Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT04260165Recruiting
Wrist surgery options for certain wrist arthritis
This trial compares two types of wrist surgery for osteoarthritis in the wrist bones (SLAC/SNAC stage II–III). It may help you and your surgeon choose the procedure that best improves pain and wrist function for your specific wrist arthritis pattern.
HelsinkiAges 18–75 - NCT04276181Recruiting
Nerve and tendon transfer surgery for hand function after spinal cord injury
This trial studies a specialized surgery that reroutes nerves and tendons to help restore hand and grip function after a spinal cord injury. It may help some people regain more useful hand movement if their arm muscle strength and nerve signals are strong enough.
MölndalAges 15–55 - NCT04246138Recruiting
Robot-assisted knee replacement alignment: best function
This trial compares two types of robot-guided knee replacement alignment to see which one helps people do everyday activities better after surgery. If you have “wear-and-tear” knee arthritis, you may be offered one of the two surgical alignment approaches as part of a study.
Hull, East YorkshireAges 18–90 - NCT04576169Recruiting
Comparing treatment options for a TFCC tear in the wrist
This trial looks at which treatment works best for a specific kind of wrist cartilage (TFCC) tear. It may help you choose the most effective option if you have ulnar-sided wrist pain that didn’t improve with non-surgical care.
CopenhagenAges 18–65 - NCT04458584Recruiting
Thumb surgery trial comparing treatments for basal joint arthritis
This study looks at how well different thumb (basal joint) surgery approaches restore strength and function. You would be having planned (non-replacement) thumb surgery, and your chosen surgeon would care for you while researchers compare outcomes.
Lebanon, New HampshireAges 21 years+ - NCT04294693Recruiting
Study of total joint replacement in children and young adults
This study looks at outcomes after total joint replacement in people ages 10–25 at Children’s Hospital Colorado. It may help doctors better understand which patients do well after surgery (or after trying non-surgical pain treatments first).
Aurora, ColoradoAges 10–25 - NCT02996656Recruiting
Antibiotic prevention for skin bacteria in shoulder surgery
This study checks whether giving an antibiotic “ahead of surgery” can reduce problems from common skin bacteria (Propionibacterium acnes) during primary shoulder surgery. It may help lower the risk of infection around the new joint/repair.
Montreal, QuebecAges 18 years+ - NCT01909375Recruiting
Joint replacement registry study for people getting new joints
This is a registry study that collects information about people in the US who are getting a total joint replacement. It may help researchers understand outcomes and improve care for patients like you.
Rosemont, IllinoisAges Any age - NCT01747291Recruiting
Study of incomplete atypical bone fractures
This study follows people who have had a specific type of bone injury called an atypical fracture, or a similar fracture after little or no trauma. It aims to better understand who is affected and how these injuries behave over time.
Hamilton, OntarioAges 20–100 - NCT03552705RecruitingPhase 2
Tranexamic acid to reduce knee inflammation after ACL injury
This Phase 2 study tests whether tranexamic acid can reduce swelling and protect knee cartilage after an ACL injury. It may help by limiting bleeding-related inflammation in the injured joint soon after injury.
Stanford, CaliforniaAges 18–30 - NCT05805410Recruiting
Trunk therapy in children with spastic cerebral palsy
This study looks at how special trunk (core) exercises or positioning affect movement and muscle control in children with spastic cerebral palsy (CP). It may help families understand which trunk-focused interventions improve function and comfort.
Chicago, IllinoisAges 4–12 - NCT06974474RecruitingPhase 4
Guselkumab for pain in psoriatic arthritis
This study tests if guselkumab can reduce pain and inflammation in people with psoriatic arthritis. You may join if standard treatments have not worked well enough or caused side effects.
Rome, ItalyAges 18–80 - NCT03328611Recruiting
Joint replacement outcomes database for degenerative joint disease
This study collects information about people with “wear-and-tear” joint disease who need joint replacement. The goal is to better understand outcomes after surgery and improve future care.
Indianapolis, IndianaAges Any age - NCT02563600Recruiting
Text support to help women attend pelvic floor physiotherapy
This study tests whether brief text-message support can improve how often people attend pelvic floor physiotherapy appointments. It may help by offering reminders or encouragement while you are waiting for care.
SwanseaAges 18 years+ - NCT05294068Recruiting
Study barriers to physical activity in aging with disabilities
This study looks at what makes it hard or easier for people with cognitive, physical movement, or sensory (hearing/vision) impairments to be active as they age. It may help improve support and services for physical activity at a rehabilitation/parasport clinic.
GarchesAges 6 years+ - NCT05487274Recruiting
Shoulder arthritis surgery plan for specific shoulder bone alignment
This study compares two types of surgery for advanced shoulder osteoarthritis when the shoulder socket is turned backward more than 15 degrees. It aims to see which surgical approach works best for pain and function when the bone alignment issue can be corrected.
Ottawa, OntarioAges 65 years+ - NCT02653079Recruiting
Blood testing and low-dose radiation for painful joint conditions
This study collects blood samples and treats certain painful joint/soft-tissue problems with low-dose local radiation therapy. It aims to understand disease features and how patients may respond to this treatment.
Erlangen, BavariaAges 18 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT00527839Recruiting
Shoulder replacement patient registry at a single hospital
This is a non-interventional patient registry that follows people having total shoulder replacement. You help researchers by completing questionnaires, which may improve how shoulder replacement care is understood and planned.
New York, New YorkAges 18 years+ - NCT03017118Recruiting
Turmeric study for early thumb basal joint arthritis
This trial studies whether turmeric can reduce pain from “basal joint” arthritis in the thumb, especially early stages seen on X-ray. You may be a good fit if you’re having thumb base pain and meet specific exam and X-ray requirements.
Boston, MassachusettsAges 40 years+ - NCT05574582Recruiting
Keyhole versus open surgery for an unhealed scaphoid bone
This study compares two surgical approaches—keyhole surgery versus open surgery—for scaphoid fractures that are not healing on their own. It aims to see which approach better helps the scaphoid heal after a delay or complete non-healing.
HellerupAges 18–68 - NCT05267093Recruiting
Acupuncture for hand osteoarthritis pain
This study compares real acupuncture to sham (placebo) acupuncture to see which one better reduces pain and improves function in people with hand osteoarthritis. It may help you understand whether acupuncture provides meaningful relief beyond placebo.
BeijingAges 18–80 - NCT07590674Recruiting
Balance training for competitive tennis players
This study compares two types of balance training to see which one better improves tennis players' ability to move quickly and change direction on court. You'll do either reactive balance exercises (responding to sudden movements) or traditional balance exercises over the study period.
IslamabadAges 18–25
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.