Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07230470Recruiting
Walking rehabilitation after stroke: Exoskeleton vs treadmill
This study compares two robotic devices (the LoKomat exoskeleton and the C-Mill treadmill) to see which one helps people walk better after a stroke. If you are recovering from a stroke and able to understand instructions, you may be able to join.
SalamancaAges 18–65 - NCT07232511Recruiting
Cuff-assisted exercise for shoulder pain
This study tests whether using a blood pressure cuff during gentle shoulder exercises can help reduce pain and improve movement. It is for people with ongoing shoulder pain related to the rotator cuff (the muscles and tendons that help lift and rotate your arm).
Valencia, ValenciaAges 18–65 - NCT05463757Recruiting
Oral drugs for advanced or multiple basal cell skin cancer
This study registers people in the Netherlands who have certain types of basal cell skin cancer and take an oral hedgehog-blocking medicine. It may help doctors understand how well these tablets work and how patients do in real life.
Nijmegen, GelderlandAges Any age - NCT05519332Recruiting
Procedure to stabilize very severe osteoporotic spine fractures
This trial studies a minimally invasive procedure to treat very severe, unstable compression fractures in the spine caused by osteoporosis. It may help people who have trouble tolerating standard open spine surgery, by aiming to restore stability and alignment.
Nantong, JiangsuAges 58–84 - NCT07228754Recruiting
Stroke caregiver expectations study
This study looks at how realistic caregivers' expectations are for people recovering from a stroke, within the first 6 months. It may help understand what caregivers need to know to better support their loved one.
Ankara, YenimahalleAges 18–75 - NCT07228611Recruiting
Osteoporosis risk after stroke
This study looks at bone health in people who have had a stroke. It aims to find out who is at risk for weak bones (osteoporosis) after a stroke, so doctors can help prevent fractures.
Ankara, YenimahalleAges 55–85 - NCT07228897Recruiting
Walking study for women with fibromyalgia
This study compares walking on a treadmill to walking outdoors to see which helps more with fibromyalgia symptoms. If you're a woman between 25 and 55 who hasn't been active lately, this may be a good fit.
Ankara, YenimahalleAges 25–55 - NCT06337786Recruiting
RheumaBuddy app study for rheumatoid arthritis
This study tests if a digital app called RheumaBuddy4.1 can help manage rheumatoid arthritis symptoms. You would use the app at home and report how you feel.
Frederiksberg, Copenhagen FAges 18–65 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06883669Recruiting
AI for wrist and hand joint ultrasound
This study is testing if an artificial intelligence program can help doctors take clearer images of the wrist and hand using ultrasound. It is for healthy volunteers to help build the AI system, and for experienced sonographers to test how well it works.
Chengdu, SichuanAges 18–100 - NCT06911190Recruiting
10-year follow-up study for FSHD patients
This study follows FSHD patients for 10 years to see how the disease progresses. It includes people who were in earlier FSHD studies and some new patients with genetic confirmation of FSHD.
NijmegenAges 6 years+ - NCT07230171Recruiting
Short-term S-ketamine for fibromyalgia pain relief
This trial tests if low-dose S-ketamine, given as a short intravenous infusion, can safely improve fibromyalgia pain and other symptoms for people who haven't gotten enough relief from non-drug treatments. S-ketamine is a fast-acting medicine that blocks pain signals and may help reset how the brain processes pain.
BeijingAges 18 years+ - NCT07228936Recruiting
Pectoralis minor tightness and rotator cuff tears
This trial looks at whether tightness in a small chest muscle (pectoralis minor) is linked to rotator cuff tears. If you have a partial rotator cuff tear or a healthy shoulder, you might be able to join to help answer this question.
Ankara, CankayaAges 18–55 - NCT07226297Enrolling by invitationPhase 1/Phase 2
Personalized treatment for GARS1-related CMT2D
This trial tests a personalized medicine designed for a single person with a specific genetic mutation (GARS1) that causes Charcot-Marie-Tooth disease type 2D. The treatment is an antisense oligonucleotide, a custom-made molecule that targets the faulty gene.
Houston, TexasAges 13 years+ - NCT07226973Recruiting
Gait after hip replacement: comparing surgical approaches
This study compares how well people walk after three different types of hip replacement surgery for arthritis. It aims to see if one approach leads to a better walking pattern.
Metairie, LouisianaAges 18 years+ - NCT07230197Recruiting
Pregabalin and dexmedetomidine for fibromyalgia pain
This trial tests whether combining two medications, pregabalin and dexmedetomidine, works better than standard treatments for fibromyalgia pain. It may help people with moderate to severe fibromyalgia who haven't found relief from non-drug therapies.
BeijingAges 18 years+ - NCT07226388Enrolling by invitation
Pyrocarbon hemiarthroplasty vs total shoulder replacement for osteoarthritis
This study compares two types of shoulder replacement surgery for people with osteoarthritis: one that replaces only the ball of the joint (hemiarthroplasty with a pyrocarbon ball) and one that replaces both the ball and socket (total shoulder arthroplasty). The goal is to see which option works better for people with this condition.
St Louis, MissouriAges 40–65 - NCT07229079Recruiting
Body awareness therapy for flat feet
This study tests whether basic body awareness therapy can help people with flexible flat feet (when the foot arch flattens under weight but returns when not standing). If you have flat feet without other foot problems, you may qualify.
Mardin, Mardi̇nAges 18–45 - NCT07222696Recruiting
Health coaching for rheumatoid arthritis to improve mental wellbeing
This study tests if working with a health coach (a trained peer) can help people with rheumatoid arthritis feel better emotionally, especially if they are dealing with depression or anxiety. You would meet with a coach remotely using your phone or computer.
New York, New YorkAges 18 years+ - NCT07229495RecruitingPhase 4
Tegileridine for pain after scoliosis surgery in teens
This trial tests a new pain medicine, tegileridine, for teenagers having spine surgery for scoliosis. It aims to see if it controls pain well after the operation, and if it's safe.
Zhengzhou, HenanAges 10–17 - NCT07230327Recruiting
Whole body MRI for inflammatory back disease
This trial uses a whole body MRI scan to find inflammation in the spine and joints in people with a type of arthritis called axial spondyloarthritis (axSpA). It aims to see if the scan can detect disease activity and track changes over time, helping doctors choose the right treatment.
Nanjing, JiangsuAges 18 years+ - NCT07227493Recruiting
Bioactive glass for open pilon fracture repair
This trial tests a special glass material to help heal severe ankle bone fractures. It may help people who need a bone graft after an open pilon fracture.
Columbia, MissouriAges 18 years+ - NCT07224646Recruiting
Light therapy for professional soccer players during a championship
This trial tests if a type of light therapy (called photobiomodulation) on the whole body can help professional soccer players recover faster and perform better during a championship. It involves 8 weeks of sessions alongside your regular training.
Porto Feliz, São PauloAges 18–35 - NCT07227441Recruiting
Chronic Infections and Inflammation in ME/CFS
This study looks at how chronic infections and inflammation affect people with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) compared to healthy people. Researchers want to understand what causes symptoms and find better ways to help.
San Francisco, CaliforniaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.