Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05323929Recruiting
Checks how scar depth after stomach tumor removal affects healing
This study looks at early stomach cancer treated with ESD, a procedure to remove the tumor through the stomach lining, and how the depth of the scar relates to healing. It may help doctors predict better outcomes and improve the procedure for suitable patients.
Hangzhou, ZhejiangAges 18–75 - NCT05325424Recruiting
Laparoscopic spleen surgery for people with cirrhosis
This study looks at whether removing the spleen using keyhole surgery can improve “liver reserve function” in people with cirrhosis. It may be considered for patients who have an enlarged spleen and very low platelets, but it also has several safety exclusions.
Yangzhou, JiangsuAges 18 years+ - NCT05325437Recruiting
Laparoscopic spleen surgery to protect liver function in cirrhosis
This trial looks at whether a minimally invasive spleen surgery (with a specific vein-disconnection procedure) can better protect liver function in people with cirrhosis who have had variceal bleeding. It may help reduce stress on the liver after treatment, but you must meet several safety criteria.
Yangzhou, JiangsuAges 18 years+ - NCT05327517Recruiting
Surgery or chemo-radiation for cervical esophagus cancer
This study compares two ways to treat cervical esophagus squamous cell cancer: surgery alone versus chemo-radiation (chemotherapy plus radiation). It may help find the best approach to control the cancer while keeping side effects manageable.
BeijingAges 18–75 - NCT05327790RecruitingPhase 2
Fecal transplant to boost new biologic treatment for ulcerative colitis
This trial tests whether fecal microbiota transfer (a stool-based therapy) can improve outcomes when added to starting a new biologic medicine for ulcerative colitis. It compares fecal transplant versus placebo (a sham treatment) to see if symptoms and inflammation improve faster or more strongly.
Edmonton, AlbertaAges 18–75 - NCT05330923Recruiting
HIV and fatty liver check-in study with ultrasound follow-up
This study follows people with HIV who also have fatty liver disease and checks their health over time. It may help by improving monitoring and care planning, especially using ultrasound scans and regular follow-up.
Beijing, Beijing MunicipalityAges Any age - NCT05330910Recruiting
Repair of a stomach valve during sleeve weight-loss surgery
This trial tests whether doing a specific repair near the stomach valve (the gastroesophageal junction) during laparoscopic sleeve gastrectomy can help people with a loose valve. It is aimed at adults who have a particular endoscopy finding (Hill grade III) and choose this weight-loss surgery.
SingaporeAges 21–65 - NCT05331911RecruitingPhase 4
Propofol anesthesia vs sevoflurane for liver tumor surgery
This study compares two types of general anesthesia—propofol-based total intravenous anesthesia versus sevoflurane inhaled anesthesia—during planned surgery to remove liver tumors. The goal is to see whether the anesthesia choice affects long-term outcomes after partial liver removal for hepatocellular carcinoma.
Kaohsiung CityAges 20–80 - NCT05332002RecruitingPhase 2
Study chemotherapy plus immunotherapy for HER2-negative esophageal cancer
This Phase 2 trial tests a combination treatment called sFOLFOXIRI for advanced esophageal or stomach-area cancer that is HER2-negative. It aims to see how well the treatment works and whether it is safe for people who have not had standard chemotherapy for this metastatic cancer yet.
Hamilton, New JerseyAges 18 years+ - NCT05332613Recruiting
Diet and meal timing study for fatty liver
This study looks at whether changing when and how people eat can improve fatty liver disease caused by metabolic problems. It uses MRI to measure liver fat and compares outcomes while participants follow a structured eating schedule.
New York, New YorkAges 18–65 - NCT05332639Recruiting
Risk tracking test for Crohn’s disease in teens
This study checks whether a personalized tool can estimate someone’s risk for Crohn’s disease before symptoms start. It may help families learn early risk and decide on next steps sooner.
Boston, MassachusettsAges 14 years+ - NCT05334836Recruiting
Scan for fat in the pancreas and link it to cyst features
This study uses scans to measure how common “fatty change” is in the pancreas. It then looks at whether fatty change is related to specific features of pancreatic cysts (and may also include healthy people).
