Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT05107947Recruiting
Dynamic room lighting to improve sleep and daily body rhythm
This study tests whether changing the light in a hospital room can improve sleep and help your body clock work better in older adults. It may be most helpful if sleep problems or irregular daily rhythms are affecting you in the hospital.
MalmöAges 65 years+ - NCT05117463Recruiting
Balance testing while doing thinking tasks and eye-movement training
This study tests how well your balance and coordination work while you do a thinking task, using special visual (eye-movement) stimulation. It may help researchers understand why some people have balance problems and how training could improve safety.
Greenville, North CarolinaAges 25–85 - NCT05041569Recruiting
MRI study of brain vein damage and swelling patterns
This pilot study uses an MRI scan that involves an injected contrast to look at how brain blood-flow pathways are being blocked or narrowed. The goal is to better understand the kind of damage caused by these vein problems, which may help doctors monitor and plan care.
Paris, ParisAges 18 years+ - NCT04938765RecruitingPhase 4
Magnesium before surgery to improve nerve monitoring
This trial tests whether giving a one-time magnesium dose (through an IV) before or during surgery changes how well doctors can monitor nerves while you’re under anesthesia. It may help make nerve monitoring more reliable during spine or brain operations.
Loma Linda, CaliforniaAges 18–80 - NCT04957355Recruiting
NMES therapy to improve balance and reduce falls after stroke
This trial tests whether NMES (a small electrical stimulation you feel on the skin) can improve balance and lower fall risk in people with stroke-related weakness. It may help you walk more steadily and safely, while the study measures balance and fall-related outcomes.
Chicago, IllinoisAges 18–90 - NCT05183971Recruiting
Testing balance changes in older people with neck spinal cord wear
This trial studies how changes in balance and body sensing (proprioception) show up in people with age-related neck spinal cord problems. It may help researchers understand symptoms and how best to evaluate or manage degenerative cervical myelopathy.
Hong Kong, Hong KongAges 50 years+ - NCT05136976RecruitingPhase 3
Rituximab for anti-MAG neuropathy in specific patients
This Phase 3 study tests rituximab, an antibody medicine, for people with a particular type of nerve damage called anti-MAG–related demyelinating polyneuropathy. It aims to see if rituximab improves symptoms or function in patients who are considered “good responders.”
BrestAges 18 years+ - NCT05257161Recruiting
Carotid stent study comparing two stent positions using brain MRI
This study looks at how well a carotid artery stent works soon after the procedure, using special MRI pictures of the brain. It compares outcomes between stent placement closer to the top versus closer to the bottom of the narrowed area, to see which approach is safer for early brain effects.
NovosibirskAges 45–80 - NCT04824040Enrolling by invitation
Study of immune, muscle, and genetic features in LGMD 2B
This study looks at immune function, muscle appearance, and genetic information in people with limb-girdle muscular dystrophy type 2B. It may help researchers understand the condition better, which can support future treatments.
MoscowAges 18–85 - NCT04989608Recruiting
Study links brain scan results with thinking after a TIA
This study looks at how brain imaging findings match up with thinking and memory in people after a TIA (a temporary stroke-like event). If you join, your role is mainly to contribute data from brain scans soon after the event, plus study questionnaires.
CaenAges 60 years+ - NCT05229224Recruiting
Study of a new device for frequent tension headaches
This pilot study tests a device approach (“Osteo-Fluidic-Sensitive”) for people who get frequent episodic tension-type headaches. It aims to see whether the device is safe and can reduce headache burden for the right kind of headache pattern.
PoitiersAges 18–75 - NCT05151718Recruiting
Study of ependymoma treatment resistance in children
This trial looks at why ependymoma can resist (be harder to treat) after radiation or treatment. It studies children who are already being followed in specific existing programs, which may help researchers find better treatment approaches in the future.
