Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT04462042Recruiting
Proton vs photon radiation for anal canal cancer
This study compares two types of radiation—protons versus photons—for anal canal squamous cell carcinoma. It may help find which option delivers treatment more effectively or with fewer side effects.
GothenburgAges 18 years+ - NCT04469439Recruiting
Sinus surgery in adults with cystic fibrosis
This study looks at how endoscopic sinus surgery affects people with cystic fibrosis who have ongoing sinus problems even after medical treatments. It may help doctors understand whether surgery plus ongoing care improves symptoms and quality of life.
Los Angeles, CaliforniaAges 18–99 - NCT04471493Recruiting
Study of children’s common infections in a clinic program
This trial is for children under 16 who have one of several common infections seen in outpatient or clinic visits. It aims to better study and manage these illnesses using a specific clinical documentation software.
CréteilAges 1 day–16 years - NCT04473794Recruiting
Testing ways to assess pancreatic cyst risk and progression
This study looks at patients who have been referred for evaluation of a pancreatic cyst. It aims to improve how doctors estimate risk and predict how cysts may change over time.
Baltimore, MarylandAges 18 years+ - NCT04475952Recruiting
Diagnosing upper digestive problems earlier during routine care
This study aims to learn how to detect problems in the upper digestive tract earlier. People may be asked to help with diagnosis while they are already undergoing routine tests or treatment, which could improve future care.
LondonAges 18–90 - NCT04477460Recruiting
Testing thicker feeds for babies after unexplained brief events
This trial looks at whether using thicker baby feeds can improve health outcomes for infants who have had their first “brief resolved unexplained event” (a short episode with no clear cause). It may help babies who are being monitored after this first episode.
Boston, MassachusettsAges birth–1 year - NCT04477928Recruiting
Checking type 1 diabetes risk using routine child care
This study estimates the chance of developing type 1 diabetes in children by using information gathered during regular well-child visits. It may help identify children who could benefit from earlier monitoring.
Bemidji, MinnesotaAges birth–17 years - NCT04477967Recruiting
Creating a liver transplant biobank for children
This trial sets up a long-term collection of medical information and samples from children who have had a liver transplant. It helps doctors study outcomes over time and improve care for future patients.
Chongqing, Chongqing MunicipalityAges 1 month–18 years - NCT04478851Recruiting
Exercise program to help people live well with cancer
This study offers an exercise program meant to help people with cancer improve how they live day to day. It may fit you if you are getting treatment now, starting soon, or finished within the last 5 years and can safely do mild activity.
Calgary, AlbertaAges 18–100 - NCT04481256Recruiting
Immunotherapy with chemoradiation for esophageal cancer
This trial tests adding medicines that block TGF-beta and PD-L1 to standard chemoradiation for esophageal squamous cell cancer that can’t be removed with surgery. It aims to improve control of the cancer where it sits, while keeping treatment safe.
AmsterdamAges 18 years+ - NCT04483076RecruitingPhase 3
Chemo before stomach surgery with different cycles
This trial studies whether giving oxaliplatin plus S-1 (SOX) chemotherapy before stomach surgery works best when given for different cycle lengths. It may help shrink stage III gastric cancer before a standard D2 gastrectomy and improve outcomes.
Beijing, Beijing MunicipalityAges 18–70 - NCT04485013RecruitingPhase 1
Study drug TTX-080 for advanced colorectal cancer
This Phase 1 study tests TTX-080, a drug designed to block a cancer immune “signal” (HLA-G) to help the body fight advanced colorectal cancer. It mainly checks safety and how the treatment works in people with cancer that has spread.
Tucson, ArizonaAges 18 years+ - NCT04486131Recruiting
Test for treatment of recurrent rectal cancer in side lymph nodes
This trial focuses on rectal cancer that has come back in the side lymph nodes near the pelvis. It tests how to treat that “lateral nodal recurrence” to improve outcomes by targeting these specific lymph nodes.
Amsterdam, North HollandAges 18 years+ - NCT04489238Recruiting
Study of young and average-age colorectal cancer causes
This research collects health information (and for some groups, stool samples) to better understand why colorectal cancer happens in different age groups. If you fit the age and diagnosis criteria, your participation could help researchers find patterns that may improve future care.
Basking Ridge, New JerseyAges 18 years+ - NCT04490733Recruiting
Test dual-task walking to improve thinking in colorectal cancer
This study looks at a walking exercise that makes you do two tasks at once (for example, walking while focusing on something) to see if it can improve thinking and memory. It is for people newly diagnosed with early to mid-stage colorectal cancer, and excludes people with other cancers or cancer coming back.
TaipeiAges 40–75 - NCT04493385Recruiting
Heart transplant after a hepatitis C–positive donor
This trial follows people who receive a heart from a donor whose blood tested positive for hepatitis C. It also includes people getting a heart transplant again, and it aims to learn about outcomes and safety for these specific transplant situations.
Dallas, TexasAges 18 years+ - NCT04493632Recruiting
Registry for an OncoSil implant in locally advanced pancreatic cancer
This observational registry tracks patients with locally advanced, unresectable pancreatic cancer who receive an OncoSil implant and then start standard chemotherapy. It may help doctors understand how the implant is used in real life and how patients do over time.
Las Palmas de Gran CanariaAges 18–90 - NCT04494048Recruiting
Registry for people considering endoscopic weight-loss procedures
This study keeps a record of people who are planning or recently had an endoscopic (camera-based) weight-loss procedure. The goal is to learn how these procedures work in real life and help doctors improve care.
New York, New YorkAges 18–89 - NCT04495088RecruitingPhase 3
Before vs after chemotherapy for locally advanced rectal cancer
This Phase 3 study compares giving chemotherapy before rectal surgery versus giving it after surgery, using a tailored plan based on your risk. The goal is to see which timing helps more people with locally advanced rectal cancer stay cancer-free and live longer.
MannheimAges 18 years+ - NCT04496479RecruitingPhase 2
Transplanting donor liver cells near lymph nodes in advanced liver disease
This Phase 2 study tests whether transplanting donor liver cells near lymph nodes can improve outcomes in people with advanced cirrhosis from certain liver conditions. It may help your liver function by adding healthy liver cells, but eligibility is tightly based on your current liver status and other health factors.
Boston, MassachusettsAges 18–70 - NCT04496895Recruiting
Orange peel drink study for reducing body fat
This trial looks at whether a fermented orange peel product can lower body fat in adults. It may help if you have higher body fat and/or fatty liver, and you meet safety and health limits.
Taipei, TaiwanAges 20–65 - NCT04498767Recruiting
Radiation to treat a few metastatic spots in rare cancers
This trial studies whether stereotactic (high-precision) radiation given in a few sessions can control rare cancers that have spread to a small number of sites. It aims to help by treating all known spots while keeping side effects manageable.
AnderlechtAges 18 years+ - NCT04499833Recruiting
Test an AI score to guide liver transplant decisions
This study looks at a prediction tool that estimates outcomes for people with liver cancer and cirrhosis, to help decide whether a liver transplant is a good option. It may help doctors choose the right timing and patients who could benefit most from transplantation.
LisbonAges 18–70 - NCT04499898RecruitingPhase 2/Phase 3
Carvedilol vs banding to prevent first bleeding from esophageal veins
This trial compares two ways to prevent bleeding from enlarged veins in the food pipe (esophageal varices) in people with cirrhosis. It tests whether carvedilol (a blood-pressure/heart medicine) works as well as an endoscopic procedure that places small bands to reduce bleeding risk.
TantaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.