Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT04460872RecruitingPhase 2
Testosterone plus walking training to support bones and muscles
This Phase 2 study tests whether testosterone therapy combined with walking training can improve bone and muscle health after a spinal cord injury. It aims to help men with low testosterone and walking problems by improving strength, body composition, and related health markers.
Gainesville, FloridaAges 18 years+ - NCT04463316Recruiting
Clinic study for people with rare genetic conditions
This study is for people who have a rare syndrome or rare congenital condition and are seen at a rare-disease clinic. It aims to better understand these conditions and how care works in a team setting, which may help guide future treatment decisions.
Rotterdam, South HollandAges 18 years+ - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT04468178Recruiting
Testing a new shoulder implant and checking its position over time
This study looks at how well a specific shoulder replacement implant works for people with worn-out (arthritic) shoulder joints. It also checks how well the implant stays in the right position as you heal after surgery.
Hanover, Lower SaxonyAges 18–80 - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT04473196Recruiting
See if weight-bearing changes recovery after first toe joint fusion
This study looks at whether doing more or less weight-bearing affects recovery after a first toe (1st MTP) joint fusion. It may help improve walking comfort and healing after surgery for people whose non-surgical treatments did not work.
Halifax, Nova ScotiaAges 18 years+ - NCT04489342Recruiting
Tests sensor-based movement assessment in axial spondyloarthritis patients
This trial studies an advanced “sensor-based” way to assess how your spine and hips move in people with axial spondyloarthritis. It may help researchers better measure function and choose/monitor treatment, especially for those considered for biologic therapy.
Londonderry, N.IrelandAges 18–80 - NCT04504136Recruiting
Study how gut lining heals in inflammatory bowel disease
This study looks at how the lining of the colon heals in people with inflammatory bowel disease (ulcerative colitis or Crohn’s disease). It may help researchers understand whether anti-TNF treatment improves healing, especially when people have limited prior response or are starting biologic therapy.
Lexington, KentuckyAges 18–90 - NCT04515459RecruitingPhase 2
Pre-surgery exercise and care program for limb sarcoma
This Phase 2 trial tests a “prehabilitation” program done before surgery to help people with arm or leg (limb) sarcoma be better prepared for their operation. It may help improve how well patients tolerate treatment and recover by planning supportive care around the weeks before surgery.
ToulouseAges 16 years+ - NCT04522622RecruitingPhase 4
Teriparatide for low bone turnover in advanced kidney disease
This trial tests teriparatide (a hormone-like bone medicine) to improve bone health in people with advanced chronic kidney disease who are at risk for weak, low-turnover bone. It may help by changing how quickly your bones break down and rebuild.
AalborgAges 18–120 - NCT04528355Recruiting
Study of hospital data after stem cell transplant for non-cancer illness
This study collects medical information from people with certain non-cancer conditions who receive a stem cell transplant. It may help doctors better understand transplant outcomes and care, since the study focuses on data collection rather than adding new treatment.
Pittsburgh, PennsylvaniaAges 2 months–60 years - NCT04528446Recruiting
Study bone strength in people with kidney filtering disorders
This study looks at how kidney filtering problems (glomerular disorders) may affect bone quality and strength. It may help researchers understand who is at higher risk for weak bones and fractures and why.
New York, New YorkAges 5–55 - NCT04529798Recruiting
Testing outcomes after reverse shoulder replacement with a SMR implant
This study looks at how well a type of shoulder replacement (reverse shoulder arthroplasty) works for people with shoulder arthritis. It may help improve understanding of expected results and safety with a specific stemless implant called SMR.
Basel, Canton of Basel-CityAges 18 years+ - NCT04536103Recruiting
Accelerated MRI scans after ACL knee injury surgery
This trial tests a faster MRI scan method to measure healing in the knee after an ACL (anterior cruciate ligament) tear and reconstruction. It may help researchers compare scan quality while participants go through standard rehab.
Cleveland, OhioAges 18–50 - NCT04538053RecruitingPhase 4
Simpler antibiotics for uncomplicated bone and joint infections in children
This trial looks at whether a simpler antibiotic plan can work for children with uncomplicated bone or joint infections that start in the community. It may help reduce the need for complicated treatment while still keeping the infection under control.
Kingswood, New South WalesAges 1–18 - NCT04540432Recruiting
Study how gut bacteria change with juvenile arthritis treatments
This study looks at how the “gut microbiome” (the helpful bacteria in the intestines) changes in children with juvenile enthesitis-related arthritis. It may help doctors understand how different treatment approaches affect gut bacteria over time.
Nîmes, GardAges 6–18 - NCT04540068Recruiting
Predicting whether a sciatica procedure will work
This study looks for ways to predict how well a specific sciatica procedure (TEI) will help. If you have one-sided nerve pain from the low back, the trial may help personalize treatment so you’re less likely to go through ineffective care.
HaarlemAges 18 years+ - NCT04552145Recruiting
Physical therapy versus surgery for lumbar spinal stenosis
This study compares physical therapy to surgery to help relieve symptoms from narrowing in the lower spine. It looks at which treatment works best for walking discomfort caused by spinal stenosis.
LillehammerAges 50–80 - NCT04561557RecruitingEarly Phase 1
Cell therapy for relapsing nervous system autoimmune diseases
This early-phase trial tests CT103A “CAR-T” cell therapy to treat certain relapsing or treatment-resistant autoimmune diseases that affect the nervous system. It aims to see whether the cells are safe and may help reduce disease activity when standard treatments haven’t controlled symptoms.
Wuhan, HubeiAges 18–75 - NCT04569162Recruiting
RCDP patient registry for children with related genetic conditions
This trial is a registry that collects medical and genetic information from people with rhizomelic chondrodysplasia punctata (RCDP) or closely related conditions. It helps researchers better understand the condition and plan future studies that could lead to better care.
Wilmington, DelawareAges Any age - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT04580225Recruiting
Tested partial wrist fusion with or without bone removal
This study compares two surgical options for certain types of advanced wrist arthritis—one with partial wrist fusion alone, and one with partial wrist fusion plus removal of a small wrist bone. It may help find which approach works better for pain and function after surgery.
Calgary, AlbertaAges 18–75 - NCT04601363Recruiting
Personalized spine registry for people with spinal hardware
This registry follows people who recently had spinal surgery where custom (patient-specific) spine hardware (like rods) was placed. It collects consent and health questionnaires to learn how these implants affect patients over time.
Aurora, ColoradoAges 10–85
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.