Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,883 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio79
- Pennsylvania72
Recruiting studies7,883 total
- NCT04616131Recruiting
Testing ctDNA as a marker in pancreatic cancer treatment
This trial is studying a blood test that looks for tumor DNA (ctDNA) to see if it can help predict how well treatment is working in people with pancreatic cancer that hasn't spread. It is for patients getting chemotherapy before possible surgery.
DeKalb, IllinoisAges 18 years+ - NCT04617184Recruiting
Join an inflammatory bowel disease registry and sample bank
This study asks people with known or suspected inflammatory bowel disease to enroll in a registry and biorepository. It helps researchers better understand the condition using health information and stored biological samples.
Austin, TexasAges 18–100 - NCT04617522RecruitingPhase 1
Sacituzumab govitecan for advanced cancers with moderate liver issues
This Phase 1 study tests how safe and tolerable sacituzumab govitecan is for people with advanced or metastatic solid tumors who also have moderate liver impairment. It aims to find the right dosing so the treatment can be used more safely in this liver-risk group.
Long Beach, CaliforniaAges 18 years+ - NCT04622410Recruiting
Hirschsprung disease patient registry study
This study keeps a research record of people who have Hirschsprung disease and have had surgery. It helps doctors better understand long-term outcomes and care needs for future patients.
LeuvenAges Up to 18 years - NCT04622423Recruiting
Advanced therapies for colon or pancreas liver metastases
This study tests advanced treatments for cancer that has spread to the liver, either from colon cancer or pancreatic cancer. It may help by targeting liver tumors using treatment plans and, for some participants, liver tissue samples.
Milan, MilanAges 18 years+ - NCT04624490RecruitingPhase 1
Lung function MRI using a special gas in volunteers
This Phase 1 study tests a lung scan that uses a special gas and MRI to measure how well your lungs work. It includes healthy volunteers and people with lung disease to see how well the scan works and how safe it is.
Kansas City, KansasAges 3 years+ - NCT04624555Recruiting
Check how well stool DNA tests help watch for colon cancer return
This trial studies whether an at-home stool DNA test (Mt-sDNA) can safely and usefully monitor people after colon or rectal cancer treatment. It’s mainly about whether the test is practical and helpful during routine follow-up.
Cleveland, OhioAges 18 years+ - NCT04629014Recruiting
Quality of life study for kids with intestinal failure
This study looks at how children with intestinal failure feel and function day to day, using questionnaires. It aims to better understand quality of life to improve care for families managing specialized nutrition needs.
Birmingham, AlabamaAges 6 months–25 years - NCT04629326Recruiting
Imaging scan that targets PD-L1 in digestive cancer
This study tests an imaging method that looks for PD-L1 (a protein linked to some cancers) in solid tumors, including gastrointestinal cancers. It may help doctors better see where PD-L1 is in the body using a scan.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04633356RecruitingPhase 1/Phase 2
Measuring pressure in the liver using an endoscopy device
This early-phase study tests a technique to measure blood pressure changes in people with cirrhosis (scarring of the liver). It may help doctors better understand liver circulation problems and guide safer treatment decisions.
Hong Kong, Hong KongAges 18–75 - NCT04636008RecruitingPhase 1/Phase 2
Immunotherapy with radiation for MSI-H or dMMR rectal cancer
This trial tests the drug sintilimab combined with a specific radiation schedule to treat rectal cancer that is MSI-H or dMMR (tumor DNA repair/instability markers). It may help shrink the tumor and improve outcomes when standard options are limited or not yet started.
Chengdu, SichuanAges 18 years+ - NCT04637438Recruiting
Fecal transplant for Crohn’s around the small and large bowel
This trial studies fecal microbiota transplantation (a transplant of beneficial gut bacteria from a donor) to help people with Crohn’s disease that is causing narrowing (strictures) and/or abnormal tunnels (fistulas) and who need bowel surgery. You may qualify if you’re an adult, planning ileal/ileocecal surgery, and can complete the colonoscopy while not on certain gut-altering medicines.
