Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT04247672Recruiting
Study of knee replacement outcomes using a specific knee implant
This study follows people who need knee replacement for “end-stage” knee osteoarthritis and will receive a specific knee implant system as part of routine care. It aims to measure how well the knee replacement works for patients over time, which may help improve future care.
Hoofddorp, North HollandAges 21–90 - NCT04250454Recruiting
Early treatment for babies at risk of cerebral palsy
This trial looks at an early intervention for very young babies who show signs they may develop cerebral palsy. The goal is to improve development as early as possible, especially in babies with concerning brain scan findings or movement patterns.
Charlottenlund, København CityAges 2 months–5 months - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT04274374Recruiting
Gluten-free diet study for people with axial spondyloarthritis
This trial looks at whether eating gluten-free improves quality of life in people with axial spondyloarthritis. You may be asked to follow a gluten-free diet for the study and keep your current symptoms treatment stable.
BordeauxAges 18 years+ - NCT04292067Recruiting
Study gut bacteria in people with arthritis
This study compares the gut microbiome (the bacteria in your intestines) in adults with spondyloarthritis or rheumatoid arthritis versus healthy adults. It aims to better describe differences that may help explain these diseases.
Boulogne-BillancourtAges 18 years+ - NCT04296487Recruiting
ACI treatment for cartilage repair after failed knee care
This trial tests a cartilage-repair procedure called ACI for people whose knee cartilage injury has not improved after at least 6 months of prior treatment. If you qualify, it may help your cartilage heal and reduce symptoms.
Lausanne, Canton of VaudAges 15–50 - NCT04318041RecruitingPhase 3
Diacerein to improve knee osteoarthritis symptoms
This Phase 3 study tests diacerein (Artrodar®) to see if it can improve symptoms in people with knee osteoarthritis, and it uses movement and scan-based assessments. It may help reduce walking pain and improve knee function for the right patient group.
Bangkoknoi, BangkokAges 40–65 - NCT04334031Recruiting
Hospital follow-up study for immune-related disease
This is a study that follows people with an immune-related illness at Lille University Hospital to better understand their care needs over time. By collecting information regularly, the study may help improve how future patients are monitored and treated.
LilleAges 18 years+ - NCT04342234Recruiting
Neural network tool to measure cleft palate from scans
This trial studies a computer “neural network” that uses existing dental impressions, scans, and photos to measure cleft palate features. The goal is to reduce the amount of repeated cleft lip and palate clinic work for patients and families.
BaselAges Any age - NCT04354649RecruitingPhase 2
Test triage and treatment for immune-related arthritis from immunotherapy
This trial studies how doctors assess and manage immune-related arthritis or joint pain that happens after PD-1/PD-L1 cancer immunotherapy (sometimes with CTLA-4). It may help people get faster, more targeted care while monitoring safety.
Edmonton, AlbertaAges 18 years+ - NCT04364334Recruiting
Knee care registry for people treated at UMC Utrecht
This study is a “registry,” meaning researchers collect information about your knee care over time. It may help improve understanding and care for people who receive knee treatment at UMC Utrecht.
UtrechtAges Any age - NCT04388332Recruiting
Neck surgery compares two bone graft materials
This study compares two materials used during neck surgery for degenerative disc disease: donor bone (structural allograft) versus a titanium cage (Tritanium C). It aims to see which option works better for healing the fused neck bones and improving symptoms.
Pittsburgh, PennsylvaniaAges 18–80 - NCT04394052Recruiting
Imaging tests for suspected bone or soft-tissue tumors
This trial studies new imaging methods to better identify and stage (find how far it has spread) suspected bone or soft-tissue tumors. It may help your care team choose the most accurate next steps based on your scans.
Nancy, LorraineAges 18 years+ - NCT04395495Recruiting
RASopathy disorder study biobank for kids and families
This study collects and stores health samples and information from people with RASopathy conditions (like Noonan or Costello syndromes) and from family members who may not have the condition. It helps researchers understand these disorders and supports future studies that could lead to better care.
Cincinnati, OhioAges Any age - NCT04397484RecruitingPhase 4
Compare two local anesthetics after foot nerve blocks
This study tests whether lidocaine or levobupivacaine works better for how a nerve block behaves after foot surgery. It may help doctors choose the anesthetic that provides more reliable pain control after surgery.
Shatin, New TerritoriesAges 18–75 - NCT04402086Recruiting
Rheumatology patient and skin sample registry study at Yale
This study builds a health record and blood/skin sample collection for people with rheumatic autoimmune diseases who are getting care at Yale. It may help researchers understand these conditions and develop better tests or treatments over time.
New Haven, ConnecticutAges 18–99 - NCT04407338Recruiting
B-DYN device versus standard fusion for lumbar stenosis
This trial compares a specific spinal fusion approach (B-DYN) with the standard fusion surgery for people with lumbar spinal stenosis. It aims to improve function after surgery and check whether the newer approach is well tolerated.
BordeauxAges 40 years+ - NCT04441411Recruiting
Non-fusion surgery for teens with idiopathic scoliosis
This trial studies a “non-fusion” surgery approach for teenagers with a spinal curve that has worsened despite non-surgical treatments. It aims to see if this surgery can better treat adolescent idiopathic scoliosis while avoiding spinal fusion in eligible patients.
Amsterdam, North HollandAges 10–17 - NCT04441567Recruiting
Personalized follow-up visits for specific injuries using an app
This study tests whether using the Memora platform to tailor clinic visit timing improves care after certain injuries. You may get more or fewer check-ins based on your recovery information entered on your phone.
Boston, MassachusettsAges 18 years+ - NCT04445545Recruiting
Laser treatment for tight neck trigger points
This trial tests whether high-intensity laser therapy applied to specific “trigger points” in the neck muscles can help people with painful tight spots. You may be eligible if you have those trigger points and meet safety rules about recent neck/shoulder problems and skin and nerve conditions.
Santiago, Las CondesAges 18 years+ - NCT04449211RecruitingEarly Phase 1
3D-printed implant for large bone defects
This trial studies whether a custom 3D-printed implant helps heal a large bone defect after injury or tumor removal. If you have a bone gap bigger than 5 centimeters and can safely have surgery, this may be a treatment option being tested.
Ho Chi Minh CityAges 18 years+ - NCT04452721Recruiting
Predicting outcomes for a chest brace in pectus carinatum
This study looks at what factors help predict how well a dynamic compression brace works for people with pectus carinatum (a chest wall that sticks out). It uses past patients’ records and later patients to see which early details relate to better or worse results.
Saint-EtienneAges 6–40 - NCT04460989Recruiting
Compare knee replacement satisfaction by implant type
This study asks how satisfied people are after knee replacement, comparing different knee implant types. You may help researchers understand which implant approach leads to better patient experience.
LyonAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.