Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07415616Enrolling by invitation
Cold vs warm tube feeding and stomach emptying in ICU
This study compares giving liquid food at room temperature (cold) versus body temperature (warm) through a feeding tube to see which helps the stomach empty better in ICU patients. It may help find a way to improve comfort and nutrition for people who need tube feeding.
BursaAges 18 years+ - NCT07412613RecruitingPhase 3
Immunotherapy Before and After Surgery for MSI-H Colon Cancer
This trial tests a new immunotherapy drug (AK104) given before and after surgery for a specific type of colon cancer that is MSI-H or dMMR. The goal is to see if the drug helps shrink the tumor and prevent the cancer from coming back.
GuangzhouAges 18–75 - NCT07407777Recruiting
Can a daily drink improve your gut health and mood?
This trial tests a powder made from mushrooms and algae that you mix into a drink once a day for 30 days. Researchers want to see if it helps with minor tummy troubles and how you feel emotionally.
San Francisco, CaliforniaAges 18 years+ - NCT07409272RecruitingPhase 3
Study of setidegrasib with chemo for pancreatic cancer
This trial tests a new drug called setidegrasib, given with two types of chemotherapy (mFOLFIRINOX or NALIRIFOX), for people whose pancreatic cancer has spread and has a specific genetic change called KRAS G12D. The goal is to see if adding setidegrasib helps control the cancer better than chemo alone.
Tucson, ArizonaAges 18 years+ - NCT07414576Recruiting
AI-driven nutrition platform for newborns in the NICU
This trial tests an AI tool to help manage total parenteral nutrition (IV feeding) for newborns in the neonatal ICU who need daily lab tests. It aims to make nutrition safer and more personalized.
Stanford, CaliforniaAges Up to 6 months - NCT07415044RecruitingPhase 2
Study of LY4268989 for moderate to severe ulcerative colitis
This study tests an investigational medication called LY4268989 for adults with moderate to severe ulcerative colitis (UC). It's for people who have tried other treatments without success. The goal is to see if the drug can reduce inflammation and improve symptoms.
Phoenix, ArizonaAges 18–80 - NCT07413549RecruitingPhase 1/Phase 2
Stem cell injection for hepatitis B cirrhosis
This trial tests an injection of stem cells from donated umbilical cords to see if it can help people with advanced liver scarring from hepatitis B. You may be able to join if standard treatments haven’t helped enough and you aren’t able to get a liver transplant.
WuhanAges 18–75 - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT06641375Recruiting
Heat treatment for chronic acid reflux (AREA study)
This trial tests a new way to treat GERD (chronic acid reflux) using a tiny camera and a device that delivers a gentle heat treatment (argon plasma coagulation) to the area where the stomach meets the esophagus. It's compared to a 'sham' procedure (you won't know which you get) to see if it stops acid from backing up better than medicine alone.
Hyderabad, TelanganaAges 18–70 - NCT07413640Recruiting
Microwave ablation volume study for liver tumors
This study looks at how microwave ablation (a heat treatment for liver tumors) affects the size of the treated area. It aims to understand what factors influence the result, so doctors can better plan future treatments.
Vandœuvre-lès-NancyAges 18–100 - NCT07411599RecruitingPhase 1/Phase 2
CAR-NK cell therapy plus cetuximab for belly-spread colorectal cancer
This trial tests a new cell therapy (CAR-NK cells given directly into your belly and a vein) combined with a targeted drug (cetuximab) for colorectal cancer that has spread mainly to the lining of your belly. It aims to see if this treatment can shrink tumors and help people who have run out of standard chemotherapy options.
Houston, TexasAges 18 years+ - NCT07407491RecruitingPhase 2
Antibiotic during ERCP for bile duct infection
This trial tests if giving an antibiotic directly into the bile duct during an ERCP procedure helps treat acute cholangitis better than standard care. If you have mild or moderate cholangitis and are scheduled for ERCP within 48 hours, you may be a candidate.
