Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT07426549Recruiting
Knee Exercises With Blood Flow Restriction for Osteoarthritis
This study compares two types of knee exercises (closed chain and open chain) with a special blood flow restriction technique to see which helps reduce pain and improve function in people with mild to moderate knee osteoarthritis.
RawalpindiAges 45–75 - NCT07402408Recruiting
Blood flow restriction training for knee osteoarthritis
This trial tests whether using a special band to limit blood flow during exercise can help reduce pain and improve movement in people with mild knee osteoarthritis. It may be an option if you have knee pain and stiffness but no other serious health conditions.
Islamabad, FederalAges 40–60 - NCT07484529Recruiting
Water vs land exercises for knee osteoarthritis
This study compares two types of physical therapy exercises — one done in water and one done on land — to see which is better for reducing pain and improving movement in people with knee osteoarthritis.
RawalpindiAges 40–65 - NCT07672210Recruiting
Pregnancy-related aortic dissection in China
This study is looking at cases of aortic dissection that happen during pregnancy or shortly after childbirth in China. It aims to understand how these events occur and how they can best be managed.
Shanghai, Shanghai MunicipalityAges 16–55 - NCT07711730Recruiting
Telehealth support for kids with limb-girdle muscular dystrophy
This study tests an online program to help children and teens with limb-girdle muscular dystrophy improve their thinking, social skills, and emotional well-being. You join from home using a computer with a camera and internet.
Bilbao, BiscayAges 7–17 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT07711353Recruiting
Nerve stimulation plus physical therapy for frozen shoulder
This trial tests whether adding a gentle nerve stimulation device to standard physical therapy helps people with frozen shoulder (adhesive capsulitis) recover better. The stimulation is applied to the ear and is designed to be safe and non-invasive.
Istanbul, IstanbulAges 18–65 - NCT07710885RecruitingPhase 3
Futibatinib for advanced bile duct cancer
This trial tests a new targeted therapy, futibatinib, for people with advanced or unresectable bile duct cancer who have not had prior treatment for advanced disease. It aims to see if this drug can help shrink or control the cancer.
BrisbaneAges 18 years+ - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT02359812Recruiting
Robot-assisted arm and hand rehab after recent stroke
This study tests whether a robot-guided therapy program can help people regain arm and hand movement after a recent stroke. You may be able to join if you are within a month of a first stroke on one side and have specific levels of arm and hand recovery.
Baltimore, MarylandAges 18–85 - NCT04692493RecruitingPhase 3
Testing two treatment paths for active rheumatoid arthritis
This Phase 3 study compares two ways to treat active rheumatoid arthritis: a TNF-blocking biologic versus a targeted pill treatment. It may help people who are not doing well on (or cannot tolerate) certain biologic therapies to find a better, more practical option.
Auburn, AlabamaAges 18 years+ - NCT06888193RecruitingPhase 1
Bimekizumab in breast milk of mothers being treated
This study measures how much bimekizumab (Bimzelx) gets into breast milk. It helps us understand if the medicine is safe for breastfeeding babies whose mothers take this drug.
Santa Monica, CaliforniaAges 18 years+ - NCT06723106Enrolling by invitationPhase 1
Long-term safety study of RAY121 for immune conditions
This study is for people who already took RAY121 in a previous trial and did well. It tests whether continuing the treatment is safe and effective over a longer period. The goal is to manage chronic immune conditions.
Camperdown, New South WalesAges 18–85 - NCT07276958RecruitingPhase 1
Study of LY4298445 for Lupus and Rheumatoid Arthritis
This trial tests a new drug called LY4298445 in healthy people and those with lupus or rheumatoid arthritis. It aims to see if the drug is safe and how the body processes it.
BrisbaneAges 18–55 - NCT02359253Recruiting
Robot-assisted arm therapy after a recent stroke
This study tests whether robot-guided therapy can improve arm and hand recovery after a stroke. You may be a candidate if your stroke was recent and you still have certain levels of arm weakness and movement.
Baltimore, MarylandAges 18–85 - NCT06788990RecruitingPhase 2/Phase 3
Study of ficerafusp alfa with pembrolizumab for advanced head and neck cancer
This study tests a new drug called ficerafusp alfa (BCA101) combined with the immunotherapy pembrolizumab for people with advanced head and neck cancer that has not been treated before. The goal is to see if adding ficerafusp alfa helps shrink tumors better than pembrolizumab alone.
Birmingham, AlabamaAges 18 years+ - NCT06016634RecruitingPhase 2
Alendronate for bone damage in adults with sickle cell disease
This trial tests if the drug alendronate can help heal bone damage caused by sickle cell disease. It may be an option if you have this bone problem and are between 18 and 80 years old.
Sacramento, CaliforniaAges 18–80 - NCT07653828Recruiting
Self-rehab after foot surgery via app
This trial tests if using a connected app to do self-guided rehab at home helps people recover better after bunion (hallux valgus) surgery. It may offer a convenient way to follow your exercises and track progress.
Saint-JeanAges 18–85 - NCT06917742RecruitingPhase 1
Study of CPTX2309 for rheumatoid arthritis and lupus
This trial tests an investigational drug called CPTX2309, given intravenously, for people with moderate to severe rheumatoid arthritis or systemic lupus erythematosus. It aims to see if the drug is safe and effective.
Herston, QueenslandAges 18–65 - NCT07669792Recruiting
Bone shell vs fabric for narrow lower jawbone
This study compares two ways to rebuild a narrow lower jawbone so you can get dental implants. One method uses a special bone shell technique, and the other uses a strong fabric material. Your doctor will check if your jawbone is wide enough and healthy for this surgery.
CairoAges 18–65 - NCT06873035Enrolling by invitationPhase 2/Phase 3
Infigratinib for children with hypochondroplasia
This study tests an oral medication called infigratinib in children with hypochondroplasia, a form of short stature. It aims to see if the drug can help improve growth and is for children who are still growing.
Oakland, CaliforniaAges 3–18 - NCT07543692Recruiting
Ultrasound-guided injection therapy for spine pain
This study tests whether using ultrasound imaging to guide a special injection treatment (pharmacopuncture) is safe and effective for people with spine-related neck or lower back pain that radiates into the arms or legs. The treatment is already being offered as routine care, and this study tracks how well it works.
Daejeon, DaejeonAges 19–69 - NCT07706569Recruiting
Fetuin-A and COMP levels in knee osteoarthritis
This study looks at two substances in the blood (fetuin-A and COMP) to see if they are linked to knee osteoarthritis severity. Results may help understand the disease better.
AntalyaAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.