Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT04505579Recruiting
Study of a spinal tether to treat worsening scoliosis
This trial studies a surgically placed “tether” system to help stop or slow worsening in certain types of scoliosis in growing teens. It’s for people whose curve is moderate-to-severe and who could not tolerate or didn’t respond to bracing.
San Diego, CaliforniaAges Any age - NCT04117334Recruiting
Finding the best brace timing for scoliosis in growing teens
This study looks at adolescent idiopathic scoliosis—a common sideways curve in otherwise healthy teens—and tests which bracing approach is best for teens who are still growing. It may help guide families on the most helpful brace type and when it’s likely to work best.
Hong KongAges 10–18 - NCT04236492Recruiting
Fresh cartilage graft study for large knee joint damage
This trial studies how well a fresh cartilage and bone graft works to repair large, full-thickness defects in the knee. It also looks at imaging results (pictures of the knee) to see how the repair is healing over time.
Barcelona, CataloniaAges 15–50 - NCT03935139Recruiting
Monitoring bone flap healing with tiny fluid sensors
This study looks at how well a bone-free flap heals after head and neck reconstruction, using tiny pressure/fluid sensors (called microdialysis) to monitor healing. It may help surgeons catch healing problems earlier and improve outcomes.
AmiensAges 18 years+ - NCT04028401RecruitingPhase 3
Skin prep study to reduce bacteria in shoulder replacement surgery
This study tests whether a specific skin-cleaning method before shoulder replacement surgery can reduce a common bacteria (Cutibacterium acnes) found on skin and deeper samples. It may help lower the risk of infection or contamination during prosthetic shoulder surgery.
AngersAges 18 years+ - NCT04496024Recruiting
How ofloxacin levels may affect older adults with bone infections
This study looks at whether blood levels of the antibiotic ofloxacin in people over 65 are linked to side effects, in older adults hospitalized for bone and joint infections. It may help doctors choose safer doses, especially when switching from IV treatment to pills.
AmiensAges 65 years+ - NCT04104126Recruiting
Blood flow restriction therapy for an Achilles injury
This trial looks at whether “blood flow restriction” during exercise can improve healing for people with an Achilles injury. You may be asked to also do standard physical therapy, but the study focuses on the added blood-flow-restriction approach.
New York, New YorkAges 18–65 - NCT04218617RecruitingPhase 2
One vs two radiation treatments for spine metastases
This trial tests whether giving radiation to a spine metastasis in one dose works as well as giving it in two smaller doses. It aims to control tumors while keeping side effects and risk to the spinal cord low.
Cleveland, OhioAges 18 years+ - NCT04462458Recruiting
Study tracking outcomes after ACL reconstruction surgery
This is a study that follows adults who had an ACL tear treated with ACL reconstruction. It helps understand how the surgical device/material performs in real-world care.
InnsbruckAges 18 years+ - NCT04542720Recruiting
Nerve-Pressure Surgery Alone or With Spine Fusion
This trial compares two surgical options for the level just above a prior lumbar fusion: removing pressure on the nerve versus removing pressure plus adding a fusion. It may help determine which approach better treats ongoing nerve-related symptoms when other non-surgical treatments have not worked.
Boston, MassachusettsAges 18 years+ - NCT04635891Recruiting
Study motor function tests in FSHD
This trial studies how well certain physical/movement tests work in people with facioscapulohumeral muscular dystrophy (FSHD). It may help clinicians measure changes more accurately and tailor care over time.
Los Angeles, CaliforniaAges Any age - NCT04664517Recruiting
Casting or flexible rods for broken pediatric forearms
This study compares two ways to treat certain forearm bone breaks in children: a cast versus flexible metal rods inside the bone. It aims to see which method works better for healing and hand/arm function.
HelsinkiAges 7–12 - NCT03977493RecruitingPhase 3
Xeomin injections for focal hand muscle spasms
This trial tests incobotulinumtoxinA (Xeomin) injections to reduce focal hand dystonia—unwanted muscle tightening in the hand. You may be able to join whether you’ve had this condition before or have tried similar injections in the past, as long as certain safety rules are met.
BernAges 18 years+ - NCT04574336Recruiting
Tested treatment timing for specific upper-arm bone fractures
This study looks at treating certain types of upper-arm (humerus) shaft fractures started within 14 days of injury. It aims to see which approach works best for healing and recovery in the right kinds of fractures.
AabenraaAges 18 years+ - NCT05446259Recruiting
Study for a cervical spine condition database
This trial builds a “repository,” or database, of people with a neck-spine condition. It aims to better understand degenerative problems in the neck that may or may not be causing spinal cord symptoms, which could help future research and care.
Lexington, KentuckyAges 18–100 - NCT03908931Recruiting
Study of knee cartilage repair results
This study looks at how well certain types of knee cartilage repair work, using clinical check-ins and imaging (scans). You may be able to help researchers understand which method restores knee surface cartilage best.
Le ChesnayAges 18 years+ - NCT03859895Enrolling by invitation
Zoledronate to help prevent Paget’s disease over time
This trial is a long-term follow-up for people who already took part in a previous study called ZiPP. It tests whether continuing treatment with zoledronate can help prevent Paget’s disease from developing or worsening.
GeelongAges Any age - NCT04235517Recruiting
Study of growth plate behavior after temporary growth plate surgery
This study looks at how a child’s growth plate grows during and after a temporary growth plate procedure. It may help doctors better time and plan treatment for children whose leg alignment or leg length differs.
OsloAges 3–16 - NCT04348253Recruiting
Study of surgery for scapholunate ligament wrist instability
This study looks at people aged 18–60 who have ongoing, painful wrist instability from a fully torn scapholunate ligament. It may help improve surgical approaches by carefully selecting patients whose ligament tear is complete and causing measurable joint looseness.
AarhusAges 18–60 - NCT04277416Enrolling by invitation
Testing a new hip replacement system and how patients do
This study follows people getting a primary total hip replacement using the Entrada hip system to see how long it lasts and how well it works. You may be offered this specific hip implant and would be followed through study visits to measure recovery and outcomes.
Portland, OregonAges 18–80 - NCT04007783Recruiting
Test of a new plan for jaw reconstruction and implants
This study checks whether the “O-bridge protocol” helps people who need jaw surgery—either for osteonecrosis of the jaw or for oral/jaw tumors—followed by dental implant placement to support fixed teeth (not removable dentures). The goal is to improve your ability to eat, speak, and get a stable tooth replacement plan after surgery.
AntwerpAges 18 years+ - NCT03849443RecruitingEarly Phase 1
Testing tranexamic acid to reduce bleeding after spine fusion
This trial studies whether a single dose or multiple doses of tranexamic acid (TXA) can reduce the chance you need a blood transfusion after spine fusion surgery. It also compares two different ways TXA may be given (by mouth and through a vein) to see which approach works best and is safe.
Chicago, IllinoisAges 18 years+ - NCT04441983Recruiting
High-resolution foot MRI trial for patients and volunteers
This trial uses a powerful 7T MRI scanner to get detailed images of the foot and extremities. It includes patients with specific conditions (like Morton neuroma or tendon tears) and healthy volunteers, aiming to understand normal and diseased tissue better.
Zurich, Canton of ZurichAges 18 years+ - NCT04369209Recruiting
Study of people with FSHD1 gene changes
This is a study that follows people who have a confirmed FSHD1 genetic change (and some healthy people for comparison). It may help researchers better understand the condition and how it affects people over time.
Fuzhou, FujianAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.