Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06296979Recruiting
Nerve stimulation for shoulder pain from liver or gallbladder issues
This study tests if stimulating a nerve in the neck can reduce right shoulder pain caused by liver or gallbladder problems. It may offer a non-drug option for managing this type of pain.
Seville, SevillaAges 18 years+ - NCT06794008RecruitingPhase 2
CAR-T cell therapy for hard-to-treat autoimmune diseases
This trial tests a new treatment using your own immune cells (called CAR-T cells) designed to target and attack cells that cause autoimmune diseases. It is for people with lupus, Sjögren's syndrome, inflammatory myopathy, scleroderma, Behcet's disease, ANCA-associated vasculitis, IgG4-related disease, antiphospholipid syndrome, or thrombotic thrombocytopenic purpura who have not improved with standard therapies.
Beijing, Beijing MunicipalityAges 18–65 - NCT06906406Recruiting
Quality of life in children with clubfoot
This study looks at how clubfoot affects the daily life and well-being of children aged 2 to 15. It uses questionnaires to understand their physical and emotional health, which can help improve care and support for kids with this condition.
Drammen, BuskerudAges 2–15 - NCT07235982Recruiting
Shoulder block plus steroid vs. steroid alone for frozen shoulder pain
This trial compares two treatments for frozen shoulder (adhesive capsulitis): a steroid injection alone versus a steroid injection plus a nerve block. The goal is to find which approach provides better pain relief for people who have not improved after two weeks of conservative care.
ZagazigAges 41–65 - NCT07236658Recruiting
Using AI to detect arm problems after breast cancer surgery
This trial uses artificial intelligence (a computer program) to help predict arm and shoulder problems that can happen after breast cancer surgery. It aims to find these issues early so they can be treated better.
AnkaraAges 18 years+ - NCT07234773RecruitingPhase 1
Study of a new injectable drug for rheumatoid arthritis
This early-stage study tests a new injectable medicine (KT501) for people with moderate to severe rheumatoid arthritis who have not responded well enough to other treatments and have specific antibodies in their blood. It aims to see how safe and well-tolerated the drug is.
BayswaterAges 18–75 - NCT07237568RecruitingPhase 3
Testing LNK01001 for active ankylosing spondylitis
This trial tests a new oral medication called LNK01001 for adults with active ankylosing spondylitis. It aims to reduce pain, stiffness, and inflammation when standard NSAID treatments no longer help.
BeijingAges 18 years+ - NCT07236801RecruitingPhase 1
Cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with several autoimmune diseases that have not improved with standard medications. It aims to see if this treatment can help control the disease when other treatments have failed.
Xuzhou, JiangsuAges 18–65 - NCT07238478Recruiting
Supplement for menopause quality of life in postmenopausal women
This trial tests a dietary supplement to see if it can improve menopause-related symptoms, like hot flashes and joint discomfort, in healthy postmenopausal women.
Harrison, New YorkAges 50–70 - NCT07230353RecruitingPhase 1
Plamotamab for moderate to severe rheumatoid arthritis
This trial tests a new treatment called plamotamab for people with moderate to severe rheumatoid arthritis (RA) who have not had enough relief from current treatments. The goal is to see if it is safe and to help control RA symptoms.
TbilisiAges 18 years+ - NCT07237659RecruitingPhase 1
Testing safety of NTR-1011 in lupus and rheumatoid arthritis
This trial is testing a new medicine called NTR-1011 to see if it is safe and tolerable for people with lupus or rheumatoid arthritis. If you have active lupus or RA and are on a stable treatment plan, you may be able to join.
Apple Valley, CaliforniaAges 18–75 - NCT07236762RecruitingPhase 1
YTS109 cell therapy for severe autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with severe autoimmune diseases like lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. It's for those whose disease hasn't improved with standard treatments.
BengbuAges 18–65 - NCT06086080Recruiting
Non-surgical care after first kneecap dislocation
This study compares non-surgical treatment for people who have dislocated their kneecap for the first time in the past week. It aims to find the best way to help the knee heal without an operation.
Cali, Valle del Cauca DepartmentAges 10–40 - NCT06212947Recruiting
An observational study for children with hypochondroplasia
This study observes children with hypochondroplasia to learn more about the condition. It does not involve any treatment—just monitoring and data collection to help future research.
Phoenix, ArizonaAges Up to 15 years - NCT06863701RecruitingPhase 3
Combination therapy for acute gout flare
This trial tests a combination of two medicines, etoricoxib and betamethasone, for quickly treating a painful gout flare. It is for people who have had gout before and whose current attack started within two days.
Mexico CityAges 18 years+ - NCT07239427Recruiting
Brain stimulation with pain coping for fibromyalgia
This study tests whether a gentle electrical brain stimulation method (tDCS), combined with a pain coping program, can help reduce fibromyalgia pain. It compares two groups to see if adding brain stimulation makes the coping program more effective.
Valladolid, ValladolidAges 18 years+ - NCT07234747Recruiting
Core stability: exergaming vs. standard exercises for kids with JIA
This study compares two types of core-strengthening exercises for children with juvenile idiopathic arthritis (JIA). One group does standard core-stability exercises, and the other plays active video games (exergaming) that work the same muscles. The goal is to see which approach works better and is more fun for kids.
Istanbul, BuyukcekmeceAges 8–12 - NCT07232836Recruiting
Body chemicals and brain changes after back surgery
This trial studies how certain chemicals in your body and brain change after a type of back surgery called endoscopic decompression. If you have lumbar spinal stenosis (narrowing of the spine) or a herniated disc and are scheduled for this surgery, you may be able to join.
Poznan, WielkopolskaAges 18–90 - NCT07237867Recruiting
Nerve stimulation for knee pain in athletes
This study tests if a mild electrical current to a nerve in the groin area can improve thigh muscle strength in athletes with long-standing jumper's knee (patellar tendinopathy). The goal is to see if this treatment can help reduce pain and improve function.
Barcelona, BarcelonaAges 18–40 - NCT07238751Recruiting
Bowen technique and backward walking for knee osteoarthritis
This study tests whether the Bowen technique (a gentle hands-on therapy) combined with walking backward can improve hamstring flexibility and reduce pain in people with knee osteoarthritis. It may help if you have tight hamstrings and mild to moderate knee arthritis.
Islamabad, Punjab ProvinceAges 40–60 - NCT07230470Recruiting
Walking rehabilitation after stroke: Exoskeleton vs treadmill
This study compares two robotic devices (the LoKomat exoskeleton and the C-Mill treadmill) to see which one helps people walk better after a stroke. If you are recovering from a stroke and able to understand instructions, you may be able to join.
SalamancaAges 18–65 - NCT07237321Recruiting
Magnetic stimulation for flat feet: effects on arch and strength
This study tests whether magnetic stimulation of foot muscles can improve the arch of the foot and muscle strength in adults with flat feet. If you have flat feet without major leg or health problems, this trial may help find a new way to strengthen your feet.
Ljubljana, LjubljanaAges 18–50 - NCT07232511Recruiting
Cuff-assisted exercise for shoulder pain
This study tests whether using a blood pressure cuff during gentle shoulder exercises can help reduce pain and improve movement. It is for people with ongoing shoulder pain related to the rotator cuff (the muscles and tendons that help lift and rotate your arm).
Valencia, ValenciaAges 18–65 - NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.