Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06477393Enrolling by invitation
Mud and mineral water baths for hand and foot osteoarthritis
This study tests whether natural mud and mineral water baths can help reduce pain and improve function in people with osteoarthritis of the hands or feet. If you have hand or foot pain from osteoarthritis and are looking for non-drug treatment options, this may be a good fit.
BirštonasAges 18 years+ - NCT06475365Enrolling by invitation
Salt water gargling after neck surgery to help swallowing
This study tests whether gargling with salt water after multi-level neck fusion surgery can improve swallowing recovery. If you are having this surgery, the trial aims to find a simple, low-cost way to protect your swallowing function.
Los Angeles, CaliforniaAges 18–80 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06451783Enrolling by invitationEarly Phase 1
Herbal Medicine and Joint Manipulation for Knee Osteoarthritis
This trial tests a combination of a Chinese herbal formula (Shengyu Decoction) and a hands-on joint manipulation technique (Lijin Manipulation) to improve knee movement and reduce pain in people with knee osteoarthritis. It uses special 3D walking analysis to see how well the treatment works.
ShanghaiAges 45–85 - NCT06444945Enrolling by invitation
Comparing two hands-on therapies for knee osteoarthritis
This study compares two hands-on therapy techniques (Mulligan and Kaltenborn mobilizations) to see which works better for reducing pain and improving movement in people with knee osteoarthritis. If you have mild to moderate knee pain and are between 40 and 70, this trial may help you find a gentler treatment option.
IslamabadAges 40–70 - NCT06444932Enrolling by invitation
Strength training plus joint mobilization for knee osteoarthritis
This study looks at whether adding resistance (strength) exercises to joint mobilization helps people with knee osteoarthritis move better, feel less pain, and get stronger. You'll do standard joint mobilization plus a program of exercises like leg presses and squats.
IslamabadAges 40–70 - NCT06438679Enrolling by invitationPhase 4
3T therapy for MDA5-positive dermatomyositis with lung involvement
This trial tests a treatment called 3T therapy for people with MDA5-positive dermatomyositis, a rare autoimmune disease that affects the skin, muscles, and often the lungs. The goal is to see if 3T therapy can help control the disease and improve lung function.
Hangzhou, ZhejiangAges 18 years+ - NCT06435494Enrolling by invitation
Using patient reports to improve shoulder care across clinics
This study tests whether asking patients about their shoulder symptoms using a phone or computer app can help doctors and therapists work together to improve care. It is for adults with shoulder pain that started without a sudden injury.
Gentofte Municipality, HellerupAges 18–120 - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06424041Enrolling by invitationPhase 2
Fecal transplant for fibromyalgia pain relief
This study tests whether transferring healthy gut bacteria from a donor can reduce pain in women with fibromyalgia. You would first take antibiotics and laxatives to prepare your gut, then receive the transplant through a colonoscopy.
Haifa, NorthAges 18–75 - NCT06415136Enrolling by invitation
Comparing two ways to fuse neck bones after prior surgery
This study tests two methods for adding a new fusion to the level next to a previous neck surgery. It compares using a special plate system versus removing the old plate and putting in a new one.
Southfield, MichiganAges 18 years+ - NCT06415123Enrolling by invitation
Study comparing new bone graft to standard for spinal fusion
This study tests a new bone graft material (MagnetOs Flex Matrix) compared to a standard bone graft for spinal fusion surgery. It may be an option if you have ongoing back or leg pain that hasn't improved with other treatments and you need a one-time fusion of up to 4 levels in your lower back.
Southfield, MichiganAges 18 years+ - NCT06415110Enrolling by invitation
Comparing bone grafts for lower back fusion surgery
This study tests if a special bone graft material (Allosync Expand) plus your own bone is as good as using just your own bone for spinal fusion surgery. It might help people with back or leg pain caused by a slipped vertebra and narrowed spine.
Southfield, MichiganAges 22 years+ - NCT06412328Enrolling by invitation
Psychoeducation for parents of children with DMD
This study offers a psychoeducation program for parents of children with Duchenne Muscular Dystrophy. It aims to provide support and education to help you care for your child.
Ankara, CankayaAges 18–65 - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06377085Enrolling by invitationPhase 1
Testing an old drug for tight muscles in kids with cerebral palsy
This trial tests a drug called 5-Azacytidine, which is being used in a new way—to help loosen tight muscles (contractures) in children with cerebral palsy. It aims to see if it can reduce the need for surgery.
San Diego, CaliforniaAges 2–18 - NCT06375993Enrolling by invitationPhase 1
Prula-cel for autoimmune diseases: a phase 1 study
This trial tests a new treatment called prulacabtagene leucel (prula-cel), which is a type of immune cell therapy (CAR T-cells) for people with certain autoimmune diseases. It aims to see if it can reset the immune system and reduce disease activity in conditions like lupus, scleroderma, vasculitis, or myositis.
Redwood City, CaliforniaAges 18–80 - NCT06363526Enrolling by invitation
Digital breathing exercises for children with muscular dystrophy
This trial tests a 5-week digital breathing exercise program for children with Duchenne or Becker muscular dystrophy. It aims to improve lung function using simple exercises done at home.
MálagaAges 5–20 - NCT06338319Enrolling by invitation
Book sharing study for toddlers with cleft palate
This study tests whether a book-sharing program can help toddlers (20-32 months) who had cleft palate repair improve their language and communication skills. Families will use a smartphone or tablet to record and send videos.
Seattle, WashingtonAges 1.7 years–2.7 years - NCT06337513Enrolling by invitation
Back pain study for early arthritis diagnosis
This trial looks at people with low back pain to find early signs of a spine arthritis condition. It may help diagnose the condition sooner and guide better treatment.
Sønderborg, Southern DenmarkAges 18–48 - NCT06335862Enrolling by invitation
Surgery to stop windpipe collapse in babies with esophageal atresia
This trial tests a surgery called posterior tracheopexy to prevent the windpipe from collapsing in babies with esophageal atresia and tracheomalacia. It may help your child breathe more easily.
RotterdamAges 8 months+ - NCT06330324Enrolling by invitation
Reproductive choices for genetic skin conditions
This study looks at the choices families have when they carry a genetic skin condition. It aims to learn more about how prenatal testing and IVF with genetic testing can help.
Maastricht, LimburgAges Any age - NCT06311331Enrolling by invitation
Total talus replacement for ankle bone damage
This trial tests a new total talus replacement implant for people with severe talus bone problems like avascular necrosis, non-healing fractures, or large bone defects. It aims to see how well the implant works and how patients recover.
Charlotte, North CarolinaAges 22 years+ - NCT06304428Enrolling by invitation
Preventing falls and fractures by optimizing medications in nursing homes
This study tests whether carefully reviewing and adjusting medications in a skilled nursing facility can help prevent future fractures and injuries in older adults who were recently hospitalized for a broken bone.
Boston, MassachusettsAges 65 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.