Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07362654Recruiting
Gluten challenge study in kids with celiac disease
This study looks at how the immune system of children with celiac disease responds to a small amount of gluten. It may help researchers understand the disease better and find new ways to monitor it.
MálagaAges 8–14 - NCT07369830Recruiting
Probiotics for bowel function after rectal cancer surgery
This trial tests whether taking a probiotic supplement (Clostridium butyricum) can improve gut health and bowel function after surgery for very low rectal cancer. It may help patients who have a temporary ileostomy and are planning to have it reversed within 6 months.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07369414Recruiting
NTM Germs in CF Homes: A Household Study
This study looks at whether people with cystic fibrosis (CF) can pick up nontuberculous mycobacteria (NTM) from their home environment. It compares homes of people with CF who have NTM to those who don't, to see where germs might be hiding.
Borstel, Schleswig-HolsteinAges Any age - NCT07363304Recruiting
How ETI therapy affects body and gut in cystic fibrosis
This study looks at how the triple combination therapy (elexacaftor/tezacaftor/ivacaftor, or ETI) affects your body's metabolism, epigenetics, and gut bacteria in people with cystic fibrosis. It aims to understand the broader health benefits of this treatment.
Bari, BariAges 2 years+ - NCT07366528RecruitingPhase 3
Comparing two chemo combos for stage III stomach cancer after surgery
This trial compares two chemotherapy combinations (oxaliplatin plus S-1 vs docetaxel plus S-1) for people with stage III stomach cancer who have had complete surgical removal of the tumor. The goal is to see which combination works better to prevent cancer from returning.
Shaoguan, GuandongAges 18–80 - NCT07366138Recruiting
Nerve blocks for pain after sleeve gastrectomy surgery
This trial compares two ultrasound-guided nerve blocks to manage pain after laparoscopic sleeve gastrectomy. If you are having this weight-loss surgery, these blocks might help reduce your need for pain medicine and improve your recovery.
Banhā, BenhaAges 18–65 - NCT07364734Recruiting
Study of hard-to-treat Crohn's disease
This study looks at people with Crohn's disease that is hard to treat. It aims to understand the disease better and see how well current treatments work.
Guangzhou, GuangdongAges 18–65 - NCT07369531Recruiting
Stoma-free survival after new anal-sparing surgery for low rectal cancer
This study compares a two-stage surgical technique (Turnbull-Cutait pull-through) to standard surgery for people with low rectal cancer. The goal is to see which approach helps more patients avoid a permanent stoma (bag) after surgery.
Changchun, JilinAges 18–75 - NCT07363044Recruiting
Biologic selection guided by epigenetic markers in Crohn's disease
This trial compares two different ways to choose your Crohn's treatment: one based on a special test of your cells (epigenetic markers) and the other based on standard care. It aims to see which approach works better for people with moderate to severe Crohn's disease.
AntwerpAges 18 years+ - NCT07365527Recruiting
Ultrasound and Tumor Response in Colorectal Liver Metastases
This study is testing a new way to use ultrasound to help treat colorectal cancer that has spread to the liver. It may help doctors see how tumors respond to treatment.
CopenhagenAges 18 years+ - NCT07367516RecruitingPhase 1/Phase 2
A new study of TQB6411 for esophageal cancer
This study tests an experimental drug, TQB6411, for people with esophageal cancer that has come back or spread. It may be an option if previous treatments, including immunotherapy and chemotherapy, have stopped working or caused side effects.
Hefei, AnhuiAges 18–75 - NCT07370207RecruitingPhase 2
Study of AHB-137 for HBeAg negative chronic hepatitis B
This study tests a new medicine called AHB-137 for people with chronic hepatitis B who are HBeAg negative and currently on antiviral therapy. The goal is to see if it can help control the virus better or allow you to stop your current medication safely.
Fitzroy, VictoriaAges 18–65 - NCT07370740Recruiting
Bloat relief study for healthy women with frequent bloating
This trial tests a supplement called 'Bloat' to see if it reduces post-meal bloating in healthy women who often feel bloated. If you're a woman aged 18–65 with regular bloating, this study might help find a gentle solution.
