Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05350371RecruitingPhase 1/Phase 2
Testing pirfenidone to treat severe acute pancreatitis
This early-stage hospital study tests whether pirfenidone is safe and tolerable for people with acute pancreatitis that may become severe. It may help by reducing the risk of complications, while researchers carefully track side effects.
Birmingham, AlabamaAges 18–85 - NCT05355363Recruiting
Check what happens after missed colon follow-up for colon polyps
This study looks at the risk of new or advanced colon findings in people who had certain colon polyp results, but then did not get the recommended follow-up colonoscopy on time. It may help doctors fine-tune how urgently different patients need repeat colon checks.
Montreal, QuebecAges 45–80 - NCT05356039Recruiting
Study of surgery options and quality of life in pancreatic cancer
This study looks at people with borderline-resectable or locally advanced pancreatic cancer to see how treatment choices affect survival, quality of life, and whether tumors can be removed by surgery. It may help doctors better predict who can benefit from surgical approaches and what outcomes matter most to patients.
UmeåAges 18 years+ - NCT05356117Recruiting
Exercise plus protein shakes for people with pancreatic cancer
This trial studies whether a supervised resistance exercise program combined with protein supplementation can help people with non-metastatic pancreatic cancer during chemotherapy. It may improve strength and how well you tolerate treatment, with safety monitoring throughout.
Boston, MassachusettsAges 18 years+ - NCT05357846RecruitingPhase 3
Check whether PD-1 treatment helps esophagus cancer before surgery
This Phase 3 trial tests whether adding a PD-1 medicine (sintilimab) to standard chemo-radiation before surgery improves outcomes for locally advanced esophageal squamous cell cancer. It may help by strengthening the immune response while shrinking the tumor before an operation.
Guangzhou, GuangdongAges 18–70 - NCT05358262RecruitingPhase 2
Heated, humid air during stem cell transplant to reduce mouth injury
This Phase 2 study tests whether breathing in warm, very humid air through your nose during stem cell transplant (with high-dose melphalan) can reduce painful mouth or throat injury. It may help your comfort and recovery during and after treatment.
Edmonton, AlbertaAges 18 years+ - NCT05359939Recruiting
MRI, CT, and PET scans compared for liver cancer
This study compares different scan types (MRI, CT, and two PET scans) in people with hepatocellular carcinoma (a primary liver cancer). It may help doctors figure out which scan gives the most useful information for diagnosis and treatment planning.
AarhusAges 18 years+ - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05361603Recruiting
Screening for hepatitis B, C, and HIV at the same time
This trial tests how acceptable it is for people who use services outside traditional clinics to be screened for hepatitis B, hepatitis C, and HIV during the same visit. If you join, you would be asked to participate and provide consent for the screening process.
Limoges, Haute VienneAges 18 years+ - NCT05361785Recruiting
Fecal transplant to help IBS food sensitivity
This study tests whether transferring gut bacteria from a healthy donor to a participant can reduce irritable bowel syndrome (IBS) symptoms related to food sensitivity. You may be asked to follow a low-FODMAP diet and receive a fecal microbiota transplant if you meet the study’s safety and health requirements.
Helsinki, Helsinki and UusimaaAges 18–75 - NCT05364788Recruiting
Study of tumor tissue in appendiceal cancer after surgery
This study looks at stored tumor samples to better understand appendiceal cancer that has spread to the lining of the abdomen (peritoneal metastases). Your tumor tissue from past procedures may help researchers learn more about the cancer and how it behaves.
ManchesterAges 18 years+ - NCT05365412Recruiting
Study of colon cancer in younger adults
This study looks at the clinic and lab features of colon cancer in people diagnosed at a young age. Your information from your diagnosis and treatment may help doctors understand how colon cancer differs by age.
Seongnam-si, Gyeonggi-doAges 18 years+ - NCT05366829RecruitingPhase 2
Tislelizumab after liver tumor radiation to reduce cancer return
This Phase 2 trial tests tislelizumab (an immunotherapy medicine) given after liver-directed radiation to help prevent hepatocellular carcinoma (liver cancer) from coming back or spreading. It may help by boosting the immune system to better control remaining cancer.
