Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT04607538Recruiting
Study of knee joint shape and patella dislocations in Faroese teens
This study looks at how knee joint shape differences may relate to repeated kneecap (patella) instability or near-dislocation, and what that means long-term. It specifically includes teens from the Faroe Islands and asks about symptoms and knee function over time.
HvidovreAges 15–20 - NCT04608630RecruitingPhase 2
Preventing bone loss in ICU patients with anti-bone drugs
This Phase 2 study tests whether zoledronic acid or denosumab can prevent bone thinning in critically ill adults after staying in the ICU. It may help reduce the risk of future bone fractures if your body is at higher risk during and after critical illness.
Sydney, New South WalesAges 50 years+ - NCT04623593Recruiting
Study of cost and value of neck disc surgery
This study looks at how cost-effective (good value for the money) anterior neck disc surgery is for people with nerve or spinal cord symptoms. If you need this type of operation, it may help doctors better choose treatments and plan healthcare resources.
Maastricht, LimburgAges 18 years+ - NCT04626674RecruitingPhase 1
Gene therapy safety study for non-ambulatory Duchenne
This Phase 1 trial studies a one-time gene therapy treatment (SRP-9001) to see if it is safe and whether it can produce the needed gene activity in people with Duchenne muscular dystrophy (DMD) who are not walking. It may help researchers understand whether this approach could be useful for DMD patients, especially in later stages.
Little Rock, ArkansasAges 2 years+ - NCT04631133Recruiting
Study of outcomes after surgery using the LISA implant
This study follows adults who get back surgery using the LISA implant to see how well they do afterward and how outcomes change over time. It focuses on people whose long-term, non-surgical care did not relieve low-back pain from specific age-related disc changes.
SilkeborgAges 18 years+ - NCT04635111Recruiting
Long-term study of liver side effects from Turalio
This study follows adults taking Turalio (pexidartinib) to understand how often it causes liver problems and what those liver changes look like over time. It may help improve monitoring and safety for people who develop liver test abnormalities during treatment.
Santa Monica, CaliforniaAges 18 years+ - NCT04639388Recruiting
Learning about psychosis in children with 22q11.2 deletion syndrome
This study looks at how “psychotic disorders” (like unusual beliefs, hallucinations, or thought changes) show up in children with 22q11.2 deletion syndrome. It mainly focuses on understanding the condition and may help improve care in the future.
Lyon, Auvergne-Rhône-AlpesAges 4–13 - NCT04644042Recruiting
Surgery for shoulder pain after non-surgical treatment fails
This trial looks at whether arthroscopic subacromial decompression surgery helps people whose “impingement” shoulder pain hasn’t improved after supervised exercises and an injection. It may help if your symptoms match their specific non-responder pattern and you can complete rehab visits.
Hvidovre, DenmarkAges 18–99 - NCT04669548Recruiting
Accuryn monitoring study for people having heart surgery
This registry collects information from patients who are monitored with the Accuryn system during heart surgery and their ICU stay. It helps researchers learn from the system’s signals to better understand patient care around cardiac procedures.
Los Angeles, CaliforniaAges 18 years+ - NCT04678635Recruiting
Brain stimulation study for autoimmune muscle disease
This trial tests whether a noninvasive brain stimulation treatment can help people with systemic autoimmune muscle diseases. It may improve symptoms by changing how the brain and muscles communicate.
São Paulo, São PauloAges 18–70 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04684602RecruitingPhase 1/Phase 2
Study of stem cells for several short- and long-term illnesses
This early-stage study tests whether injections of mesenchymal stem cells can be safe and helpful for certain chronic (long-term) and acute (short-term) conditions. You might be considered if you can consent, are able to return for follow-up visits, and do not have key reasons that would make stem-cell treatment unsafe.
Culver City, CaliforniaAges 18 years+ - NCT04688593Recruiting
Follow-up study of a hip implant cup and stem system
This study looks at how well a specific hip implant (the acetabular cup and femoral stem) works over short, mid, and long-term follow-up. It may help you and other patients by improving understanding of implant outcomes after surgery.
KielAges 18 years+ - NCT04695028Recruiting
Study to better understand crystal-related joint pain
This study looks at people with certain types of crystal deposits in joints (like gout, CPPD, or hydroxyapatite crystal disease). It uses scans such as ultrasound and a special CT-type scan called DECT to confirm and better understand what’s causing your symptoms.
LommeAges 18 years+ - NCT04698785RecruitingPhase 2
Regorafenib to help prevent cancer return after treatment
This Phase 2 study tests whether regorafenib, given after your main treatments, can help keep high-grade bone sarcoma from coming back or progressing. It checks safety and whether this “maintenance” approach works better than best supportive care alone.
BesançonAges 12 years+ - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04711551Recruiting
Monitoring patients after regenerative treatments for joint or tendon pain
This trial follows people who receive “regenerative medicine” treatments (orthobiologics) for joint or tendon problems, like osteoarthritis or tendon pain. The goal is to study whether clinical check-ins and lab/biologic measurements can help monitor how patients are doing after treatment.
Milan, ItaliaAges 6 years+ - NCT04713774Recruiting
Tracking bone and blood vessel changes after kidney transplant
This study follows people who recently received a kidney transplant to see how bone strength and blood-vessel calcifications change over time. It may help doctors better understand what to monitor after transplant and how best to protect bone and heart health.
LiègeAges 18 years+ - NCT04713800Recruiting
Dental implant bridge comparison with two implant types
This trial tests two ways of making a small back teeth bridge (a “cantilever” dental implant crown) using different materials. It may help show which material works best when replacing missing back teeth with implant support.
GenevaAges 22 years+ - NCT04716140Recruiting
Study of outcomes after bunion surgery for cartilage damage
This study looks at how well bunion (hallux valgus) surgery works, especially when there is cartilage damage in the joint. The goal is to see what factors predict better or worse outcomes after treatment.
GhentAges 30–60 - NCT04729686RecruitingPhase 4
Nerve block during hip replacement for less postoperative pain
This trial tests whether a specific nerve block given during planned hip replacement surgery can reduce pain afterward. It may help you use less opioid pain medicine, but you must meet certain safety and medication criteria.
Baltimore, MarylandAges 18–80 - NCT04730622Recruiting
Studying muscle and bone changes after a hip fracture
This study looks at how bone health and muscle strength (“osteosarcopenia” — loss of both bone and muscle) change after a hip fracture in older adults. It may help doctors understand who is at higher risk and how to better support recovery after hip surgery.
BolognaAges 65 years+ - NCT04731831Recruiting
Testing how well TNF medicines work in inflammatory arthritis
This study looks at how your immune system responds to starting infliximab or adalimumab for rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Results may help doctors understand why some people don’t respond as well and how to improve treatment.
AalborgAges 18 years+ - NCT04732962Recruiting
Special shoes to help knee osteoarthritis symptoms without surgery
This study tests whether custom biomechanical footwear can reduce pain and improve function in people with knee osteoarthritis. It may help as a non-surgical option to ease symptoms while you’re considering or preparing for care.
Danville, PennsylvaniaAges 45–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.