London, OntarioAges 18–65 - NCT07368972RecruitingPhase 2
Study of DISC-0974-201 for IBD and Anemia
This trial tests a new medicine called DISC-0974-201 for people with inflammatory bowel disease and anemia. It aims to see if the drug can improve anemia symptoms and is for people with mild disease activity who have not responded well to standard treatments.
Birmingham, AlabamaAges 18 years+ - NCT07362186RecruitingPhase 3
LM-108 with Toripalimab vs Paclitaxel for advanced stomach cancer
This trial tests a new combination of two immunotherapy drugs (LM-108 and Toripalimab) against a standard chemotherapy drug (Paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has a specific marker called CCR8. It may be an option if you have already tried a first-line therapy and your cancer has progressed or you had side effects from chemotherapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07369505RecruitingPhase 1
A study of Sapu003 for advanced tumors sensitive to mTOR
This trial tests a new drug, Sapu003, in people with certain advanced cancers that may respond to mTOR-targeted therapy. It is looking at two groups: postmenopausal women with a type of breast cancer (HR+/HER2-), and adults with kidney, liver, neuroendocrine, or TSC-related tumors. The goal is to see if Sapu003 is safe and effective.
AdelaideAges 18 years+ - NCT06839209Recruiting
Add-on TOXCLEAN for recurrent C. difficile diarrhea
This trial tests an add-on treatment called TOXCLEAN for people with repeat C. difficile diarrhea. It aims to see if adding TOXCLEAN to standard antibiotics helps more than antibiotics alone.
RomaAges 18 years+ - NCT04970446RecruitingPhase 1/Phase 2
Fecal transplant to restore gut microbes in Crohn’s
This Phase 1/2 study tests whether a fecal microbiome transplant (FMT) can reduce active inflammation in people with Crohn’s disease. It’s designed for people who currently have signs of active bowel inflammation and can attend regular procedure visits.
Melbourne, VictoriaAges 18–70 - NCT04964310Recruiting
Testing genetic risk for acetaminophen-related liver injury
This study looks at whether certain genes can predict who is more likely to get liver injury after taking acetaminophen (also found in some cold/flu medicines). By comparing people who were affected with people who were not, it may help doctors identify higher-risk patients in the future.
Nanjing, JiangsuAges 14 years+ - NCT05461664Recruiting
Avapritinib for advanced GIST without PDGFRA exon 18 changes
This trial studies avapritinib, a targeted medicine, for people with advanced or returning gastrointestinal stromal tumors (GIST) whose tumor does not have PDGFRA exon 18 mutations. It aims to see how well the drug can shrink tumors or control the disease.
GuangzhouAges 18 years+ - NCT05464875Recruiting
Testing avapritinib for advanced GI stromal tumors
This study looks at how well avapritinib works and how safe it is for people with metastatic or unresectable gastrointestinal stromal tumors (GIST). It focuses on whether the tumor has certain marker and gene features and whether you can tolerate related medications.
GuangzhouAges 18 years+ - NCT05098847RecruitingPhase 2
Freezing liver tumors plus anti-cancer drugs for spread cancer
This trial tests whether freezing (cryoablation) liver metastases works better when combined with immunotherapy (sintilimab) and a targeted pill (lenvatinib). It’s for people whose cancer has spread to the liver and has not responded to earlier treatments.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT03957902RecruitingPhase 2
Aspirin blood markers to guide prevention after colon cancer
This Phase 2 trial studies how aspirin affects specific “biomarkers” (measurable body signals) in people newly diagnosed with colon or rectal cancer. The goal is to see whether aspirin-related changes can help design more personalized prevention treatment plans.
Zaragoza, ZaragozaAges 18–79 - NCT05057052RecruitingPhase 2
Freezing liver tumors with immunotherapy and a pill drug
This Phase 2 trial tests whether freezing (cryoablation) plus sintilimab (an immune system medicine) and regorafenib (a pill) can shrink colorectal cancer that has spread to the liver. It is for people whose cancer has come back or progressed after at least two prior chemotherapy treatments.
Shanghai, Shanghai MunicipalityAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.