Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT04022109Recruiting
Check gastric cancer using breath chemical signals
This study looks at chemical signals in your breath to help screen for or understand gastric (stomach) cancer. It may help doctors improve earlier detection, or better sort out who may need further tests.
São PauloAges 18 years+ - NCT04024917Recruiting
Cardiac coherence training to reduce anxiety before abdominal surgery
This trial tests whether “cardiac coherence” breathing/relaxation practice can lower anxiety in people with peritoneal cancer who are scheduled for a major surgery. It may help by calming stress before and around the operation.
Montpellier, HéraultAges 18 years+ - NCT04025541Recruiting
Blood tests to study tumor markers
This trial looks at blood samples to measure substances that may reflect cancer (tumor markers). It may help doctors understand cancer better and improve future monitoring, as long as you can safely and regularly take part.
MontpellierAges 18 years+ - NCT04025944Recruiting
Study of long-term hepatitis B or C infection
This study looks at people with hepatitis B or C infections that have lasted more than 6 months. It aims to better understand long-term management and how treatments may help over time.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04026360Recruiting
Study early lung, virus, and gut changes in children with cystic fibrosis
This study looks at how a child’s early lung function, viral infections, and gut (microbiome) changes affect cystic fibrosis over time. It may help doctors understand what predicts how lung disease develops, which could improve future care.
BernAges birth–18 years - NCT04030676Recruiting
Test for CMV reactivation risk during ulcerative colitis flare
This study checks whether a blood test (QuantiFERON-CMV, related to prior CMV infection) can predict if CMV might reactivate during a severe ulcerative colitis flare. It may help doctors spot people at higher risk and potentially guide monitoring and treatment during hospitalization.
LyonAges 18 years+ - NCT04033614Recruiting
Device to help close an open abdomen between surgeries
This study looks at a device (“Fasciotens”) used to help manage an open abdomen and support closure during planned or necessary return surgeries. It aims to see how safely and effectively the device works in people who need a temporary open belly treatment.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT04037007Recruiting
Fistulotomy during ERCP to open the bile duct entrance
This trial looks at whether a specific small procedure during ERCP helps doctors reach and drain the bile duct when gallstones or bile duct narrowing are suspected. It may help people avoid getting stuck during the procedure and improve how successfully the bile duct can be reached.
Mexico City, Mexico CityAges 18–90 - NCT04036357Recruiting
Study of liver fat disease with heart and metabolism problems
This study looks at people with fatty liver disease and common health issues like obesity, diabetes, high blood pressure, or abnormal cholesterol. It may help researchers understand how liver fat and heart/metabolism problems relate and how they affect health over time.
RomeAges 18–80 - NCT04037995Recruiting
Real-world study of advanced liver disease in China
This study looks at people with very advanced liver problems to better understand what happens in real life. It may help doctors improve care for advanced cirrhosis and certain liver cancers.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04038619RecruitingPhase 1
Fecal transplant for immune-therapy diarrhea or bowel inflammation
This early-phase study tests whether stool/fecal microbiota transplant (a fecal transplant) can help people who develop significant diarrhea or colitis after immune-checkpoint therapy. It aims to reduce bowel inflammation and improve symptoms, while carefully checking for infections.
Houston, TexasAges 18 years+ - NCT04043897RecruitingPhase 2
Oral rifaximin for active microscopic colitis flare
This trial tests whether an oral antibiotic called rifaximin can improve symptoms during a microscopic colitis flare. It aims to see if it is safe and effective for people whose colitis was confirmed by colon biopsy.
Evanston, IllinoisAges 18 years+ - NCT04048278RecruitingEarly Phase 1
Lidocaine IV infusion for pancreatic cancer treatment
This early-phase study tests whether giving lidocaine through an IV infusion can help treat pancreatic cancer. It will enroll people with confirmed pancreatic cancer that can be measured on scans, including some cases discovered to have spread during surgery.
Chicago, IllinoisAges 18 years+ - NCT04047953Recruiting
Chemo for stomach cancer to make tumors easier to remove
This trial tests a combination chemotherapy plan—paclitaxel (albumin-bound), oxaliplatin, and S-1 given before surgery—to try to shrink stomach cancer and improve the chance of successful tumor removal. It is for people whose cancer is locally advanced or has spread, but might still be resectable (removable) in certain cases.
Beijing, Beijing MunicipalityAges 18–75 - NCT04050345Recruiting
Blood test to spot DNA changes after early colon cancer surgery
This study checks a “cell-free tumor DNA” blood test to see if cancer mutations can predict relapse after surgery for early colorectal cancer. If results look risky, they may help guide closer follow-up and future treatment decisions.
Milton Keynes, BuckinghamshireAges 18 years+ - NCT04054310Recruiting
Test MRI to measure liver fat and NASH using biopsy
This study checks whether an MRI scan can measure liver health in people with suspected fatty liver disease that may have progressed to NASH. Everyone in the study is also scheduled for a standard liver biopsy, which is used to compare the scan results.
Chandler, ArizonaAges 18–75 - NCT04068480Recruiting
Robotic magnetic capsule to check the small bowel
This trial tests a capsule camera that doctors can steer using magnets to look at the small intestine. It may help patients who need small-bowel endoscopy when a standard approach isn’t enough, but several safety checks are required.
Székesfehérvár, --None---Ages 18 years+ - NCT04073290RecruitingPhase 4
Rifaximin and lactulose to prevent confusion after TIPS
This trial studies whether taking rifaximin plus lactulose can prevent a brain problem called hepatic encephalopathy (confusion) after TIPS, a procedure to reduce pressure in the liver. It may help people who are having TIPS planned and are at risk of this complication.
LeuvenAges 18–80 - NCT04074135RecruitingPhase 2
Study of pancreatic tumors in people with VHL
This trial studies the natural course and management of pancreatic neuroendocrine tumors in people with von Hippel–Lindau (VHL) disease. It may help doctors better predict how these pancreatic findings change over time and how to manage them.
Bethesda, MarylandAges 12 years+ - NCT04074538Recruiting
Colorectal cancer study to help researchers learn patterns
This study is collecting information from people with newly diagnosed colon or rectal cancer, to better understand the disease and support future research. It may help you and others by improving how colorectal cancer is studied and potentially treated over time.
Hangzhou, ZhejiangAges 18 years+ - NCT04075305Recruiting
Study measuring radiation treatment outcomes with an MR-Linac
This study follows what happens when radiation treatment is guided using an MR-Linac (a special machine that combines MRI imaging with radiation). It may help improve how radiation therapy is planned and assessed, especially for people who can safely have MRI scans.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04084067RecruitingPhase 1
ICG dye helps surgeons remove tumors
This early-phase study tests whether a special dye can help doctors see a tumor more clearly during surgery in children and young people. If you have a solid tumor or certain lymphomas that need removal, the dye may help guide the surgeon to the right tissue.
Memphis, TennesseeAges Any age - NCT04084496RecruitingPhase 2
FOLFIRINOX chemo after surgery for pancreatic cancer
This Phase 2 study tests whether FOLFIRINOX given after pancreatic surgery can lower the chance the cancer comes back. It focuses on people with pancreatic ductal adenocarcinoma who had their tumor completely removed and have no spread to distant organs.
Guangzhou, GuangdongAges 18–79 - NCT04087421RecruitingPhase 3
Transanal irrigation vs glycerol suppositories for LARS
This trial compares two ways to help bowel control in people with low anterior resection syndrome (LARS) after low rectal surgery. It aims to see which option works better when standard treatments have not helped enough.
AarhusAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.