Shatin, New TerritoriesAges 18 years+ - NCT05335603Recruiting
Study of adults with liver conditions linked to fatty liver
This study looks at adults with different long-term liver conditions that are associated with fatty liver. It helps researchers better understand these diseases and factors linked to them.
HvidovreAges 18 years+ - NCT05336539Recruiting
Community screening study for colorectal cancer using methylation testing
This study recruits adults in Yangzhou to help screen for colorectal cancer risk using a lab test based on “methylation,” a way cells can carry disease-related changes. You would mainly complete a risk questionnaire and phone follow-ups, and agree to share any cancer diagnosis information during the study.
Yangzhou, JiangsuAges 40–74 - NCT05338294Recruiting
Tested surgery to help immune function in cirrhosis
This study looks at whether a type of keyhole spleen surgery plus cutting a large vein can improve immune function in people with cirrhosis. It may help reduce immune problems that can happen after complications like bleeding from varices (enlarged veins in the esophagus/stomach).
Yangzhou, JiangsuAges 18 years+ - NCT05339984Recruiting
MRI-based planning during liver surgery and related procedures
This study uses MRI imaging and computer modeling to better plan liver surgery and related liver treatments. It may help doctors predict circulation (blood flow) changes during surgery and choose safer surgical timing or approaches.
Villejuif, Val de MarneAges 18 years+ - NCT05343013RecruitingPhase 2
TAS-102 with or without celecoxib for leftover colon cancer DNA
This Phase 2 study tests TAS-102, with or without celecoxib, to treat “minimal residual disease” (tiny traces of colon cancer) found in a blood test after standard chemotherapy. The goal is to reduce the chance that colon cancer returns after treatment.
Houston, TexasAges 18 years+ - NCT05344339Recruiting
Compare two stomach reconstruction methods after stomach cancer surgery
This study compares two surgical reconstruction techniques after a distal gastrectomy (removing the lower part of the stomach) for gastric (stomach) cancer. It may help find which method leads to better recovery and outcomes after surgery.
Ho Chi Minh CityAges 18–80 - NCT05345613RecruitingPhase 4
Tranexamic acid during colon scope removal procedures
This trial tests whether tranexamic acid (a medicine that helps reduce bleeding) lowers bleeding during colon procedures where abnormal growths are removed with a flexible camera. You might benefit if you’re having one of these colonoscopic resection procedures and don’t have certain key risk factors.
Be’er Ya‘aqovAges 18 years+ - NCT05346393Recruiting
TIPS procedure for kidney failure in people with cirrhosis
This trial studies whether a liver procedure called TIPS can help people with cirrhosis who develop sudden kidney failure (HRS-AKI). It aims to improve kidney function and overall outcomes, but participation depends on several safety checks.
AachenAges 18–80 - NCT05346536Recruiting
Test blood test for a specific type of pancreatic cancer cell
This trial looks for pancreatic cancer markers in a blood sample (“liquid biopsy”), focusing on cells that show a certain protein (AXL). It may help doctors detect and better track advanced pancreatic cancer before or during first-line treatment.
MontpellierAges 18 years+ - NCT05346757Recruiting
Test stool DNA changes to screen or find colorectal cancer
This study checks whether a stool test that looks for tiny genetic signals can help detect colorectal cancer (or find it again after prior findings). You may be asked to provide a stool sample around the time you get a colonoscopy.
BarcelonaAges 18–80 - NCT05347524Recruiting
Blood test study to detect stomach cancer spread in the belly
This study checks whether a blood liquid biopsy test can detect when stomach cancer has spread to the lining of the abdomen (peritoneal metastasis). It compares people with confirmed belly spread to people whose belly lining tests were negative, using blood samples before/around treatment decisions.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT05349227Recruiting
After-cancer digital coaching and wearable tracking outcomes study
This study tests a digital health coaching program (using phone/tablet check-ins and wearable data) to understand health and quality-of-life outcomes after cancer treatment. It may help you learn healthy habits and track progress over time.
Gainesville, FloridaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.