Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07383701RecruitingPhase 2
Probiotic for diabetic macular edema
This trial tests whether a daily probiotic supplement (Lactiplantibacillus plantarum 299v) can help improve diabetic macular edema, a swelling in the back of the eye caused by diabetes. The goal is to see if adding this probiotic to your regular care could reduce swelling and protect your vision.
Boston, MassachusettsAges 18 years+ - NCT07388459Recruiting
Study of autoimmune atrophic gastritis over time
This study follows people with autoimmune atrophic gastritis to understand how the condition changes over time and what symptoms or complications may arise. It aims to collect information that could improve future care.
Pavia, PaviaAges 18 years+ - NCT07388615RecruitingPhase 2
Echinacea for cryptosporidiosis in children with weak immune systems
This trial tests whether the herb echinacea (Immulant) can help treat cryptosporidiosis, a diarrheal infection, in children aged 5 to 12 whose immune systems are weakened. It aims to find a safe and effective treatment for these children.
CairoAges 5–12 - NCT07387952Recruiting
Fecal transplant with nutrition help for chronic constipation
This trial tests if a fecal microbiota transplant combined with nutritional support can improve chronic constipation that hasn't gotten better with standard treatments. It's a small early study to see if the approach is safe and works.
BeijingAges 18–70 - NCT07383844Recruiting
Physical activity for teens with IBD
This study looks at what helps or stops teenagers with inflammatory bowel disease (Crohn's disease or ulcerative colitis) from being physically active. It involves completing questionnaires and an interview to understand your experience.
NiceAges 10–17 - NCT07385131Recruiting
Steroid before infliximab for inflammatory bowel disease
This study tests whether giving a steroid (dexamethasone) before an infliximab infusion can prevent allergic reactions in people with moderate-to-severe Crohn's disease or ulcerative colitis. If you qualify, you will receive either the steroid or a placebo before your infliximab treatment.
Hangzhou, ZhejiangAges 14–80 - NCT07382791Recruiting
Stomach emptying after pancreas surgery
This study looks at how the stomach empties after pancreas surgery. It aims to understand and possibly help with slow stomach emptying, a common issue after this operation.
Taipei, TaiwnAges 20–75 - NCT07381192Recruiting
AI system for diagnosing solid pancreatic lesions via endoscopy
This trial is testing an artificial intelligence (AI) system that helps doctors identify solid masses in the pancreas using images from a special endoscope (endoscopic ultrasound). The goal is to see if the AI can make a more accurate diagnosis than the standard approach.
Jinan, ShandongAges 18 years+ - NCT07385001RecruitingPhase 1/Phase 2
Ivonescimab with chemotherapy before surgery for esophageal cancer
This trial tests a new drug called Ivonescimab (AK112) combined with two chemotherapy drugs (Abraxane and cisplatin) given before surgery for esophageal cancer. The goal is to see if this combination can shrink tumors and improve surgery outcomes for patients with locally advanced disease.
Xi'an, ShannxiAges 18–75 - NCT07381985Enrolling by invitation
Managing hereditary cancer risk in rural areas
This study tests a way to help people with inherited cancer gene mutations manage their health, especially if they live in rural areas. You join if you found out about the mutation more than a year ago.
Burlington, VermontAges 18 years+ - NCT07388420Recruiting
Adding evolocumab to standard lipid-lowering therapy for hypertriglyceridemia-induced acute pancreatitis
This trial tests if adding a medication called evolocumab to usual cholesterol-lowering treatment helps people who have had a specific type of pancreatitis caused by very high triglycerides (a type of fat in the blood). It aims to reduce triglyceride levels and prevent another episode.
Shenyang, LiaoningAges 18–75 - NCT07386379Recruiting
Propofol infusion for nausea after heart bypass surgery
This study tests whether a continuous infusion of propofol (a common anesthesia medicine) during and after heart bypass surgery can reduce postoperative nausea and vomiting. If you are having planned bypass surgery and meet basic health criteria, this trial may help find a better way to feel more comfortable after your operation.
