Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT06776874Recruiting
Predicting risks after an ERCP procedure
This observational study looks at patients who need an ERCP (a scope procedure for the bile ducts, liver, or pancreas). The goal is to create a score that can predict side effects after the procedure, which may help doctors better manage care.
BolognaAges 18 years+ - NCT06777030Recruiting
Study of exosomes in pancreatic cancer
This study looks at tiny particles called exosomes in pancreatic cancer. Researchers want to understand how exosomes may help the cancer grow, which could lead to better treatments in the future.
BolognaAges 18 years+ - NCT06776757RecruitingPhase 1/Phase 2
Sintilimab plus cetuximab and chemo for first-line advanced colorectal cancer
This trial tests a combination of immunotherapy (sintilimab), a targeted therapy (cetuximab), and chemotherapy as a first treatment for advanced colorectal cancer that hasn't spread or come back after earlier treatment. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and show signs of immune activity (PD-L1 or CD8+ TILs).
Shenzhen, GuangdongAges 18–75 - NCT06775951Recruiting
Colonoscopy use: a look at its impact
This trial studies how well colonoscopies are used in normal care. It aims to understand the medical and economic effects of doing colonoscopies for the right reasons.
BolognaAges 18 years+ - NCT06776770RecruitingPhase 1/Phase 2
Study of adebrelimab with chemo for stomach cancer
This trial tests a new combination of an immunotherapy drug (adebrelimab) plus two chemotherapy drugs (capecitabine and oxaliplatin) for people with stomach cancer or cancer where the stomach meets the esophagus. It aims to see if this combination is safe and effective for patients who have not had prior treatment for advanced disease.
Shenzhen, GuangdongAges 18 years+ - NCT06776536Recruiting
Testing ultrasound depth in endometriosis bowel surgery
This trial uses an ultrasound probe placed inside the rectum during surgery to see how accurately it measures how deep and how far endometriosis has spread into the bowel wall. The goal is to help surgeons decide exactly how much bowel needs to be removed.
IstanbulAges 18–55 - NCT06777017Recruiting
Can liver stiffness predict cancer return after ablation?
This trial studies if measuring liver and spleen stiffness can help predict the risk of liver cancer coming back after radiofrequency ablation (RFA), a treatment that uses heat to destroy tumors. It aims to improve follow-up care for people with chronic liver disease and early-stage liver cancer.
BolognaAges 18 years+ - NCT06777628Recruiting
Blood test study to predict immunotherapy success in liver cancer
This study looks at blood cells from people with liver cancer (HCC) to see if we can predict early whether immunotherapy will work for them. It's a research study that involves blood tests during your normal care.
Bologna, Laura GramantieriAges 18 years+ - NCT06777914Recruiting
Genes linked to rare liver disease and cancer risk
This study looks at whether certain family-related genes make people more likely to develop liver or bile duct cancers without a clear cause. If you had surgery or a transplant for one of these cancers and have had unexplained high liver enzymes or itching, this trial may help find genetic clues.
Bologna, BolognaAges 1 year+ - NCT06485609Recruiting
Dye-guided surgery for right colon cancer
This trial tests whether adding a special dye (indocyanine green) during surgery to remove right-sided colon cancer helps the surgeon see and remove more lymph nodes. The goal is to improve cancer removal without adding extra risks.
GuangzhouAges 18–75 - NCT05793554Recruiting
AI checks cancer type during rectal surgery in real time
This study tests an AI system that helps identify cancer or polyp findings during rectal surgery or assessment, using real-time information. It may help surgeons classify tissue more accurately while you are already getting treatment.
Dublin, IrelandAges 18 years+ - NCT07473687Recruiting
Monitoring vital signs without touching in the operating room
This study uses a camera to monitor your heart rate, breathing, and oxygen levels without any sensors touching your skin. It may help make surgery safer and more comfortable.
TaipeiAges 18 years+ - NCT07476560Recruiting
Suture Mesh vs. Planar Mesh for Small Ventral Hernias
This trial compares two types of mesh used to repair small ventral hernias (belly hernias up to 3 cm). It tests whether a suture mesh works better than a standard planar mesh, helping surgeons choose the best approach.
HjørringAges 18 years+ - NCT07479485RecruitingPhase 1/Phase 2
MRG006A combo for advanced liver cancer
This trial tests a new drug combination called MRG006A for people with advanced liver cancer (hepatocellular carcinoma) that cannot be removed by surgery or treated with local therapies. The goal is to see if it helps shrink tumors or slow cancer growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07474727RecruitingPhase 2
Study of AMT-676 combination therapy for advanced colorectal cancer
This trial tests a new drug combination for people with advanced colorectal cancer that cannot be removed by surgery. It aims to see if the treatment can shrink tumors and help patients live longer.
Fuzhou, FujianAges 18–80 - NCT06779864Recruiting
Hepatitis B virus genetics and drug resistance study
This study looks at how hepatitis B virus changes in your body, including mutations and drug resistance, using your blood or liver tissue samples. Understanding these changes could help improve treatment for hepatitis B.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06780683Recruiting
Testing upadacitinib for inflammatory bowel disease
This study tests a medication called upadacitinib for people with inflammatory bowel disease (ulcerative colitis or Crohn's). The goal is to see how well it works and if it's safe.
Guangzhou, GuangdongAges Any age - NCT06781242Recruiting
Genes and symptoms in inherited bile flow problems
This study looks at how genes affect bile flow problems in the liver. If you have a rare genetic condition like PFIC, researchers want to understand your specific type better by comparing your genes to your symptoms.
Bologna, BolognaAges 18 years+ - NCT07472686Recruiting
Capsule endoscopy for small bowel in Lynch syndrome
This study looks at how well a tiny camera in a pill (capsule endoscopy) can find early growths or cancer in the small intestine of people with Lynch syndrome. Lynch syndrome increases your risk for certain cancers, and this test might help catch them earlier.
ParisAges 18 years+ - NCT07473583Recruiting
Hernia surgery study on gas timing and blood changes
This study looks at how long the gas used during laparoscopic hernia surgery affects bicarbonate levels in the blood. It may help doctors understand how to better manage your body's chemistry during this type of hernia repair.
IstanbulAges 18 years+ - NCT07475052Enrolling by invitation
Heart rate monitoring to predict biologic therapy response in IBD
This study tests whether a wearable heart rate monitor can help predict how well biologic medications work for people with Crohn's disease or ulcerative colitis. If you are starting infliximab or vedolizumab for the first time, you may be eligible.
Xi'an, ShaanxiAges 18–75 - NCT07476703Recruiting
Extended study on the SCAPIS Stockholm reexamined group
This trial studies data and samples from people already taking part in the main SCAPIS reexamination study in Stockholm. It looks for new findings to help understand heart and lung health.
StockholmAges 56–74 - NCT07478029Recruiting
PEG bowel preparation study for appendectomy patients
This study tests if a bowel-cleaning solution (PEG) works well before colonoscopy. It compares people who have had their appendix removed to those who haven't.
Wuhan, HubeiAges 18–75 - NCT07478185Recruiting
Prehab before pancreatic cancer surgery
This trial tests a pre-surgery exercise program (prehab) for people with pancreatic cancer who plan to have chemotherapy first. The goal is to see if getting stronger before surgery helps with recovery.
Worester, MassachusettsAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.