Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT06225843RecruitingPhase 2
Testing a new drug combo before liver surgery for colorectal cancer
This trial is for people with colorectal cancer that has spread to the liver. It tests whether adding a new drug (sotevtamab) to standard chemotherapy (FOLFOX) before surgery can help shrink tumors and improve outcomes.
Montreal, QuebecAges 18 years+ - NCT06387147RecruitingPhase 3
Oral antibiotics for acute mesenteric ischemia
This trial tests whether taking oral antibiotics (gentamicin and metronidazole) can treat acute mesenteric ischemia caused by an artery blockage, instead of using IV antibiotics. It's for people who don't need emergency surgery and don't have a serious infection.
Clichy, FranceAges 18–90 - NCT06631001Recruiting
Abdominal massage for digestion in ICU patients on tube feeding
This study tests if gentle abdominal massage can improve digestion in intensive care patients who are on a breathing machine and receiving liquid food through a tube. It might help prevent gastrointestinal issues like bloating or slow digestion.
MersinAges 18 years+ - NCT06697964Recruiting
High resolution anuscopy study
This trial is studying high-resolution anuscopy (a detailed exam of the anal area) in people who are referred for this procedure. It aims to learn more about the findings and help improve care.
JetteAges 18 years+ - NCT06725433Recruiting
Nissen vs Dor repair for hiatal hernia
This trial compares two types of hiatal hernia repair: Nissen and Dor fundoplication. It aims to see which one works better for patients having keyhole surgery for a large hiatal hernia.
KuopioAges 18 years+ - NCT06812728RecruitingPhase 2
Chemo and radiation before surgery for advanced rectal cancer
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Shibīn al Kawm, MenoufiaAges 18–70 - NCT06819748Recruiting
Numbing medicine mix for less pain after gallbladder surgery
This trial tests a mixture of numbing medicines (ropivacaine cocktail) injected into the surgery area to reduce pain after gallbladder removal. It's for people having same-day laparoscopic surgery and aims to help you recover with less pain.
Chengdu, SichuanAges 18–70 - NCT07387549RecruitingPhase 3
Elafibranor for primary sclerosing cholangitis
This study tests a new medication called elafibranor for adults with primary sclerosing cholangitis (PSC), a chronic liver disease. It aims to see if elafibranor can safely help improve liver health when compared to no treatment.
Chandler, ArizonaAges 18–75 - NCT07389044RecruitingPhase 1
Testing a new treatment for chronic hepatitis B
This trial tests an investigational drug called IB-001 to see how well it works and how safe it is. It is for healthy volunteers and people with chronic hepatitis B. The goal is to find the best dose and understand side effects.
Hong KongAges 18–70 - NCT07385235RecruitingPhase 1
Safety and drug level study of AD-115 in healthy volunteers
This trial tests a new drug (AD-115A or AD-1151) in healthy volunteers to see how safe it is and how the body processes it. If you qualify, you'll receive a single dose and be monitored closely.
SeoulAges 19 years+ - NCT07382167RecruitingPhase 3
Study of Tenapanor for Chronic Constipation in Adults
This study tests an investigational drug called tenapanor for people with chronic idiopathic constipation (constipation with no clear cause). It aims to see if the drug can safely improve bowel movements in adults.
Foley, AlabamaAges 18–80 - NCT06833619Recruiting
A new way to get a liver biopsy using endoscopic ultrasound
This trial tests a new method for taking a small piece of liver tissue using a special ultrasound camera on a thin, flexible tube. It is for adults who need a liver biopsy because their liver function tests are not normal.
SohagAges 18–100 - NCT06405113RecruitingPhase 2
Fecal transplant, chemo, and immunotherapy for advanced stomach cancer
This trial tests a combination of fecal microbiota transplant (FMT), chemotherapy (SOX), and an immunotherapy drug (Sintilimab) as a first treatment for advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. The goal is to see if this combination can shrink tumors and improve outcomes.
ChangzhouAges 18–80 - NCT06397235RecruitingPhase 2
Combination therapy for large liver cancer tumors
This trial tests whether a combination of two treatments—chemoembolization (DEB-TACE) plus chemotherapy given through the liver artery (RALOX-HAIC)—works better than chemoembolization alone for people with large liver cancer tumors (over 7 cm). The goal is to see if the combination shrinks tumors more effectively.
Guangzhou, GuangdongAges 18–75 - NCT06836453Recruiting
New sweat test for cystic fibrosis diagnosis
This trial tests a new device that measures how your sweat glands react to a common asthma medication. It aims to better classify people with cystic fibrosis or related diseases, and also includes healthy volunteers and carriers.
BrusselsAges Any age - NCT06293378Recruiting
Sulfasalazine for liver fibrosis and cirrhosis
This study tests if sulfasalazine, a medicine already used for other conditions, is safe and helpful for people with liver scarring (fibrosis or cirrhosis). It is for patients with cirrhosis caused by certain liver diseases, like PBC, hepatitis B, hepatitis C, or alcohol use.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06287112Recruiting
Preventing gallbladder inflammation after bile duct drainage
This study tests whether a new drainage method can help prevent acute cholecystitis (inflammation of the gallbladder) in people who need a bile duct procedure. If you are at risk for gallbladder issues, this approach might reduce complications.
SeoulAges 19 years+ - NCT07385807Recruiting
Gut health and pregnancy in inflammatory bowel disease
This study looks at gut health in pregnant women with and without inflammatory bowel disease (IBD). It tracks a protein called calprotectin in stool samples, along with diet and baby health, to learn how IBD affects pregnancy and infant development.
Vancouver, British ColumbiaAges 19 years+ - NCT07381322Recruiting
Tracking rectal cancer response to immunotherapy with MRI scans
This study uses special MRI scans taken before and during immunotherapy to see if the cancer is truly growing or just appearing to grow, which is called 'pseudoprogression'. It helps doctors better understand how well the treatment is working for rectal cancer.
Guangzhou, GuangdongAges Any age - NCT07385196Recruiting
Understanding symptoms after ileorectal surgery
This study observes patients who have had a surgery connecting the small intestine to the rectum (ileorectal anastomosis) or who kept their rectum after colon surgery. Researchers want to better understand what symptoms these patients experience, which could help improve care.
DiyarbakırAges 18 years+ - NCT07384234RecruitingPhase 2
Testing a new drug plus chemo for stomach cancer with belly spread
This trial tests a new immunotherapy drug (SHR-1701) combined with chemotherapy for people with stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen (peritoneal metastasis) but not to other organs like the liver or lungs. The goal is to see if this combination can help shrink or control the cancer before any surgery.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07383935Recruiting
Stress ball use during chemotherapy for GI cancer patients
This study tests whether using a stress ball during chemotherapy helps patients with gastrointestinal cancer feel better. It may reduce stress or discomfort during treatment.
ArtvinAges 18 years+ - NCT07381634RecruitingPhase 2
Testing ondansetron to reduce immunotherapy side effects in liver cancer
This study tests whether adding ondansetron (a common anti-nausea drug) can reduce side effects from immunotherapy in people with liver cancer. If you are starting a specific combination treatment for liver cancer, you may be eligible.
Wenzhou, ZhejiangAges 18–80 - NCT07381660RecruitingPhase 3
SBRT vs. Surgery for small liver cancer
This trial compares two treatments—radiation (SBRT) and surgery—for people with a small liver tumor (≤5 cm) that hasn't spread. The goal is to see which treatment works better.
Guangzhou, GuangdongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.