Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT06065852Recruiting
National registry for rare kidney diseases
This study creates a registry to collect health information from people with rare kidney diseases. It aims to improve understanding and future treatments by tracking patient experiences.
Bristol, South WestAges Any age - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT04954690Recruiting
Exercise program after kidney transplant for older adults
This trial tests a structured, coached exercise program for people who recently received a living-donor kidney and are coming from dialysis. It may help improve strength and daily function after transplant, especially if starting fitness is difficult.
San Francisco, CaliforniaAges 50 years+ - NCT06077942Recruiting
FX shoulder replacement study
This study looks at how well FX shoulder replacement devices work for people who received them between 2018 and 2023. It helps doctors learn more about the outcomes of these implants.
Gilbert, ArizonaAges Any age - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT05484089Recruiting
CapFlex implant trial for finger joint replacement
This trial studies a new implant (the CapFlex) to replace a damaged finger joint (the PIP joint) when conservative treatments are not enough. It may help reduce pain and improve stability for the right type of joint problem.
Zoetermeer, South HollandAges 18 years+ - NCT04086368Recruiting
Testing treatment planning for hip bone rotation in teens
This study looks at teens with hip (and sometimes knee) pain and a specific pattern of hip bone rotation seen on X-rays. It aims to test an approach (the “FDR” trail) that may improve how the hip’s rotation is treated.
OsloAges 10–18 - NCT06025448Recruiting
Comparing two types of reverse shoulder replacement
This study compares two types of reverse shoulder replacements: one that uses a small piece of your own bone (BIO-RSA) and another that uses a special metal implant (MIO-RSA) to fill the socket. The goal is to see which one stays more stable in the bone after surgery.
OsloAges 45–80 - NCT06025331Recruiting
BIO-RSA vs standard reverse shoulder replacement study
This study compares two types of reverse shoulder replacement: one that uses a bone graft (BIO-RSA) and one that doesn't. It aims to see if the BIO-RSA method gives better pain relief and function for people with arthritis, large rotator cuff tears, or failed prior cuff surgery.
Skien, TelemarkAges 45–80 - NCT06120426Recruiting
Surgery types and radiation for spinal tumors that have spread
This study compares two types of spinal surgery combined with radiation for people whose cancer has spread to the spine in a limited way (no more than 5 spots). It aims to find which approach better controls pain, tumor growth, and spinal stability.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05719935Recruiting
KinematX wrist replacement registry for people with wrist arthritis
This trial is a registry that follows people who get (or already had) a KinematX total wrist replacement. It collects health and recovery information to better understand outcomes for different wrist problems, like arthritis or certain bone alignment issues.
Loma Linda, CaliforniaAges 18–85 - NCT06076083Recruiting
Microbiome study in Korean patients with ankylosing spondylitis
This study looks at the bacteria living in your body (the microbiome) in people with ankylosing spondylitis and their close family members. Researchers hope to better understand how these bacteria relate to the disease, which may lead to better treatments in the future.
Seoul, Kyungheedae-ro 23Ages 19–60 - NCT05908214Recruiting
Electrical stimulation for leg stiffness and overactive nerves
This study tests a treatment using high-frequency electrical stimulation to reduce overactive nerve signals that can cause stiff legs, poor ankle control, cramps, or restless legs. It may help improve movement and comfort during walking or at night, depending on the condition.
LausanneAges 18 years+ - NCT06153940Recruiting
Study of three hip implants after surgery
This study is testing three different hip implants (Everglade Stem, World Cup, and World Liner) to see how well they work in people needing a hip replacement. It aims to help patients with hip arthritis or other joint damage get back to their daily activities.
Cleveland, OhioAges 18–75 - NCT05310799Recruiting
Personalized risk estimates for children with newly diagnosed JIA
This study looks at how best to estimate a child’s likely symptoms and treatment response in the first phase after a new JIA diagnosis. It may help families and clinicians make clearer, more personalized decisions about care.
Vancouver, British ColumbiaAges 1–18 - NCT04364334Recruiting
Knee care registry for people treated at UMC Utrecht
This study is a “registry,” meaning researchers collect information about your knee care over time. It may help improve understanding and care for people who receive knee treatment at UMC Utrecht.
UtrechtAges Any age - NCT06152497Recruiting
Histamine and muscle growth after strength training
This study looks at how histamine affects muscle building after resistance exercise. It may help us understand why some people build muscle better than others after strength training.
Ghent, Oost-VlaanderenAges 18–45 - NCT05892133Recruiting
Exercise program before knee replacement to improve recovery
This trial studies whether doing a structured exercise or “prehab” program before total knee replacement can improve knee function and patient satisfaction after surgery. It may help you recover better and feel more confident in your outcome.
Molde, Møre og RomsdalAges 50–80 - NCT06172569Recruiting
Study of a new hip replacement system
This study is testing a new hip replacement system (Spartan, World Cup, and World Liner) in people who need their first hip replacement due to arthritis or similar conditions. It aims to see how well the implant works and how safe it is over time.
Cleveland, OhioAges 18–75 - NCT05757609Recruiting
Brain stimulation therapy for chronic low back pain
This trial tests whether a non-invasive brain stimulation treatment can improve physiotherapy results for people with long-lasting low back pain. You may be asked to do questionnaires and follow a treatment plan, and some people may be able to reduce pain or improve function.
GenevaAges 18–65 - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT05936593Recruiting
Compare two knee implant positions during robotic knee replacement
This study compares how a knee implant’s components “fit” and move when placed in two different ways during robotic knee replacement. It uses special imaging to see which placement works best for stability and long-term performance.
Zoetermeer, South HollandAges 18–70 - NCT06166628Recruiting
Comparing two procedures for knee osteoarthritis pain
This study compares two minimally invasive procedures—embolization (blocking blood flow) and nerve ablation (blocking pain signals)—to see which works better for knee osteoarthritis pain. If you have long-lasting knee pain and are considering knee replacement surgery, this trial may help find another option.
Kingston, OntarioAges 40 years+ - NCT07869680Recruiting
Comparing knee function in people with similar knee arthritis pain
This study looks at how knee osteoarthritis (a common condition where the cushioning in the knee joint wears down) affects physical function, even when people report similar levels of pain. It aims to understand why some people with the same pain might have more difficulty with daily activities, which could lead to better targeted treatments.
MardinAges 40–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.