Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07413640Recruiting
Microwave ablation volume study for liver tumors
This study looks at how microwave ablation (a heat treatment for liver tumors) affects the size of the treated area. It aims to understand what factors influence the result, so doctors can better plan future treatments.
Vandœuvre-lès-NancyAges 18–100 - NCT07407647RecruitingPhase 2
Vaginal DHEA for better vaginal health after pelvic radiation
This study tests whether a vaginal insert of DHEA (a hormone) can help with vaginal health problems caused by pelvic radiation for anal, rectal, or gynecologic cancers. It is for women who are already postmenopausal and are about to start radiation.
Columbus, OhioAges 50 years+ - NCT07414095Recruiting
Frailty assessment before liver transplant and outcomes
This study looks at how frail liver transplant candidates are before surgery and whether that affects their recovery afterward. Participants will complete simple physical and mental tasks to help doctors better understand their overall health before the transplant.
IzmirAges 18–65 - NCT06821958Recruiting
Radio wave treatment for advanced liver cancer
This trial tests a new type of treatment using low-energy radio waves (called electromagnetic fields) for people with advanced liver cancer that can't be removed by surgery. The goal is to see if adding this therapy can help your immune system fight the cancer better.
BerlinAges 18 years+ - NCT06822634Recruiting
Advanced imaging for rectal cancer treatment response
This trial uses advanced MRI scans to see how well rectal cancer is responding to radiotherapy. It may help doctors better understand which treatments work best for patients with more advanced disease.
GlasgowAges 18 years+ - NCT03875625Recruiting
Tracking body fat and liver fat after weight-loss treatment
This study looks at how body fat and liver fat change after bariatric (weight-loss) surgery or a lifestyle program. You may join if you have overweight or obesity and can safely have MRI scans, so researchers can compare results between treatment approaches.
Hong Kong, ShatinAges 18–65 - NCT04006951Recruiting
Registry study for people with rectal cancer in Montpellier
This is a hospital-based study that builds a clinical and biological database for people treated for rectal cancer at the Montpellier Cancer Institute. It helps researchers organize health information to better understand rectal cancer and improve future care.
MontpellierAges 18 years+ - NCT05257135Recruiting
Study database and blood samples for colon cancer cachexia
This study collects clinical information and planned blood samples to better understand “cachexia,” which is a serious wasting condition that can happen with advanced cancer. It may help doctors find better ways to predict and manage symptoms in people with colon cancer who can’t have surgery.
MontpellierAges 18 years+ - NCT05869591RecruitingPhase 2
Test drug to prevent clots in mild to moderate liver disease
This Phase 2 study tests a blood-thinner called a DOAC in people with previously diagnosed mild or moderate liver cirrhosis (Child A or B). It may help doctors understand whether the medicine is safe and effective in this group.
Lausanne, Canton of VaudAges 18 years+ - NCT05974358Recruiting
Compare two bowel-connection methods to prevent Crohn’s flare-ups
This trial tests whether a specific type of bowel connection during Crohn’s surgery can lower the chances that the disease comes back. It may help people having their first ileocolonic (small-to-large bowel) surgery for certain Crohn’s complications.
BesançonAges 18–75 - NCT06040801Recruiting
Geriatric care for older adults with advanced stomach, bile duct, or pancreatic cancer
This study tests a special geriatric (older-adult) care program for people over 65 with advanced stomach, bile duct, or pancreatic cancer who are receiving palliative chemotherapy. The goal is to see if extra support from a geriatric team can help improve quality of life and treatment outcomes.
Taoyuan, TaiwanAges 65 years+ - NCT06313827Recruiting
Online program to prevent flare-ups in cystic fibrosis
This trial tests an online program designed to help people with cystic fibrosis avoid exacerbations (sudden worsening of symptoms). You participate from home using a device with internet, camera, and microphone.
ValenciaAges 6 years+ - NCT06594744RecruitingPhase 4
Preventing first bleeding from varices in liver cancer patients
This trial compares two treatments (banding or a medication called carvedilol) to prevent the first episode of bleeding from enlarged veins in the esophagus in people with liver cancer. The goal is to find which approach is safer and more effective.
TaipeiAges 20–90 - NCT06809660Recruiting
Gut bacteria and cancer risk from everyday chemicals
This study looks at how chemicals in the environment (called endocrine disruptors) might affect the natural bacteria in your gut and whether that could play a role in colorectal cancer. If you are having a colonoscopy (endoscopy), you may be able to participate.
PoitiersAges 18 years+ - NCT06824909Recruiting
Faster pancreas tumor diagnosis with AI
This trial uses a new, faster method to diagnose solid pancreatic tumors during an endoscopic ultrasound procedure. It combines rapid staining of cells with artificial intelligence to give a quick and accurate diagnosis.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07400289Recruiting
Testing a single-probe liver exam for chronic disease
This study is testing a new way to use a FibroScan (a non-invasive liver scanner) with a single probe to measure liver health in people with chronic liver disease. If you have a long-term liver condition, this trial may help improve how liver exams are done.
BesançonAges 18 years+ - NCT07405151RecruitingPhase 1/Phase 2
New drug for advanced esophageal cancer after other treatments
This trial tests a new drug called Ifinatamab Deruxtecan for people with advanced esophageal squamous cell carcinoma that has progressed after one or two prior treatments. It aims to see if the drug can shrink tumors or slow the disease.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07398339RecruitingPhase 2
Photodynamic therapy for bile duct cancer
This trial tests a light-activated drug called cosiporfin sodium for people with advanced bile duct cancer that cannot be surgically removed. The treatment targets tumors in the bile ducts and may help shrink them.
Shanghai, Pudong New AreaAges 18 years+ - NCT07403968RecruitingPhase 2
Study of Zasocitinib for Active Crohn's Disease
This trial tests a new oral medicine called Zasocitinib for people with active Crohn's disease who have tried other treatments that no longer work or are not tolerated. The goal is to see if it can reduce inflammation and improve symptoms.
OxfordAges 18–75 - NCT07401862RecruitingPhase 1
Study of Eloralintide in people with different levels of liver damage
This trial tests a new medicine called eloralintide in people with healthy livers and in those with mild, moderate, or severe liver damage. It helps researchers learn how the liver affects the medicine in the body.
Orlando, FloridaAges 18–85 - NCT07406633RecruitingPhase 2
KQB198 plus imatinib for advanced GIST
This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT06825624RecruitingPhase 1
Testing HS-20093 combinations for advanced colorectal cancer
This trial tests a new drug combination (HS-20093) for people with advanced colorectal cancer that has spread or cannot be removed by surgery. It aims to see if the combination is safe and effective.
Hangzhou, ZhejiangAges 18 years+ - NCT06578052Recruiting
Irinotecan liposome with capecitabine for advanced pancreatic cancer
This trial tests a combination of two chemotherapy drugs (irinotecan liposome and capecitabine) for people with pancreatic cancer that has spread or cannot be removed by surgery and has gotten worse after initial treatment. The goal is to see if this combination can help slow the disease.
Shenzhen, GuangdongAges 18–80 - NCT04731558RecruitingPhase 4
Blood clot prevention before versus after liver surgery
This study compares two approaches to preventing blood clots around the time of liver surgery. If you’re having planned liver surgery, it may help doctors choose the safest timing and method for clot prevention.
HelsinkiAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.