Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07371273RecruitingPhase 2
Comparing three surgeries for low rectal cancer
This trial tests three different surgical methods for rectal cancer located very close to the anal canal. The goal is to see which method works best in the short and long term while preserving anal function.
ShanghaiAges 18–75 - NCT07370987RecruitingPhase 2
Preventing pancreatic fistula after surgery with pre-surgery radiation
This trial tests if a short course of radiation before surgery can lower the risk of a pancreatic leak (a common complication). It is for people who are overweight, older than 45, and have a small pancreatic duct.
ParisAges 45 years+ - NCT07376486Recruiting
Early treatment for type 2 diabetes using a new duodenal procedure
This study tests a new procedure called pulsENDO, which is done in the first part of the small intestine (the duodenum) to help treat type 2 diabetes. It may be an option for people who were recently diagnosed and have good blood sugar control with little or no diabetes medication.
ShatinAges 18–60 - NCT07378436RecruitingEarly Phase 1
Testing a new drug for cancer-related belly fluid
This early-phase trial tests an experimental drug called GK02 for people with advanced cancer who have fluid buildup in the belly (malignant ascites). The drug is given directly into the belly to try to reduce the fluid and control symptoms.
BeijingAges 18–75 - NCT07374185Recruiting
Bone marrow cells with Wharton gel for liver cirrhosis
This trial tests whether your own bone marrow cells, combined with a special gel from donated umbilical cords (Wharton's jelly exosomes), can help repair your liver. Researchers hope to improve liver function in people with cirrhosis.
Baghdad, IraqAges Up to 80 years - NCT07371663RecruitingPhase 1/Phase 2
TCC1727 combination therapy for advanced solid tumors
This trial tests a new drug, TCC1727, combined with other treatments for people with advanced solid tumors that have stopped responding to standard therapy. It aims to see if these combinations can help shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07379047RecruitingPhase 2/Phase 3
Testing NB003 for advanced GIST after prior treatments
This trial tests a new drug called NB003 for people with advanced GIST (a type of stomach or intestinal tumor) that has stopped responding to or could not be tolerated after standard treatments like imatinib or sunitinib. The goal is to see if NB003 can help shrink or control the tumor.
Hefei, AnhuiAges 18 years+ - NCT07377045RecruitingPhase 1
New combo for advanced pancreatic cancer
This trial tests a new drug (OMTX705) combined with standard chemotherapy (gemcitabine/nab-paclitaxel) and an immunotherapy (tislelizumab) for people with advanced pancreatic cancer. It may be an option if you have had little or no prior chemotherapy.
Boston, MassachusettsAges 18 years+ - NCT07377487Recruiting
TheraSphere for liver cancer before market in Japan
This trial tests a treatment called TheraSphere for people with liver cancer that hasn't responded to standard care or can't have it. TheraSphere uses tiny radioactive beads to target tumors in the liver, and this study is being done to get it approved in Japan.
Nishinomiya, HyōgoAges 18 years+ - NCT07373457RecruitingPhase 1
Testing a new drug in healthy volunteers
This early-stage study tests a new investigational drug called HW201877 in healthy volunteers. The goal is to see if the drug is safe and how the body processes it.
ChangchunAges 18–55 - NCT06756672Recruiting
Helping with recovery in laparoscopic colorectal surgery
This study looks at how a system called HPI (a way to track your body's response during surgery) might help people recover better after laparoscopic colorectal surgery. It is for people having this planned surgery who do not have serious heart or lung problems.
TaipeiAges 20 years+ - NCT06841484Recruiting
Robotic tools vs. human-assisted tools in stomach cancer surgery
This study tests two ways of using robotic tools during stomach cancer surgery: one where the surgeon controls all instruments from a console, and another where a human assistant operates some tools. It aims to see which method works better for patients having the lower part of the stomach removed.
