Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT03718403RecruitingPhase 4
Theophylline trial for pseudohypoparathyroidism
This Phase 4 study tests whether the medicine theophylline can help people with pseudohypoparathyroidism type 1A or 1B. It may be considered if you’re trying to improve how your body uses parathyroid hormone and manage related calcium levels.
Boston, MassachusettsAges 5–21 - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT05471752Recruiting
Study of special cells taken during orthopedic surgery
This study collects small cell samples from certain body tissues during planned orthopedic surgeries. The researchers will study these cells to understand their potential use in future treatments and to see if using them is safe and helpful.
MilanAges 18 years+ - NCT05504499Recruiting
Test a new implant for low back pain with mild narrowing
This trial studies a new spine implant placed between the bones to help relieve low back pain. You may be a candidate if imaging shows mild-to-moderate spinal narrowing and you’ve already tried non-surgical treatments for at least 3 months.
Santa Rosa, CaliforniaAges 18 years+ - NCT05497609Recruiting
Study of tiny muscle changes in children with cerebral palsy
This study follows children with cerebral palsy (and sometimes acquired brain injury) to learn how the muscles look and change over time at a very small, microscopic level. The results may help researchers better understand what’s happening in the muscles and guide future treatments.
StockholmAges 2–18 - NCT01581294Recruiting
Norwegian arthritis drug registry for new biologic or kinase treatment
This study is a real-world registry that follows adults with inflammatory arthritis when they start a new targeted medicine. It helps researchers understand how these drugs work in everyday care.
Drammen, BuskerudAges 18 years+ - NCT05506228Recruiting
Muscle biopsy during surgery study in brain injury conditions
This study looks at how muscles are affected in children and teens with cerebral palsy or an acquired brain injury. Researchers take a small muscle tissue sample during surgery that you were already having for medical reasons, to better understand muscle changes.
StockholmAges 2–18 - NCT04226339Recruiting
Test walking analysis after knee replacement, different alignment methods
This study compares two ways of aligning the knee during a total knee replacement and checks how people walk afterward using a walking test. It may help doctors choose the alignment method that best supports safer, smoother walking.
LyonAges 55–80 - NCT05518565Recruiting
Study muscle changes in people with cerebral palsy
This study looks at how muscles work in the body in people with cerebral palsy or an acquired brain injury. It may help researchers understand muscle structure and changes over time, which could guide future treatments.
StockholmAges 2–18 - NCT05587777Recruiting
Tracking chronic conditions during standard breast cancer treatment
This study monitors health problems that can happen over time in people with breast cancer while they receive usual treatments like hormone therapy, chemotherapy, and/or radiation. It may help researchers understand which extra symptoms or complications show up and when, to improve care and follow-up.
StavangerAges 19–80 - NCT04669548Recruiting
Accuryn monitoring study for people having heart surgery
This registry collects information from patients who are monitored with the Accuryn system during heart surgery and their ICU stay. It helps researchers learn from the system’s signals to better understand patient care around cardiac procedures.
Los Angeles, CaliforniaAges 18 years+ - NCT05592574Recruiting
Test of a biologic for active spondyloarthritis
This trial studies whether adding a biologic medicine (targeted therapy) can help people with active spondyloarthritis when standard anti-inflammatory pain medicines (NSAIDs) have not worked well enough. It focuses on people with ongoing symptoms despite trying at least two NSAIDs.
NiceAges 18–90 - NCT05228262Recruiting
Testing blood-vessel function and muscle strength in osteoporosis
This study looks at how well your blood vessels work and how strong your muscles are, in women after menopause with osteoporosis. You may be asked to start standard osteoporosis treatment, and the researchers will study pain and changes related to vascular function and sarcopenia (loss of muscle and strength).
Clermont-FerrandAges 50 years+ - NCT04106674Recruiting
Treating displaced shoulder fractures: non-surgery vs surgery options
This trial compares non-surgical care with two different surgical fixation methods for a displaced two-part shoulder (upper arm) fracture. It aims to see which approach leads to the best recovery and function.
Lørenskog, OsloAges 60–85 - NCT05357157Recruiting
Electroacupuncture for fibromyalgia pain and quality of life
This trial studies whether electroacupuncture can reduce fibromyalgia pain and improve quality of life. It also looks at changes in certain immune cells, which may help explain how treatments work.
HeraklionAges 18–80 - NCT05277818Recruiting
Follow-up study after certain lower-back disc surgery
This study collects health information after lower-back disc surgery to track outcomes over time. It may help improve how the surgery and devices are monitored in real-world patients.
ColmarAges 18 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT04713800Recruiting
Dental implant bridge comparison with two implant types
This trial tests two ways of making a small back teeth bridge (a “cantilever” dental implant crown) using different materials. It may help show which material works best when replacing missing back teeth with implant support.
GenevaAges 22 years+ - NCT05629130Recruiting
Blocking blood vessel procedures for bleeding-related joint inflammation
This study looks at whether a “blocking” procedure (embolization) can improve long-lasting joint inflammation caused by inherited bleeding disorders. It focuses on people with joint lining inflammation from repeated bleeding into the joint.
São PauloAges Any age - NCT05626348RecruitingPhase 4
Test immune-modulator treatments for rheumatoid arthritis with knee trouble
This Phase 4 trial studies whether immune-modulator medicines improve symptoms and function in people with rheumatoid arthritis who have knee problems. It may also compare responses in osteoarthritis and healthy volunteers, depending on the group you fit.
Jinan, ShandongAges 18–80 - NCT05314608Recruiting
Testing IOBP treatment for knee bone lesions seen on MRI
This trial studies whether an IOBP® procedure can reduce knee pain in adults with a specific bone lesion under the joint surface. It focuses on people whose MRI shows one target lesion and who are already planned for IOBP surgery.
Denver, ColoradoAges 18–60 - NCT05657847Recruiting
Imaging tests for joint disease in arthritis
This study tests new kinds of imaging (radiology pictures) to help understand arthritis in joints. It may help improve how these arthritis types are identified and followed over time.
BudapestAges 18–100 - NCT05649007Recruiting
Monitoring the Saphir hip stem after new hip replacement
This study watches how a specific hip replacement part (the Saphir stem) performs after primary hip surgery in everyday care. It helps doctors and manufacturers learn about safety and outcomes after the device is already in use.
ToulouseAges 18 years+ - NCT04883502Recruiting
Testing a technique to rebuild bone lost after injury
This study looks at a surgical method that creates an “induced membrane” to help rebuild bone after traumatic injury. It may help people whose limb bones were damaged and are missing part of the bone.
ClamartAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.