Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07718932Recruiting
Healing gel for wisdom tooth extraction recovery
This trial tests a regenerative gel placed in the socket after wisdom tooth removal to improve healing. It may reduce pain, swelling, and speed up recovery.
ThessalonikiAges 18–35 - NCT07722117Recruiting
Reiki for pain after back surgery
This trial tests if Reiki, a gentle hands-on energy therapy, can help reduce pain after lumbar (lower back) surgery. It may offer a drug-free option to help you feel better during recovery.
ParisAges 18 years+ - NCT07720401Recruiting
Exercise during dialysis for posture problems
This study tests if doing gentle exercise during dialysis can help improve posture problems like a rounded upper back or forward head tilt. It is a small, early-stage study to see if the exercises are safe and might help.
IsfahanAges 18–80 - NCT07719699Recruiting
Vibration and Pilates for chronic low back pain
This study tests if whole-body vibration or Pilates exercises can reduce pain and improve balance and movement in people with long-lasting low back pain. It aims to find a helpful treatment for chronic back pain that has lasted more than 12 weeks.
Lahore, Punjab ProvinceAges 18–40 - NCT07721220Recruiting
Nerve gliding moves for strength and endurance in athletes
This study tests whether a gentle nerve-stretching technique (neurodynamics) can improve leg strength and endurance in athletes. If you're 18–30, currently active in sports or intense training, and have no recent leg injury or surgery, you may be able to join.
High Point, North CarolinaAges 18–30 - NCT07721116Recruiting
AI Study of Knee Imaging and Treatment Results
This study uses artificial intelligence (AI) to better understand knee images from healthy people and those with knee arthritis. It aims to predict how well knee injections might work for you.
Taipei, TaiwanAges 18 years+ - NCT07718815Recruiting
HLA B leader study in psoriatic arthritis
This study looks at a specific genetic marker (HLA B leader) in people with psoriatic arthritis compared to healthy individuals. It may help researchers understand how this gene affects the disease.
Amiens, PicardieAges 18 years+ - NCT07723586Recruiting
TENS vs Ultrasound for mechanical neck pain
This trial compares two common treatments—TENS (a device that uses mild electrical pulses) and ultrasound therapy—along with neck exercises for long-lasting neck pain. You would get one of these treatments for several weeks to see which helps your pain more.
Karachi, SindhAges 18–45 - NCT07721415Enrolling by invitationPhase 4
Iodine drapes for shoulder replacement surgery
This trial is testing whether using iodine drapes during a first-time shoulder replacement reduces infection risk. It is for men who are planning this surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03332251Recruiting
Posture brace study for teens with early scoliosis
This trial tests whether a posture-correction “girdle” brace can help adolescents with early scoliosis. If you have a small curve and haven’t started treatment yet, it may help slow or improve the curve while you follow the brace plan.
Hong KongAges 10–13 - NCT05790031Recruiting
Night brace with smart padding for teenage scoliosis
This trial tests an intelligent nighttime brace with sensors and smart padding to help teens with early scoliosis straighten or stop it from worsening. You may be asked to wear the brace at night and complete tests to track curve changes and comfort.
Hong KongAges 10–13 - NCT06350110RecruitingPhase 1/Phase 2
CAR T cells for lupus
This trial tests a new type of CAR T cell therapy for people with active lupus that has not responded to other treatments. It uses specially engineered cells to target and eliminate certain immune cells that are causing the disease, with the goal of reducing symptoms and preventing flare-ups.
Beijing, Beijing MunicipalityAges 18–90 - NCT06497140RecruitingPhase 3
Genicular artery embolization for painful knee osteoarthritis
This trial tests a new procedure called genicular artery embolization to treat knee pain from osteoarthritis. If you have moderate to severe knee pain and are not a candidate for knee replacement or other surgery, this treatment may help reduce pain and improve function.
ParisAges 40–90 - NCT06413914Recruiting
CBT for long-term pain in rheumatic disease
This trial tests if cognitive behavioral therapy (a type of talk therapy that helps change pain-related thoughts and behaviors) can reduce long-term pain in people with rheumatic diseases. It also validates a new questionnaire (AE-FS) about how pain affects daily life.
OsloAges 18 years+ - NCT06596187Recruiting
Study of muscle tightness in spinal cord injury and Parkinson's
This study looks at muscle tightness (hypertonia) in people with spinal cord injury, Parkinson's disease, and healthy volunteers. It aims to better understand and measure different types of stiffness to improve treatments.
TaoyuanAges 20 years+ - NCT06637579Recruiting
Exercise Program for Walking in Children with Cerebral Palsy
This trial tests a special exercise program (Universal Exercise Unit) plus task-focused training for children with spastic cerebral palsy. It aims to help with walking, balance, and daily activities.
Sialkot, Punjab ProvinceAges 5–15 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT07706569Recruiting
Fetuin-A and COMP levels in knee osteoarthritis
This study looks at two substances in the blood (fetuin-A and COMP) to see if they are linked to knee osteoarthritis severity. Results may help understand the disease better.
AntalyaAges Any age - NCT07712939RecruitingPhase 1
Study of CND319 for rheumatic diseases
This study tests a new drug called CND319 in healthy volunteers and people with rheumatoid arthritis or Sjögren's disease. The goal is to see if it is safe and how the body responds to it.
Melbourne, VictoriaAges 18–65 - NCT07710885RecruitingPhase 3
Futibatinib for advanced bile duct cancer
This trial tests a new targeted therapy, futibatinib, for people with advanced or unresectable bile duct cancer who have not had prior treatment for advanced disease. It aims to see if this drug can help shrink or control the cancer.
BrisbaneAges 18 years+ - NCT07706777RecruitingPhase 2
Testing a new drug for acute gout flares
This trial tests an oral medication (HRS-2129) to see if it can calm a sudden gout flare and reduce joint pain. It may help if you are currently having a moderate-to-severe gout attack and are otherwise in good health.
Guangzhou, GuangdongAges 18 years+ - NCT07714811Recruiting
Hyaluronic acid vs PRP for chronic tendon pain
This study compares two treatments—hyaluronic acid (a natural lubricant) and platelet-rich plasma (PRP, made from your own blood)—for chronic tendon pain. You may be a good fit if you have had pain in your Achilles tendon or golfer's elbow for more than 3 months and are looking for a non-surgical option.
Lublin, Lublin VoivodeshipAges 18–65 - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT07715006Recruiting
Spinal nerve stimulation for children with cerebral palsy
This study adds a mild electrical stimulation to the spinal nerves during a planned SDR surgery for children with cerebral palsy, to see if it helps improve movement more than the surgery alone.
Pittsburgh, PennsylvaniaAges 3–14
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.