Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05802459Recruiting
Check how two bowel-reconstruction options affect daily life
This study looks at how surgeons rebuild the esophagus using either a jejunum (small intestine) or a colon (large intestine) piece, and how that affects your day-to-day function and quality of life. It may help doctors choose the approach that best supports recovery and independence for patients needing esophageal reconstruction.
BarcelonaAges 18 years+ - NCT05803928RecruitingPhase 1
Ablation plus lenvatinib and anti-PD-1 to prevent liver cancer return
This early-phase study tests whether adding medicines to ablation (heating/freezing to destroy liver tumors) can keep liver cancer from coming back. It’s for people whose liver cancer recurred after prior surgery/ablation but still fits specific criteria, with the goal of improving disease control.
Guangzhou, GuangdongAges 18–75 - NCT05803382RecruitingPhase 1
Adding a new drug to capecitabine for metastatic colorectal cancer
This Phase 1 study tests a new anti-cancer drug (ZEN003694) added to the usual chemotherapy capecitabine. It is for adults with colorectal cancer (and possibly other cancers) that has spread or cannot be removed and has continued despite prior standard treatment.
Irvine, CaliforniaAges 18 years+ - NCT05804331Recruiting
Endoscopy treatment study for large upper stomach/throat lesions
This trial studies a specialized endoscopy procedure to remove larger abnormal growths in the upper digestive tract. It may help people whose lesion size and depth make certain removal techniques a better fit.
Sydney, New South WalesAges 18 years+ - NCT05803993Recruiting
Fecal transplant to ease constipation in irritable bowel syndrome
This trial tests whether transferring stool bacteria to the gut (fecal microbiota transplantation) can reduce symptoms of irritable bowel syndrome with constipation. It may help by changing the gut microbiome, but you must meet safety and health requirements.
RomaAges 18 years+ - NCT05803980Recruiting
Fecal transplant to ease IBS diarrhea symptoms
This study tests whether fecal microbiota transplantation (a stool-based treatment to change gut bacteria) can reduce symptoms of irritable bowel syndrome (IBS) that comes with diarrhea. You may be eligible if you’re an adult with diarrhea-predominant IBS and recent colonoscopy results that rule out other intestinal diseases.
RomaAges 18 years+ - NCT05805020Recruiting
Testing a camera tool to check Crohn’s bowel margins
This study looks at using a special handheld imaging tool during surgery to better check the edges (“margins”) of bowel removed for Crohn’s disease in the ileum/near the cecum. It may help surgeons ensure they remove the right tissue and potentially improve surgical planning.
AmiensAges 18 years+ - NCT05806931RecruitingPhase 2
Alternating two pills plus bevacizumab for advanced colon cancer
This Phase 2 study tests a treatment plan that alternates two cancer pills and adds bevacizumab (a blood-vessel drug) for metastatic colon cancer that has come back or worsened after standard treatment. It may help shrink tumors and slow disease growth after later-line therapy options.
Elizabeth, New JerseyAges 18 years+ - NCT05808036Recruiting
Test a diet app for IBS symptoms using the DOMINO diet
This trial studies whether a specific diet plan delivered through a phone app (the DOMINO diet) can improve symptoms in people with irritable bowel syndrome (IBS). It may help by changing what you eat to reduce gut symptoms, compared with standard care rules in the study.
LeuvenAges 18–70 - NCT05808712Recruiting
Study how cancer care feels when surgery is stopped
This study looks at the quality of cancer care and patient experience in people over 18 who have gastrointestinal cancer diagnoses. It especially focuses on situations where cancer surgery is aborted or stopped and asks patients to complete a Swedish questionnaire.
LinköpingAges 18 years+ - NCT05809869RecruitingPhase 2
Immunotherapy plus liver radiation for metastatic liver cancer
This trial tests whether combining an immunotherapy drug with a special type of liver radiation (yttrium-90) can control metastatic hepatocellular carcinoma (liver cancer that has spread). It may help by boosting your immune system and shrinking liver tumors at the same time.
