Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+ - NCT07664904Recruiting
Periostin protein levels and quality of life in back pain patients
This study looks at how a protein called periostin relates to back function and quality of life in people with disc herniations or spinal stenosis. You'll fill out two questionnaires and have your periostin measured from a blood draw or MRI.
Daegu, DaeguAges 20–80 - NCT07665021RecruitingPhase 1/Phase 2
Gene therapy for children with severe bone disease
This trial tests a gene therapy that uses a child's own stem cells to treat autosomal recessive osteopetrosis (a genetic bone disease). It aims to improve bone health and reduce complications like fractures and vision loss.
Milan, ItalyAges 4 weeks–2 years - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07666347Recruiting
Botox and Hyaluronic Acid Injections for Knee Osteoarthritis
This study tests if injecting Botox and hyaluronic acid into the knee joint can reduce pain and improve function in people with advanced knee osteoarthritis. It compares this combination to a standard treatment.
Tanta, El-GharbiaAges 50 years+ - NCT07665424Recruiting
Study of a bone filling device for spine fractures
This trial tests a device called Vessel-X to treat broken vertebrae (spine bones) caused by osteoporosis or injury. It aims to see if the device is safe and helps stabilize the spine.
TaipeiAges 40–95 - NCT07666360Recruiting
Jaw pain study: factors that predict TMD severity
This trial looks at how your head, neck, and jaw work together to understand why some people have more severe jaw joint (TMD) pain. If you have jaw pain, the findings may help researchers identify better treatments.
AnkaraAges 18–55 - NCT07665801Recruiting
Foot exercises after hip replacement surgery
This trial tests whether doing special foot exercises can improve recovery in people who have had a total hip replacement. It might help with walking and balance.
Ankara, AltındağAges 50–80 - NCT07667114Recruiting
Wrist ligament repair surgery trial
This trial tests a surgical technique to repair a torn ligament in the wrist (the scapholunate ligament) using a part of a nearby tendon. It may be an option for people with this specific wrist injury who meet the health requirements.
Berlin, State of BerlinAges 18 years+ - NCT07671482Recruiting
Kinesio vs McConnell taping for knee pain relief
This study compares two types of taping (Kinesio and McConnell) to see which works better for people with pain behind the kneecap (patellofemoral pain syndrome). You may help researchers learn how to best relieve knee pain during daily activities.
Beirut, BeirutAges 18–50 - NCT07664202Recruiting
Fluoroscopic Endobutton Procedure for Collarbone Injuries
This study is testing a surgical technique called fluoroscopic endobutton repair for outer collarbone fractures or severe acromioclavicular joint dislocations. It aims to see if using a special X-ray during surgery helps improve how the bone heals or the joint is stabilized.
ParisAges 18–65 - NCT07667556Recruiting
Frozen shoulder treatment: gentle movement, pain education, and core exercises
This study tests whether a combination of gentle joint movement techniques, pain education, and core-strengthening exercises can help people with frozen shoulder move better and feel less pain. It may be a good fit if you have been diagnosed with frozen shoulder and are looking for a drug-free treatment option.
IstanbulAges 18–65 - NCT07664605Recruiting
Comparing two bone grafting methods for dental implants
This trial compares two surgical techniques for building up narrow jawbone before placing a dental implant. It may be an option if you have mild to moderate bone loss in your jaw.
CairoAges 20–75 - NCT06669702Recruiting
Exercise therapy for axial spondyloarthritis on biologics
This study tests whether a supervised exercise program can help people with axial spondyloarthritis (a type of inflammatory arthritis affecting the spine) who are already on biologic medications. It aims to see if exercise reduces inflammation and improves symptoms.
Loughborough, LeicestershireAges 18 years+ - NCT06673953Recruiting
Breathing training for heart surgery recovery with neck posture problems
This trial tests whether a breathing exercise device can improve heart and lung function in men who had heart bypass surgery at least 3 months ago and also have neck pain from poor posture. It may help you breathe better and feel stronger after surgery.
Giza, Giza GovernorateAges 45–55 - NCT03001180Recruiting
Study blood and tissue markers in vascular anomalies
This study collects extra blood (and sometimes tissue during procedures) to look for markers that can help doctors better understand vascular anomalies. It may not be a treatment, but it can improve future care by finding patterns linked to the condition.
Boston, MassachusettsAges 1 day+ - NCT07657598Recruiting
Fluid monitor for children having skull surgery
This study checks if a special monitor (called Pleth Variability Index) helps doctors manage fluids better during surgery for children with craniosynostosis. It may lead to safer recovery for your child.
Istanbul, BasaksehirAges Up to 6 years - NCT07661589Recruiting
Blood transfusion risks and cell saver in children's scoliosis surgery
This trial looks at how often blood transfusions are needed during scoliosis surgery in children and whether using a device that recycles lost blood (cell saver) can reduce that need.
TunisAges Up to 17 years - NCT07662239Recruiting
Exercise program for young sarcoma survivors
This study tests a personalized exercise service for teenagers and young adults who have had sarcoma. It aims to help you get active and stay healthy after treatment.
Boston, MassachusettsAges 15–39 - NCT07662408RecruitingPhase 4
Comparing two drugs to prevent low blood pressure during hip surgery
This trial tests two different medicines (norepinephrine and phenylephrine) given as an infusion to prevent low blood pressure after spinal anesthesia for hip surgery. It may help older adults undergoing planned hip replacement or repair.
SohagAges 60–100 - NCT07660367Recruiting
Probiotic comparison for children's diarrhea
This study compares two types of probiotics to see which works better for treating acute watery diarrhea in children aged 1 to 5 years. Children with mild to moderate dehydration and malnutrition may be eligible.
Lahore, Punjab ProvinceAges 1–5 - NCT07661784Recruiting
Saliva tests to track gum disease
This study looks at whether substances in your saliva can show if gum disease is getting worse. It might help find a simple way to monitor gum health without needles or X-rays.
IspartaAges 18–65 - NCT07658326Recruiting
Stress and rotator cuff surgery study
This study looks at how stress before surgery might affect recovery in people having rotator cuff surgery. You may be able to join if this is your first surgery for a torn rotator cuff and you don't have certain other health problems.
CornebarrieuAges 18 years+ - NCT07655921Recruiting
Enhanced recovery after knee replacement surgery
This trial tests a special care plan called ERAS to help people recover faster after total knee replacement. It compares this plan to standard care to see if it reduces hospital stay and improves recovery.
Karachi, SindhAges 50–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.