Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07405125Recruiting
Robotic surgery for stomach tumors in tricky spots
This trial tests the safety of using a robot to remove small stomach tumors (GISTs) that are in hard-to-reach places. It aims to see if robotic surgery is a good option for you.
Nanjing, JiangsuAges 18–75 - NCT07401199Recruiting
AI predicts immunotherapy response in advanced stomach cancer
This trial uses artificial intelligence to analyze CT scans, blood, and tumor tissue to predict how well your cancer will respond to chemotherapy and immunotherapy before surgery. It aims to personalize treatment for locally advanced stomach or gastroesophageal junction cancer.
Fuyang, AnhuiAges 18 years+ - NCT07404774Recruiting
stitch and laser treatment for hemorrhoids
This trial is testing a combined treatment for hemorrhoids that are causing symptoms. It uses a technique to stitch the hemorrhoid tissue back in place (suture mucopexy) plus a laser to shrink blood vessels. The goal is to see if this approach works well for people with grades II, III, or IV hemorrhoids, even if they've had other treatments before.
AthensAges 18 years+ - NCT07399054Recruiting
Acid-reducing medicine for ICU patients after surgery
This trial tests a medicine called esomeprazole, given through an IV, to see if it safely prevents stomach bleeding in patients who are in the ICU after surgery. If you qualify, you might get this medicine to help protect your stomach while you recover.
Hyderabad, TelanganaAges 18–75 - NCT07399886Recruiting
Plant or dairy shake for cancer and heart patients at risk of malnutrition
This study compares two types of nutrition shakes (one plant-based and one dairy-based) for patients who are undernourished due to cancer, lung disease, heart problems, or recovery from surgery. It aims to see if the plant-based shake is just as good as the dairy shake.
Nijmegen, GelderlandAges 18 years+ - NCT07406698Recruiting
Best timing for endoscopy in infected pancreatitis
This trial studies the best timing for using a camera down your throat to drain infected fluid pockets from severe pancreatitis. It is for people who are still in the hospital with signs of infection and who can have the procedure done within the first 26 days of their illness.
Orlando, FloridaAges 18 years+ - NCT07400354Recruiting
PD-1 drug plus chemo for advanced stomach cancer based on gut bacteria
This trial tests if adding a PD-1 immunotherapy drug to standard chemotherapy works better for advanced stomach cancer, and looks at how your gut bacteria may affect treatment. It is for people who have not had chemotherapy before and are starting their first treatment.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07403630Recruiting
Tumor chemogenomic profiler for cancer patients of all ages
This trial uses a new testing platform to analyze the genes and proteins in your tumor, aiming to find the most effective treatments for people with cancer that has come back, is not responding to treatment, or has spread. It is designed for both children and adults with any type of blood cancer or solid tumor.
Palermo, PalermoAges 1 year+ - NCT06757296Recruiting
Endoscopic revision of sleeve gastrectomy for reflux or poor weight loss
This study tests a new, less invasive way to convert a sleeve gastrectomy into a different type of weight-loss surgery (SASI) in people who have ongoing gastroesophageal reflux or haven't lost enough weight. The goal is to see if this endoscopic procedure can improve reflux and help with weight loss without the need for a traditional surgery.
SingaporeAges 21–65 - NCT06778954Recruiting
Pain control gel after stomach cancer surgery
This trial tests a gel (ropivacaine in a special polymer) applied during stomach cancer surgery to reduce pain after the operation. The goal is to help patients recover with less pain and fewer side effects from painkillers.
SeoulAges 20 years+ - NCT06827301Recruiting
Vagus nerve stimulation for swallowing problems after stroke
This trial tests a non-invasive device that stimulates a nerve in the ear to help improve swallowing after a recent stroke. It may be an option if you have moderate swallowing difficulties diagnosed within the first week after your stroke.
Roma, RMAges 18 years+ - NCT03417336Recruiting
Radiation for prostate cancer using smaller, targeted doses
This trial studies a specific radiation schedule for prostate cancer (with an extra “boost” dose) and checks whether it works well and is tolerable. It may help people with higher-risk, localized prostate cancer by aiming at the cancer while limiting side effects to surrounding tissues.