TampereAges 18–120 - NCT04640753Recruiting
Checking people after POEM for achalasia
This trial looks at people who had a procedure called POEM for achalasia and want to understand outcomes after that treatment. If you’re an adult and already had POEM for achalasia, you may be able to join.
Dallas, TexasAges 18 years+ - NCT04641702RecruitingPhase 4
Testing new esophagus study tools for achalasia patients
This study tests detailed ways to measure esophagus movement and symptoms in people with achalasia or other esophagus motility disorders. It may help doctors better diagnose these conditions and improve how treatment planning and outcomes are tracked.
Atlanta, GeorgiaAges 18 years+ - NCT04643041Recruiting
Watch-and-wait after PD-1 for certain rectal cancer
This study looks at whether people with a very strong response to a PD-1 antibody can safely delay or avoid more standard rectal cancer treatment (a “watch-and-wait” approach). It may help some people avoid surgery, radiation, or ongoing treatment while still closely monitoring the cancer.
Guangzhou, GuangdongAges 18–80 - NCT04645160RecruitingPhase 1/Phase 2
Tivozanib for bile duct and gallbladder cancers after chemotherapy
This Phase 1/2 trial tests tivozanib (a targeted anti-cancer drug) in people with bile duct or gallbladder cancer that cannot be removed by surgery and has already been treated with first-line chemotherapy. The study looks at how well the drug works and how safe it is in this setting.
Bethesda, MarylandAges 18 years+ - NCT04647097Recruiting
Quit smoking and alcohol to prevent pancreatitis coming back
This trial is studying whether stopping alcohol and quitting smoking can help keep acute pancreatitis from returning. It’s for people whose pancreatitis happened because of alcohol, and who smoke every day.
PécsAges 18–80 - NCT04650243RecruitingPhase 4
Testing whether lowering UDCA helps people with PBC
This trial looks at whether slowly reducing UDCA (a medication for primary biliary cholangitis) is safe and still helpful in people whose liver tests have improved. It may help some patients avoid higher doses if their disease is well controlled.
BeijingAges 18 years+ - NCT04652180Recruiting
Robot surgery versus open surgery for esophagus cancer
This trial compares robot-assisted surgery with the standard open chest operation to remove esophagus and nearby tissue. It may help you understand which approach works better and is safer for patients whose cancer can be surgically removed.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT04653324Recruiting
Registry for people with diagnosed food allergies
This registry aims to collect information from people who already have a diagnosed food allergy. Joining may help researchers better understand food allergy patterns and needs.
McLean, VirginiaAges Any age - NCT04654975Recruiting
Metastatic brain tumors after esophagus surgery study
This study looks at people who had esophageal cancer surgery and later developed brain metastases. It may help doctors better understand who benefits from treatment planning after the original cancer surgery.
Houston, TexasAges Any age - NCT04657042Recruiting
4D MRI scans to guide lung or liver cancer radiation
This trial tests whether special “4D” MRI scans can improve precision radiation planning for people with lung or liver cancer. You may get MRI scan data to better account for tumor movement, alongside your usual radiation treatment.
Charlottesville, VirginiaAges 18–82 - NCT04661215Recruiting
Testing stomach opening muscle problems in people with gastroparesis
This study looks at whether abnormal function of the pyloric “stomach outlet” muscle is linked to gastroparesis symptoms (slow stomach emptying). It may help researchers better understand what causes symptoms and guide future treatments.
Scottsdale, ArizonaAges 18–85 - NCT04662918Recruiting
Test the CAGIB score to predict death in cirrhosis with bleeding
This study checks whether a score called CAGIB can accurately predict the risk of dying during the hospital stay for people with cirrhosis who have sudden bleeding in the digestive tract. It may help doctors identify who needs the most urgent care and monitor outcomes more accurately.
Scranton, PennsylvaniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,883 recruiting gastroenterology studies from the U.S. registry right now, out of 12,391 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.