Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04153422RecruitingPhase 2
IVIG for small fiber nerve pain with specific antibody tests
This trial studies whether IVIG (an immune therapy made from donated antibodies) can reduce pain from autoimmune small fiber neuropathy. You may be a candidate if your tests show certain autoantibodies (TS-HDS, FGFR3, or Plexin-D1) and your symptom scores are high enough.
Glenview, IllinoisAges 18 years+ - NCT04157179Recruiting
MRI study of brain oxygen use in children and adults
This study uses an MRI scan to measure how your brain uses oxygen. It includes healthy participants and people with sickle cell disease or who previously needed ECMO, which may help researchers understand brain oxygen problems and how to monitor them.
St Louis, MissouriAges 3–50 - NCT04161053RecruitingPhase 3
Nitazoxanide to prevent repeat liver brain episodes
This Phase 3 trial tests whether nitazoxanide can help stop hepatic encephalopathy (a “liver-to-brain” confusion problem) from coming back. It’s for adults with cirrhosis who have had at least one past episode, aiming to improve safety and prevent recurrence.
TantaAges 20–65 - NCT04163198Recruiting
Testing better airway clearance for weak breathing muscles
This study checks a device approach that helps move mucus out of the lungs in people with neuromuscular (nerve/muscle) conditions and weak breathing. It may help reduce mucus buildup and lower respiratory infections, but you must meet specific breathing and stability requirements.
London, LondonAges 18 years+ - NCT04165109Recruiting
Down syndrome study to test memory and thinking changes
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
Phoenix, ArizonaAges 25–55 - NCT04165486RecruitingPhase 1
Test drug safety in adults with multiple system atrophy
This Phase 1 study checks how safe a drug called ION464 is, how the body handles it, and how much of the drug reaches the bloodstream in adults with multiple system atrophy (MSA). It may help researchers find a dosing approach for future treatments for MSA.
InnsbruckAges 40–70 - NCT04171856Recruiting
Robotic training to improve movement after stroke
This study tests a robotic rehabilitation program to help improve arm movement after an acute or chronic stroke (and separately studies people with transient global amnesia). It may help by measuring how well patients can learn and control movement during repeated robot-guided sessions.
Yvoir, NamurAges 18–90 - NCT04170491Recruiting
EEG monitoring for ongoing seizures in ICU
This trial studies whether using EEG (a brain-wave test) in the ICU can help guide care for people whose seizures keep going despite initial medicines. It may benefit patients with severe, difficult-to-stop status epilepticus by improving how doctors find and treat ongoing seizure activity.
LondonAges 16 years+ - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT04174157Recruiting
Spinal muscular atrophy patient registry for OAV-101
This is a registry that collects information from people with spinal muscular atrophy (SMA) who have been treated with OAV-101. It helps researchers understand how patients do over time after this treatment.
Phoenix, ArizonaAges Any age - NCT04175691Recruiting
Study blood RNA markers after sudden ischemic stroke
This trial looks at blood “RNA markers” (molecules that may reflect brain injury) in people who have had a new ischemic stroke. It may help doctors understand what’s happening in the body soon after stroke and possibly guide future care.
Nanjing, JiangsuAges 18 years+ - NCT04177134Recruiting
French patient registry for spinal muscular atrophy (SMA 5q)
This trial is a patient registry that collects health information from people with spinal muscular atrophy (SMA) caused by changes in the 5q area. It helps researchers understand real-world care and outcomes for these patients across French hospitals.
GarchesAges birth+ - NCT04177914RecruitingPhase 3
Compare endoscopy vs shunt surgery for infant hydrocephalus
This Phase 3 study compares two common surgery options to treat hydrocephalus (extra fluid in the brain) in infants. It aims to find which approach works better and is safer for babies who have symptoms and need a first permanent treatment.
Birmingham, AlabamaAges 1 day–2 years - NCT04179981Recruiting
CPAP treatment effects in older COPD and sleep apnea patients
This study looks at whether using positive airway pressure (often called CPAP) improves health outcomes in older adults who have both COPD and obstructive sleep apnea. It may help find ways to reduce symptoms and complications from “overlap” breathing problems.
Detroit, MichiganAges 60 years+ - NCT04179695Recruiting
Testing a new communication aid to improve patient-centered care
This study tests a new tool meant to help patients and healthcare teams communicate better and support “patient-centered care.” You may be invited to use the tool and complete study activities during your neurology care visits.
LilleAges 18–90 - NCT04182984Recruiting
Compare immunosuppressant medicines for eye-only myasthenia gravis
This real-world study looks at how different immunosuppressant medicines work for people with non-thymoma ocular myasthenia gravis (eye symptoms due to MG). It may help doctors understand which treatments control symptoms best in everyday care.
Xi'an, ShaanxiAges 18–75 - NCT04182087Recruiting
Testing thinking skills after a localized brain injury
This trial studies how your thinking and memory abilities work after a single, localized brain injury seen on MRI. It involves cognitive (thinking) tasks to assess changes and may help researchers understand brain function after injury.
GrenobleAges 18–70 - NCT04185038RecruitingPhase 1
CAR T therapy through a catheter for pediatric brain tumors
This Phase 1 trial tests a personalized immune-cell treatment (CAR T) delivered directly in the brain-area space using a catheter. It may help children and young adults with hard-to-treat (recurrent or refractory) diffuse midline brain tumors like DIPG/DMG when standard options aren’t working.
Seattle, WashingtonAges 1–26 - NCT04186078Recruiting
Study symptoms and traits of sleep apnea in Korea
This study looks at people in Korea who may have sleep apnea based on common symptoms. The goal is to better understand who has sleep apnea and how it shows up, which may help improve future diagnosis and care.
SeoulAges 19 years+ - NCT04186286RecruitingPhase 2
Testing propranolol vs ivabradine for POTS symptoms
This study compares two heart-rate medicines—propranolol and ivabradine—to see which better improves symptoms in people with POTS. It uses a “crossover” design, meaning you may try one medicine and then switch to the other.
Calgary, AlbertaAges 18–60 - NCT04189471Recruiting
Improving care for people in the Neuro ICU
This trial looks at improving outcomes for people who have a potentially life-threatening neurologic illness and are admitted to a Neuro ICU soon after injury. If you qualify, you may receive care strategies being tested to improve recovery and survival.
Baltimore, MarylandAges 18 years+ - NCT04188522Recruiting
MEG study of memory after a small stroke
This study uses a special brain scan called MEG to understand how thinking and memory change after a small ischemic stroke. If you qualify, you may get scanned about 4–6 weeks after your stroke and help researchers learn what brain signals relate to recovery.
Baltimore, MarylandAges 18–100 - NCT04190134RecruitingPhase 1
Robot training to help you use a reading magnifier
This study tests a “socially assistive robot” that coaches and supports you in using your reading magnifier. It may help you use the device more easily and comfortably for reading tasks.
Los Angeles, CaliforniaAges 18 years+ - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.