Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT05906147Recruiting
Bone health improvement program for adults over 40
This study tests a structured bone health improvement program for adults over age 40 who are attending a health checkup at the hospital. It aims to improve or maintain bone strength, using bone density measurements as part of the study.
Changsha, HunanAges 40–100 - NCT04695028Recruiting
Study to better understand crystal-related joint pain
This study looks at people with certain types of crystal deposits in joints (like gout, CPPD, or hydroxyapatite crystal disease). It uses scans such as ultrasound and a special CT-type scan called DECT to confirm and better understand what’s causing your symptoms.
LommeAges 18 years+ - NCT05883371Recruiting
IMPACT autoimmune study registry for people on biologic medicines
This study is a registry that collects health information from adults with certain autoimmune conditions who are currently using (or have been recommended) biologic or DMARD medicines. It may help researchers better understand these diseases and how treatments affect people over time.
Columbus, OhioAges 18–70 - NCT05924347Recruiting
Imaging study to spot early spine changes in at-risk children
This study uses MRI and physical measurements to look for early signs of scoliosis (a side-bending of the spine) in children who are at higher risk. It may help doctors understand when scoliosis starts and improve early monitoring.
UtrechtAges 8–11 - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT02193841RecruitingPhase 3
Treating simple bone cysts in children with new bone support
This study looks at how well a treatment works for children with a simple bone cyst in an arm or leg. The goal is to prevent problems like fractures while the cyst heals, using a stabilizing implant in the bone.
Birmingham, AlabamaAges 2–21 - NCT05676775Recruiting
Study for people recently diagnosed with axial spondyloarthritis
This study follows people who were diagnosed with axial spondyloarthritis (axSpA) recently to better understand the condition over time. It’s mainly for adults and teens who can consent and can communicate in English.
LeedsAges 16–50 - NCT05954364Recruiting
Study of advanced treatments for psoriatic arthritis based on sex and gender
This study looks at how well advanced treatments work for people with psoriatic arthritis, and whether results differ for sex and gender. You may be eligible if your psoriatic arthritis is active and you are planning to start an advanced treatment for symptoms in the joints and surrounding areas.
Toronto, OntarioAges 18 years+ - NCT05617859RecruitingPhase 2
Lenvatinib treatment for advanced bone or soft tissue sarcoma
This trial tests lenvatinib to shrink or control advanced bone or soft tissue sarcoma that can’t be safely treated with surgery. You may be eligible if your cancer has measurable spots and you’ve had specific prior drug treatments without a durable response.
Zhengzhou, HenanAges 10–70 - NCT06005246Recruiting
Munich ME/CFS Study for Young People
This study is tracking children, teens, and young adults (up to age 25) who developed ME/CFS after an infection. It aims to better understand the condition in younger people.
Munich, BavariaAges Up to 25 years - NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT04744402RecruitingPhase 2
Cartilage repair treatment test for knee joint damage
This Phase 2 study tests CartiLife® to help repair a specific type of damaged knee cartilage. You may be considered if you have a moderate-sized cartilage defect in the knee and enough pain and function limits to need treatment.
Irvine, CaliforniaAges 18 years+ - NCT05942430Recruiting
Bone-cartilage transplant for ankle joint cartilage damage
This trial studies an “autologous” transplant, meaning using your own bone and cartilage, to treat painful cartilage damage in the ankle (on the talus). It may help people whose ankle cartilage injury is deep, has not improved with non-surgical care, and meets specific side and health requirements.
Guangzhou, GuangdongAges 18–60 - NCT04463316Recruiting
Clinic study for people with rare genetic conditions
This study is for people who have a rare syndrome or rare congenital condition and are seen at a rare-disease clinic. It aims to better understand these conditions and how care works in a team setting, which may help guide future treatment decisions.
Rotterdam, South HollandAges 18 years+ - NCT06029764Recruiting
Extended fusion for spinal disc vacuum signs
This trial tests a surgery that fuses one extra spinal disc to treat a 'vacuum sign' (air pockets in the disc) that hasn't caused symptoms yet. It aims to prevent future problems in people with lumbar disc disease who need fusion surgery.
Beijing, Beijing MunicipalityAges 18–60 - NCT00041600Recruiting
Brain Development and Genetic Study for Family Members
This research study investigates how genetic factors affect brain development and function in families where members have brain malformations, intellectual disability, or autism. Researchers hope to identify genetic causes that could lead to better understanding and future treatments.
Boston, MassachusettsAges Any age - NCT03076658Recruiting
Standing full-body X-rays from healthy adults
This trial is building a database of full-body standing X-rays in people who do not have spine problems or certain health conditions. If you qualify, your X-rays may help researchers study normal body alignment for future medical use.
Aurora, ColoradoAges 21–85 - NCT02315729Recruiting
Testing blood or tissue signals in teen scoliosis prognosis
This study looks at cell “signaling factors” to understand what predicts how adolescent idiopathic scoliosis may change over time. It may help doctors better forecast which curves are more likely to progress and tailor follow-up care.
Denver, ColoradoAges 10–13 - NCT02257723Recruiting
Testing combined Korean herbal and therapy for hospitalized spine or joint pain
This trial studies whether a combined complementary treatment approach helps people who are hospitalized for spine or joint problems. It may help reduce the types of pain that come from those areas.
Seoul, Gangnam-GuAges Any age - NCT05963815Recruiting
Spine surgery follow-up using online patient-reported questionnaires
This study looks at recovery after planned (elective) surgery for common lower-back (“lumbar”) spine problems like slipped discs, disc bulges, and narrowing of the spinal canal. You may be asked to complete online questionnaires, and the study uses your answers to understand symptoms and outcomes after surgery.
Rotterdam, South HollandAges 18–80 - NCT05408715Recruiting
Natural history study of growth in children with type II collagen disorders
This study follows children with certain inherited “type II collagen” conditions that cause short height, to better understand how growth changes over time. It does not test a new treatment; it mainly tracks health and growth so doctors can learn what to expect.
ParisAges Up to 12 years - NCT05767762Recruiting
Tests whether leg muscle patterns predict treatment outcome in clubfoot
This study looks at how certain leg muscles move to see if that can predict how well an Achilles tenotomy (a small procedure to release tight tendon) works for children with idiopathic clubfoot. It may help doctors choose the best timing and approach for treatment.
NiceAges birth–1 year - NCT06062927Recruiting
Genes and scans predict response to immunotherapy and targeted therapy for advanced sarcoma
This trial is testing whether a combination of two drugs—a targeted therapy (surufatinib) and an immunotherapy (envafolimab)—can help people with advanced soft tissue sarcoma that has spread or cannot be removed by surgery. Researchers will also use a person's genetic information and scans to see if they can predict who will benefit the most.
Beijing, Beijing MunicipalityAges 18–75 - NCT05537545Recruiting
Timing of gum tissue graft after a new tooth implant
This trial studies the best timing for placing a gum (soft tissue) graft after getting an implant right away when a tooth is removed. It may help improve healing and the long-term appearance and stability of the implant.
Ghent, Oost-VlaanderenAges 20 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.