Istanbul, Outside of the USAges 18 years+ - NCT07386704Enrolling by invitationPhase 2
Nimotuzumab with chemo and radiation for advanced pancreatic cancer
This trial tests adding nimotuzumab (a targeted antibody) to standard chemoradiation for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18–80 - NCT07388121Recruiting
Vitamin C and gut health in healthy adults
This trial tests whether taking vitamin C supplements changes the bacteria in your gut and how well your gut works. If you are a healthy adult, you may be able to join.
GlasgowAges 18–65 - NCT07381322Recruiting
Tracking rectal cancer response to immunotherapy with MRI scans
This study uses special MRI scans taken before and during immunotherapy to see if the cancer is truly growing or just appearing to grow, which is called 'pseudoprogression'. It helps doctors better understand how well the treatment is working for rectal cancer.
Guangzhou, GuangdongAges Any age - NCT07381257RecruitingEarly Phase 1
Rifaximin for fatty liver disease
This trial tests if rifaximin, a gut medication, can help reduce liver fat in people with metabolic fatty liver disease. It may be an option if you have at least one metabolic risk factor and a certain amount of liver fat.
ShanghaiAges 18–75 - NCT07381764RecruitingPhase 2
Rechallenge with targeted drugs for certain colorectal cancers
This study tests a new approach for people with a specific type of metastatic colorectal cancer that has stopped responding to initial treatments. It compares reusing a targeted drug combination (irinotecan plus cetuximab) versus a different chemotherapy plus a targeted drug (trifluridine/tipiracil plus bevacizumab) to see which works better for patients whose tumors have a certain genetic profile.
AlessandriaAges 18 years+ - NCT07387263Recruiting
Digital tool for genetic testing in cancer care
This study tests a digital tool that helps cancer doctors offer genetic testing to more patients. If you've already had genetic testing started by your oncologist, you may be able to join.
Toronto, OntarioAges 18 years+ - NCT07385807Recruiting
Gut health and pregnancy in inflammatory bowel disease
This study looks at gut health in pregnant women with and without inflammatory bowel disease (IBD). It tracks a protein called calprotectin in stool samples, along with diet and baby health, to learn how IBD affects pregnancy and infant development.
Vancouver, British ColumbiaAges 19 years+ - NCT07382349Recruiting
Decision support tools for fatty liver disease
This study tests electronic tools to help doctors identify and care for patients with steatotic liver disease (fatty liver). If you have risk factors like diabetes or elevated liver enzymes, this trial may help improve your care.
Nashville, TennesseeAges 18 years+ - NCT07382999Recruiting
Gluten-free diet and thinking skills in teens with celiac disease
This study looks at how well teenagers with celiac disease can do two things at once, like thinking and moving, and whether sticking to a gluten-free diet helps. You will be compared to healthy teens to see if there are differences.
MalatyaAges 8–18 - NCT07388953Recruiting
Nerve block for better pain relief after colon surgery
This study tests adding a special nerve block (peripheral autonomic block) to a standard abdominal wall block to see if it provides better pain relief after minimally invasive left-sided colon surgery. It may help patients experience less pain and use fewer pain medications.
Belo Horizonte, Minas GeraisAges 18–80 - NCT07388264Recruiting
Probiotic for bloating and gut health
This study tests a probiotic (a good bacteria) called Weizmannia coagulans to see if it helps reduce bloating and improves gut health. Researchers will check how your digestion changes by looking at your stool and gut bacteria.
Saint Charles, MissouriAges 18–50 - NCT06219200Recruiting
Voice analysis for swallowing screening in neurological patients
This trial is testing if automatic voice analysis can help screen for swallowing problems in people with neurological conditions like stroke, Parkinson's disease, or ALS. It may help identify who needs further swallowing evaluation.
Lissone, LombardyAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.