Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,883 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio79
- Pennsylvania72
Recruiting studies7,883 total
- NCT04556019Recruiting
Study of past and future liver and bile-pancreas surgeries
This is a research study using information from people who had certain liver, bile duct, and pancreas surgeries in the hospital’s surgical team. It aims to review surgical results and may help improve how these operations are done.
Pamplona, NavarreAges 15–90 - NCT04557969Recruiting
Surgery and tumor testing in gastrointestinal stromal tumors (GIST)
This study looks at how surgery for gastrointestinal stromal tumors (GIST) works, and collects tumor samples to study them under the microscope and by DNA testing. Your results may help researchers better predict tumor behavior and guide future treatment.
Bethesda, MarylandAges 6 years+ - NCT04571294Recruiting
Removing lymph nodes during Whipple surgery for pancreatic cancer
This study looks at removing certain lymph nodes near the aorta while doing a standard Whipple operation for pancreatic head cancer. The goal is to see whether this approach can improve how well doctors manage the cancer spread.
Rozzano, Italy/MilanAges 18 years+ - NCT04573283Recruiting
Study of fatty liver in adults in China
This study follows adults with fatty liver to learn more about how it progresses and what patterns are common. It may help improve future ways of identifying and monitoring fatty liver.
Guangzhou, GuangdongAges 18–80 - NCT04578301Recruiting
Predicting who develops serious liver worsening after surgery
This study looks at your liver health before and after surgery to predict the risk of “acute-on-chronic liver failure,” which means a sudden worsening of liver function on top of an existing liver condition. If you qualify, your doctors may use study data to better identify who needs closer monitoring after surgery.
BonnAges 18 years+ - NCT04578769Recruiting
Testing two modified POEM methods for achalasia
This study compares different versions of a procedure called POEM for treating achalasia, a condition where the food pipe has trouble moving food into the stomach. You may be considered if you have specific achalasia types and symptoms that are still significant despite treatment.
Beijing, Beijing MunicipalityAges 14–70 - NCT04580368Recruiting
Personalized drug testing for cystic fibrosis using small trials
This trial tests how well cystic fibrosis (CF) medicine works for you using an “n-of-1” approach, meaning you try treatments in a structured, repeated way to see what helps you most. It may help your care team choose the best option for your specific CF genetics and health status.
Cincinnati, OhioAges 6 years+ - NCT04585750RecruitingPhase 1/Phase 2
Study drug for TP53 Y220C-mutated advanced cancers
This early-phase study tests PC14586 (rezatapopt) in people with advanced or metastatic solid cancers that carry a specific TP53 mutation called Y220C. It mainly looks at safety and how well the treatment may work, sometimes combined with pembrolizumab.
Irvine, CaliforniaAges 12 years+ - NCT04587739RecruitingPhase 1
Radiation before surgery for a single liver tumor
This early feasibility study tests a radiation plan given before surgery for hepatocellular carcinoma (a type of liver cancer) to see if it’s safe and doable. It may help shrink or control the tumor before an operation that aims to fully remove it.
LilleAges 18–70 - NCT04588025Recruiting
MRI study using a special model to measure pancreatic cancer response
This study tests a new, harmless “disposable” setup for MRI scans to measure how pancreatic cancer treatments affect the body. It may help doctors get more accurate MRI measurements, so treatment response can be assessed better.
Columbus, OhioAges 19 years+ - NCT04588077RecruitingPhase 4
Two-dose vs three-dose hepatitis B vaccine for cirrhosis
This study compares giving the hepatitis B vaccine in 2 doses versus 3 doses for people with cirrhosis who do not yet have protection against hepatitis B. It may help your care team choose the schedule most likely to build lasting immunity.
Baltimore, MarylandAges 18 years+ - NCT04592211RecruitingPhase 1/Phase 2
Study pembrolizumab plus olaparib for stomach cancer after treatment
This Phase 1/2 study tests whether combining pembrolizumab (an immunotherapy) with olaparib (a targeted cancer pill) can shrink or control recurrent or advanced stomach and GEJ cancer. You may be eligible if your cancer has already been treated with trastuzumab and certain body-function and blood/vital checks look safe.
