Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05157282Recruiting
Spinal cord stimulation to improve hand function after tetraplegia
This trial tests whether a special device that stimulates the spinal cord can help people with long-lasting neck spinal cord injuries recover useful hand movement and grip strength. It may help your nervous system communicate better so daily hand tasks become easier.
Chicago, IllinoisAges 18–70 - NCT05156112Recruiting
PAP breathing treatment for veterans with PTSD and substance use
This trial studies whether using a PAP breathing device (a machine that helps keep airways open during sleep) can help veterans who have PTSD and a substance use disorder while they receive residential treatment. It’s specifically for people with obstructive sleep apnea and aims to see if this treatment is safe and helpful during recovery.
San Diego, CaliforniaAges 18 years+ - NCT05158101RecruitingPhase 1
Nasal stem cell exosome treatment safety for stroke
This early-stage study (Phase 1) tests whether a tiny dose given through the nose is safe for people who have had a stroke. It uses exosomes made from adult umbilical cord stem cells, mainly to look for side effects and dosing safety.
St John'sAges Any age - NCT05158894Recruiting
Pregnancy safety registry for migraine medicines Ubrelvy and Qulipta
This is an observational study (no treatment is assigned) that tracks side effects and pregnancy outcomes in people taking Ubrelvy or Qulipta for migraine during pregnancy. It may help doctors better understand how these medicines affect mothers and babies.
Durham, North CarolinaAges 18 years+ - NCT05159687RecruitingPhase 3
Atomoxetine to help prevent fainting from vasovagal episodes
This Phase 3 study tests whether atomoxetine can reduce how often vasovagal fainting happens. It may help people who have frequent fainting episodes with triggers like stress or standing for long periods.
Calgary, AlbertaAges 18 years+ - NCT05159856Recruiting
Early checks for long-term complications in young type 1 diabetes
This study looks for early signs of long-term complications in children and teens who have type 1 diabetes for more than a year. It may help your clinic spot problems sooner, when treatment could be easier.
Herlev, HerlevAges 6–18 - NCT05160987Recruiting
Sedation choice for ICU patients on breathing machines
This study compares two sedation medicines—remimazolam vs midazolam—for very sick ICU patients who are on a breathing machine. It looks at whether one sedative works better or is safer for keeping patients comfortable while they’re critically ill.
Guangzhou, GuangdongAges 18–80 - NCT05161377Recruiting
Test treatment planning for a middle brain artery aneurysm
This study looks at treatment options for aneurysms in a specific brain artery (the middle cerebral artery). It may help by guiding safer, more appropriate surgical or catheter-based treatment for aneurysms that fit certain health and imaging criteria.
EdmontonAges 18 years+ - NCT05163899Recruiting
Surgery to release an occult tethered cord
This trial studies whether a specific back surgery (cutting/releasing part of the filum terminale) helps people with an “occult” tethered cord syndrome when symptoms have not improved with medicine. It may help by reducing traction on the spinal cord to improve bladder/bowel, skin, or nerve-related symptoms.
New York, New YorkAges 2–80 - NCT05163288RecruitingPhase 3
N-acetyl-leucine trial for Niemann-Pick disease type C
This Phase 3 trial tests whether N-acetyl-leucine can improve symptoms in people with Niemann-Pick disease type C (NPC). If you qualify, you will be asked to take study medicine and complete symptom and movement tests over time.
Rochester, MinnesotaAges 4 years+ - NCT05163639RecruitingEarly Phase 1
Noninvasive brain and spinal training for spinal cord injury
This early study tests a noninvasive way of training the nervous system to see how it affects “associative plasticity,” or the brain/spinal cord’s ability to change with practice. It may help researchers learn strategies that could improve function for people with spinal cord injury.
New York, New YorkAges 18–80 - NCT05164172RecruitingPhase 3
Eptinezumab for kids with ongoing or recurring migraine
This trial studies eptinezumab, a migraine treatment, in children and teens ages 6 to 17 who already completed an earlier migraine study. It mainly helps doctors learn whether the treatment can be continued safely and effectively over time.
New Haven, ConnecticutAges 6–17 - NCT05167786Recruiting
Electrical spinal cord stimulation for walking after stroke
This trial studies whether a non-surgical electrical treatment to the spinal area can improve walking and leg control after a stroke. It’s for people who have had a single stroke and still need hands-on support to walk.
Chicago, IllinoisAges 18 years+ - NCT05168124Recruiting
Therapy or short breaks for chronic fatigue syndrome (CFS/ME)
This study tests whether Acceptance and Commitment Therapy (ACT) or doing brief “micro breaks” can improve symptoms in people with CFS/ME. It checks safety and whether you can follow the online program over the study period.
ZurichAges 18–55 - NCT05169632Recruiting
Computer brain training for thinking problems after stroke
This trial tests a computerized “cognitive rehabilitation” program aimed at improving executive thinking skills after a stroke. It may help people who still struggle with areas like attention, planning, or mental flexibility.
Lausanne, Canton of VaudAges 18 years+ - NCT05170126Recruiting
Study of ozanimod use during pregnancy in people with MS
This trial looks at the safety of ozanimod taken during pregnancy for parents with multiple sclerosis and for their babies after birth. It may help doctors understand the risks and benefits of this medicine during early pregnancy.
Bethesda, MarylandAges Any age - NCT05170815Recruiting
Spine Device Registry for Adults Getting Commercial Devices
This study is a registry that collects information about adults who use specific, commercially available spine devices. It may help doctors understand how these devices are used in real-world care and what outcomes look like over time.
LyonAges 18 years+ - NCT05171205Recruiting
Spinal cord stimulation for people with parkinsonism symptoms
This trial studies whether spinal cord stimulation can improve symptoms in people with parkinsonism (Parkinson-like movement problems). It aims to see if the treatment is safe and helpful for the right patients.
Shanghai, Shanghai MunicipalityAges 50–80 - NCT05176132Recruiting
Obesity screening to find hidden weight-related health issues
This study screens adults of different body sizes to find “unrecognized” weight-related health problems. It may help doctors spot issues earlier and understand how common they are across weight groups.
EsbjergAges 18–60 - NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65 - NCT05177055Recruiting
Sleep program for delayed sleep timing with mental health symptoms
This study offers a sleep-focused program to people whose sleep schedule is significantly shifted later than desired (delayed sleep phase disorder) along with moderate to severe mental health symptoms. It aims to see if treatment for the sleep problem can help in people already getting psychiatric care.
Bergen, TertnesAges 18–80 - NCT05177523Recruiting
MRI study of nerve damage and repair in multiple sclerosis
This trial uses MRI scans to better understand how nerve fibers are damaged and repaired in people with multiple sclerosis. It may help researchers connect scan findings to disease activity and progression.
BaselAges 18–80 - NCT05178056Recruiting
Spinal cord stimulator to improve breathing after spinal injury
This study looks at whether a spinal cord stimulator can improve breathing and lung function in adults with a certain type of spinal cord injury. It may help people who have ongoing breathing weakness after their injury.
Louisville, KentuckyAges 18 years+ - NCT05177809Recruiting
Study of RFC1 gene changes in patients and healthy controls
This study tracks people with a specific genetic cause of RFC1-related disease, and compares them with healthy people without nervous system or mental health conditions. It helps researchers learn how the condition develops over time and what changes to watch for.
Melbourne, VictoriaAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.