Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT05031507Recruiting
Study of bone disorders and inherited genetic factors
This study looks at bone (skeletal) disorders to better understand possible genetic causes, especially when phosphate levels or bone growth are affected. You may join either if you (or your child) has a bone disorder, or if you’re an unaffected family member who might help compare results.
Bethesda, MarylandAges 2 months–100 years - NCT06164795Recruiting
Next steps after strong bone-building therapy
This study looks at what medicine works best for women who have finished a 1-year course of a strong bone-building drug (romosozumab or teriparatide) for severe osteoporosis. The goal is to find a good follow-up treatment to keep bones strong and prevent fractures.
AthensAges 50–85 - NCT07716488Recruiting
Screening for high cholesterol in children with chronic conditions
This study screens children and teens with certain chronic conditions (like heart defects or inflammatory bowel disease) for early signs of high cholesterol or other lipid problems. The goal is to find and manage these risks sooner.
JenaAges 6–18 - NCT07715838Recruiting
PEM as a starting point to study ME/CFS
This study looks at how post-exertional malaise (PEM) affects people with ME/CFS. It aims to understand the condition better and find new ways to help.
GroningenAges 18–65 - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100 - NCT04798690Recruiting
Long-term growth injections for short children
This trial studies the long-term safety and effectiveness of Growtropin®-II, a growth hormone–type injection, in children who are short due to certain causes. It may help your child’s growth over time, while also closely tracking side effects.
Seoul, Seodaemun-guAges 2 years+ - NCT07702344Recruiting
Shift work and your body's daily rhythm
This study looks at how shift work affects your body's natural daily rhythm (circadian rhythm) and overall health. It may help find ways to support the health of shift workers like you.
IstanbulAges 18–65 - NCT06907849Enrolling by invitationPhase 2
Imaging amyloid in spinal stenosis and carpal tunnel
This trial tests a special scan that uses a radioactive tracer to look for amyloid protein deposits in people who have had surgery for lumbar spinal stenosis (narrowing of the spine in the lower back) or carpal tunnel syndrome. The goal is to see if the scan can detect these deposits, which may be linked to ongoing orthopedic issues.
Knoxville, TennesseeAges 60 years+ - NCT07484243Recruiting
Chinese and Western medicine for rheumatoid arthritis
This study combines traditional Chinese medicine with Western medicine to treat rheumatoid arthritis. It aims to see how well this approach works for people with hard-to-treat RA or RA-related lung disease.
ShanghaiAges 18 years+ - NCT05979441Enrolling by invitationPhase 3
Long-term safety of efgartigimod injection for myositis
This study tests the long-term safety and effectiveness of a subcutaneous (under-the-skin) version of efgartigimod for adults with active idiopathic inflammatory myopathy. It is for people who have already completed an earlier study of this medicine.
Phoenix, ArizonaAges 18 years+ - NCT03582800RecruitingPhase 2
Sodium thiosulfate shots for abnormal calcium or bone spots
This pilot study tests a medicine called sodium thiosulfate (given as a skin shot) to treat abnormal calcium or bone formation in places they don’t belong. It’s meant for people whose condition is causing significant problems, and who are not planning surgery for the next year.
BordeauxAges 6 months+ - NCT07172971RecruitingPhase 1
SGLT2i drug for heart health in Duchenne muscular dystrophy
This trial tests if an SGLT2i medication can help protect heart function in people with Duchenne muscular dystrophy (DMD). The drug is already approved for other conditions, and researchers want to see if it can slow or prevent heart muscle damage.
Nashville, TennesseeAges 8–18 - NCT05709782RecruitingPhase 2
MR-guided targeted radiation for limited-spine spinal metastasis
This Phase 2 study tests an MRI-guided radiation machine (an MR LINAC) to deliver very focused treatment to spine tumors. It may help by improving accuracy while treating up to a small number of spine levels affected by cancer.
Houston, TexasAges 18 years+ - NCT07484516Recruiting
Eccentric exercises and muscle energy for tennis elbow
This trial tests whether combining eccentric exercises with muscle energy technique can help reduce pain and improve function in people with tennis elbow. It is for those who have had symptoms for more than a few weeks.
Karachi, SindhAges 20–50 - NCT05492266Recruiting
Breathing muscle training for nasal speech in children
This trial tests whether strengthening the muscles you use to breathe out can help children ages 5–17 who have too much nasal sound in their speech. If it works, it could reduce the need for surgery.
Pittsburgh, PennsylvaniaAges 5–17 - NCT07715006Recruiting
Spinal nerve stimulation for children with cerebral palsy
This study adds a mild electrical stimulation to the spinal nerves during a planned SDR surgery for children with cerebral palsy, to see if it helps improve movement more than the surgery alone.
Pittsburgh, PennsylvaniaAges 3–14 - NCT07715136RecruitingPhase 1
BCMA-CD19 CAR-T for Refractory Inflammatory Myopathy
This trial tests a new type of cell therapy (BCMA-CD19 cCAR-T) for people with inflammatory myopathy that hasn't improved with standard treatments. The goal is to see if this treatment can help control the disease.
Chengdu, SichuanAges 18–60 - NCT07715188Recruiting
Low dose radiation for osteoarthritis
This trial tests if a very low dose of radiation can help relieve pain from osteoarthritis in joints like hips, knees, hands, shoulders, ankles, or elbows. It is for people whose pain has not improved with standard treatments or who want to try a gentler option before considering surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07714811Recruiting
Hyaluronic acid vs PRP for chronic tendon pain
This study compares two treatments—hyaluronic acid (a natural lubricant) and platelet-rich plasma (PRP, made from your own blood)—for chronic tendon pain. You may be a good fit if you have had pain in your Achilles tendon or golfer's elbow for more than 3 months and are looking for a non-surgical option.
Lublin, Lublin VoivodeshipAges 18–65 - NCT07237659RecruitingPhase 1
Testing safety of NTR-1011 in lupus and rheumatoid arthritis
This trial is testing a new medicine called NTR-1011 to see if it is safe and tolerable for people with lupus or rheumatoid arthritis. If you have active lupus or RA and are on a stable treatment plan, you may be able to join.
Apple Valley, CaliforniaAges 18–75 - NCT07484594Recruiting
Trunk stabilization plus knee rehab for knee-spine syndrome
This trial tests whether adding trunk stabilization exercises to standard knee osteoarthritis rehab can improve outcomes for people with both knee pain and low back pain. It may help if you have moderate knee arthritis and have had back pain for at least 3 months.
Islamabad, ALAges 40–60 - NCT07325578Recruiting
Testing a new device for CT-guided spine and pelvis procedures
This study is testing a new device called EPIONE that helps doctors perform CT-guided needle procedures in the spine or pelvis. It aims to see if the device improves accuracy and safety for patients under general anesthesia.
San Diego, CaliforniaAges 22 years+ - NCT06564974Recruiting
Long-term safety study of Agamree for Duchenne muscular dystrophy
This study watches boys with Duchenne muscular dystrophy who are already taking Agamree (vamorolone) to see how safe it is over a long period. It helps doctors understand the medicine's effects over time.
Phoenix, ArizonaAges 2 years+ - NCT05933057RecruitingPhase 3
Givinostat for wheelchair-bound boys with Duchenne muscular dystrophy
This Phase 3 trial tests givinostat to see if it can improve safety and functional outcomes in boys with Duchenne muscular dystrophy who cannot walk. You might be a candidate if you meet age, genetic diagnosis, wheelchair-level mobility, and specific arm-strength/respiratory/heart criteria.
LeuvenAges 9–17
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.