Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,883 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio79
- Pennsylvania72
Recruiting studies7,883 total
- NCT04701476RecruitingPhase 2
Pembrolizumab for advanced colorectal or lung cancer
This study tests pembrolizumab (an immune system medicine) with another treatment (TATE) in people with advanced colorectal or lung cancer that is not driven by certain gene changes. It may help shrink tumors after standard chemotherapy has stopped working.
Orange, CaliforniaAges 18 years+ - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04701853Recruiting
Exercise training after permanent stoma surgery
This trial looks at a specific exercise program after planned surgery to create a permanent stoma (an opening for stool). The goal is to see whether the training helps people recover and function better after surgery.
GothenburgAges Any age - NCT04706234Recruiting
Check swallowing and voice function in neurodegenerative diseases
This study looks at how well the throat and voice-related functions work in people with certain long-term brain or nerve conditions. It uses a specific throat exam during FEES to better understand swallowing and laryngopharyngeal (throat-area) function.
Innsbruck, TyrolAges 18 years+ - NCT04706910RecruitingPhase 3
PET scan study to optimize imaging in several diseases
This trial improves a special PET scan (a type of brain/body imaging) using 18F-DOPA, to better show how certain conditions behave in the body. If you or your child may have one of the listed conditions, the study may help your doctors get clearer scan results.
Edmonton, AlbertaAges Any age - NCT04707976Recruiting
Smart anal irrigation vs standard care for bowel issues in MS
This study compares a smart device for transanal irrigation with regular bowel care in people with multiple sclerosis (MS) who have ongoing bowel problems. It aims to see if the smart irrigation approach improves bowel control and reduces symptoms.
AarhusAges 18 years+ - NCT04710758Recruiting
Keyhole surgery for advanced stomach cancer
This trial looks at laparoscopic (keyhole) total stomach removal for people with advanced stomach cancer in the upper or middle part of the stomach. It aims to see whether this operation approach is safe and useful based on your tumor stage and overall health.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04714957Recruiting
Personalized study for cancer spread in the belly lining
This trial studies people whose cancer has spread to the lining of the abdomen (the “belly lining”), including cancers from the digestive tract or ovaries. You may be asked to join because the study aims to learn how to better match care to different patterns of this belly lining cancer spread.
LyonAges 18 years+ - NCT04716257Recruiting
Study of treatment outcomes in ovarian-spread colorectal cancer
This study follows women with colorectal cancer that has spread to the ovaries to see how care works in real life. It may help doctors understand which patients benefit most and how treatment choices affect outcomes.
Guangzhou, GuangdongAges 18 years+ - NCT04715581Recruiting
Pre-surgery rehab program for frail older adults having stomach surgery
This trial studies a “prehabilitation” program—exercise and coaching before surgery—to help frail older adults recover better after major digestive cancer surgery. It may help you strengthen your body and function before the operation, which can improve outcomes after surgery.
Beijing, Beijing MunicipalityAges 65–89 - NCT04720456RecruitingPhase 2
Ultrasound test study for high pressure in liver veins in kids
This Phase 2 trial looks at a special ultrasound approach to better understand and measure portal hypertension—high pressure in the liver’s vein system—in children with long-term (chronic) liver disease. The results may help doctors track this condition more accurately and safely.
Philadelphia, PennsylvaniaAges 6–21 - NCT04720560Recruiting
Study how immune cells affect fatty liver disease
This study looks at how certain immune cells (“regulatory B cells”) may contribute to metabolic fatty liver disease. You might be able to join if you’re an adult with fatty liver but not pregnant and not on certain treatments.
AsyutAges 18–80 - NCT04721873RecruitingPhase 2
Weight-loss medicine for people with ulcerative colitis
This study tests whether a weight-loss medication, along with usual ulcerative colitis care, can help people who have both ulcerative colitis and obesity. It focuses on people with active symptoms or who need ongoing steroid medicine, and it also checks safety with heart, blood, infection, and mental-health screenings.
La Jolla, CaliforniaAges 18–80 - NCT04722341Recruiting
Time-limited eating for people with certain breast or rectal cancers
This study tests whether eating only within a shorter daily time window can improve cancer outcomes in people with specific breast or rectal cancers. It also looks at how this affects the body (such as metabolism) and who is most likely to benefit.
Birmingham, AlabamaAges 18 years+ - NCT04731272RecruitingPhase 2
Weekly GLP-1 medicine for blood sugar issues in adults with CF
This Phase 2 trial tests a weekly GLP-1 medicine (dulaglutide) to improve blood sugar control in adults with cystic fibrosis (CF) who have trouble managing glucose. It may help people with CF-related prediabetes or diabetes by improving how their body handles sugar.
Aurora, ColoradoAges 18 years+ - NCT04731558RecruitingPhase 4
Blood clot prevention before versus after liver surgery
This study compares two approaches to preventing blood clots around the time of liver surgery. If you’re having planned liver surgery, it may help doctors choose the safest timing and method for clot prevention.
HelsinkiAges 18 years+ - NCT04732546Recruiting
Study of reproductive health in women with uterine variations
This study looks at how certain uterine (womb) variations affect diagnosis, treatment choices, and reproductive outcomes. It may help doctors better understand these conditions and improve care for affected women.
Ghent, East FlandersAges Up to 45 years - NCT04732910Recruiting
Study of CFTR-modulator effects using body samples
This study looks at how well CFTR-modulator medicines are working in people with cystic fibrosis, by checking specific “biomarkers” (measurable signals) in samples. Your care team may use the results to better understand how these medicines help, especially for certain CFTR changes.
Berlin, State of BerlinAges 6 months+ - NCT04734821Recruiting
Fluorescent imaging during stomach or esophagus surgery
This study tests whether a special fluorescent camera during surgery can help surgeons better operate on resectable (removable) stomach or esophagus cancer. It may help improve how surgery is guided, with the goal of safer and more accurate tumor removal.
StrasbourgAges 18 years+ - NCT04735198Recruiting
Preventive gallbladder removal for midgut neuroendocrine tumors
This trial looks at whether removing the gallbladder before it causes problems can be helpful for people with midgut neuroendocrine tumors who are already planning primary tumor surgery. It may reduce future gallbladder-related complications around the time of cancer treatment.
Badalona, BarcelonaAges 18 years+ - NCT04739072Recruiting
Check colorectal cancer blood tests after curative treatment
This study measures “minimal residual disease,” meaning tiny amounts of cancer that may remain after surgery, using blood samples. It may help doctors better detect who is at higher risk of cancer coming back and guide follow-up care.
Gilbert, ArizonaAges 18 years+ - NCT04740346Recruiting
Study survival and quality of life by follow-up time after stomach surgery
This study looks at how long people with stage II or III stomach (gastric) cancer tend to live and how their day-to-day well-being changes over different follow-up times after surgery. It may help doctors understand the best follow-up schedule to support recovery.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT04740541Recruiting
Diet study for adult men with Crohn’s disease
This study looks at how a specific amino-acid (threonine) diet affects adults with Crohn’s disease and signs of intestinal inflammation. It may help researchers understand what dietary protein needs could support more stable disease.
Toronto, OntarioAges 18–49 - NCT04743102Recruiting
Multi-point full-thickness biopsy to confirm complete rectal cancer response
This trial checks whether taking small samples from the full thickness of rectal tissue can accurately confirm that rectal cancer has fully responded to chemotherapy and/or radiation. It may help doctors decide the best next step if no tumor is seen after treatment.
Beijing, Beijing MunicipalityAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,883 recruiting gastroenterology studies from the U.S. registry right now, out of 12,391 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.