DijonAges 18–85 - NCT05783908Recruiting
Self-guided breathing help during MRI-guided radiotherapy for moving tumors
This study tests whether a self-guidance approach for breathing can improve radiotherapy sessions when the tumor moves during breathing and is treated with an MRI-guided machine. It may help make treatments more accurate and easier to follow during each session.
Dijon, Côte d'OrAges 1.5 years+ - NCT06282445RecruitingPhase 2
Combination therapy for first-line metastatic colorectal cancer
This trial tests whether adding the immunotherapy drug adebrelimab to standard chemotherapy plus bevacizumab can help people with a specific type of metastatic colorectal cancer that cannot be removed by surgery. It is for patients whose tumors are microsatellite stable (MSS) or have normal mismatch repair (pMMR).
Jinhua, ZhejiangAges 18–75 - NCT06342011Recruiting
Anti-inflammatory diet for inflammatory bowel disease
This trial tests whether an anti-inflammatory diet can help people with inflammatory bowel disease (IBD). Researchers want to see if this diet reduces inflammation and improves symptoms.
Yiwu, ZhejiangAges 18–65 - NCT06456515Recruiting
Regorafenib, sintilimab, and electroacupuncture for advanced colorectal cancer
This trial tests a combination of two drugs (regorafenib and sintilimab) plus electroacupuncture for people with advanced colorectal cancer that hasn't responded to standard treatments. The goal is to see if this triple therapy can help shrink tumors or slow the cancer's growth.
ChangzhouAges 18–75 - NCT07390838RecruitingPhase 1
Study of SH009 for advanced solid tumors
This trial tests an investigational drug called SH009 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective.
ShanghaiAges 18 years+ - NCT07391670RecruitingPhase 1
Testing subcutaneous durvalumab for lung and liver cancer
This trial tests a new way to give the immunotherapy drug durvalumab as a shot under the skin (subcutaneous) instead of through an IV. It is for people with certain types of lung cancer or liver cancer that has not spread widely and who have not had immunotherapy before. The goal is to see if the subcutaneous injection is safe and works similarly to the IV form.
FitzroyAges 18 years+ - NCT07390344Recruiting
Study of VIATORR TIPS device for liver pressure
This study tests a new version of a device (VIATORR TIPS) that helps lower high blood pressure in the liver for people with cirrhosis. The device is placed to create a small channel that reroutes blood flow and reduces pressure.
Atlanta, GeorgiaAges 18 years+ - NCT07392892RecruitingPhase 2/Phase 3
Study of PF-08634404 plus chemo for stomach and esophagus cancer
This trial tests a new study drug called PF-08634404 in combination with standard chemotherapy for people with stomach, gastroesophageal junction, or esophagus cancer that has spread. It aims to see if adding this drug helps the treatment work better.
Atascadero, CaliforniaAges 18 years+ - NCT07397338RecruitingPhase 1/Phase 2
RAS inhibitors with ivonescimab for solid tumors
This trial tests new drugs called RAS(ON) inhibitors combined with ivonescimab for people with solid tumors that have a RAS mutation. It aims to see if this combination can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT06829095Recruiting
Nutrition counseling for esophageal and head and neck cancer patients
This trial tests whether personalized nutrition advice can improve the health of people with esophageal cancer or head and neck cancer who are getting chemoradiation. It may help you stay stronger and better manage treatment side effects.
New Taipei CityAges 18 years+ - NCT06829290Recruiting
How muscle loss affects disease course in GI cancers
This study looks at how loss of muscle mass (sarcopenia) affects the course of illness in people with gastrointestinal cancers, liver cirrhosis, or those in the ICU. It will help doctors better understand and treat muscle wasting.
Mainz, Rhineland-PalatinateAges 18 years+ - NCT06829355RecruitingPhase 2
Thymalfasin plus triple therapy for advanced colorectal cancer
This trial tests a combination of three drugs plus thymalfasin, an immune-boosting medicine, for people whose advanced colorectal cancer has not responded to at least two prior treatments. It's designed specifically for the common type of colorectal cancer (pMMR/MSS) to see if adding this immune therapy can help.
Beijing, ChinaAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.