Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06022419Recruiting
Comparing two treatments for finger fractures
This trial compares two non-surgical treatments for fractures of the finger bone closest to the hand. It will help find out which approach—a special cast or a simple splint—works better for healing.
ViennaAges 18–70 - NCT05968729Recruiting
Study testing walking changes after ACL surgery
This study looks at how your walking pattern adapts when you follow a purposely uneven walking setup. It may help researchers understand recovery after ACL surgery and how to improve return-to-sport safety.
Storrs, ConnecticutAges 18–30 - NCT05955976Recruiting
Fat tissue study in knee osteoarthritis patients
This study looks at fat tissue around the knee and inside the thigh muscle in people having knee replacement surgery for osteoarthritis. It may help researchers understand how fat tissue affects the knee joint.
NiceAges 40–85 - NCT06041763Recruiting
Bridge-enhanced ACL repair for meniscus repair
This study tests a special bridge implant to help heal a torn meniscus during surgery. It may help improve recovery and reduce the need for additional surgeries.
New York, New YorkAges 18–75 - NCT06087341RecruitingPhase 1
CAR T-Cell Therapy for Advanced Sarcoma in Young People
This trial tests a special type of immune cell (called a CAR T-cell) that is trained to attack sarcoma cells. It is for children, teens, and young adults up to age 40 whose sarcoma has not responded to standard therapy. The treatment is given directly into the tumor, and the goal is to see if it is safe and how well it works.
MadridAges Up to 30 years - NCT06078189Recruiting
Thumb joint surgery for arthritis: comparing two procedures
This trial tests two surgical treatments for thumb base arthritis (rhizarthrosis) when other treatments like splints and injections haven't worked. It compares a newer joint implant (arthroplasty) with a standard procedure to remove a small bone (trapezectomy). The goal is to see which helps patients recover hand function better.
ParisAges 45–85 - NCT06090357Recruiting
How footplant changes after foot and ankle surgery
This study uses special pressure mats to measure how your foot pushes against the ground before and after surgery. It helps doctors learn how surgeries change your walking and balance.
BolognaAges 18–75 - NCT05919459Recruiting
Therapy program to help parents and teens with scoliosis anxiety
This study tests whether Acceptance and Commitment Therapy (a structured talk-therapy approach) can improve parents’ and teens’ psychological well-being. It compares this therapy to other active support programs for families dealing with adolescent idiopathic scoliosis.
Hong KongAges 10–60 - NCT06091397Recruiting
Italian ankle replacement survey study
This study tests a new Italian questionnaire for people who have had total ankle replacement surgery. It helps doctors understand how well patients forget about their new ankle in daily life.
BolognaAges 25–80 - NCT06078852Recruiting
FSHD Diaphragm Ultrasound Study
This study uses ultrasound to look at the diaphragm in people with FSHD. It aims to better understand how FSHD affects breathing muscles over time.
RomaAges 18 years+ - NCT05972876Recruiting
Blood-flow restriction rehab after ACL surgery
This trial looks at how well your ACL graft (the repaired tissue) heals after ACL reconstruction when you use a specific rehab method called blood-flow restriction training. It may help your care team understand whether this rehab approach leads to better healing and function.
Sittard, LimburgAges 18–65 - NCT06075966Enrolling by invitation
A new surgery for lumbar disc disease without fusion
This trial tests a surgical technique that treats a damaged disc in your lower back without permanently fusing the bones together. It may be an option if you have had at least 3 months of other treatments like physical therapy or medication and they have not helped enough.
Jinan, ShandongAges 18–85 - NCT06078813RecruitingPhase 1/Phase 2
Higher dose spine radiation for limited spread cancers
This trial tests a higher dose of focused radiation (SABR) for people whose solid cancer has spread to the spine in a few spots. The goal is to control those tumors with fewer side effects.
CorkAges 18 years+ - NCT05956236Recruiting
Hip implant study for adults with severe hip pain
This study follows adults who will receive an investigational hip implant because their hip pain or disability is severe and not improved by other options. It checks how the implant system works and monitors patients over time with scheduled visits and questionnaires.
Saint-Priest-en-JarezAges 18 years+ - NCT05976347RecruitingPhase 4
Treatment for depression after certain bone fractures
This trial tries to find and treat depression in people who have recently had surgery for an arm, leg, or pelvis fracture. It may help by screening for depression soon after surgery and offering a new depression treatment approach if you qualify.
Winston-Salem, North CarolinaAges 18 years+ - NCT06029374Recruiting
Comparing treatments for hand bone fractures
This trial compares two treatments for a common hand fracture—the boxer's fracture—to see if one is better. It will help people recover quickly without surgery.
ViennaAges 18–70 - NCT05993845Recruiting
Hip replacement surgery study
This study looks at how doctors plan and perform hip replacement surgery using a special front approach. It may help improve how the surgery is done.
Baden, Canton of AargauAges 18 years+ - NCT05934994Recruiting
Extra bone scan tests to study unclear single bone spots
This study adds extra measurements during a bone scan to better understand a single unclear spot seen on standard imaging. The goal is to help doctors decide whether a biopsy (sample) or removal is needed, possibly reducing uncertainty.
Vandœuvre-lès-NancyAges 18–90 - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT06080152Recruiting
Wheeled device use after knee replacement
This study observes how people use wheeled devices (like walkers) after a total knee replacement. It helps doctors understand what patients need during recovery.
Redwood City, CaliforniaAges 18–99 - NCT05928403Recruiting
Compare knee implant types by how well people return to sport
This study compares three types of knee replacement implants to see how quickly and how well people can return to sports. It may help doctors understand which implant design supports better movement and recovery.
BiarritzAges 18–70 - NCT05978414Recruiting
Jaw and Pelvis Connections in Women After Prolapse Surgery
This study looks at how the jaw joint and pelvis may be connected in women who have had surgery for pelvic organ prolapse and also have endometriosis. It aims to find new links that could help guide treatment.
PoznanAges 18–60 - NCT05981833Recruiting
Donated skin graft for large rotator cuff tears
This study tests whether adding a donated skin graft during rotator cuff repair helps heal large tears better than repair alone. It may be an option for people with a first-time, large rotator cuff tear who have moderate to severe fatty changes in the muscle.
Scottsdale, ArizonaAges 30–75 - NCT06031571Recruiting
Cupping vs myofascial release for neck pain
This trial compares two hands-on treatments for long-term neck pain that isn't caused by injury or serious spine problems. It aims to see if dynamic cupping or myofascial release works better to relieve pain.
Qina, Qena GovernorateAges 18–40
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.