Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07711353Recruiting
Nerve stimulation plus physical therapy for frozen shoulder
This trial tests whether adding a gentle nerve stimulation device to standard physical therapy helps people with frozen shoulder (adhesive capsulitis) recover better. The stimulation is applied to the ear and is designed to be safe and non-invasive.
Istanbul, IstanbulAges 18–65 - NCT07708584Recruiting
Brostrom repair with BioBrace for chronic ankle instability
This trial tests whether adding a BioBrace scaffold to standard Brostrom surgery improves outcomes for people with chronic ankle instability. It may help if you have had a weak or unstable ankle for more than 3 months and haven't had prior ankle surgery.
Boston, MassachusettsAges 18–65 - NCT07714031Recruiting
Wrist Release Therapy for Overuse Syndrome
This study tests a special hands-on therapy technique for people with wrist pain from overuse, like computer workers. It may help improve movement and reduce pain without surgery.
Faisalabad, Punjab ProvinceAges 20–50 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07709416Recruiting
Testing toludesvenlafaxine for long-lasting low back pain
This study tests an experimental medication called toludesvenlafaxine to see if it can help people with long-lasting low back pain that has no clear cause. If you have moderate to severe lower back pain for more than 3 months and haven't taken antidepressants before, this may be an option for you to explore.
BeijingAges 18–75 - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT07709819Recruiting
A second look inside the knee after surgery
This study looks inside your knee again after a previous surgery, using a very small camera to see how your knee has healed. It could help doctors learn more about how well these knee repairs work.
Las Vegas, NevadaAges 18 years+ - NCT06639802Recruiting
Therapy for balance and coordination in ataxic cerebral palsy
This trial tests a hand-arm and leg therapy program to improve balance and coordination in children with ataxic cerebral palsy. It may help your child move more steadily and confidently.
RawalpindiAges 6–15 - NCT06642870Recruiting
Self-management programme for rare rheumatic conditions
This trial is developing a self-management programme for people with rare rheumatic conditions like lupus, vasculitis, myositis, or Sjogren syndrome. It aims to help participants better manage their condition and improve their quality of life.
BristolAges 18 years+ - NCT06641206Recruiting
Dexmedetomidine injection for chronic knee pain
This trial tests whether a single injection of dexmedetomidine into the knee joint can reduce chronic knee pain. It is for people who are not scheduled for knee surgery and have no serious health problems.
Tanta, El GharbyiaAges 40–75 - NCT04981145RecruitingPhase 4
Iguratimod for Sjögren’s syndrome symptoms and safety
This trial studies whether iguratimod improves symptoms in people with primary Sjögren’s syndrome, and checks how safe it is. It focuses on people with confirmed disease markers (anti-SSA/Ro-60) and ongoing dry eyes and dry mouth.
Hangzhou, ZhejiangAges 18–70 - NCT06643104Recruiting
Testing a 3D scan method for scoliosis in teens
This study tests a new 3D imaging method to assess scoliosis by comparing back height difference and trunk rotation angle. It aims to find a simpler way to measure spinal curves in teenagers with adolescent idiopathic scoliosis.
HangzhouAges 10–18 - NCT06640309RecruitingPhase 2
Nicotinamide for rheumatoid arthritis: a clinical trial
This trial tests if taking a vitamin B3 supplement (nicotinamide) can improve outcomes for people with rheumatoid arthritis. Researchers want to see if adding this over-the-counter vitamin to your usual arthritis medicines helps reduce disease activity.
CairoAges 18–65 - NCT07704580RecruitingPhase 1/Phase 2
Sarilumab for active rheumatoid arthritis
This trial tests sarilumab, an injected antibody that blocks a key protein involved in inflammation, for people with moderate-to-severe rheumatoid arthritis (RA) who haven't had success with standard treatments. The goal is to see if adding sarilumab can help control joint pain and swelling.
Centennial, ColoradoAges 18 years+ - NCT07704099RecruitingPhase 2
Study of KER-065 for Duchenne Muscular Dystrophy
This study tests a new medication called KER-065 to see if it helps people with Duchenne Muscular Dystrophy (DMD). It may help boys and men who are still walking, as well as those who use a wheelchair, as long as they are on a stable corticosteroid treatment.
Auckland, North IslandAges 9 years+ - NCT03716843Recruiting
Testing a pressure-sensing brace for teen scoliosis care
This trial tests a dynamic pressure monitoring system that tracks how a brace is applying pressure during treatment for adolescent idiopathic scoliosis. It may help doctors better adjust brace therapy to improve outcomes and comfort.
Tsim Sha Tsui, KolwoonAges 10–15 - NCT07704840RecruitingPhase 2
Testing a new pill for post-stroke arm stiffness
This study tests an experimental pill (BMS-986368) that targets two brain chemicals to reduce muscle stiffness after a stroke. It's for people who had a stroke in the last 4 to 18 months and have moderate tightness in their elbow and wrist.
Elkins Park, PennsylvaniaAges 18–80 - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
Kirikkale, KırıkkaleAges 18–40 - NCT07705698Recruiting
Nordic exercise for young female pole vaulters
This study compares two types of Nordic hamstring exercises—one with blood flow restriction and one without—to see which better helps elite young female pole vaulters strengthen their hamstrings and reduce injury risk.
AdanaAges 12–18 - NCT07701174Recruiting
Weighted exercise vs muscle stimulation for knee arthritis
This study compares two treatments for knee osteoarthritis: weighted dangling exercises and neuromuscular electrical stimulation of the knee muscle. It aims to see which one reduces pain and improves function better.
Lahore, Punjab ProvinceAges 40–60 - NCT07703293Recruiting
Testing nerve branches for chronic knee pain relief
This study tests a procedure targeting specific nerve branches in the thigh to treat long-lasting knee pain from osteoarthritis. It may help people who haven't found relief from standard treatments like pain relievers or physical therapy.
AnkaraAges 45–80 - NCT07703007Enrolling by invitation
Clear aligners for growing kids with mild underbite
This study tests whether clear aligners can fix a mild underbite in growing children aged 8 to 11. It compares how well the aligners move teeth and jaws compared to other treatments.
Al Mansurah, Dakahlia GovernorateAges 8–11 - NCT07706244Recruiting
Does reducing pre-surgery anxiety help orthopedic patients recover better?
This study tests if a program to reduce anxiety before surgery (Enhanced Recovery After Surgery) improves how patients feel one year after major orthopedic surgery like knee, hip, or spine procedures, compared to standard care.
Hualien City, Hualien CountyAges 20–100 - NCT07699575Recruiting
Can turmeric and ginger help runner recovery?
This trial tests whether taking turmeric, ginger, and black pepper supplements can reduce inflammation and aid recovery in runners completing the 175 km 'Diagonale des Fous' race. It could help you understand natural ways to manage post-race inflammation.
Saint-Pierre, CHU de La RéunionAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.