Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07262892Recruiting
3D study of jaw widening methods in children
This trial uses 3D imaging to compare two ways of widening the upper jaw in children. It may help your child if they need jaw expansion and haven't had it before.
Istanbul, FatihAges 6–12 - NCT07260630Enrolling by invitation
Hamstring tightness relief study
This trial tests different massage-type techniques to see which helps tight hamstrings best. If you are between 18 and 30 and have stiff hamstrings, this may help find a quick, drug-free solution.
Ankara, AnkaraAges 18–30 - NCT07266038Recruiting
Comparing two wire methods for children's elbow fracture
This trial is testing two ways of using small wires (K-wires) to hold a child's broken elbow bone in place after it's been set. The goal is to see which method keeps the bone correctly aligned as it heals.
Bahawalpur, Punjab ProvinceAges 2–13 - NCT07266922Enrolling by invitation
Web-based education for runners with knee pain
This study tests if a self-guided online program helps Boston Marathon runners manage patellofemoral pain (pain around or behind the kneecap). It aims to improve your understanding and control of the condition without in-person visits.
Waltham, MassachusettsAges 18–45 - NCT06362057Recruiting
3D dental implants for severe bone loss
This trial tests a new type of dental implant that sits on top of the jawbone under the gums, which may help people who have severe bone loss in the upper jaw and cannot get regular implants.
Al MansurahAges 30–70 - NCT06754982Recruiting
Timing of pain, stiffness, and function in plantar fasciitis after muscle release
This trial tests whether a hands-on therapy called myofascial release can help with morning pain, stiffness, and walking in people with plantar fasciitis. It aims to see how these symptoms change over time after treatment.
Talca, Maule RegionAges 18–60 - NCT06898554Recruiting
Understanding Ankle Control in Athletes with Unstable Ankles
This trial studies how your brain and spinal cord control your ankle if you have chronic ankle instability (a long-term wobbly ankle). It is for athletes between 18 and 25 who play team sports and have had repeated ankle sprains.
IstanbulAges 18–25 - NCT06897943Recruiting
Gonococcal arthritis study (2014-2024)
This study looks at people who had a joint infection caused by gonorrhea bacteria between 2014 and 2024. Researchers want to learn more about how common this condition is and how it affects people.
Rennes, Brittany RegionAges Any age - NCT04102930Recruiting
Study of immune and genetic features in GCA and PMR
This study looks at immune system and genetic (inherited) differences in people diagnosed with giant cell arteritis or polymyalgia rheumatica. It aims to improve understanding of why these conditions happen and how they vary between people.
Canterbury, KentAges 50 years+ - NCT06711744Recruiting
Comparing dental implants after tooth extraction
This study compares different types of dental implants placed right after a tooth is removed. It may help people with a failing tooth who have healthy gums and surrounding teeth.
Rome, RMAges 18–99 - NCT06899932Recruiting
Genutech knee replacement survival study
This study tracks how long Genutech knee replacements last in people with knee arthritis. It is for adults whose arthritis did not improve with non-surgical treatments like physical therapy or medication.
Barcelona, BarcelonaAges 18 years+ - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT05030220Recruiting
Testing testosterone and a skin bacteria during shoulder surgery
This study looks at how testosterone levels and a common skin bacteria (Cutibacterium) may relate to outcomes around elective shoulder replacement surgery. Results could help improve how doctors prevent and understand infection risk or healing after surgery.
Seattle, WashingtonAges 18–89 - NCT05218785Recruiting
Botulinum toxin for calf tightness and long-term heel pain
This trial tests whether injections of botulinum toxin A can loosen a tight calf muscle and improve long-lasting plantar fasciitis (heel/foot pain). It’s for people whose symptoms have lasted at least a year and who haven’t improved enough with physical therapy.
Oslo, OsloAges 18–75 - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT07253493Recruiting
Bone loss and nerve activity study for postmenopausal women
This study looks at how bone loss in the hip might affect nerve signals to muscles. It compares postmenopausal women with weak bones (osteoporosis in the hip) to those with normal bone density.
Bahçelievler, IstanbulAges 18–65 - NCT07256522Recruiting
Comparing treatments for trigger finger
This study compares three non-surgical treatments for a single trigger finger: a splint, paraffin wax, and a type of mud therapy. It aims to find which works best for improving finger movement and reducing pain.
Konya, KonyaAges 18–75 - NCT07258849RecruitingPhase 1
Study of LY4213663 in healthy people and rheumatoid arthritis
This study tests a new medicine called LY4213663 in healthy volunteers and people with rheumatoid arthritis. It aims to see if the medicine is safe and how the body handles it.
Anniston, AlabamaAges 18–75 - NCT07255534Recruiting
Digital therapy for shoulder recovery after rotator cuff repair
This trial tests a digital app-based therapy to improve shoulder function after rotator cuff repair surgery. It uses your smartphone to guide your rehabilitation exercises at home.
Seoul, Republic of KoreaAges 19 years+ - NCT07255248RecruitingPhase 4
Knee fat pad pain study for young female athletes
This study tests a treatment for knee fat pad pain in teenage girls who play organized sports. It aims to see if a specific injection helps after physical therapy hasn't worked.
Norwood, MassachusettsAges 12–18 - NCT07258537Enrolling by invitation
Comparing two hand therapies for sacroiliac joint pain
This study compares two types of hands-on therapy (a gentle side-lying adjustment vs. a lower back roll) to see which works better for long-lasting low back pain caused by the sacroiliac joint. If you have ongoing pain and are open to physical treatments, this trial may help find the best approach.
Gujrat, Punjab ProvinceAges Any age - NCT07256795Enrolling by invitation
ME/CFS after COVID-19 vs. before the pandemic
This study looks at how the brain's protective barrier and immune system work in people with ME/CFS, comparing those who got sick before the COVID-19 pandemic to those who developed ME/CFS after a COVID-19 infection. It aims to understand why some people have lasting brain fog, fatigue, and other neuropsychiatric symptoms.
Baltimore, MarylandAges 18–70 - NCT07258355Enrolling by invitation
Fall prevention program for older adults
This study is testing a program that combines everyday activities (like dressing or cooking) with other measures to reduce falls in older adults. If you're 65+, have fallen recently, and don't have certain health issues, this trial might help you stay safer at home.
AnkaraAges 65 years+ - NCT07254351Recruiting
Limb length inequality study in children
This study looks at how a difference in leg length affects balance and movement in children aged 10 to 15. It uses a special low-dose X-ray (EOS) to take pictures of the child's spine and legs while they stand still.
BronAges 10–15
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.