SeoulAges 19 years+ - NCT04592003Recruiting
French study of colorectal ESD performed by expert centers
This study follows people who are having a colon or rectum procedure called ESD in expert hospital centers in France. It mainly aims to collect information about outcomes and safety; joining depends on consent.
AmiensAges 18 years+ - NCT04593407Recruiting
Check the best method to remove large flat colon polyps
This study compares two endoscopy techniques to remove large, flat-looking colon polyps. It aims to see which method removes the polyp more completely and safely.
MadridAges 18–85 - NCT04595864RecruitingPhase 3
Chemotherapy into the liver before transplant for liver cancer
This trial tests whether giving chemotherapy directly into the liver blood supply before a liver transplant can help people with liver cancer that is beyond standard transplant criteria. It may help lower cancer risk around the time of transplant while keeping people healthy enough to receive the transplant.
Nanjing, JiangsuAges 18–75 - NCT04595929Recruiting
Tested aerosol chemotherapy inside the abdomen for stomach cancer
This trial looks at a way to give chemotherapy into the abdomen (through a small tube during laparoscopy) for certain stomach cancers. It aims to see whether this approach improves cancer control and surgical outcomes for people whose tumors can potentially be removed.
Saint PetersburgAges 18–65 - NCT04597164Recruiting
Test a hepatitis B–targeted treatment for serious liver failure
This trial studies a combination approach called DPMAS and low-volume plasma exchange for people with hepatitis B–related acute-on-chronic liver failure. If you qualify, the goal is to improve your liver function and reduce serious complications from liver failure.
Guangzhou, GuangdongAges 18–65 - NCT04597294RecruitingPhase 3
Preventive pre-op HIPEC for advanced stomach cancer
This Phase 3 trial studies whether adding a heated chemotherapy procedure during surgery (HIPEC) before the main cancer treatment can lower the chance that stomach cancer returns in the belly. It is for people with advanced stomach cancer who are at higher risk of cancer coming back in the peritoneum (the lining of the abdomen).
Krakow, Lesser Poland VoivodshipAges 18–75 - NCT04604730Recruiting
Testing a protective stoma after bowel reconnection for infection
This study looks at whether creating a temporary “protective stoma” (an opening that diverts stool) after reconnecting the bowel can reduce complications for people with severe abdominal infection from a perforated diverticulitis. It’s for adults who had surgery to reconnect their colon right away.
Beauvais, BeauvaisAges 18 years+ - NCT04605913RecruitingPhase 1/Phase 2
Testing a new combination chemo plus portable TTF therapy for pancreatic cancer
This trial tests a combination of chemotherapy drugs plus a portable TTF device (TTF-100L) to treat pancreatic cancer that has spread to the liver. It may help by trying to shrink or control the cancer in people who haven’t already had treatment specifically for stage IV metastatic disease.
Jacksonville, FloridaAges 18 years+ - NCT04613570Recruiting
Follow-up endoscopy plan for early stomach changes
This study looks at how often and how intensely to do follow-up stomach camera exams (endoscopy) with small biopsies for people at risk of stomach cancer. It may help personalize your follow-up schedule based on your specific stomach findings.
PortoAges 45 years+ - NCT04613921Recruiting
Liver transplant study for severe worsening liver failure
This study looks at when liver transplant is offered and what outcomes happen in people with cirrhosis who have severe “acute-on-chronic” worsening. It may help doctors decide which patients benefit most from transplant and improve care after listing or not listing.
Los Angeles, CaliforniaAges 18–80 - NCT04615143RecruitingPhase 2
Tislelizumab with or without lenvatinib before liver surgery
This trial studies whether taking tislelizumab alone or with lenvatinib before surgery can shrink recurrent liver cancer and improve outcomes. It may help by treating the cancer earlier (before the tumor is removed).
Guangzhou, GuangdongAges 18–75 - NCT04616495Recruiting
Liver transplant for colorectal cancer that can’t be removed
This trial studies liver transplantation for people with colorectal cancer that has spread to the liver but cannot be surgically removed. It aims to see if transplant can improve outcomes when the cancer is limited to the liver.
ValenciaAges 18–65
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,883 recruiting gastroenterology studies from the U.S. registry right now, out of 12,391 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.