New Brunswick, New JerseyAges 18 years+ - NCT05366816RecruitingPhase 2
Blood test–guided sunitinib or regorafenib for GIST
This study uses a blood test (ctDNA) to look for specific tumor DNA changes, then guides treatment with sunitinib or regorafenib in people with GIST that has spread or cannot be removed by surgery. It aims to see whether this ctDNA-guided approach improves outcomes compared with standard decision-making.
Miami, FloridaAges 18 years+ - NCT05366881Recruiting
Blood test study to spot early cancer signal and cancer leftovers
This observational study checks whether a blood test (a “cfDNA” test) can detect early signs of cancer or small amounts of cancer left after treatment. It may help doctors use a simple blood sample to improve cancer detection and follow-up.
Duarte, CaliforniaAges 40 years+ - NCT05368168Recruiting
Early nerve stimulation to reduce rectal surgery after-effects
This trial tests whether starting a specific nerve stimulation treatment soon after rectal surgery can lower how often and how long a post-surgery bowel problem lasts. It may help patients recover with fewer symptoms after a low rectal anastomosis.
Vigo, PontevedraAges 18 years+ - NCT05368974Recruiting
Pregnancy registry for hepatitis C treatment timing
This study is a pregnancy registry that collects information about people who have hepatitis C during pregnancy and took hepatitis C medicines early in pregnancy. It aims to better understand the safety and outcomes of treatment around conception.
Atlanta, GeorgiaAges Any age - NCT05370144Recruiting
Pre-surgery chemotherapy and radiation for esophagus cancer
This study tests a new pre-surgery treatment plan that combines chemotherapy with focused, shorter-course radiation for esophagus or stomach-where-it-meets-the-esophagus (GEJ) adenocarcinoma. The goal is to shrink the tumor before surgery and improve treatment outcomes.
Calgary, AlbertaAges 18–80 - NCT05375370Recruiting
Testing a blood test to predict liver cancer coming back
This study checks whether a blood test (circulating tumor DNA) can help predict if hepatocellular carcinoma (HCC) will return after curative treatment like surgery or ablation. If it works, it may help doctors plan closer follow-up or earlier treatment if recurrence risk is higher.
RouenAges 18 years+ - NCT05375643Recruiting
Get help enrolling in a genomics-based cancer trial
This study helps support people who are from groups less represented in cancer genetics research to get enrolled in genomics-based cancer trials. If you’re starting a new patient visit for an advanced stomach, blood, or lung cancer, this may guide you through options that use your genetic information.
Boston, MassachusettsAges 18 years+ - NCT05377034RecruitingPhase 2
Y-90 and immunotherapy vs Y-90 plus placebo for liver cancer
This phase 2 study tests whether adding immunotherapy drugs (atezolizumab and bevacizumab) after Y-90 treatment works better and is safe compared with Y-90 followed by placebo. It is for people with liver cancer that has not spread outside the liver but is difficult to treat.
BeijingAges 21–99 - NCT05376592Recruiting
Study genes and weight loss in pancreatic cancer
This study looks at how a person’s genetic variations may relate to cancer-related weight loss (cachexia) in pancreatic cancer. It may help researchers better understand who is most at risk and guide future treatments.
Charlotte, North CarolinaAges 18 years+ - NCT05379595RecruitingPhase 1/Phase 2
Amivantamab for advanced colon or rectal cancer with specific tumor traits
This Phase 1/2 study tests amivantamab alone or combined with standard chemotherapy to treat advanced or metastatic colon or rectal cancer. You may be able to join if your tumor has the right genetic profile (typically “wild-type” for certain genes and no HER2 amplification) and your cancer has measurable or biopsy-able lesions.
Birmingham, AlabamaAges 18 years+ - NCT05379985RecruitingPhase 1/Phase 2
Test drug RMC-6236 for certain RAS mutations in advanced cancers
This trial tests whether RMC-6236 can treat advanced solid tumors that have specific RAS-related gene changes (especially certain KRAS G12 mutations). You may be able to join if your tumor’s DNA test shows the right mutation and your overall health is good enough for study visits.
Orange, CaliforniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.