Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07301892Recruiting
AI help for rheumatoid arthritis diagnosis
This trial tests whether artificial intelligence (AI) can improve how doctors spot complications in people newly diagnosed with rheumatoid arthritis (RA), a condition that causes joint pain and swelling. The goal is to see if AI can make diagnosis faster and more accurate in real-world hospital settings.
Beijing, Beijing MunicipalityAges Any age - NCT07302074Recruiting
Comparing Rare vs. Common Inflammatory Arthritis
This study compares rare inflammatory arthritis (from rare autoimmune diseases or drugs) to more common types (like rheumatoid arthritis). Researchers will look at tissue samples to understand the differences and help improve diagnosis and treatment.
BordeauxAges 18 years+ - NCT07304167Recruiting
Exercise video game program for women with fibromyalgia
This study tests whether playing a special exercise video game can help women with fibromyalgia feel better. You will be asked to play the game regularly and report how you feel.
IstanbulAges 30–70 - NCT07301918Recruiting
Comparing two expanders for crossbite in children
This trial compares two types of expanders (Leaf Expander vs. Hyrax Expander) to fix crossbites in children who still have some baby teeth. The goal is to see which device works better and is more comfortable.
CairoAges 6–12 - NCT07304323Recruiting
Predicting recovery after hip or knee replacement in 2018
This trial is for people who had hip or knee replacement surgery in 2018 at a specific hospital in Milan and then went to its rehabilitation unit. Researchers will use your medical records to build and test a tool that predicts recovery after joint replacement.
MilanAges 18 years+ - NCT07301164RecruitingEarly Phase 1
BCT301 cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell treatment called BCT301 for people with certain autoimmune diseases like lupus or scleroderma that haven't gotten better with standard medicines. It aims to see if this treatment can help control the disease.
BeijingAges 18–80 - NCT07300384Recruiting
Blood flow restriction training for knee pain relief before surgery
This study tests whether a special type of strength training (called blood flow restriction training) can reduce pain in people with severe knee arthritis who are waiting for knee replacement surgery. The training uses a cuff on the thigh to lightly restrict blood flow while doing exercises until failure.
Valencia, ValenciaAges 50–85 - NCT07298265Recruiting
Screening for psoriatic arthritis in people with psoriasis
This study compares two ways to find psoriatic arthritis (joint pain and swelling related to psoriasis) in people who only have psoriasis so far. Your answers to a simple questionnaire or a doctor's exam may help detect joint problems early.
Toronto, OntarioAges 18 years+ - NCT07301242Recruiting
Study of ciprofol in older adults having limb surgery
This trial studies how the drug ciprofol works in older adults undergoing elective orthopedic limb surgery. The goal is to understand how the body processes the drug and how it affects patients, which may help improve its use for anesthesia in the elderly.
ShanghaiAges 65 years+ - NCT07302204Recruiting
Exercise for knee osteoarthritis pain relief
This study compares two types of exercise — aerobic (like walking or cycling) versus specific therapeutic exercises — to see which one better helps people with knee osteoarthritis who do not get pain relief from exercise. It aims to find an exercise plan that reduces knee pain and improves movement.
São PauloAges 40–75 - NCT07302958Recruiting
Comparing remote, in-person, and mixed exercise for neck pain
This trial compares three ways to treat chronic neck pain: doing exercises at home with remote guidance, doing them in a clinic with a therapist, or a mix of both. It aims to find which method works best for people with ongoing neck pain.
CairoAges 20–45 - NCT07304076Recruiting
JHG002 Injection for Chronic Low Back Pain
This study tests if JHG002 injections (made from human placenta) are safe and effective for treating chronic low back pain. It may help people who have had low back pain for at least 6 months and rate their pain as a 5 or higher on a 0–10 scale.
Seoul, Gangdong-guAges 19–70 - NCT07303335Enrolling by invitation
Sarcopenia in ICU patients on long-term ventilation
This study checks for muscle loss (sarcopenia) in ICU patients who need a breathing machine (mechanical ventilation). It aims to track how muscle health changes during hospital stay.
Terrassa, BarcelonaAges 18 years+ - NCT06864897Recruiting
10-year follow-up of the Delta-TT trial
This study checks on people who took part in the original Delta-TT trial to see how they are doing after 10 years. It helps researchers understand the long-term effects of the treatment.
Amsterdam, North HollandAges Any age - NCT06877936Recruiting
Shoulder replacement imaging study
This study uses a special low-dose X-ray machine (EOS®) to take 3D pictures of your shoulder after reverse total shoulder replacement. The goal is to better understand how the replacement parts move and fit together. It may help improve future surgeries.
LyonAges 18 years+ - NCT06238076Recruiting
Universal surgical device for jaw reconstruction
This trial tests a universal surgical device for rebuilding the lower jaw using a bone flap from the leg. It aims to make the procedure more reliable and easier for patients needing reconstruction of the front part of the jaw.
ToulouseAges 18 years+ - NCT06289114Recruiting
Can physical activity predict treatment success in rheumatoid arthritis?
This study tests if measuring your physical activity over a short time can help predict how well a new biologic medication will work for your rheumatoid arthritis. The goal is to find a simple way to see if the treatment is helping.
EsbjergAges 18 years+ - NCT06856824Recruiting
Ultrasound-Guided Injection vs Surgical Repair for Biceps Pain
This study compares two ways to treat biceps tendon pain: a ultrasound-guided injection versus a minor surgical repair. The goal is to see which method gives better function and less pain.
BogotáAges 18–99 - NCT06867952Recruiting
Vitamin K2 for bone loss with a specific gene change
This study tests whether taking vitamin K2 can help people with low bone density (osteopenia or osteoporosis) who have a specific change in the VDR gene. If you have this gene change, vitamin K2 may work better for you than standard supplements.
NovosibirskAges 40–75 - NCT06879743Recruiting
Gentle neck release for fibromyalgia pain
This study tests whether a gentle hands-on technique called suboccipital release can help ease fibromyalgia pain. It’s for women aged 20–45 with a stable fibromyalgia diagnosis who do not have certain other conditions or use strong pain medications.
CairoAges 20–45 - NCT07289620Recruiting
Nerve block boosters for kids' leg surgery
This study tests whether adding dexamethasone, dexmedetomidine, or both to a numbing shot (nerve block) provides better pain relief after leg surgery in children. The goal is to find which combination works best to keep your child comfortable with fewer side effects.
PoznanAges 3–12 - NCT07293676Recruiting
Massage and vibration for low back disc pain
This study tests if hand-held massage tools (IASTM) and gentle vibration therapy can reduce pain, improve movement, and lessen fear of movement in people with a bulging disc in their lower back. It is for adults aged 30-60 with moderate to severe pain lasting 3 months or longer.
IstanbulAges 30–60 - NCT07291310Enrolling by invitation
Virtual reality therapy for children with brachial plexus injury
This trial tests if playing virtual reality games while doing dual tasks can help the brain rewire and improve arm function in children with a brachial plexus injury. It could offer a fun and engaging new approach to rehabilitation.
Istanbul, CevizlibağAges 7–14 - NCT07292168RecruitingPhase 1/Phase 2
Study of a new antibody for advanced tumors with FGFR1 protein
This trial tests an experimental antibody, OM-RCA-01, in people with advanced solid tumors that have high levels of a protein called FGFR1. It aims to see if the drug is safe and effective for those who have already tried other treatments.
Kazan'Ages 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.