Cheras, Kuala LumpurAges 18 years+ - NCT07410676RecruitingPhase 1/Phase 2
Donor NK cells with IL-15 and pembrolizumab for advanced solid tumors
This trial tests a new type of cell therapy (natural killer cells) made from a donor, combined with low-dose IL-15 (a protein that helps these cells work) and sometimes with pembrolizumab (Keytruda), for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges Any age - NCT07411716Recruiting
Children's liver disease registry in Canada
This study creates a registry to track children with specific genetic liver conditions that cause cholestasis (slow bile flow). Being in the registry helps researchers better understand these diseases and may help future patients.
Calgary, AlbertaAges Up to 18 years - NCT07414095Recruiting
Frailty assessment before liver transplant and outcomes
This study looks at how frail liver transplant candidates are before surgery and whether that affects their recovery afterward. Participants will complete simple physical and mental tasks to help doctors better understand their overall health before the transplant.
IzmirAges 18–65 - NCT07410494RecruitingPhase 1/Phase 2
Personalized donor cell therapy for advanced solid tumors
This trial tests a personalized cell therapy (CAR-NK) using donor immune cells that are engineered to find and attack one or two markers on advanced solid tumors. It may be an option for people whose tumors have these specific markers and have exhausted other treatments.
Beijing, Beijing MunicipalityAges 8–85 - NCT07409805RecruitingPhase 1
Vaccine trial for advanced colorectal cancer with liver spread
This trial tests a new vaccine (YMN-136) for people with colorectal cancer that has spread to the liver and hasn't responded to at least three prior treatments. The goal is to see if the vaccine can help control the cancer.
Chengdu, SichuanAges 18–75 - NCT07413068Recruiting
Comparing treatments for gallstones and bile duct stones
This trial looks at three different ways to treat people who have both gallstones and stones in the bile duct. It aims to find which approach works best and with the fewest complications.
Jinan, ShandongAges 18 years+ - NCT07409688RecruitingPhase 4
Pain relief after gallbladder surgery: comparing two ways to give local anesthetic
This trial compares two methods of giving local anesthetic during laparoscopic gallbladder removal to see which provides better pain relief. It may help patients recover with less pain after surgery.
Rawalpindi, Punjab ProvinceAges 15–60 - NCT07413354RecruitingPhase 2
Tislelizumab and huaier granule for advanced liver cancer
This trial tests a combination of two drugs: tislelizumab (an immunotherapy that helps your immune system attack cancer) and huaier granule (a traditional Chinese medicine extract). It is for people with advanced liver cancer that cannot be removed by surgery and who have not had other systemic treatments before.
Wuhan, HubeiAges 18 years+ - NCT07408505Recruiting
New appetite drug for weight loss in advanced pancreatic cancer
This trial tests a new form of a drug (nano-megestrol acetate) to help people with advanced pancreatic cancer who are losing weight and have poor appetite. It aims to see if it can improve cachexia, a condition of severe weight loss and muscle wasting.
JinanAges 18–75 - NCT07407647RecruitingPhase 2
Vaginal DHEA for better vaginal health after pelvic radiation
This study tests whether a vaginal insert of DHEA (a hormone) can help with vaginal health problems caused by pelvic radiation for anal, rectal, or gynecologic cancers. It is for women who are already postmenopausal and are about to start radiation.
Columbus, OhioAges 50 years+ - NCT07410715Recruiting
Surgery or observation after successful liver cancer treatment
This study compares surgery versus watch-and-wait for people whose liver cancer shrank significantly after treatment. It aims to find out if surgery is always needed or if watching closely is just as good.
ChengduAges 18–80 - NCT07411118Recruiting
Comparing two ways to remove stomach GIST tumors with an endoscope
This trial compares two endoscopic techniques (EFTR and STER) for removing small to medium-sized GIST tumors from the stomach wall. It aims to see which method is safer and more effective.
ShanghaiAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.