ToulouseAges Up to 25 years - NCT05256745RecruitingPhase 1/Phase 2
A medicine to protect the heart during breast cancer chemotherapy
This early-phase study tests azeliragon to lower the risk of chemotherapy-related heart damage in women with early-stage breast cancer. Participants get their planned standard chemotherapy, plus the study medicine, and are monitored for safety and heart health.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04786977Recruiting
Measuring a nerve-related eye signal in children on vincristine
This study checks how children’s pupil responses look while they are receiving vincristine (a cancer medicine). The goal is to learn whether a simple eye measurement can reflect how the body is responding to treatment.
Washington D.C., District of ColumbiaAges 6–18 - NCT04933149Enrolling by invitationPhase 4
Ketamine infusion for nerve pain after shoulder nerve injuries
This trial tests whether a ketamine infusion can reduce nerve-related pain after traumatic brachial plexus (shoulder/arm nerve) injuries. It specifically targets people with pain caused by nerve damage who are scheduled for surgery to repair the nerve.
Rochester, MinnesotaAges 18 years+ - NCT05108948Recruiting
Study factors linked to better quality of life after spine surgery
This study looks at what helps adults with spinal deformity have a better quality of life one year after surgery. It may help doctors understand which patients benefit most and how to improve follow-up care.
BrugesAges 18 years+ - NCT05344469Recruiting
Testing new MS medicines in people with active relapsing MS
This study tests different approved “disease-modifying” MS medicines (shots and pills) in adults with relapsing multiple sclerosis that is currently active. It mainly looks at outcomes based on how newly starting—or recently started—treatments are handled for people with recent relapses and mild disability.
Albstadt, Baden-WurttembergAges 18–100 - NCT04908709Recruiting
MRI-guided proton therapy for high-grade brain tumors in children
This study looks at how metabolism in a child’s brain tumor changes during proton therapy, using special MRI scans. It may help doctors better understand treatment response and tailor care for pediatric high-grade gliomas.
Atlanta, GeorgiaAges Up to 21 years - NCT04961515RecruitingPhase 2
Orelabrutinib with immunotherapy and temozolomide for CNS lymphoma
This Phase 2 trial studies a combination of anti-cancer medicines to treat lymphoma that is only in the brain/spinal fluid (central nervous system, or CNS), especially when it has come back or not responded. If you qualify, you may benefit from improved tumor control and possibly better symptom control.
Hangzhou, ZhejiangAges 18–75 - NCT04763655Recruiting
Testing brain signals to predict response to ECT
This study looks at “neural biomarkers,” or brain-measurement signals, to see who is most likely to benefit from electroconvulsive therapy (ECT). It focuses on people with certain active psychosis symptoms and specific mental health diagnoses who have tried antipsychotic medication without enough improvement.
Glen Oaks, New YorkAges 18–80 - NCT04998175Recruiting
Study of blood and brain data in normal pressure hydrocephalus
This study collects different kinds of health information (“multi-omics” data, like blood-based markers) in people with idiopathic normal pressure hydrocephalus (iNPH). It aims to better understand the condition and how it may relate to treatment, such as shunt surgery.
Hangzhou, ZhejiangAges 60–90 - NCT04752319Recruiting
Breathing-based stimulation to improve arm movement after stroke
This pilot study tests a breathing-related stimulation approach (called BreEStim) to improve arm and hand movement in people with chronic stroke. It may help reduce stiffness and improve motor control, especially if you still have moderate movement difficulty.
Houston, TexasAges 18–75 - NCT04668261Recruiting
Brain blood flow changes in neurosurgery patients over time
This study uses repeated MRI scans to measure how blood flow to the brain changes over time in people with certain neurosurgical conditions. It aims to better understand brain circulation changes, which may help doctors plan care more effectively.
ZurichAges 18 years+ - NCT04775485RecruitingPhase 2
Targeted medicine for children with certain brain or solid tumors
This Phase 2 study tests tovorafenib, a targeted cancer medicine, in children and young adults whose tumors have specific BRAF or RAF changes. It is for cancers that have come back or grown despite previous treatment, with measurable signs on scans.
San Francisco, CaliforniaAges 6 months–25 years
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.