Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Birmingham, AlabamaAges 18–70 - NCT07151417RecruitingPhase 2/Phase 3
Steroid injection during total knee replacement
This study tests whether adding a corticosteroid (a type of anti-inflammatory medicine) to the standard pain injection during total knee replacement can improve pain relief. It is for adults getting their first knee replacement at certain military hospitals.
Bethesda, MarylandAges 18 years+ - NCT06859801Recruiting
Bone pain study combining ablation and radiation
This study looks at combining two treatments for painful bone tumors that have spread from other cancers. It tests if using both treatments together provides better pain relief than either alone.
San Diego, CaliforniaAges 21 years+ - NCT06395883Recruiting
Steroids and Your Bones in Joint Disease
This study looks at how steroids affect bone health in people with inflammatory joint diseases like rheumatoid arthritis. Researchers will track markers in your blood to see if short-term steroid use impacts your bones.
DrammenAges 25–90 - NCT07008469Enrolling by invitationPhase 3
Long-term safety study of del-desiran for DM1
This study tests whether the drug del-desiran continues to be safe and effective for people with DM1 (myotonic dystrophy type 1) after they complete an earlier study. You'll receive the drug and have regular check-ups to see how you're doing.
Los Angeles, CaliforniaAges 16 years+ - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT07604714Recruiting
Shoulder Replacement Surgery: Testing a Bone-Removal Technique
This trial compares two surgical approaches for reverse total shoulder replacement—a procedure that replaces a damaged shoulder joint. Researchers are testing whether removing part of a shoulder bone (the coracoid) helps improve your arm's ability to rotate inward after surgery.
AnnecyAges 18 years+ - NCT07708584Recruiting
Brostrom repair with BioBrace for chronic ankle instability
This trial tests whether adding a BioBrace scaffold to standard Brostrom surgery improves outcomes for people with chronic ankle instability. It may help if you have had a weak or unstable ankle for more than 3 months and haven't had prior ankle surgery.
Boston, MassachusettsAges 18–65 - NCT07584356Recruiting
Comparing Shoulder Replacement Methods for Arthritis
This study compares two different surgical approaches for replacing a shoulder damaged by arthritis, but only in patients whose rotator cuff (the muscles that stabilize the shoulder) is still working well. The goal is to find which method works better for your specific situation.
Rochester, MinnesotaAges 60–85 - NCT07685496Recruiting
How shoes affect walking for below-knee amputees
This study looks at how different types of footwear affect walking in people with a below-knee amputation. If you use a specific energy-returning prosthetic foot and can walk without aids, you may be able to join and help improve understanding of what shoes work best.
Manchester, Greate ManchesterAges 18–65 - NCT07769619Recruiting
AI and brain scans for chronic pain in rheumatoid arthritis
This study uses AI, brain scans, and blood tests to understand chronic pain in rheumatoid arthritis (RA). It may help find better ways to treat pain in the future.
WroclawAges 18 years+ - NCT06401317RecruitingPhase 2
Steroid vs saline injections for thumb arthritis pain
This study compares two types of injections for thumb arthritis pain: a steroid (cortisone) and salt water (saline). We want to see if the steroid provides better pain relief than the salt water.
Montreal, QuebecAges 18 years+ - NCT06666673RecruitingEarly Phase 1
Effects of a muscle relaxant on arm movement after stroke
This study looks at how the brain controls arm movements after a stroke. It tests whether a medication called tizanidine, which relaxes muscles, can improve arm function when combined with physical therapy.
Chicago, IllinoisAges 18–80 - NCT04789746Enrolling by invitation
Physical fitness program for children with mobility challenges
This study tests a physical fitness program designed for children who have mobility challenges due to conditions like cerebral palsy. The program aims to improve fitness and overall well-being in a safe and supportive environment.
Chicago Heights, IllinoisAges 6–18 - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT06905288Recruiting
Secukinumab for Ankylosing Spondylitis in Biologic-Free Patients
This study is looking at how well secukinumab works for people with ankylosing spondylitis in Korea who have never taken a biologic or JAK inhibitor before. It aims to understand if the drug helps control symptoms over a short period of time.
Jinju, Gyeongsangnam-doAges 18–40 - NCT07621809RecruitingPhase 3
Ianalumab versus placebo for Sjögren's disease with high symptom burden
This study tests whether a new drug called ianalumab can reduce dry mouth and other symptoms in people with Sjögren's disease—a condition where the immune system attacks moisture-producing glands. Participants will receive either ianalumab or a placebo (inactive injection) over 52 weeks to see if the drug helps.
Peoria, ArizonaAges 18 years+ - NCT03072927Recruiting
Study of Medicare patients after mild back decompression
This study uses Medicare records to look at outcomes for people who receive MILD or an interspinous process decompression procedure for lumbar spinal stenosis with nerve symptoms. It may help confirm how well these less-invasive procedures work in real-world patients.
Athens, AlabamaAges 18 years+ - NCT07726082Recruiting
A group program to help with long-term fatigue
This study tests a new way to help people with long-term fatigue that gets in the way of daily life. It uses a group program that focuses on making small, helpful choices to feel better.
BaselAges 18–65 - NCT07218133Recruiting
Ear Stimulation to Reduce Pain After Spine Surgery
This trial tests whether a gentle electrical stimulation delivered through the ear can reduce inflammation and pain after major spinal fusion surgery. If you are having a long spinal fusion, you might be able to join.
St Louis, MissouriAges 18 years+ - NCT07770139Enrolling by invitation
Online yoga and breathing for student stress relief
This study compares two online programs—one with yoga poses and breathing, the other adding a special breathing technique—to see if they help reduce stress and improve well-being in university students.
IstanbulAges 18–30 - NCT07647354Recruiting
Mako robotic joint replacement surgery registry study
This study collects information from patients undergoing hip or knee replacement surgery with either traditional or robotic-assisted techniques. Researchers track your recovery and joint function to understand how well these procedures work.
Jacksonville, FloridaAges 18 years+ - NCT06457373Recruiting
Donated vs. your own tooth graft for bone preservation
This trial tests whether a special bone graft made from donated teeth works as well as a graft made from your own teeth to preserve the bone after wisdom tooth removal. It may help you keep more bone in your jaw for future dental work.
Damietta, New-DamiettaAges 25–35 - NCT07265154Recruiting
Gait training with AI for above-knee amputees
This trial tests a new way to help people with above-knee amputations improve how they walk, using artificial intelligence to guide their gait training. It may help you walk more naturally and safely.
Banhā, BenhaAges 16–50
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.