Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07318987Recruiting
Nerve release surgery for knee pain relief
This study tests if surgically releasing a nerve in the knee (the saphenous nerve) can reduce pain in people with patellofemoral pain syndrome (pain around the kneecap). If you've had anterior knee pain for at least six weeks and the nerve test is positive, this trial may offer relief.
CairoAges 18–35 - NCT07321977Recruiting
Walking test with a portable device for neuromuscular disease
This study tests a portable device that analyzes walking without markers. It aims to see if it can help assess walking in people with neuromuscular diseases and healthy volunteers, which could lead to simpler check-ups.
ParisAges 18–65 - NCT07322198Enrolling by invitation
Gong's mobilization with scapular lift for frozen shoulder
This trial tests two types of physical therapy for frozen shoulder (adhesive capsulitis) to see which better improves shoulder movement and function. One therapy includes a special lift of the shoulder blade (scapular high lift), and the other does not.
Sialkot, Punjab ProvinceAges 40–60 - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07323745RecruitingEarly Phase 1
Mobithron Advance for knee osteoarthritis: long-term effects
This trial tests a supplement called Mobithron Advance to see if it can slow down knee osteoarthritis over time. It may help people with mild to moderate knee arthritis find a non-surgical option.
Kota Bharu, KelantanAges 50 years+ - NCT07320807Recruiting
Shock wave therapy after flexor tendon repair
This study tests whether a non-invasive treatment called extracorporeal shock wave therapy can help improve hand function after flexor tendon repair surgery. The therapy uses sound waves to stimulate healing and reduce scar tissue, and it may help you regain movement more quickly.
AnkaraAges 18–50 - NCT07315997Recruiting
Heart health study for people with rheumatoid arthritis
This study looks at whether calcium in the heart arteries and a blood test (troponin) can help predict heart disease risk in people with rheumatoid arthritis. It may help doctors better prevent heart attacks and strokes.
Boston, MassachusettsAges 35–79 - NCT07321600Recruiting
Breathing muscle training with Schroth exercises for scoliosis in teens
This trial tests whether adding a special breathing exercise (inspiratory muscle training) to standard Schroth exercises improves breathing and posture in teenage girls with scoliosis. It may help strengthen the muscles used for breathing.
Kırşehir, MerkezAges 10–18 - NCT07315841RecruitingPhase 4
Dye Imaging for Tenosynovial Giant Cell Tumor Surgery
This trial tests whether a special dye (Indocyanine Green) used during surgery can help doctors see Tenosynovial Giant Cell Tumors more clearly. It may help make the surgery more precise.
ShanghaiAges 18–75 - NCT07321340Recruiting
Optimizing insoles for rheumatoid arthritis patients
This trial tests whether custom-fit insoles can improve foot pain and walking for people with rheumatoid arthritis. It aims to find the best insole design for each patient.
Saint-EtienneAges 18 years+ - NCT03718637RecruitingPhase 4
Bioinductive implant for tennis elbow that therapy didn’t fix
This trial tests a special implant placed in the elbow to improve healing in people with tennis elbow (lateral epicondylitis) when physical therapy and other non-surgical treatments haven’t worked. If you qualify, you may receive the implant to see if it helps reduce pain and improve elbow function.
Detroit, MichiganAges 18 years+ - NCT04540068Recruiting
Predicting whether a sciatica procedure will work
This study looks for ways to predict how well a specific sciatica procedure (TEI) will help. If you have one-sided nerve pain from the low back, the trial may help personalize treatment so you’re less likely to go through ineffective care.
HaarlemAges 18 years+ - NCT04716140Recruiting
Study of outcomes after bunion surgery for cartilage damage
This study looks at how well bunion (hallux valgus) surgery works, especially when there is cartilage damage in the joint. The goal is to see what factors predict better or worse outcomes after treatment.
GhentAges 30–60 - NCT05092984RecruitingPhase 3
Spironolactone for rheumatoid arthritis with active symptoms
This trial tests whether spironolactone can reduce symptoms and inflammation in people with rheumatoid arthritis that is still active despite standard arthritis medicines. You may be able to join if your rheumatoid arthritis remains active and your current treatment plan has been stable for at least several months.
Strasbourg, AlsaceAges 18 years+ - NCT05927688Recruiting
Using patient reports to adjust treatment for autoimmune diseases
This study looks at whether doctors consider patient “electronic reports” (completed online/phone) when deciding how often to change treatment. It may help improve how well treatment plans match how patients feel over time.
StrasbourgAges 18 years+ - NCT06514677Recruiting
Nonsurgical treatment for implant infection with ultrasonic carbon tip
This study tests whether using a special ultrasonic carbon tip (a gentle cleaning tool) can treat infection around a dental implant without surgery. It is for people with a single problem implant who are otherwise healthy and have good oral hygiene.
KütahyaAges 18–99 - NCT06872918Recruiting
Study of a back manipulation for lumbar disc herniation
This study tests a specific type of back manipulation (Lever Positioning Manipulation) to understand how it affects the discs in the lower spine. It may help people with a herniated disc at L4-L5 find a non-surgical treatment option.
Hangzhou, ZhejiangAges 20–60 - NCT06873100RecruitingPhase 1/Phase 2
Upadacitinib for relapsing polychondritis
This trial tests whether upadacitinib, an oral medication, is safe and effective for people with relapsing polychondritis that hasn't improved enough with standard treatments. It aims to reduce inflammation and control symptoms.
Beijing, Beijing MunicipalityAges 18–70 - NCT02589106Recruiting
Brace study for teens with early scoliosis
This trial tests a special type of brace made with “anisotropic textile” material for adolescents with a specific kind of side-bending spine problem called adolescent idiopathic scoliosis (AIS). It may help by improving curve measurements while you follow a structured brace plan.
Hong Kong, GuangdongAges 10–14 - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT06186830Recruiting
Questionnaire for jaw and face pain
This study tests a special questionnaire (BETY-BQ) to see how well it measures the impact of jaw and face pain in people with temporomandibular disorders. It helps doctors better understand your symptoms and guide treatment.
Karabük, Karabük ProvinceAges 18–64 - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT07315061RecruitingPhase 2
Testing D-2570 for active psoriatic arthritis
This trial tests an oral medication, D-2570, for people with active psoriatic arthritis. It aims to see if the drug can reduce joint pain and swelling.
Chengdu, SichuanAges 18–70 - NCT07307495Recruiting
Pain relief after back surgery and its effect on recovery
This study tests a new painkiller, oliceridine fumarate, given through a pump after lumbar spine surgery. The goal is to see if it helps the bowels and stomach recover faster compared to standard pain relief.
Xi'an, ShaanxiAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.