acetaminophen/paracetamol) if needed.
Decatur, GeorgiaAges 45–75 - NCT06502613Recruiting
Scoliosis and Sleep Cycle in Children
This study looks at how sleep timing (melatonin levels) might be linked to new cases of scoliosis in children. If you have scoliosis and are between 6 and 15, you may help researchers understand this connection.
Wenzhou, ZhejiangAges 6–15 - NCT07807163RecruitingPhase 2
Study of ficerafusp alfa with pembrolizumab for head and neck cancer
This study tests a new drug called ficerafusp alfa combined with pembrolizumab (an immunotherapy) in people with head and neck cancer that has returned or spread. The drug targets a protein that may help the immune system fight the cancer. The study is comparing two different schedules of giving the drug to see which is better.
Fort Myers, FloridaAges 18 years+ - NCT07801495RecruitingPhase 2
Study of an investigational medicine for moderate to severe psoriatic arthritis
This trial tests an investigational drug (DDY391) in people with moderate to severe psoriatic arthritis. The goal is to see how well it works and if it is safe, which might help reduce joint pain and skin symptoms.
Memphis, TennesseeAges 18–100 - NCT07808619Recruiting
AI health data study for adults
This study is collecting health data to train an AI system that may help predict or improve health outcomes. By joining, you help develop technology that could benefit patients in the future.
Boulder, ColoradoAges 18 years+ - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT07808294Recruiting
Bone marrow injection for hip fractures
This trial tests whether injecting bone marrow (cells from your own bone) directly into the hip fracture helps it heal better and reduces the chance of complications. It is for adults who have a broken hip (femoral neck) and can be treated within 24 hours of the injury.
IdlibAges 18–55 - NCT07802678RecruitingPhase 4
Stopping RA medicines in combination therapy
This study looks at whether people with rheumatoid arthritis who are stable on a TNF inhibitor plus another drug can safely stop the second drug. It aims to see if stopping the extra medicine keeps the disease under control and reduces side effects.
Nijmegen, GelderlandAges 18 years+ - NCT07801573Recruiting
Immediate dental implants with custom healing caps for back teeth
This trial tests placing a dental implant right after removing a damaged back tooth, using a custom healing cap. It may help people who need a tooth extraction and want a faster path to a replacement tooth.
PlovdivAges 18 years+ - NCT07802639Recruiting
Botulinum toxin injections for uneven lower lip in children
This study tests a weekly injection of botulinum toxin type A (a muscle-relaxing medication, like Botox) to see if it can improve the appearance and movement of an uneven lower lip in children with craniofacial microsomia. If successful, this treatment might reduce the visible asymmetry when smiling or baring teeth.
BeijingAges 5–18 - NCT07807943Recruiting
Knee arthritis pain relief procedure for cancer patients
This study tests a procedure called geniculate artery embolization (GAE) to reduce knee pain from osteoarthritis in people who also have cancer. It may help those who cannot or do not want to have knee surgery.
Houston, TexasAges 40 years+ - NCT07804446Recruiting
Knee injection: comparing two needle angles for knee arthritis pain
This study compares two ways of giving a knee steroid injection to see which works better for pain and function in people with medial knee arthritis. You will get the injection as part of your normal care.
Bolingbrook, IllinoisAges 40 years+ - NCT06196567Recruiting
Pulsed magnetic therapy for knee strength before replacement
This study tests whether pulsed electromagnetic field therapy (a non-invasive treatment using magnetic pulses) can improve muscle strength and function in people with severe knee osteoarthritis who are waiting for knee replacement surgery. It may help you feel stronger and move better before your operation.
Hong Kong, NEW TerritoriesAges 50–100 - NCT07800871RecruitingPhase 1/Phase 2
FT839 cell therapy for autoimmune diseases
This trial tests a new cell therapy (FT839) designed to target and reset the immune system's B cells to help treat moderate to severe autoimmune diseases that haven't improved with standard treatments. It's an early-phase study, so the main goals are to see if it's safe and if it helps control the disease.
Fullerton, CaliforniaAges 18–70 - NCT07798609RecruitingPhase 1/Phase 2
Testing SFL-0821 for people with FSHD
This study is testing a new medicine, SFL-0821, to see if it is safe and useful for people with FSHD. It may help if it works, but it is still experimental.
Concord, New South WalesAges 18–65 - NCT07799831Recruiting
Oral health and saliva bacteria in children with juvenile idiopathic arthritis
This study looks at how oral health and mouth bacteria relate to disease activity in children with juvenile idiopathic arthritis (JIA). If your child has JIA, participating could help doctors understand more about the condition and may guide future treatments.
Shanghai, PudongxinquAges 6–16 - NCT07796607Enrolling by invitation
Knee cartilage therapy research
This study looks at knee osteoarthritis to find new ways to treat it. If you have knee pain from worn-down cartilage, this research may lead to better therapies.
Kunming, YunnanAges Any age - NCT07796516RecruitingPhase 2
Telitacicept for difficult-to-treat rheumatoid arthritis
This trial tests if a new medication, telitacicept, is safe and effective for people with difficult-to-treat rheumatoid arthritis. It may be an option for patients who have not found relief from other treatments.
Hefei, AnhuiAges 18 years+ - NCT07795736Recruiting
Understanding growth hormone problems after brain injury
This study looks at how a traumatic brain injury might affect your body's growth hormone, which is important for energy, strength, and overall health. If you've had a brain injury and still have symptoms a year later, you may be able to help researchers learn more and possibly find better treatments.
Calgary, AlbertaAges 18–70 - NCT07793266RecruitingPhase 1
Seeing the knee better with dye during arthroscopy
This study tests whether a special dye helps doctors see knee structures better during knee arthroscopy (a minimally invasive surgery to look inside the knee). It may improve the accuracy of the procedure.
Detroit, MichiganAges 14–89 - NCT07795008Recruiting
MRI for sports knee injuries
This study uses MRI to look at knee injuries caused by sports. It aims to better understand these injuries and help guide treatment. You may join if your knee injury is sports-related and you haven't had knee surgery or arthritis.
Sohag, Sohag GovernorateAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.