Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07677072Recruiting
Studying a blood protein to detect hidden bone fragility
This study looks at a protein called lumican in the blood to see if it can help find women who have fragile bones even if their bone density test looks normal. It's for postmenopausal women who are already getting a bone density scan as part of their routine care.
Küçükçekmece, IstanbulAges 45 years+ - NCT07672210Recruiting
Pregnancy-related aortic dissection in China
This study is looking at cases of aortic dissection that happen during pregnancy or shortly after childbirth in China. It aims to understand how these events occur and how they can best be managed.
Shanghai, Shanghai MunicipalityAges 16–55 - NCT07677033Recruiting
Bone and muscle health study for adults
This study looks at how well your bones and muscles work together. By measuring your bone density and handgrip strength, doctors can better understand your bone health and find ways to keep you strong as you age.
Küçükçekmece, IstanbulAges 18 years+ - NCT07675967Recruiting
Blood Cell Changes During Cancer Treatment
This study is for people with solid tumors who are about to start chemotherapy or radiation. It looks at how these treatments affect blood cells and may help doctors understand changes in blood health over time.
Boston, MassachusettsAges 18 years+ - NCT07675655Recruiting
Mulligan vs. PNF exercises for shoulder pain
This trial compares two hands-on therapy techniques for people with shoulder impingement (pain when lifting the arm). It tests if one method works better for reducing pain and improving movement.
Sohag, TahtaAges 20–40 - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT07678112Recruiting
Trial of a device to keep rheumatoid arthritis in remission
This trial tests a medical device to help people with rheumatoid arthritis stay in remission while on biologic therapy. The goal is to see if the device can prevent flares and maintain disease control.
A Coruña, A CoruñaAges 18 years+ - NCT07672093Recruiting
Dry needling for forearm muscle knots
This study tests whether inserting a thin needle (dry needling) into a tight muscle knot in your forearm can help release it without causing pain. It's for healthy adults who have a non-painful knot in their dominant arm.
Reus, TarragonaAges 18–40 - NCT07676058Recruiting
Massage vs. tool therapy for heel pain in pregnancy
This trial compares two types of hands-on therapy—myofascial release and instrument-assisted tissue mobilization—to see which works better for pregnant women who have heel pain from plantar fasciitis. It aims to find a safe and effective treatment during pregnancy.
Lahore, Punjab ProvinceAges 20–40 - NCT07672834Recruiting
Resistance band training for leg strength in older adults
This study tests whether using simple elastic resistance bands can help improve leg muscle strength in older adults who have weak leg muscles. It involves supervised training sessions and may help you move better and feel stronger.
LondonAges 50 years+ - NCT07677722Recruiting
Comparing two types of partial knee replacements
This trial compares two designs of partial knee replacements (fixed bearing vs mobile bearing) to see which offers better results and fewer problems for people with arthritis in the inner part of the knee. If you meet the criteria, this study might help you and your doctor choose the best option.
Ieper, Oost-VlaanderenAges 50–80 - NCT07674134Recruiting
A Study of a JAK Inhibitor Pill for Rheumatoid Arthritis
This trial tests taking a JAK inhibitor (a type of pill that helps calm inflammation in rheumatoid arthritis) by mouth. It aims to see how well it works and if it's safe for people with RA who need this kind of medicine.
MonacoAges 18 years+ - NCT06665607Recruiting
Foot muscle training for people with MS
This study tests whether training the small muscles in your feet can improve your walking and balance if you have multiple sclerosis (MS). It is for people with moderate disability, so you can still walk but may have some trouble.
ValladolidAges 18–70 - NCT06669013RecruitingPhase 3
Chemo-immunotherapy for young people with bone or soft tissue sarcoma
This trial tests whether adding immunotherapy (a treatment that helps your immune system fight cancer) to chemotherapy can help young people whose bone or soft tissue sarcoma has come back or hasn't responded to previous treatment.
Saint PetersburgAges Up to 18 years - NCT06080347Recruiting
Anti-inflammatory diet for knee osteoarthritis
This study tests whether an anti-inflammatory diet can help with knee osteoarthritis. If you have OA in one knee and are open to changing your eating habits, you may be able to join.
San Diego, CaliforniaAges 18 years+ - NCT06672354Recruiting
Virtual reality vs. exercises for balance in older adults
This trial tests whether a fun virtual reality game (like a video game you do standing up) can improve balance and walking better than a set of simple exercises. It is for older adults who can still walk on their own but want to stay steady on their feet.
IslamabadAges 55 years+ - NCT06671860Recruiting
Exercises and hands-on therapy for neck pain
This study tests whether combining eye exercises with hands-on therapy helps people with non-specific neck pain (pain not caused by a known injury or disease). It may help improve how your neck moves and reduce discomfort.
IstanbulAges 18–65 - NCT04195256RecruitingPhase 2/Phase 3
Nasal sedation medicine for kids needing a quick procedure
This trial tests whether a nose spray (dexmedetomidine plus ketamine) can safely and effectively sedate children during an ED procedure for certain arm injuries. It may help reduce distress and improve comfort compared with usual care.
Edmonton, AlbertaAges 2–17 - NCT06672328Recruiting
Can watching movements boost function in kids with CP?
This study tests whether watching and then practicing movements (action observation training) can improve everyday functional skills in children with spastic cerebral palsy. It could help children move better and more independently.
IslamabadAges 5–12 - NCT06428188RecruitingPhase 1/Phase 2
CAR-T cells targeting BCMA/CD19 for autoimmune diseases
This trial tests a new treatment called CAR-T cells that target two proteins (BCMA and CD19) on immune cells. It is for people with certain autoimmune diseases that have not improved with standard treatments.
Beijing, Beijing MunicipalityAges 21–90 - NCT06674057Recruiting
Taping with physical therapy for arm function after stroke
This study tests whether adding kinesio-taping to standard physical therapy helps improve arm movement and reduce stiffness in people recovering from a recent stroke.
IslamabadAges 40–65 - NCT06674707Recruiting
Agility training with foot exercises for kneecap pain
This trial tests whether adding foot exercises to agility training can better relieve long-lasting knee pain (patellofemoral pain syndrome) in adults ages 20 to 40. Eligible participants will have had pain behind the kneecap for over 6 months.
Lahore, Punjab ProvinceAges 20–40 - NCT06674668Recruiting
Vibration therapy for tennis elbow pain
This study tests whether gentle vibrations applied to the elbow can help reduce pain and improve function in people with tennis elbow (lateral epicondylitis). It compares the effects of this new therapy to standard care.
IstanbulAges 18–65 - NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.