SeoulAges 20 years+ - NCT06841406RecruitingPhase 4
Budesonide for chronic stomach discomfort after meals
This trial tests whether a medicine called budesonide can help people with a type of chronic stomach discomfort that gets worse after meals (functional dyspepsia). If you often feel full or bloated after eating and have had a normal stomach exam, this study may be a good fit for you.
LeuvenAges 18–70 - NCT02674100Recruiting
Registry for pancreatic cancer patients getting a specific ablation
This is a research registry that collects information from adults with pancreatic cancer who are treated with an ablation procedure called irreversible electroporation (IRE). It may help doctors better understand which patients benefit from this approach and how the treatment is used in real life.
Birmingham, AlabamaAges 18 years+ - NCT05473793Recruiting
Dried vegetables study for constipation and gut bacteria
This study tests whether eating a dried vegetable can improve bowel habits and change gut bacteria. It may help people who feel their bowel function is not working well and have hard or infrequent stools.
Wageningen, GelderlandAges 20–80 - NCT06713421Recruiting
Pronase to improve stomach cleanliness during endoscopy
This study tests whether a medicine called pronase, taken before an upper endoscopy (a scope test to look at your stomach), helps keep the stomach lining cleaner so the doctor can see better. If you are having a routine upper endoscopy, this might help make the exam more accurate.
ShanghaiAges 18–70 - NCT05989958RecruitingPhase 1/Phase 2
HepaCure for acute-on-chronic liver failure
This trial tests a new treatment called HepaCure for people with acute-on-chronic liver failure (a sudden worsening of liver function in someone with long-term liver disease). The goal is to see if it is safe and can help improve liver function.
Beijing, Beijing MunicipalityAges 18–65 - NCT06839716Recruiting
Comparing a numbing gel with standard pain block after stomach cancer surgery
This study tests a gel made of ropivacaine (a numbing medicine) in a special hydrogel to see if it works as well as the standard pain block injection (TAP block) for controlling pain after minimally invasive stomach cancer surgery. The gel is applied directly near the surgical wound.
SeoulAges 20 years+ - NCT07362706Enrolling by invitation
Extended breathing tube use for stomach cancer with sleep apnea
This trial looks at keeping a breathing tube in longer after stomach cancer surgery for patients who also have severe sleep apnea. The goal is to see if this helps with recovery and safety.
Jinan, ShandongAges 18–85 - NCT07365436Enrolling by invitation
Better colon imaging with a new probe
This trial tests a new camera probe that works with a standard colonoscope to take better images of the colon. It may help doctors find polyps or other issues more clearly during a routine colonoscopy.
Boston, MassachusettsAges 45–75 - NCT07364357RecruitingPhase 1
Study of CREPT-618 for advanced liver cancer
This phase 1 trial tests a new drug called CREPT-618 for people with advanced liver cancer that hasn't responded to standard treatments. The drug is designed to target cancer cells with specific markers (CREPT and ASGPR), so only patients whose tumors have these markers can join.
BeijingAges 18–75 - NCT07370311Recruiting
Support for Chinese American dementia caregivers on feeding choices
This study tests a decision aid designed to help Chinese American caregivers of older adults with dementia make feeding-related choices, especially near the end of life. It aims to support you in decisions about feeding options.
Austin, TexasAges 21–99 - NCT07365930Recruiting
TIPS treatment support for liver cancer patients on Atezo + Bev
This study looks at whether adding TIPS (a procedure to reduce fluid buildup) to standard immunotherapy (atezolizumab and bevacizumab) helps people with advanced liver cancer who also have cirrhosis. It's for patients whose cancer cannot be removed by surgery or has progressed after other local treatments.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT07366528RecruitingPhase 3
Comparing two chemo combos for stage III stomach cancer after surgery
This trial compares two chemotherapy combinations (oxaliplatin plus S-1 vs docetaxel plus S-1) for people with stage III stomach cancer who have had complete surgical removal of the tumor. The goal is to see which combination works better to prevent cancer from returning.
Shaoguan, GuandongAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.