Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT07294131RecruitingPhase 2
Preventing muscle loss in hospitalized older adults
This trial tests a special exercise approach using blood-flow restriction and a video game to help older adults in the hospital keep their muscle strength. The goal is to find a safe way for bedridden patients to exercise and recover better.
AntwerpAges 65 years+ - NCT02315729Recruiting
Testing blood or tissue signals in teen scoliosis prognosis
This study looks at cell “signaling factors” to understand what predicts how adolescent idiopathic scoliosis may change over time. It may help doctors better forecast which curves are more likely to progress and tailor follow-up care.
Denver, ColoradoAges 10–13 - NCT07134257Recruiting
Smart crutch tips for leg fracture recovery
This study tests a special crutch tip that helps guide how much weight you put on your leg after shinbone surgery. It may help you recover more safely by giving you feedback on your weight-bearing.
Kyiv, Kyiv OblastAges 18–80 - NCT03347877Enrolling by invitation
Autologous bone graft surgery for severe ankle cartilage damage
This trial studies a surgery that uses your own tissue (bone/cartilage part) to repair a specific, advanced ankle cartilage injury (Hepple V) in the talus bone. It may help people with ongoing ankle pain when rest and anti-inflammatory treatments haven’t worked.
Beijing, Beijing MunicipalityAges 18–60 - NCT06812611Recruiting
High intensity laser therapy for muscle injuries
This trial tests if high intensity laser therapy helps heal severe muscle tears in the leg. If you have a recent, serious muscle tear from sports, this treatment might speed up your recovery.
BariAges 16 years+ - NCT06812143Recruiting
Strength Training Study for Adults 65 and Older
This study tests a strength training program designed for older adults who are not currently active. The goal is to find the best way to improve strength and overall health in people over 65.
Flushing, New YorkAges 65 years+ - NCT07135843Recruiting
Digital home exercise program after hip replacement
This study tests a home-based digital program that encourages physical activity in older adults after hip replacement surgery. It aims to help you stay active and recover better from home.
Heidelberg, Baden-WurttembergAges 65 years+ - NCT03037242Enrolling by invitation
Surgery outcomes for meniscus root tears with a specific repair technique
This study looks at results after a particular surgery to repair a meniscus root tear in the knee. It may help doctors understand which patients benefit most and what outcomes to expect.
Rochester, MinnesotaAges 18–65 - NCT06099600Recruiting
ACL reconstruction study with follow-up via app
This trial is for people getting ACL (anterior cruciate ligament) surgery. It tests if tracking your recovery through questionnaires on a phone or tablet helps improve outcomes.
LyonAges 18 years+ - NCT07108920Recruiting
Balance and Botox for Stiff Knee Gait
This study tests whether botulinum toxin (Botox) injections into the rectus femoris thigh muscle can improve balance and walking in people with a stiff knee gait (a common problem after stroke, brain injury, or multiple sclerosis).
Héricourt, Nord Franche-ComtéAges 18 years+ - NCT07155967Enrolling by invitation
Blood flow restriction training for leg strength in older women
This trial tests whether a type of strength training that partly uses blood flow restriction can help older women build leg strength on one side, which may also benefit the other leg. It's for women who are generally healthy and have not had recent leg injuries or surgeries.
Presidente Prudente, São PauloAges 60 years+ - NCT06798623RecruitingPhase 1
ACL repair with stem cells from your own knee fat
This trial tests whether adding stem cells from your knee fat pad to a standard ACL reconstruction helps you heal better. It is for Houston Methodist patients who can do physical therapy there and meet basic health requirements.
Houston, TexasAges 18 years+ - NCT03713853Recruiting
Compare hip surgery methods for new pelvic bone fractures
This study compares two ways of fixing a recently broken acetabulum (the hip socket): one method keeps/repairs the socket (ORIF) and the other replaces it (THA). It aims to find which surgery approach leads to better outcomes for people who can have surgery soon after the injury.
Toronto, OntarioAges 60 years+ - NCT03168802Recruiting
Ultrasound and nerve treatment for facet-joint low back pain
This study tests whether a procedure that uses focused ultrasound (MRgFUS) and/or a radiofrequency nerve treatment can reduce long-lasting low back pain caused by facet-joint arthritis. It may help people whose pain improves strongly after a targeted numbing injection to specific back nerves.
Taipei, Please SelectAges 20–79 - NCT03307109Recruiting
Quality of life study for adults with an infected joint implant
This study looks at how treatment affects quality of life for adults who have an infection around a joint implant. You may be asked to complete questionnaires to understand symptoms and daily well-being.
LyonAges 18 years+ - NCT07120659Recruiting
Comparing vacuum and tactile massage for chronic neck pain
This study compares two types of massage (vacuum massage and tactile massage) to see which one works better for people with long-term neck pain. If you have had neck pain for at least 3 months, you may be able to join.
Tromsø, TromsAges 21–75 - NCT07153302Recruiting
Can almonds help heal broken leg bones?
This study tests if eating almonds can help femur (thigh) or tibia (shin) fractures heal faster. If you have a fresh leg break and are 18 to 55, you may be able to join.
KarachiAges 18–55 - NCT03584815Recruiting
Test of physiotherapy versus surgery for exercise leg muscle pressure
This trial compares a physiotherapy program to a surgical procedure (fasciotomy) for chronic “compartment” pressure in the lower leg triggered by exercise. If you have symptoms that reliably come on with walking/running and improve with rest, the study may offer a structured way to find the best treatment for you.
Copenhagen, CopehagenAges 18–50 - NCT02503228Enrolling by invitation
Registry study of a preserved bone-cartilage graft
This registry study follows people who get a preserved graft to repair damaged bone and cartilage in a joint. It helps doctors understand how well the graft is preserved and how patients do after surgery over time.
Columbia, MissouriAges 13 years+ - NCT07130357Recruiting
Collagen scaffold for Achilles tendon repair
This study tests whether adding a special collagen scaffold during surgery helps heal a torn Achilles tendon better than standard repair alone. The scaffold is made from cow collagen and is placed over the repair to support healing.
Shatin, New TerritoriesAges 18 years+ - NCT03716843Recruiting
Testing a pressure-sensing brace for teen scoliosis care
This trial tests a dynamic pressure monitoring system that tracks how a brace is applying pressure during treatment for adolescent idiopathic scoliosis. It may help doctors better adjust brace therapy to improve outcomes and comfort.
Tsim Sha Tsui, KolwoonAges 10–15 - NCT06524531RecruitingEarly Phase 1
Pulse Energy and Blood Injection for Stubborn Back Pain
This trial tests a new treatment for stubborn low back pain that involves a short pulse of radio waves (a type of energy) and an injection of your own blood cells (called PRP) to help the muscles in your back work better. It is for people whose pain comes from a specific muscle problem and has not gone away with other care.
Lahore, Punjab ProvinceAges 30–70 - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.