Hong KongAges 18 years+ - NCT05810402Recruiting
Testing immunotherapy for advanced liver cancer using blood tests
This study looks at how well immune-checkpoint therapy (a PD-1 or PD-L1 immunotherapy) works for advanced liver cancer, using “liquid biopsy” blood testing to guide or monitor care. It may help your team better track your cancer and response without needing repeated tissue biopsies.
MontpellierAges 18 years+ - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT05815602RecruitingPhase 3
Ebastine vs mebeverine for non-constipation IBS
This Phase 3 study compares ebastine and mebeverine to see which works better for people with IBS that is not constipation-predominant. If you have IBS symptoms without an underlying intestinal disease, you may be offered one of these medicines and monitored for symptom improvement.
Antwerp, AntwerpenAges 18–65 - NCT05816915Recruiting
Lifestyle changes for fatty liver with metabolic health issues
This trial studies whether a lifestyle program can improve fatty liver disease in people who also have metabolic syndrome (a cluster of health problems like high blood sugar and cholesterol). It may help by improving liver health through diet, activity, and other lifestyle changes.
PragueAges 18 years+ - NCT05818072Recruiting
Biopsy approach study for Barrett-like esophagus changes
This study looks at how common certain esophagus lining changes are, what increases risk, and which biopsy sampling method works best. It may help improve how doctors take tissue samples when Barrett’s esophagus is suspected.
Kaohsiung CityAges 20 years+ - NCT05818319Recruiting
Tracking kidney urine effects after a short pause in CF therapy
This study checks how a common cystic fibrosis (CF) medicine affects urine markers after briefly stopping it and then restarting. The goal is to better understand whether the treatment shift changes kidney-related signals in people with CF.
Aarhus C, Central JutlandAges 18 years+ - NCT05821010RecruitingPhase 2
Synbiotics and fecal transplant for non-alcoholic liver inflammation
This Phase 2 study tests whether taking special gut-helping products (synbiotics) and/or a fecal microbiota transplant can improve non-alcoholic steatohepatitis (NASH), a type of liver inflammation. It may help by changing gut bacteria that may affect liver health, but you must meet specific safety and medical criteria.
Amsterdam, North HollandAges 18–75 - NCT05824403Recruiting
Pancreas disease study for non-cancer patients
This study follows people with certain inflammatory or cyst-related pancreas conditions to learn more about their health and outcomes. It may help improve understanding of these pancreas problems and guide better care.
ToulouseAges 18 years+ - NCT05824975RecruitingPhase 1/Phase 2
Test drug GI-102 alone or with cancer medicines
This Phase 1/2 study tests whether GI-102 is safe and can help shrink advanced solid tumors. It also looks at GI-102 used with standard cancer treatments like pembrolizumab or trastuzumab deruxtecan (T-DXd).
Scottsdale, ArizonaAges 18 years+ - NCT05827796RecruitingPhase 1/Phase 2
Testing IN10018 plus chemo with an added antibody in pancreatic cancer
This Phase 1/2 trial tests a new medicine (IN10018) and a specific added antibody (KN046) together with standard chemotherapy for advanced pancreatic cancer. It aims to see whether this combination can better control the cancer and how safely it can be given.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05828446Recruiting
Improving liver cancer screening for people at risk
This study looks at ways to improve screening for liver cancer in adults with long-term liver disease. It may help catch liver cancer earlier, which can make treatment easier.
Lausanne, Canton of VaudAges 18 years+ - NCT05829343Recruiting
Robotic versus laparoscopic surgery for left-sided diverticulitis
This trial compares robotic surgery versus laparoscopic surgery to remove part of the bowel for left-sided diverticulitis. It may help show which approach is safer or leads to better recovery for people needing elective or delayed-urgency surgery.
Grosseto, TuscanyAges 18 years+ - NCT05832229RecruitingPhase 2
Studying rosuvastatin to slow liver scarring in cirrhosis
This Phase 2 trial tests whether rosuvastatin (a cholesterol-lowering medicine) can improve how well the liver functions and slow worsening scarring in people with cirrhosis. It also checks for side effects and safety.
La Jolla, CaliforniaAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.